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Original Article

Captopril Inhibits Capillary Degeneration in the Early Stages of Diabetic Retinopathy

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Pages 883-889 | Received 11 Mar 2007, Accepted 18 Jul 2007, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Jie Gao, Liming Tao & Zhengxuan Jiang. (2023) Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies. Redox Report 28:1.
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Bruce A Berkowitz, David Bissig, Oliver Dutczak, Shannon Corbett, Rob North & Robin Roberts. (2013) MRI biomarkers for evaluation of treatment efficacy in preclinical diabetic retinopathy. Expert Opinion on Medical Diagnostics 7:4, pages 393-403.
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Wenbo Zhang, Hua Liu, Modesto Rojas, Robert W Caldwell & Ruth B Caldwell. (2011) Anti-Inflammatory Therapy for Diabetic Retinopathy. Immunotherapy 3:5, pages 609-628.
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Erdinc Aydin, Helin Deniz Demir & Semsettin Sahin. (2010) Plasma and Aqueous Humor Angiotensin-Converting Enzyme Levels in Patients with Diabetic Retinopathy. Current Eye Research 35:3, pages 230-234.
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Xin Li, Yu-Hong Fu, Xue-Wei Tong, Yi-Tong Zhang, Yong-Yan Shan, Yu-Xin Xu, Sheng-Dan Pu & Xin-Yuan Gao. (2024) RAAS in diabetic retinopathy: mechanisms and therapies. Archives of Endocrinology and Metabolism 68.
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Shanshan Tang, Xuedong An, Wenjie Sun, Yuehong Zhang, Cunqing Yang, Xiaomin Kang, Yuting Sun, Linlin Jiang, Xuefei Zhao, Qing Gao, Hangyu Ji & Fengmei Lian. (2024) Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy. Frontiers in Endocrinology 15.
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Hugo Ramos, Cristina Hernández, Rafael Simó & Olga Simó-Servat. (2023) Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications. International Journal of Molecular Sciences 24:10, pages 8796.
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Andrea Kovács-Valasek, Tibor Rák, Etelka Pöstyéni, Adrienne Csutak & Robert Gábriel. (2023) Three Major Causes of Metabolic Retinal Degenerations and Three Ways to Avoid Them. International Journal of Molecular Sciences 24:10, pages 8728.
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Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman & Timothy S. Kern. (2023) CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice. Diabetologia 66:3, pages 590-602.
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Lei Tang, Guo-Tong Xu & Jing-Fa Zhang. (2023) Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy. Neural Regeneration Research 18:5, pages 976.
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Xiang Gao, Kou Liu, Chengyang Hu, Keyang Chen & Zhengxuan Jiang. (2022) Captopril alleviates oxidative damage in diabetic retinopathy. Life Sciences 290, pages 120246.
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Urmas Roostalu, Louise Thisted, Jacob Lercke Skytte, Casper Gravesen Salinas, Philip Juhl Pedersen, Jacob Hecksher-Sørensen, Bidda Rolin, Henrik H. Hansen, James G. MacKrell, Robert M. Christie, Niels Vrang, Jacob Jelsing & Nora Elisabeth Zois. (2021) Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography. Scientific Reports 11:1.
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Sadie K. Dierschke, Allyson L. Toro, Alistair J. Barber, Amy C. Arnold & Michael D. Dennis. (2020) Angiotensin-(1–7) Attenuates Protein O -GlcNAcylation in the Retina by EPAC/Rap1-Dependent Inhibition of O -GlcNAc Transferase . Investigative Opthalmology & Visual Science 61:2, pages 24.
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Jennifer L. Wilkinson-Berka, Varaporn Suphapimol, Jack R. Jerome, Devy Deliyanti & Michael J. Allingham. (2019) Angiotensin II and aldosterone in retinal vasculopathy and inflammation. Experimental Eye Research 187, pages 107766.
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Joanna A. Phipps, Michael A. Dixon, Andrew I. Jobling, Anna Y. Wang, Ursula Greferath, Kirstan A. Vessey & Erica L. Fletcher. (2019) The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease. Experimental Eye Research 187, pages 107753.
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Timothy S. Kern, David A. Antonetti & Lois E.H. Smith. (2019) Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Research 62:4, pages 196-202.
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Li Liu & Xiaodong Liu. 2019. Drug Transporters in Drug Disposition, Effects and Toxicity. Drug Transporters in Drug Disposition, Effects and Toxicity 467 504 .
