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Research Article

Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

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Pages 421-425 | Received 16 Nov 2007, Accepted 04 Mar 2008, Published online: 08 Oct 2008

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Read on this site (5)

Alesya A. Fokina, Boris P. Chelobanov, Masayuki Fujii & Dmitry A. Stetsenko. (2017) Delivery of therapeutic RNA-cleaving oligodeoxyribonucleotides (deoxyribozymes): from cell culture studies to clinical trials. Expert Opinion on Drug Delivery 14:9, pages 1077-1089.
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Alesya A Fokina, Dmitry A Stetsenko & Jean-Christophe François. (2015) DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes. Expert Opinion on Biological Therapy 15:5, pages 689-711.
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Matthew L Broadhead, Jonathan CM Clark, Peter FM Choong & Crispin R Dass. (2010) Making gene therapy for osteosarcoma a reality. Expert Review of Anticancer Therapy 10:4, pages 477-480.
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Dennis PM Hughes. (2009) Strategies for the targeted delivery of therapeutics for osteosarcoma. Expert Opinion on Drug Delivery 6:12, pages 1311-1321.
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Mei Lin Tan, Peter FM Choong & Crispin R Dass. (2009) DNAzyme Delivery Systems: Getting Past First Base. Expert Opinion on Drug Delivery 6:2, pages 127-138.
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Articles from other publishers (23)

Lang Xiao, Yan Zhao, Meng Yang, Guangxin Luan, Ting Du, Shanshan Deng & Xu Jia. (2023) A promising nucleic acid therapy drug: DNAzymes and its delivery system. Frontiers in Molecular Biosciences 10.
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I. B. K. Thomas, K. A. P. Gaminda, C. D. Jayasinghe, D. T. Abeysinghe & R. Senthilnithy. (2021) DNAzymes, Novel Therapeutic Agents in Cancer Therapy: A Review of Concepts to Applications. Journal of Nucleic Acids 2021, pages 1-21.
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Chun Yuen Jerry Wong, Hani Al-Salami & Crispin R Dass. (2021) β-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption. Journal of Pharmacy and Pharmacology 73:6, pages 726-739.
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Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia & Bahman Yousefi. (2021) Chitosan applications in studying and managing osteosarcoma. International Journal of Biological Macromolecules 169, pages 321-329.
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Mohammad Moradi, Mansoreh Abdolhosseini, Ali Zarrabi & Behrooz johari. (2019) A review on application of Nano-structures and Nano-objects with high potential for managing different aspects of bone malignancies. Nano-Structures & Nano-Objects 19, pages 100348.
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Levon M. Khachigian. (2019) Deoxyribozymes as Catalytic Nanotherapeutic Agents. Cancer Research 79:5, pages 879-888.
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Fatemeh Farrokhi, Zahra Karami, Saeed Esmaeili-Mahani & Abolfazl Heydari. (2018) Delivery of DNAzyme targeting c-Myc gene using β-cyclodextrin polymer nanocarrier for therapeutic application in human breast cancer cell line. Journal of Drug Delivery Science and Technology 47, pages 477-484.
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Shu-Pin Sun, Ching-Ping Liu, I-Ping Huang, Chia-Hui Chu, Ming-Fang Chung, Shih-Hsun Cheng, Shu-Yi Lin & Leu-Wei Lo. (2017) A co-delivery nanosystem of chemotherapeutics and DNAzyme overcomes cancer drug resistance and metastasis. Nano Futures 1:3, pages 035005.
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Aylin ŞENDEMİR ÜRKMEZ, Ece BAYIR, Eyüp BİLGİ & Mehmet Özgün ÖZEN. (2017) Biocompatible polymeric coatings do not inherently reducethe cytotoxicity of iron oxide nanoparticles. TURKISH JOURNAL OF BIOLOGY 41, pages 322-332.
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Shivangi Goyal, Nidhi Gupta & Ramesh Chandra. 2017. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids 151 164 .
Anna M Friedhuber, Vijay Chandolu, Somkamon Manchun, Osaana Donkor, Pornsak Sriamornsak & Crispin R Dass. (2015) Nucleotropic doxorubicin nanoparticles decrease cancer cell viability, destroy mitochondria, induce autophagy and enhance tumour necrosis. Journal of Pharmacy and Pharmacology 67:1, pages 68-77.
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Peter F. M. Choong. (2014) New Medical/Biologic Paradigms in the Treatment of Bone Tumors. Current Surgery Reports 2:6.
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Khaleelulla Saheb Shaik & Bernard Moussian. 2013. Handbook of Biopolymer‐Based Materials. Handbook of Biopolymer‐Based Materials 109 142 .
Mei Lin Tan, Anna M Friedhuber & Crispin R Dass. (2013) Co-nanoencapsulated doxorubicin and Dz13 control osteosarcoma progression in a murine model. Journal of Pharmacy and Pharmacology 65:1, pages 35-43.
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Claudia Philippi, Brigitta Loretz, Ulrich F. Schaefer & Claus‐Michael Lehr. 2012. Chitosan‐Based Systems for Biopharmaceuticals. Chitosan‐Based Systems for Biopharmaceuticals 381 392 .
Soo-Hyun KimCrispin R. Dass. (2012) Induction of Caspase-2 Activation by a DNA Enzyme Evokes Tumor Cell Apoptosis. DNA and Cell Biology 31:1, pages 1-7.
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Mina Elahy & Crispin R. Dass. (2011) Dz13: c-Jun Downregulation and Tumour Cell Death. Chemical Biology & Drug Design 78:6, pages 909-912.
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Mei Lin Tan, Peter FM Choong & Crispin R Dass. (2010) Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours. Cancer Cell International 10:1.
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Mei Lin Tan, Dave E. Dunstan, Anna M. Friedhuber, Peter F.M. Choong & Crispin R. Dass. (2010) A nanoparticulate system that enhances the efficacy of the tumoricide Dz13 when administered proximal to the lesion site. Journal of Controlled Release 144:2, pages 196-202.
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Crispin R. DassMei Lin TanStuart J. GallowayPeter F.M. Choong. (2010) Dz13 Induces a Cytotoxic Stress Response with Upregulation of E2F1 in Tumor Cells Metastasizing to or from Bone. Oligonucleotides 20:2, pages 79-91.
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Crispin R. DassPeter F.M. Choong. (2010) Sequence-Related Off-Target Effect of Dz13 Against Human Tumor Cells and Safety in Adult and Fetal Mice Following Systemic Administration. Oligonucleotides 20:2, pages 51-60.
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Dmitri Simberg, Wan-Ming Zhang, Sergei Merkulov, Keith McCrae, Ji-Ho Park, Michael J. Sailor & Erkki Ruoslahti. (2009) Contact activation of kallikrein–kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo. Journal of Controlled Release 140:3, pages 301-305.
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Hang T. Ta, Crispin R. Dass, Peter F. M. Choong & Dave E. Dunstan. (2009) Osteosarcoma treatment: state of the art. Cancer and Metastasis Reviews 28:1-2, pages 247-263.
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