124
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Amino acid prodrugs of acyclovir as possible antiviral agents against ocular HSV-1 infections: Interactions with the neutral and cationic amino acid transporter on the corneal epithelium

, , &
Pages 153-166 | Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Vrinda Gote, Michael Ansong & Dhananjay Pal. (2020) Prodrugs and nanomicelles to overcome ocular barriers for drug penetration. Expert Opinion on Drug Metabolism & Toxicology 16:10, pages 885-906.
Read now
Eun-Young Kwak, Won-Sik Shim, Ji-Eun Chang, Saeho Chong, Dae-Duk Kim, Suk-Jae Chung & Chang-Koo Shim. (2012) Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters. Xenobiotica 42:7, pages 603-613.
Read now
Stephan Reichl, Christian Kölln, Matthias Hahne & Jessica Verstraelen. (2011) In vitro cell culture models to study the corneal drug absorption. Expert Opinion on Drug Metabolism & Toxicology 7:5, pages 559-578.
Read now
Ivanka Stankova, Kiril Chuchkov, Peter Wutzler & Michaela Schmidtke. (2010) Cinnamic Esters of Acyclovir-Synthesis and Biological Activity. Nucleosides, Nucleotides & Nucleic Acids 29:10, pages 760-767.
Read now
Rita Cortesi & Elisabetta Esposito. (2008) Acyclovir delivery systems. Expert Opinion on Drug Delivery 5:11, pages 1217-1230.
Read now
Kumar G Janoria, Sriram Gunda, Sai HS Boddu & Ashim K Mitra. (2007) Novel approaches to retinal drug delivery. Expert Opinion on Drug Delivery 4:4, pages 371-388.
Read now
Kumar G. Janoria, Sudharshan Hariharan, Durga Paturi, Dhananjay Pal & Ashim K. Mitra. (2006) Biotin Uptake by Rabbit Corneal Epithelial Cells: Role of Sodium-Dependent Multivitamin Transporter (SMVT). Current Eye Research 31:10, pages 797-809.
Read now
Sudharshan Hariharan, Kumar G. Janoria, Sriram Gunda, Xiaodong Zhu, Dhananjay Pal & Ashim K. Mitra. (2006) Identification and Functional Expression of a Carrier-Mediated Riboflavin Transport System on Rabbit Corneal Epithelium. Current Eye Research 31:10, pages 811-824.
Read now

Articles from other publishers (29)

