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Research Article

The Effect of the Rho-Associated Protein Kinase Inhibitor, HA-1077, in the Rabbit Ocular Hypertension Model Induced by Water Loading

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Pages 42-47 | Received 11 Jul 2008, Accepted 06 Oct 2008, Published online: 02 Jul 2009

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Read on this site (8)

Ghadeer Al-Humimat, Ibtisam Marashdeh, Duaa Daradkeh & Karanjit Kooner. (2021) Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma. Journal of Experimental Pharmacology 13, pages 197-212.
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Muhammad Irfan Kamaruddin, Momoko Nakamura-Shibasaki, Yu Mizuno & Yoshiaki Kiuchi. (2017) Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits. Clinical Ophthalmology 11, pages 591-597.
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Mark S. Dikopf, Thasarat S. Vajaranant & Deepak P. Edward. (2017) Topical treatment of glaucoma: established and emerging pharmacology. Expert Opinion on Pharmacotherapy 18:9, pages 885-898.
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Seniz Demiryürek, Seydi Okumus, İbrahim Bozgeyik, Serdar Oztuzcu, Erol Coskun, Emrah Mat, Ela Durucu, Mehmet G. Tatar, İbrahim Erbagci, Bülent Gürler & Abdullah T. Demiryürek. (2016) Investigation of the Rho-kinase Gene Polymorphism in Primary Open-angle Glaucoma. Ophthalmic Genetics 37:1, pages 9-13.
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Sean K Wang & Robert T Chang. (2014) An emerging treatment option for glaucoma: Rho kinase inhibitors. Clinical Ophthalmology 8, pages 883-890.
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Pratap Challa & John J Arnold. (2014) Rho-kinase inhibitors offer a new approach in the treatment of glaucoma. Expert Opinion on Investigational Drugs 23:1, pages 81-95.
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Kenneth J Mandell, Matthew R Kudelka & Barbara Wirostko. (2011) Rho kinase inhibitors for treatment of glaucoma. Expert Review of Ophthalmology 6:6, pages 611-622.
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Masahiro Nishio, Takaki Fukunaga, Masahiko Sugimoto, Kengo Ikesugi, Kengo Sumi, Hiroyoshi Hidaka & Yukitaka Uji. (2009) The Effect of the H-1152P, a Potent Rho-Associated Coiled Coil-Formed Protein Kinase Inhibitor, in Rabbit Normal and Ocular Hypertensive Eyes. Current Eye Research 34:4, pages 282-286.
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Articles from other publishers (16)

Jun Wang, Hanke Wang & Yalong Dang. (2023) Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy. Ophthalmology and Therapy 12:6, pages 2943-2957.
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Chao Wang, Yalong Dang, Susannah Waxman, Ying Hong, Priyal Shah, Ralitsa T. Loewen, Xiaobo Xia & Nils A. Loewen. (2020) Ripasudil in a Model of Pigmentary Glaucoma. Translational Vision Science & Technology 9:10, pages 27.
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Yusuke Ohta, Sanae Takaseki & Takeshi Yoshitomi. (2017) Effects of ripasudil hydrochloride hydrate (K-115), a Rho-kinase inhibitor, on ocular blood flow and ciliary artery smooth muscle contraction in rabbits. Japanese Journal of Ophthalmology 61:5, pages 423-432.
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Ponugoti Vasantha Rao, Padmanabhan P. Pattabiraman & Casey Kopczynski. (2017) Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. Experimental Eye Research 158, pages 23-32.
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Vanessa Andrés-Guerrero, Julián García-Feijoo & Anastasios Georgios Konstas. (2017) Targeting Schlemm’s Canal in the Medical Therapy of Glaucoma: Current and Future Considerations. Advances in Therapy 34:5, pages 1049-1069.
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Hiroshi YamadaMasahiko YonedaShingo InagumaMasahiko GoshoYusuke MurasawaZenzo IsogaiMasahiro Zako. (2017) A Rho-Associated Kinase Inhibitor Protects Permeability in a Cell Culture Model of Ocular Disease, and Reduces Aqueous Flare in Anterior Uveitis. Journal of Ocular Pharmacology and Therapeutics 33:3, pages 176-185.
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Sarah Van de Velde, Lies De Groef, Ingeborg Stalmans, Lieve Moons & Inge Van Hove. (2015) Towards axonal regeneration and neuroprotection in glaucoma: Rho kinase inhibitors as promising therapeutics. Progress in Neurobiology 131, pages 105-119.
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Rong-Fang Wang, Jennifer E. Williamson, Casey Kopczynski & Janet B. Serle. (2015) Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes. Journal of Glaucoma 24:1, pages 51-54.
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Sarah Van de Velde, Tine Van Bergen, Evelien Vandewalle, Nele Kindt, Karolien Castermans, Lieve Moons & Ingeborg Stalmans. 2015. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part A. New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System, Part A 283 297 .
Haiyan GongChen-Yuan Charlie Yang. (2014) Morphological and Hydrodynamic Correlations with Increasing Outflow Facility by Rho-Kinase Inhibitor Y-27632. Journal of Ocular Pharmacology and Therapeutics 30:2-3, pages 143-153.
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Kengo Sumi, Yoshihiro Inoue, Masahiro Nishio, Yasuhito Naito, Takamitsu Hosoya, Masaaki Suzuki & Hiroyoshi Hidaka. (2014) IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys. Bioorganic & Medicinal Chemistry Letters 24:3, pages 831-834.
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JING WANG, XIAOHONG LIU & YISHENG ZHONG. (2013) Rho/Rho-associated kinase pathway in glaucoma. International Journal of Oncology 43:5, pages 1357-1367.
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Toshihiro Inoue & Hidenobu Tanihara. (2013) Rho-associated kinase inhibitors: A novel glaucoma therapy. Progress in Retinal and Eye Research 37, pages 1-12.
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Masahiro NISHIO, Yusuke KUMITA, Yukitaka UJI, Naoto ISONO & Hayato UMEKAWA. (2013) ^|^beta;-1,3-Glucan Attenuates Neuronal Cell Death after Transient Retinal Ischemia and Reperfusion. Food Science and Technology Research 19:3, pages 485-489.
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Annegret Ulke-Lemée & Justin A. MacDonald. (2010) Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors. Pharmaceuticals 3:6, pages 1739-1760.
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Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant, Thomas Schröter, Weimin Chen, Derek Duckett, Stephan Schürer, Philip LoGrasso & Yangbo Feng. (2009) Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. Bioorganic & Medicinal Chemistry Letters 19:23, pages 6686-6690.
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