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Original Article

Activation of a Caspase-3-Independent Mode of Cell Death Associated with Lysosomal Destabilization in Cultured Human Retinal Pigment Epithelial Cells (ARPE-19) Exposed to 7β-Hydroxycholesterol

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Pages 769-781 | Received 11 Mar 2008, Accepted 06 Jul 2008, Published online: 27 Jun 2012

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Randa Sghaier, Amira Zarrouk, Thomas Nury, Ilham Badreddine, Nora O’Brien, John J. Mackrill, Anne Vejux, Mohammad Samadi, Boubker Nasser, Claudio Caccia, Valerio Leoni, Thibault Moreau, Mustapha Cherkaoui-Malki, Ahmed Salhedine Masmoudi & Gérard Lizard. (2019) Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radical Research 53:5, pages 535-561.
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Wei Li, Henrik Johnson, Xi-Ming Yuan & Lena Jonasson. (2009) 7β-hydroxycholesterol induces natural killer cell death via oxidative lysosomal destabilization. Free Radical Research 43:11, pages 1072-1079.
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Shubhrima Ghosh, Imen Ghzaiel, Anne Vejux, Steve Meaney, Sagnik Nag, Gérard Lizard, Garima Tripathi, Falal Naez & Srijita Paul. 2024. Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Implication of Oxysterols and Phytosterols in Aging and Human Diseases 163 191 .
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Afshin Samadi, Suna Sabuncuoglu, Mahshid Samadi, Selen Yilmaz Isikhan, Salvatore Chirumbolo, Massimiliano Peana, Incilay Lay, Ahmet Yalcinkaya & Geir Bjørklund. (2020) A Comprehensive Review on Oxysterols and Related Diseases. Current Medicinal Chemistry 28:1, pages 110-136.
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Anne Vejux, Dehbia Abed-Vieillard, Khadija Hajji, Amira Zarrouk, John J. Mackrill, Shubhrima Ghosh, Thomas Nury, Aline Yammine, Mohamed Zaibi, Wafa Mihoubi, Habiba Bouchab, Boubker Nasser, Yaël Grosjean & Gérard Lizard. (2020) 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochemical Pharmacology 173, pages 113648.
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Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J. Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard & Amira Zarrouk. (2019) Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. The Journal of Steroid Biochemistry and Molecular Biology 194, pages 105432.
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Asmaa Badreddine, Amira Zarrouk, El Mostafa Karym, Meryam Debbabi, Thomas Nury, Wiem Meddeb, Randa Sghaier, Maryem Bezine, Anne Vejux, Lucy Martine, Stéphane Grégoire, Lionel Bretillon, Emmanuelle Prost-Camus, Philippe Durand, Michel Prost, Thibault Moreau, Mustapha Cherkaoui-Malki, Boubker Nasser & Gérard Lizard. (2017) Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N. International Journal of Molecular Sciences 18:10, pages 2220.
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Elodie Olivier, Mélody Dutot, Anne Regazzetti, Teddy Leguillier, Delphine Dargère, Nicolas Auzeil, Olivier Laprévote & Patrice Rat. (2016) P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?. Biochimie 127, pages 70-78.
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Amira Zarrouk, Anne Vejux, John Mackrill, Yvonne O’Callaghan, Mohamed Hammami, Nora O’Brien & Gérard Lizard. (2014) Involvement of oxysterols in age-related diseases and ageing processes. Ageing Research Reviews 18, pages 148-162.
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Wei Li, Moumita Ghosh, Sina Eftekhari & Xi-Ming Yuan. (2011) Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. Biochemical and Biophysical Research Communications 409:4, pages 711-716.
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Ignacio R. Rodríguez & Ignacio M. Larrayoz. (2010) Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. Journal of Lipid Research 51:10, pages 2847-2862.
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B. Dugas, S. Charbonnier, M. Baarine, K. Ragot, D. Delmas, F. Ménétrier, J. Lherminier, L. Malvitte, T. Khalfaoui, A. Bron, C. Creuzot-Garcher, N. Latruffe & Gérard Lizard. (2010) Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol. European Journal of Nutrition 49:7, pages 435-446.
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Amit Laskar, Sayem Miah, Rolf G.G. Andersson & Wei Li. (2010) Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways. European Journal of Pharmacology 640:1-3, pages 124-128.
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