Yaqian Duan, Eleni Beli, Sergio Li Calzi, Judith L. Quigley, Rehae C. Miller, Leni Moldovan, Dongni Feng, Tatiana E. Salazar, Sugata Hazra, Jude Al-Sabah, Kakarla V. Chalam, Thao Le Phuong Trinh, Marya Meroueh, Troy A. Markel, Matthew C. Murray, Ruchi J. Vyas, Michael E. Boulton, Patricia Parsons-Wingerter, Gavin Y. Oudit, Alexander G. Obukhov & Maria B. Grant. (2018) Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction. Stem Cells 36:9, pages 1430-1440.
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Preenie deS Senanayake, Vera L Bonilha, John W Peterson, Yoshiro Yamada, Sadashiva S Karnik, Firouz Daneshgari, K Bridget Brosnihan & Joe G Hollyfield. (2018) Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril. Journal of the Renin-Angiotensin-Aldosterone System 19:3, pages 147032031878932.
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Michael W. StewartMichael W. Stewart. 2017. Diabetic Retinopathy. Diabetic Retinopathy 29 72 .
James M. DominguezIIII, Ping Hu, Sergio Caballero, Leni Moldovan, Amrisha Verma, Gavin Y. Oudit, Qiuhong Li & Maria B. Grant. (2016) Adeno-Associated Virus Overexpression of Angiotensin-Converting Enzyme-2 Reverses Diabetic Retinopathy in Type 1 Diabetes in Mice. The American Journal of Pathology 186:6, pages 1688-1700.
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G. Foureaux, B. S. Nogueira, D. C. O. Coutinho, M. K. Raizada, J. C. Nogueira & A. J. Ferreira. (2015) Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina. Brazilian Journal of Medical and Biological Research 48:12, pages 1109-1114.
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Krisztina Szabadfi, Erika Pinter, Dora Reglodi & Robert Gabriel. 2014. 1 121 .
Snježana Kaštelan, Martina Tomić, Antonela Gverović Antunica, Jasminka Salopek Rabatić & Spomenka Ljubić. (2013) Inflammation and Pharmacological Treatment in Diabetic Retinopathy. Mediators of Inflammation 2013, pages 1-8.
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Jennifer L. Wilkinson-Berka, Alex Agrotis & Devy Deliyanti. (2012) The retinal renin–angiotensin system: Roles of angiotensin II and aldosterone. Peptides 36:1, pages 142-150.
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Toshihide Kurihara, Yoko Ozawa, Susumu Ishida, Hideyuki Okano & Kazuo Tsubota. (2012) Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction. International Journal of Inflammation 2012, pages 1-14.
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Amrisha Verma, Zhiying Shan, Bo Lei, Lihui Yuan, Xuan Liu, Takahiko Nakagawa, Maria B Grant, Alfred S Lewin, William W Hauswirth, Mohan K Raizada & Qiuhong Li. (2012) ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy. Molecular Therapy 20:1, pages 28-36.
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Timothy S. Kern. 2012. Visual Dysfunction in Diabetes. Visual Dysfunction in Diabetes 143 155 .
J. L. Wilkinson-Berka, G. Tan, K. J. Binger, L. Sutton, K. McMaster, D. Deliyanti, G. Perera, D. J. Campbell & A. G. Miller. (2011) Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat. Diabetologia 54:10, pages 2724-2735.
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Harumasa YokotaTaiji Nagaoka, Tomofumi Tani, Atsushi Takahashi, Eiichi Sato, Yuji Kato & Akitoshi Yoshida. (2011) Higher levels of prorenin predict development of diabetic retinopathy in patients with type 2 diabetes. Journal of the Renin-Angiotensin-Aldosterone System 12:3, pages 290-294.
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Johnny Tang & Timothy S. Kern. (2011) Inflammation in diabetic retinopathy. Progress in Retinal and Eye Research 30:5, pages 343-358.
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H. P. Hammes, W. Kerner, S. Hofer, O. Kordonouri, K. Raile & R. W. Holl. (2011) Diabetic retinopathy in type 1 diabetes—a contemporary analysis of 8,784 patients. Diabetologia 54:8, pages 1977-1984.
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J.G. Garweg & A. Wenzel. (2010) Diabetische Makulopathie und RetinopathieDiabetic maculopathy and retinopathy. Der Ophthalmologe 107:7, pages 628-635.
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Timothy S Kern & Suber Huang. 2010. Ocular Disease. Ocular Disease 506 513 .
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Anna B Einarsdóttir & Einar Stefánsson. (2009) Prevention of diabetic retinopathy. The Lancet 373:9672, pages 1316-1318.
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