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Brain Injury Volume 32, 2018 - Issue 3
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Original Articles

Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy

Jeremy L HolzmacherCenter for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USAView further author information
,
Cassandra ReynoldsDepartment of Surgery, East Carolina University Brody School of Medicine, Greenville, NCView further author information
,
Mayur PatelDivision of Trauma, Emergency General Surgery, and Surgical Critical Care, Departments of Surgery, Neurosurgery, and Hearing and Speech Sciences, Section of Surgical Sciences, Vanderbilt Brain Institute, Vanderbilt Center for Health Services Research, Vanderbilt University Medical Center; Surgical Service, General Surgery Section, Nashville VA, Medical Center, Tennessee Valley Healthcare System, US Department of Veterans Affairs, Nashville, TNView further author information
,
Patrick MalusoCenter for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USAView further author information
,
Seth HollandDepartment of Surgery, San Antonio Military Medical Center, Fort Sam Houston, TXView further author information
,
Nathaniel GamskyCenter for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USAView further author information
,
Henry MooreDepartment of Surgery, Carle Foundation Hospital, Urbana, ILView further author information
,
Elizabeth AcquistaDepartment of Surgery, University of North Carolina At Chapel Hill, Chapel Hill, NCView further author information
,
Matthew CarrickDepartment of Surgery, Medical Center at Plano, Plano, TXView further author information
,
Richard AmdurCenter for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USAView further author information
,
Heather HancockDepartment of Surgery, San Antonio Military Medical Center, Fort Sam Houston, TXView further author information
,
Michael MetzlerDepartment of Surgery, Medical Center of The Rockies, Loveland, COView further author information
,
Julie DunnDepartment of Surgery, Medical Center of The Rockies, Loveland, COView further author information
&
Babak SaraniCenter for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6247-3004View further author information
ORCID Icon show all
Pages 325-330 | Received 04 Jul 2017, Accepted 05 Jan 2018, Published online: 17 Jan 2018

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Andrew R. Guillotte, Joseph P. Herbert, Richard Madsen, Richard D. Hammer & N. Scott Litofsky. (2018) Effects of platelet dysfunction and platelet transfusion on outcomes in traumatic brain injury patients. Brain Injury 32:13-14, pages 1849-1857.
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Articles from other publishers (43)

