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Original Article

The Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K(gK) is Essential for Viral Corneal Spread and Neuroinvasiveness

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Pages 455-467 | Received 25 Feb 2008, Accepted 14 Apr 2008, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Shuyong Zhu & Abel Viejo-Borbolla. (2021) Pathogenesis and virulence of herpes simplex virus. Virulence 12:1, pages 2670-2702.
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Jiucheng He, Richard Cosby, James M. Hill & Haydee E. P. Bazan. (2017) Changes in Corneal Innervation after HSV-1 Latency Established with Different Reactivation Phenotypes. Current Eye Research 42:2, pages 181-186.
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Nicolas AS Sokolowski, Helen Rizos & Russell J Diefenbach. (2015) Oncolytic virotherapy using herpes simplex virus: how far have we come?. Oncolytic Virotherapy 4, pages 207-219.
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Alex M Agelidis & Deepak Shukla. (2015) Cell Entry Mechanisms of HSV: What we have Learned in Recent Years. Future Virology 10:10, pages 1145-1154.
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In-Joong Kim, Ahmad A. Saied, Vladimir N. Chouljenko, Ramesh Subramanian & Konstantin G. Kousoulas. (2014) Functional Hierarchy of Herpes Simplex Virus Type-1 Membrane Proteins in Corneal Infection and Virus Transmission to Ganglionic Neurons. Current Eye Research 39:12, pages 1169-1177.
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Ahmad A. Saied, V. N. Chouljenko, Ramesh Subramanian & K.G. Kousoulas. (2014) A Replication Competent HSV-1(McKrae) with a Mutation in the Amino-terminus of Glycoprotein K (gK) is Unable to Infect Mouse Trigeminal Ganglia after Cornea Infection. Current Eye Research 39:6, pages 596-603.
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Shaohui Wang, Ujjaldeep Jaggi & Homayon Ghiasi. (2022) Knockout of signal peptide peptidase in the eye reduces HSV-1 replication and eye disease in ocularly infected mice. PLOS Pathogens 18:10, pages e1010898.
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Xixi Gui, Wuchao Zhang, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, John W. Wills, Jun Han & Hanchun Yang. (2022) Discovery and Characterization of an Aberrant Small Form of Glycoprotein I of Herpes Simplex Virus Type I in Cell Culture. Microbiology Spectrum 10:2.
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Li Wang, Runbiao Wang, Chuyang Xu & Hongyan Zhou. (2020) Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators. Frontiers in Immunology 11.
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Paul J. F. Rider, Lyndon M. Coghill, Misagh Naderi, Jeremy M. Brown, Michal Brylinski & Konstantin G. Kousoulas. (2019) Identification and Visualization of Functionally Important Domains and Residues in Herpes Simplex Virus Glycoprotein K(gK) Using a Combination of Phylogenetics and Protein Modeling. Scientific Reports 9:1.
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Lisa N. Akhtar, Christopher D. Bowen, Daniel W. Renner, Utsav Pandey, Ashley N. Della Fera, David W. Kimberlin, Mark N. Prichard, Richard J. Whitley, Matthew D. Weitzman & Moriah L. Szpara. (2019) Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population. mSphere 4:1.
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Jillian C. Carmichael, Hiroki Yokota, Rebecca C. Craven, Anthony Schmitt & John W. Wills. (2018) The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B. PLOS Pathogens 14:5, pages e1007054.
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Farhana Musarrat, Nithya Jambunathan, Paul J. F. Rider, V. N. Chouljenko & K. G. Kousoulas. (2018) The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes. Journal of Virology 92:6.
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Shaohui Wang, Kevin R. Mott, Marianne Cilluffo, Casey L. Kilpatrick, Shoko Murakami, Alexander V. Ljubimov, Konstantin G. Kousoulas, Sita Awasthi, Bernhard Luscher & Homayon Ghiasi. (2018) The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection. Journal of Virology 92:4.