Prakriti Diwan, Rajendra Jangde, Sulekha Khunte, Harish Bhardwaj & Preeti K. Suresh. 2022. Drug Development Life Cycle. Drug Development Life Cycle.
Stergios K Chaloulis, Georgios Mousteris & Konstantinos T Tsaousis. (2022) Incidence and Risk Factors of Bilateral Herpetic Keratitis: 2022 Update. Tropical Medicine and Infectious Disease 7:6, pages 92.
Crossref
Lloyd Mabonga, Priscilla Masamba & Abidemi Paul Kappo. 2022. Peptide and Peptidomimetic Therapeutics. Peptide and Peptidomimetic Therapeutics 37 55 .
Rachel H. Bianculli, Jonathan D. Mase & Michael D. Schulz. (2020) Antiviral Polymers: Past Approaches and Future Possibilities. Macromolecules 53:21, pages 9158-9186.
Crossref
Yong Chen & Yogeshvar N. Kalia. (2018) Short-duration ocular iontophoresis of ionizable aciclovir prodrugs: A new approach to treat herpes simplex infections in the anterior and posterior segments of the eye. International Journal of Pharmaceutics 536:1, pages 292-300.
Crossref
Anita Patel, Jayvadan K. Patel & Yashwant V. Pathak. 2018. Drug Delivery for the Retina and Posterior Segment Disease. Drug Delivery for the Retina and Posterior Segment Disease 327 349 .
Vibhuti Agrahari, Abhirup Mandal, Vivek Agrahari, Hoang M. Trinh, Mary Joseph, Animikh Ray, Hicheme Hadji, Ranjana Mitra, Dhananjay Pal & Ashim K. Mitra. (2016) A comprehensive insight on ocular pharmacokinetics. Drug Delivery and Translational Research 6:6, pages 735-754.
Crossref
Venkata Kashyap YellepeddiSrinath Palakurthi. (2016) Recent Advances in Topical Ocular Drug Delivery. Journal of Ocular Pharmacology and Therapeutics 32:2, pages 67-82.
Crossref
Yung-Ray Hsu, Shu-Wen Chang, Chang-Hao Yang, Yi-An Lee & Tzu-Yun Kao. (2016) Expression Profile of Cationic Amino Acid Transporters in Rats with Endotoxin-Induced Uveitis. Mediators of Inflammation 2016, pages 1-14.
Crossref
V. P. Krasnov, A. Yu. Vigorov, D. A. Gruzdev, G. L. Levit, A. M. Demin, I. A. Nizova, A. A. Tumashov, L. Sh. Sadretdinova, E. B. Gorbunov & V. N. Charushin. (2016) Synthesis of enantiomers of N-(2-aminopurin-6-yl)amino acids. Russian Chemical Bulletin 64:9, pages 2106-2113.
Crossref
Ye Sheng, Xiaoyan Yang, Dhananjay Pal & Ashim K. Mitra. (2015) Prodrug approach to improve absorption of prednisolone. International Journal of Pharmaceutics 487:1-2, pages 242-249.
Crossref
Joshua A. Eldridge, Mikolaj Milewski, Audra L. Stinchcomb & Peter A. Crooks. (2014) Synthesis and in vitro stability of amino acid prodrugs of 6-β-naltrexol for microneedle-enhanced transdermal delivery. Bioorganic & Medicinal Chemistry Letters 24:22, pages 5212-5215.
Crossref
Mehdi Ghaffari Sharaf, Sibel Cetinel, Lisa Heckler, Karim Damji, Larry Unsworth & Carlo Montemagno. (2014) Nanotechnology-Based Approaches for Ophthalmology Applications. Asia-Pacific Journal of Ophthalmology 3:3, pages 172-180.
Crossref
Alexey Yu. Vigorov, Viktor P. Krasnov, Dmitry A. Gruzdev, Alisa A. Men'shikova, Alexander M. Demin, Galina L. Levit & Valery N. Charushin. (2014) Novel synthetic routes to N-(2-amino-9H-purin-6-yl)-substituted amino acids. Mendeleev Communications 24:1, pages 35-36.
Crossref
Manjula Gunawardana, Madeline Mullen, John A. Moss, Richard B. Pyles, Rebecca J. Nusbaum, Jignesh Patel, Kathleen L. Vincent, Charles Wang, Chao Guo, Yate-Ching Yuan, Charles D. Warden & Marc M. Baum. (2013) Global Expression of Molecular Transporters in the Human Vaginal Tract: Implications for HIV Chemoprophylaxis. PLoS ONE 8:10, pages e77340.
Crossref
Mitesh Patel, Pranjali Dalvi, Mitan Gokulgandhi, Susamita Kesh, Tanvi Kohli, Dhananjay Pal & Ashim K. Mitra. (2013) Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells. International Journal of Pharmaceutics 443:1-2, pages 245-253.
Crossref
Megha Barot, Mitesh Patel, Deep Kwatra & Ashim K. Mitra. 2013. Ocular Transporters and Receptors. Ocular Transporters and Receptors 229 248 .
Viral Tamboli, Sujay Shah & Ashim K. Mitra. 2013. Ocular Transporters and Receptors. Ocular Transporters and Receptors 207 228 .
Kishore Cholkar, Animikh Ray, Vibhuti Agrahari, Dhananjay Pal & Ashim K. Mitra. 2013. Ocular Transporters and Receptors. Ocular Transporters and Receptors 115 168 .
Sunil K. Vooturi, Rajendra S. Kadam & Uday B. Kompella. (2012) Transporter Targeted Gatifloxacin Prodrugs: Synthesis, Permeability, and Topical Ocular Delivery. Molecular Pharmaceutics 9:11, pages 3136-3146.
Crossref
Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Deep Kwatra, Ravinder Earla, Swapan K. Samanta, Dhananjay Pal & Ashim K. Mitra. (2012) Targeted lipid based drug conjugates: A novel strategy for drug delivery. International Journal of Pharmaceutics 434:1-2, pages 315-324.
Crossref
Sherifa Hasabelnaby, Ayman Goudah, Hitesh K. Agarwal, Mosaad S.M. Abd alla & Werner Tjarks. (2012) Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors. European Journal of Medicinal Chemistry 55, pages 325-334.
Crossref
Barbara Stella, Silvia Arpicco, Flavio Rocco, Susi Burgalassi, Nadia Nicosia, Silvia Tampucci, Patrizia Chetoni & Luigi Cattel. (2012) Nonpolymeric nanoassemblies for ocular administration of acyclovir: Pharmacokinetic evaluation in rabbits. European Journal of Pharmaceutics and Biopharmaceutics 80:1, pages 39-45.
Crossref
Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky & Ashim K. Mitra. (2010) Ocular Drug Delivery. The AAPS Journal 12:3, pages 348-360.
Crossref
Soumyajit Majumdar, Tushar Hingorani, Ramesh Srirangam, Rama Sarma Gadepalli, John M. Rimoldi & Michael A. Repka. (2008) Transcorneal Permeation of l- and d-Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion Versus Transporter Involvement. Pharmaceutical Research 26:5, pages 1261-1269.
Crossref
Ravi S. TalluriRipal GaudanaSudharshan HariharanAshim K. Mitra. (2009) Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir following Intravenous and Oral Administrations in Rats: A study Involving in vivo corneal Uptake of Acyclovir following Oral Dosing. Ophthalmology and Eye Diseases 1, pages OED.S2857.
Crossref
Suresh Katragadda, Ritesh Jain, Deep Kwatra, Sudharshan Hariharan & Ashim K. Mitra. (2008) Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: Interaction with the transporters on Caco-2 cells. International Journal of Pharmaceutics 362:1-2, pages 93-101.
Crossref
Suresh Katragadda, Sriram Gunda, Sudharshan Hariharan & Ashim K. Mitra. (2008) Ocular pharmacokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: Evaluation of their utility in treating ocular HSV infections. International Journal of Pharmaceutics 359:1-2, pages 15-24.
Crossref
Banmeet S. Anand, Suresh Katragadda, Sriram Gunda & Ashim K. Mitra. (2006) In Vivo Ocular Pharmacokinetics of Acyclovir Dipeptide Ester Prodrugs by Microdialysis in Rabbits. Molecular Pharmaceutics 3:4, pages 431-440.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.