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Svetlana Kvint, Alexis Gutierrez, Anya Venezia, Eileen Maloney, James Schuster & Monisha A. Kumar. (2022) Application of a TEG-Platelet Mapping Algorithm to Guide Reversal of Antiplatelet Agents in Adults with Mild-to-Moderate Traumatic Brain Injury: An Observational Pilot Study. Neurocritical Care 37:3, pages 638-648.
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Stephen P. Miranda, Connor Wathen, James M. Schuster & Dmitriy Petrov. (2022) Letter to the Editor Regarding “Viscoelastic Hemostatic Assays and Outcomes in Traumatic Brain Injury: A Systematic Literature Review”. World Neurosurgery 166, pages 291-293.
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M. Victoria P. Miles, R. Chace Hicks, Hunter Parmer, Caroline Brown, Abigail Edwards, Kathryn Stewart, Lani Gao & Robert Maxwell. (2022) Traumatic brain injury patients with platelet inhibition receiving platelet transfusion demonstrate decreased need for neurosurgical intervention and decreased mortality. Journal of Trauma and Acute Care Surgery 92:4, pages 701-707.
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Kaiwen Wang, Qingyuan Liu, Jun Wu, Yong Cao & Shuo Wang. (2021) The role of monitoring platelet function perioperatively and platelet transfusion for operated spontaneous intracerebral hemorrhage patients with long-term oral antiplatelet therapy: A case report. International Journal of Surgery Case Reports 89, pages 106589.
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Jamie L. Bradbury, Scott G. Thomas, Nikki R. Sorg, Nicolas Mjaess, Margaret R. Berquist, Toby J. Brenner, Jack H. Langford, Mathew K. Marsee, Ashton N. Moody, Connor M. Bunch, Sandeep R. Sing, Mahmoud D. Al-Fadhl, Qussai Salamah, Tarek Saleh, Neal B. Patel, Kashif A. Shaikh, Stephen M. Smith, Walter S. Langheinrich, Daniel H. Fulkerson & Sherry Sixta. (2021) Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury. Journal of Clinical Medicine 10:21, pages 5039.
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Christina M. RiojasMichael L. EkaneySamuel W. RossKyle W. CunninghamElisa J. FurayCarlos V.R. BrownSusan L. Evans. (2021) Platelet Dysfunction after Traumatic Brain Injury: A Review. Journal of Neurotrauma 38:7, pages 819-829.
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Jun Wu, Qingyuan Liu, Kaiwen Wang, Junhua Yang, Pengjun Jiang, Maogui Li, Nuochuan Wang, Yong Cao, Zeguang Ren, Yanan Zhang & Shuo Wang. (2020) Emergency surgery is an effective way to improve the outcome of severe spontaneous intracerebral hemorrhage patients on long-term oral antiplatelet therapy. Neurosurgical Review 44:2, pages 1205-1216.
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Adil M. Lokhandwala, Samer Asmar, Muhammad Khurrum, Mohamad Chehab, Letitia Bible, Lourdes Castanon, Michael Ditillo & Bellal Joseph. (2021) Platelet Transfusion After Traumatic Intracranial Hemorrhage in Patients on Antiplatelet Agents. Journal of Surgical Research 257, pages 239-245.
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Yvonne Brennan, Marie Levade & Christopher M. Ward. (2020) Acquired platelet function disorders. Thrombosis Research 196, pages 561-568.
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Etrusca Brogi, Davide Corbella, Federico Coccolini, Emiliano Gamberini, Emanuele Russo, Vanni Agnoletti & Francesco Forfori. (2020) The Role of Platelet Transfusions After Intracranial Hemorrhage in Patients on Antiplatelet Agents: A Systematic Review and Meta-Analysis. World Neurosurgery 141, pages 455-466.e13.
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Kojo Agyabeng-Dadzie, Jocelyn E. Hunter, Timothy R. Smith, Monica Jordan, Karen Safcsak, Joseph A. Ibrahim, Michael L. Cheatham & Indermeet S. Bhullar. (2020) Antiplatelet Agent Reversal Is Unnecessary in Blunt Traumatic Brain Injury Patients Not Requiring Immediate Craniotomy. The American Surgeon 86:7, pages 826-829.
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Daniela C. Filipescu, Mihai G. Stefan, Liana Valeanu & Wanda M. Popescu. (2020) Perioperative management of antiplatelet therapy in noncardiac surgery. Current Opinion in Anaesthesiology 33:3, pages 454-462.
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Babak Sarani & Cheralyn J. Hendrix. 2020. Evidence-Based Practice of Critical Care. Evidence-Based Practice of Critical Care 584 592.e1 .
Swagata Tripathy & Suma Rabab Ahmad. 2020. Acute Neuro Care. Acute Neuro Care 57 78 .
Marion Wiegele, Herbert Schöchl, Alexander Haushofer, Martin Ortler, Johannes Leitgeb, Oskar Kwasny, Ronny Beer, Cihan Ay & Eva Schaden. (2019) Diagnostic and therapeutic approach in adult patients with traumatic brain injury receiving oral anticoagulant therapy: an Austrian interdisciplinary consensus statement. Critical Care 23:1.
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Donat R. Spahn, Bertil Bouillon, Vladimir Cerny, Jacques Duranteau, Daniela Filipescu, Beverley J. Hunt, Radko Komadina, Marc Maegele, Giuseppe Nardi, Louis Riddez, Charles-Marc Samama, Jean-Louis Vincent & Rolf Rossaint. (2019) The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition. Critical Care 23:1.
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Zachary A. Matthay & Lucy Zumwinkle Kornblith. (2019) Platelet Contributions to Trauma-Induced Coagulopathy: Updates in Post-injury Platelet Biology, Platelet Transfusions, and Emerging Platelet-Based Hemostatic Agents. Current Trauma Reports 5:4, pages 202-209.
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Sophie Thorn, Helge Güting, Tim Mathes, Nadine Schäfer & Marc Maegele. (2019) The effect of platelet transfusion in patients with traumatic brain injury and concomitant antiplatelet use: a systematic review and meta‐analysis. Transfusion 59:11, pages 3536-3544.
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Lucy Z. Kornblith, Anna Decker, Amanda S. Conroy, Carolyn M. Hendrickson, Alexander T. Fields, Anamaria J. Robles, Rachael A. Callcut & Mitchell J. Cohen. (2019) It's About Time: Transfusion effects on postinjury platelet aggregation over time. Journal of Trauma and Acute Care Surgery 87:5, pages 1042-1051.
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Philipp Störmann, William Osinloye, Thomas M. Freiman, Volker Seifert, Ingo Marzi & Thomas Lustenberger. (2019) Early Chemical Thromboprophylaxis Does not Increase the Risk of Intracranial Hematoma Progression in Patients with Isolated Severe Traumatic Brain Injury. World Journal of Surgery 43:11, pages 2804-2811.
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Eiichi Suehiro, Yuichi Fujiyama, Miwa Kiyohira, Kouhei Haji, Hideyuki Ishihara, Sadahiro Nomura & Michiyasu Suzuki. (2019) Risk of Deterioration of Geriatric Traumatic Brain Injury in Patients Treated with Antithrombotic Drugs. World Neurosurgery 127, pages e1221-e1227.
Crossref
Lucy Z. Kornblith, Hunter B. Moore & Mitchell J. Cohen. (2019) Trauma‐induced coagulopathy: The past, present, and future. Journal of Thrombosis and Haemostasis 17:6, pages 852-862.
Crossref
Benedikt Treml, Elgar Oswald & Bettina Schenk. (2019) Reversing anticoagulation in the hemorrhaging patient. Current Opinion in Anaesthesiology 32:2, pages 206-212.
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Carlos A. Pelaez, Sarah K. Spilman, Christopher T. Bell, Darla K. Eastman & Richard A. Sidwell. (2019) Not all head injured patients on antiplatelet drugs need platelets: Integrating platelet reactivity testing into platelet transfusion guidelines. Injury 50:1, pages 73-78.
Crossref
Aleksey Tadevosyan, Jovany Cruz Navarro, Izad-Yar Rasheed & Monisha A. Kumar. 2019. Textbook of Neuroanesthesia and Neurocritical Care. Textbook of Neuroanesthesia and Neurocritical Care 217 239 .
Walter L. Biffl & Fady Nasrallah. 2019. Intensive Care for Emergency Surgeons. Intensive Care for Emergency Surgeons 181 194 .

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