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Journal of Microencapsulation
Micro and Nano Carriers
Volume 24, 2007 - Issue 4
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Research Article

Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-κB

Carl W. Oettinger MD College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA
,
Martin J. D'souza College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA
,
Nima Akhavein College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA
,
Glenn T. Peer University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
,
Fletcher B. Taylor University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
&
Gary T. Kinasewitz University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Pages 337-348 | Received 28 May 2006, Accepted 01 Sep 2006, Published online: 08 Oct 2008

Citations (19)

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Read on this site (11)

Neil Patel, Richard T. Addo, Ruhi Ubale, Mohammed Nasir Uddin, Martin D’Souza & Lynetta Jobe. (2014) The effect of antisense to NF-κB in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats. Journal of Drug Targeting 22:9, pages 796-804.
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Gerald G Enriquez, Syed AA Rizvi, Martin J D’Souza & Duc P Do. (2013) Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy. International Journal of Nanomedicine 8, pages 1393-1402.
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Mohammad Nasir Uddin, Neil J. Patel, Tuhin Bhowmik, Bernadette D’Souza, Archana Akalkotkar, Frank Etzlar, Carl William Oettinger & Martin D’Souza. (2013) Enhanced bioavailability of orally administered antisense oligonucleotide to nuclear factor kappa B mRNA after microencapsulation with albumin. Journal of Drug Targeting 21:5, pages 450-457.
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Carl W. Oettinger & Martin J. D'souza. (2012) Microencapsulated drug delivery: a new approach to pro-inflammatory cytokine inhibition. Journal of Microencapsulation 29:5, pages 455-462.
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Mohammad N. Uddin, Aladin Siddiq, Carl W. Oettinger & Martin J. D’Souza. (2011) Potentiation of pro-inflammatory cytokine suppression and survival by microencapsulated dexamethasone in the treatment of experimental sepsis. Journal of Drug Targeting 19:9, pages 752-760.
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Carl W. Oettinger & Martin J. D'Souza. (2010) Synergism in survival to endotoxic shock in rats given microencapsulated CNI-1493 and antisense oligomers to NF-κB. Journal of Microencapsulation 27:4, pages 372-376.
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Sanjay G. Gayakwad, Naveen K. Bejugam, Nima Akhavein, Nasir A. Uddin, Carl E Oettinger & Martin J. D'Souza. (2009) Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-κB encapsulated albumin microspheres. Journal of Microencapsulation 26:8, pages 692-700.
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Rodney C. Siwale, George K. Yeboah, Richard Addo, Carl W. Oettinger & Martin J. D’Souza. (2009) The effect of intracellular antioxidant delivery (catalase) on hydrogen peroxide and proinflammatory cytokine synthesis: a new therapeutic horizon. Journal of Drug Targeting 17:9, pages 710-718.
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Rodney C. Siwale, Carl W. Oettinger, Richard Addo, Aladin Siddig & Martin J. D’Souza. (2009) The effect of intracellular delivery of catalase and antisense oligonucleotides to NF-κB using albumin microcapsules in the endotoxic shock model. Journal of Drug Targeting 17:9, pages 701-709.
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Pawan K. Angra, Carl Oettinger, S. Balakrishna Pai & Martin J. D’Souza. (2009) Amphotericin B microspheres: A therapeutic approach to minimize toxicity while maintaining antifungal efficacy. Journal of Microencapsulation 26:7, pages 580-587.
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Nima Akhavein, Carl W. Oettinger, Sanjay G. Gayakwad, Richard T. Addo, Naveen K. Bejugam, John D. Bauer, Duc Do, Stanley H. Pollock & Martin J. D'souza. (2009) Treatment of adjuvant arthritis using microencapsulated antisense NF-κB oligonucleotides. Journal of Microencapsulation 26:3, pages 223-234.
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Articles from other publishers (8)

Aboagyewaah Oppong-Damoah, Rokon Uz Zaman, Martin J. D'Souza & Kevin Sean Murnane. (2019) Nanoparticle encapsulation increases the brain penetrance and duration of action of intranasal oxytocin. Hormones and Behavior 108, pages 20-29.
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Rokon Uz Zaman, Nihal S. Mulla, Keegan Braz Gomes, Cherilyn D'Souza, Kevin Sean Murnane & Martin J. D'Souza. (2018) Nanoparticle formulations that allow for sustained delivery and brain targeting of the neuropeptide oxytocin. International Journal of Pharmaceutics 548:1, pages 698-706.
Crossref
Ruhi V. Ubale, Prathap Nagaraja Shastri, Carl Oettinger & Martin J. D’Souza. (2018) Pulmonary Administration of Microparticulate Antisense Oligonucleotide (ASO) for the Treatment of Lung Inflammation. AAPS PharmSciTech 19:4, pages 1908-1919.
Crossref
V. G. Metelev, E. A. Kubareva & T. S. Oretskaya. (2013) Regulation of activity of transcription factor NF-κB by synthetic oligonucleotides. Biochemistry (Moscow) 78:8, pages 867-878.
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Rodney Siwale, Fred Meadows, Vicky V Mody & Samit Shah. (2013) Formulation and drug-content assay of microencapsulated antisense oligonucleotide to NF- κ B using ATR-FTIR . Advances in Natural Sciences: Nanoscience and Nanotechnology 4:3, pages 035002.
Crossref
Pawan Kumar Angra, Syed Asad Ali Rizvi, Carl William Oettinger & Martin Joaquim D’Souza. (2011) Novel approach for preparing nontoxic stealth microspheres for drug delivery. European Journal of Chemistry 2:2, pages 125-129.
Crossref
D. J. Stearns-Kurosawa, Valta Collins, Scott Freeman, Vernon L. Tesh & Shinichiro Kurosawa. (2010) Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli . Infection and Immunity 78:6, pages 2497-2504.
Crossref
Mohammad N. Uddin, Duc P. Do, S. Balakrishna Pai, Sanjay Gayakwad, Carl W. Oettinger & Martin J. D'Souza. (2009) A methodology for quantitation and characterization of oligonucleotides in albumin microspheres. The Analyst 134:7, pages 1483.
Crossref

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