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Research Article

The stability of insulin in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol

Pages 743-756 | Published online: 29 Sep 2008

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Ravi Sheshala, Kok Khiang Peh & Yusrida Darwis. (2009) Preparation, characterization, and in vivo evaluation of insulin-loaded PLA–PEG microspheres for controlled parenteral drug delivery. Drug Development and Industrial Pharmacy 35:11, pages 1364-1374.
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Paul G Schmidt, Kathleen M Campbell, Kenneth D Hinds & Gary P Cook. (2007) PEGylated bioactive molecules in biodegradable polymer microparticles. Expert Opinion on Biological Therapy 7:9, pages 1427-1436.
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John G. Eley & Priyanka Mathew. (2007) Preparation and release characteristics of insulin and insulin-like growth factor-one from polymer nanoparticles. Journal of Microencapsulation 24:3, pages 225-234.
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Ming-Kung Yeh, Jiin-Long Chen, Chiao-Hsi Chiang & Zhi-Yang Chang. (2007) The preparation of sustained release erythropoietin microparticle. Journal of Microencapsulation 24:1, pages 82-93.
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Dinesh B. Shenoy, Reshma J. D'Souza, Sandip B. Tiwari & N. Udupa. (2003) Potential Applications of Polymeric Microsphere Suspension as Subcutaneous Depot for Insulin. Drug Development and Industrial Pharmacy 29:5, pages 555-563.
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Articles from other publishers (26)

Nisar Ul Khaliq, Dhawal Chobisa, Coralie A Richard, Monica R Swinney & Yoon Yeo. (2021) Engineering microenvironment of biodegradable polyester systems for drug stability and release control. Therapeutic Delivery 12:1, pages 37-54.
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Nirnoy Dan, Kamalika Samanta & Hassan Almoazen. (2020) An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in Adults and Pediatrics. Children 7:12, pages 307.
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Parker W. Lee & Jonathan K. Pokorski. (2018) Poly(lactic‐co‐glycolic acid) devices: Production and applications for sustained protein delivery. WIREs Nanomedicine and Nanobiotechnology 10:5.
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J. Hecq, K. Amighi & J. Goole. (2016) Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery. Journal of Drug Delivery Science and Technology 36, pages 192-200.
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Jiandong Zuo, Biqin Dong, Feng Xing, Chaoyun Luo & Dazhu Chen. (2016) Preparation of polystyrene/sodium monofluorophosphate microcapsules by W/O/W solvent evaporation method. Advanced Powder Technology 27:4, pages 1086-1092.
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Bhuvaneshwar Vaidya & Shubha Vaidya. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 757 775 .
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S. H. Gordon, A. A. Mohamed, R. E. Harry-Okuru & G. Biresaw. (2015) Identification and Measurement of Intermolecular Interaction in Polyester/Polystyrene Blends by FTIR-Photoacoustic Spectrometry. Journal of Polymers and the Environment 23:4, pages 459-469.
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Pei-Ting Ko, I-Chi Lee, Mei-Chin Chen & Shau-Wei Tsai. (2015) Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds. Journal of the Taiwan Institute of Chemical Engineers 51, pages 1-8.
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He Yang Jin, Fei Xia & Ya Ping Zhao. (2012) Preparation of hydroxypropyl methyl cellulose phthalate nanoparticles with mixed solvent using supercritical antisolvent process and its application in co-precipitation of insulin. Advanced Powder Technology 23:2, pages 157-163.
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Michael Hrynyk, Manuela Martins-Green, Annelise E. Barron & Ronald J. Neufeld. (2010) Sustained prolonged topical delivery of bioactive human insulin for potential treatment of cutaneous wounds. International Journal of Pharmaceutics 398:1-2, pages 146-154.
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A. Paillard-Giteau, V.T. Tran, O. Thomas, X. Garric, J. Coudane, S. Marchal, I. Chourpa, J.P. Benoît, C.N. Montero-Menei & M.C. Venier-Julienne. (2010) Effect of various additives and polymers on lysozyme release from PLGA microspheres prepared by an s/o/w emulsion technique. European Journal of Pharmaceutics and Biopharmaceutics 75:2, pages 128-136.
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Anchalee Jintapattanakit, Penchom Peungvicha, Achariya Sailasuta, Thomas Kissel & Varaporn Buraphacheep Junyaprasert. (2010) Nasal absorption and local tissue reaction of insulin nanocomplexes of trimethyl chitosan derivatives in rats. Journal of Pharmacy and Pharmacology 62:5, pages 583-591.
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Michael C. FlickingerI.A. Rasiah, N. Parlane, K. Grage, R. Palanisamy, A.C. Jahns, J.A. Atwood & B. H.A. Rehm. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 96 .
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Anchalee Jintapattanakit, Varaporn Buraphacheep Junyaprasert & Thomas Kissel. (2009) The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake. Journal of Pharmaceutical Sciences 98:12, pages 4818-4830.
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Xiaohong Wei, Yong-kyu Lee, Kang Moo Huh, Sungwon Kim & Kinam Park. 2009. Safety of Nanoparticles. Safety of Nanoparticles 63 88 .
Rajesh Singh, Shailesh Singh & James W. Lillard. (2008) Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins. Journal of Pharmaceutical Sciences 97:7, pages 2497-2523.
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A. Giteau, M.C. Venier-Julienne, A. Aubert-Pouëssel & J.P. Benoit. (2008) How to achieve sustained and complete protein release from PLGA-based microparticles?. International Journal of Pharmaceutics 350:1-2, pages 14-26.
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Anchalee Jintapattanakit, Varaporn B. Junyaprasert, Shirui Mao, Johannes Sitterberg, Udo Bakowsky & Thomas Kissel. (2007) Peroral delivery of insulin using chitosan derivatives: A comparative study of polyelectrolyte nanocomplexes and nanoparticles. International Journal of Pharmaceutics 342:1-2, pages 240-249.
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Ugo Bilati, Eric Allémann & Eric Doelker. (2005) Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. AAPS PharmSciTech 6:4, pages E594-E604.
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Ugo Bilati, Eric Allémann & Eric Doelker. (2005) Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microparticles. European Journal of Pharmaceutics and Biopharmaceutics 59:3, pages 375-388.
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G. Biresaw, C. J. Carriere & J. L. Willett. (2004) Interfacial adhesion in model bioblends. Journal of Applied Polymer Science 94:1, pages 65-73.
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Aaron C Foss, Takahiro Goto, Mariko Morishita & Nicholas A Peppas. (2004) Development of acrylic-based copolymers for oral insulin delivery. European Journal of Pharmaceutics and Biopharmaceutics 57:2, pages 163-169.
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M Stern, K Ulrich, D M Geddes & E W F W Alton. (2008) Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo. Gene Therapy 10:16, pages 1282-1288.
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V.R. Sinha & Aman Trehan. (2003) Biodegradable microspheres for protein delivery. Journal of Controlled Release 90:3, pages 261-280.
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