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Journal of Microencapsulation
Micro and Nano Carriers
Volume 21, 2004 - Issue 5
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Research Article

Encapsulation of insulin–cyclodextrin complex in PLGA microspheres: a new approach for prolonged pulmonary insulin delivery

M. M. G. Aguiar Laboratory of Pharmaceutical Technology of the Federal University of Minas Gerais, Av. Antônio Carlos, 6627, CEP: 31270010—Belo Horizonte— MG, Brazil
,
J. M. Rodrigues Jr Center for Tuberculosis Research, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, CEP 14390-900, Ribeirão Preto, SP, Brazil
&
A. Silva Cunha Laboratory of Pharmaceutical Technology of the Federal University of Minas Gerais, Av. Antônio Carlos, 6627, CEP: 31270010—Belo Horizonte— MG, BrazilCorrespondence[email protected]
Pages 553-564 | Received 10 Sep 2003, Accepted 02 Feb 2004, Published online: 03 Oct 2008

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Fernando Villaverde Cendon, Regina Maria Matos Jorge, Regina Weinschutz & Alvaro Luiz Mathias. (2018) Effect of matrix composition, sphere size and hormone concentration on diffusion coefficient of insulin for controlled gastrointestinal delivery for diabetes treatment. Journal of Microencapsulation 35:1, pages 13-25.
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Pratap C. Naha, V. Kanchan, P. K. Manna & Amulya K. Panda. (2008) Improved bioavailability of orally delivered insulin using Eudragit-L30D coated PLGA microparticles. Journal of Microencapsulation 25:4, pages 248-256.
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Elsie E. Gaskell, Glyn Hobbs, Christopher Rostron & Gillian A. Hutcheon. (2008) Encapsulation and release of α-chymotrypsin from poly(glycerol adipate-co-ω-pentadecalactone) microparticles. Journal of Microencapsulation 25:3, pages 187-195.
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S. N. Jayasinghe. (2007) Submerged electrosprays: A versatile approach for microencapsulation. Journal of Microencapsulation 24:5, pages 430-444.
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Maite Estevan, Carlos Gamazo, Gustavo González-Gaitano & Juan M. Irache. (2006) Optimization of the entrapment of bacterial cell envelope extracts into microparticles for vaccine delivery. Journal of Microencapsulation 23:2, pages 169-181.
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Jigar Raval, Riddhi Trivedi, Sonali Suman, Arvind Kukrety & Prajesh Prajapati. (2022) Nano-biotechnology and its Innovative Perspective in Diabetes Management. Mini-Reviews in Medicinal Chemistry 22:1, pages 89-114.
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Michael K. Danquah & Jaison Jeevanandam. 2022. Emerging Nanomedicines for Diabetes Mellitus Theranostics. Emerging Nanomedicines for Diabetes Mellitus Theranostics 33 57 .
Rosita Primavera, Elena Bellotti, Daniele Di Mascolo, Martina Di Francesco, Jing Wang, Bhavesh D. Kevadiya, Angelo De Pascale, Avnesh S. Thakor & Paolo Decuzzi. (2021) Insulin Granule-Loaded MicroPlates for Modulating Blood Glucose Levels in Type-1 Diabetes. ACS Applied Materials & Interfaces 13:45, pages 53618-53629.
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Stephanie Fuchs, Alexander U. Ernst, Long-Hai Wang, Kaavian Shariati, Xi Wang, Qingsheng Liu & Minglin Ma. (2020) Hydrogels in Emerging Technologies for Type 1 Diabetes. Chemical Reviews 121:18, pages 11458-11526.
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. 2021. Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II). Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II) 246 292 .
Xinyuan Xu, Hui Shang, Tianyu Zhang, Panjing Shu, Yanpeng Liu, Jing Xie, Dongyue Zhang, Hong Tan & Jianshu Li. (2018) A stimuli-responsive insulin delivery system based on reversible phenylboronate modified cyclodextrin with glucose triggered host-guest interaction. International Journal of Pharmaceutics 548:1, pages 649-658.
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Phatsawee Jansook, Noriko Ogawa & Thorsteinn Loftsson. (2018) Cyclodextrins: structure, physicochemical properties and pharmaceutical applications. International Journal of Pharmaceutics 535:1-2, pages 272-284.
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Feng Wan & Mingshi Yang. (2016) Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying. International Journal of Pharmaceutics 498:1-2, pages 82-95.
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Nicole A. Beinborn & Robert O. WilliamsIIIIII. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 2835 2853 .
Ran Mo, Tianyue Jiang, Jin Di, Wanyi Tai & Zhen Gu. (2014) Emerging micro- and nanotechnology based synthetic approaches for insulin delivery. Chemical Society Reviews 43:10, pages 3595.
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Feng Wan, Jian X. Wu, Adam Bohr, Stefania G. Baldursdottir, Morten Jonas Maltesen, Simon Bjerregaard, Camilla Foged, Jukka Rantanen & Mingshi Yang. (2013) Impact of PLGA molecular behavior in the feed solution on the drug release kinetics of spray dried microparticles. Polymer 54:21, pages 5920-5927.
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Jin-Seok Choi, Kyuhwa Seo & Jin-Wook Yoo. (2012) Recent advances in PLGA particulate systems for drug delivery. Journal of Pharmaceutical Investigation 42:3, pages 155-163.
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Phatsawee Jansook, Marcus E. Brewster & Thorsteinn Loftsson. 2011. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine 145 158 .
L. Belhadj Salem, C. Bosquillon, L.A. Dailey, L. Delattre, G.P. Martin, B. Evrard & B. Forbes. (2009) Sparing methylation of β-cyclodextrin mitigates cytotoxicity and permeability induction in respiratory epithelial cell layers in vitro. Journal of Controlled Release 136:2, pages 110-116.
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Jaber Emami, Hamed Hamishehkar, Abdolhossien Rouholamini Najafabadi, Kambiz Gilani, Mohsen Minaiyan, Hamid Mahdavi & Ali Nokhodchi. (2009) A Novel Approach to Prepare Insulin-Loaded Poly (Lactic-Co-Glycolic Acid) Microcapsules and the Protein Stability Study. Journal of Pharmaceutical Sciences 98:5, pages 1712-1731.
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Sunday A. Shoyele. 2008. Drug Delivery Systems. Drug Delivery Systems 141 148 .
Ana Francisca SoaresRui de Albuquerque CarvalhoFrancisco Veiga. (2007) Oral administration of peptides and proteins: nanoparticles and cyclodextrins as biocompatible delivery systems. Nanomedicine 2:2, pages 183-202.
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Ye Wang, Jian-Qing Gao, Feng Li, Sang-Hon RI & Wen-Quan Liang. (2006) Triblock copolymer Pluronic®F127 sustains insulin release and reduces initial burst of microspheres—in vitro and in vivo study. Colloid and Polymer Science 285:2, pages 233-238.
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Ingrid J. Castellanos, Giselle Flores & Kai Griebenow. (2006) Effect of cyclodextrins on α-chymotrypsin stability and loading in PLGA microspheres upon S/O/W encapsulation. Journal of Pharmaceutical Sciences 95:4, pages 849-858.
Crossref
John S. Dunn, Rajiv Nayar, Jackie Campos, Brooks M. Hybertson, Yue Zhou, Mark Cornell Manning, John E. Repine & Kathleen A. Stringer. (2005) Feasibility of Tissue Plasminogen Activator Formulated for Pulmonary Delivery. Pharmaceutical Research 22:10, pages 1700-1707.
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