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Research Article

Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia

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Pages 153-164 | Published online: 09 Jul 2009

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Claudia Geanina Farcas, Cristina Dehelean, Iulia Andreea Pinzaru, Marius Mioc, Vlad Socoliuc, Elena-Alina Moaca, Stefana Avram, Roxana Ghiulai, Dorina Coricovac, Ioana Pavel, Praveen Kumar Alla, Octavian Marius Cretu, Codruta Soica & Felicia Loghin. (2020) Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions. International Journal of Nanomedicine 15, pages 8175-8200.
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René Csuk. (2014) Betulinic acid and its derivatives: a patent review (2008 – 2013). Expert Opinion on Therapeutic Patents 24:8, pages 913-923.
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Articles from other publishers (19)

Ga Yeong Yi, Min Ju Kim, Hyo In Kim, Jinbong Park & Seung Ho Baek. (2022) Hyperthermia Treatment as a Promising Anti-Cancer Strategy: Therapeutic Targets, Perspective Mechanisms and Synergistic Combinations in Experimental Approaches. Antioxidants 11:4, pages 625.
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Dorina Coricovac, Iulia Pînzaru, Ștefana Avram, Ioana Macașoi, Codruța Șoica & Cristina Dehelean. (2020) In Vitro and In Ovo Assessment of Betulinic Acid Antimelanoma Effect. Timisoara Medical Journal 2020:1, pages 1.
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Anna Hordyjewska, Aleksandra Ostapiuk, Anna Horecka & Jacek Kurzepa. (2019) Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential. Phytochemistry Reviews 18:3, pages 929-951.
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Mohamed Ali-Seyed, Ibrahim Jantan, Kavitha Vijayaraghavan & Syed Nasir Abbas Bukhari. (2016) Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy. Chemical Biology & Drug Design 87:4, pages 517-536.
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Dong-Mei Zhang, Hong-Gui Xu, Lei Wang, Ying-Jie Li, Ping-Hua Sun, Xiao-Ming Wu, Guang-Ji Wang, Wei-Min Chen & Wen-Cai Ye. (2015) Betulinic Acid and its Derivatives as Potential Antitumor Agents. Medicinal Research Reviews 35:6, pages 1127-1155.
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Challa Suresh, Hua Zhao, Angelique Gumbs, Chellu S. Chetty & Himangshu S. Bose. (2012) New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorganic & Medicinal Chemistry Letters 22:4, pages 1734-1738.
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Boris Breiner, Kemal Kaya, Saumya Roy, Wang-Yong Yang & Igor V. Alabugin. (2012) Hybrids of amino acids and acetylenic DNA-photocleavers: optimising efficiency and selectivity for cancer phototherapy. Organic & Biomolecular Chemistry 10:20, pages 3974.
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Wang-Yong Yang, Saumya Roy, Boondaniwon Phrathep, Zach Rengert, Rachael Kenworthy, Diego A. R. Zorio & Igor V. Alabugin. (2011) Engineering pH-Gated Transitions for Selective and Efficient Double-Strand DNA Photocleavage in Hypoxic Tumors. Journal of Medicinal Chemistry 54:24, pages 8501-8516.
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Jarmo K. Laihia, Janne P. Kallio, Pekka Taimen, Harry Kujari, Veli-Matti Kähäri & Lasse Leino. (2010) Protodynamic Intracellular Acidification by cis-Urocanic Acid Promotes Apoptosis of Melanoma Cells In Vitro and In Vivo. Journal of Investigative Dermatology 130:10, pages 2431-2439.
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Franziska B. Mullauer, Jan H. Kessler & Jan Paul Medema. (2010) Betulinic acid, a natural compound with potent anticancer effects. Anti-Cancer Drugs 21:3, pages 215-227.
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Wang-Yong Yang, Boris Breiner, Serguei V. Kovalenko, Chi Ben, Mani Singh, Shauna N. LeGrand, Qing-Xiang Amy Sang, Geoffrey F. Strouse, John A. Copland & Igor V. Alabugin. (2009) C-Lysine Conjugates: pH-Controlled Light-Activated Reagents for Efficient Double-Stranded DNA Cleavage with Implications for Cancer Therapy. Journal of the American Chemical Society 131:32, pages 11458-11470.
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Barthelemy Nyasse, Jean-Jules Nono, Yves Nganso, Igor Ngantchou & Bernd Schneider. (2009) Uapaca genus (Euphorbiaceae), a good source of betulinic acid. Fitoterapia 80:1, pages 32-34.
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T. G. Tolstikova, I. V. Sorokina, G. A. Tolstikov, A. G. Tolstikov & O. B. Flekhter. (2006) Biological activity and pharmacological prospects of lupane terpenoids: I. natural lupane derivatives. Russian Journal of Bioorganic Chemistry 32:1, pages 37-49.
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Petr Dzubak, Marian Hajduch, David Vydra, Alica Hustova, Miroslav Kvasnica, David Biedermann, Lenka Markova, Milan Urban & Jan Sarek. (2006) Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports 23:3, pages 394.
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Gian Franco Baronzio, Alberto Gramaglia, Attilio Baronzio & Isabel Freitas. 2006. Hyperthermia in Cancer Treatment: A Primer. Hyperthermia in Cancer Treatment: A Primer 67 91 .
Gian Franco Baronzio, Vincenzo Cerreta, Attilio Baronzio, Isabel Freitas, Marco Mapelli & Alberto Gramaglia. 2006. Hyperthermia in Cancer Treatment: A Primer. Hyperthermia in Cancer Treatment: A Primer 128 155 .
D.V. Raghuvar Gopal, Archana A. Narkar, Y. Badrinath, K.P. Mishra & D.S. Joshi. (2005) Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl. Toxicology Letters 155:3, pages 343-351.
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N Sawada, K Kataoka, K Kondo, H Arimochi, H Fujino, Y Takahashi, T Miyoshi, T Kuwahara, Y Monden & Y Ohnishi. (2004) Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice. British Journal of Cancer 90:8, pages 1672-1678.
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Robert H. Cichewicz & Samir A. Kouzi. (2003) Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Medicinal Research Reviews 24:1, pages 90-114.
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