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Xingli Xu, Shengtao Fan, Xi Wang, Yunguang Hu, Min Feng, Lichun Wang, Ying Zhang, Yun Liao, Xiaolong Zhang & Qihan Li. (2017) Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral ul7, ul41, and LAT Genes. Frontiers in Microbiology 8.
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Shaohui Wang, Kevin R. Mott, Kolja Wawrowsky, Konstantin G. Kousoulas, Bernhard Luscher & Homayon Ghiasi. (2017) Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K. Journal of Virology 91:19.
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Muzammel Haque, Brent Stanfield & Konstantin G. Kousoulas. (2016) Bovine herpesvirus type-1 glycoprotein K (gK) interacts with UL20 and is required for infectious virus production. Virology 499, pages 156-164.
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Nithya Jambunathan, Anu-Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko & Konstantin G. Kousoulas. (2016) Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons. Journal of Virology 90:5, pages 2230-2239.
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Brent Stanfield & Konstantin Gus Kousoulas. (2015) Herpes Simplex Vaccines: Prospects of Live-Attenuated HSV Vaccines to Combat Genital and Ocular Infections. Current Clinical Microbiology Reports 2:3, pages 125-136.
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Harry H. Matundan, Kevin R. Mott, Aslam Abbasi Akhtar, Joshua J. Breunig & Homayon Ghiasi. (2015) Mutations within the Pathogenic Region of Herpes Simplex Virus 1 gK Signal Sequences Alter Cell Surface Expression and Neurovirulence. Journal of Virology 89:5, pages 2530-2542.
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Brent A. Stanfield, Jacque Stahl, Vladimir N. Chouljenko, Ramesh Subramanian, Anu-Susan Charles, Ahmad A. Saied, Jason D. Walker & Konstantin G. Kousoulas. (2014) A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains. PLoS ONE 9:10, pages e109890.
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Sariah J. Allen, Kevin R. Mott, Yoshiharu Matsuura, Kohji Moriishi, Konstantin G. Kousoulas & Homayon Ghiasi. (2014) Binding of HSV-1 Glycoprotein K (gK) to Signal Peptide Peptidase (SPP) Is Required for Virus Infectivity. PLoS ONE 9:1, pages e85360.
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Tri Komala Sari, Suzanne M. Pritchard, Cristina W. Cunha, George A. Wudiri, Elizabeth I. Laws, Hector C. Aguilar, Naomi S. Taus & Anthony V. Nicola. (2013) Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis. Journal of Virology 87:24, pages 13922-13926.
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Arun V Iyer, Bapi Pahar, Vladimir N Chouljenko, Jason D Walker, Brent Stanfield & Konstantin G Kousoulas. (2013) Single dose of Glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responses. Virology Journal 10:1.
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Hong Wang, David J. Davido & Lynda A. Morrison. (2013) HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice. Virus Research 173:2, pages 436-440.
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Sona Chowdhury, Vladimir N. Chouljenko, Misagh Naderi & Konstantin G. Kousoulas. (2013) The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K Is Required for Virion Entry via the Paired Immunoglobulin-Like Type-2 Receptor Alpha. Journal of Virology 87:6, pages 3305-3313.
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Sona Chowdhury, Misagh Naderi, Vladimir N Chouljenko, Jason D Walker & Konstantin G Kousoulas. (2012) Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L(gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α. Virology Journal 9:1.
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Andrew T. David, Ahmad Saied, Anu Charles, Ramesh Subramanian, Vladimir N. Chouljenko & Konstantin G. Kousoulas. (2012) A Herpes Simplex Virus 1 (McKrae) Mutant Lacking the Glycoprotein K Gene Is Unable To Infect via Neuronal Axons and Egress from Neuronal Cell Bodies. mBio 3:4.
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Rebecca L. Sanchez, Alistair J. Ramsay & Timothy P. Foster. (2012) Efficient generation and rapid isolation via stoplight recombination of Herpes simplex viruses expressing model antigenic and immunological epitopes. Journal of Virological Methods 179:1, pages 116-126.
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Jihan Akhtar & Deepak Shukla. (2009) Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry. The FEBS Journal 276:24, pages 7228-7236.
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