1,320
Views
56
CrossRef citations to date
0
Altmetric
Reviews

Morphology and Composition of the Inner Limiting Membrane: Species-Specific Variations and Relevance toward Drug Delivery Research

, , , & ORCID Icon
Pages 465-475 | Received 19 Oct 2018, Accepted 20 Dec 2018, Published online: 30 Jan 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Divya Ail, Hugo Malki, Emilia A Zin & Deniz Dalkara. (2023) Adeno-Associated Virus (AAV) - Based Gene Therapies for Retinal Diseases: Where are We?. The Application of Clinical Genetics 16, pages 111-130.
Read now
Karen Peynshaert, Joke Devoldere, Stefaan De Smedt & Katrien Remaut. (2023) Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy. Expert Opinion on Drug Delivery 20:2, pages 259-271.
Read now

Articles from other publishers (53)

Maria João Faria, José M. González-Méijome, M. Elisabete C.D. Real Oliveira, Gonzalo Carracedo & Marlene Lúcio. (2024) Recent advances and strategies for nanocarrier-mediated topical therapy and theranostic for posterior eye disease. Advanced Drug Delivery Reviews 210, pages 115321.
Crossref
Alexandre Assi & David Charteris. (2024) Proliferative vitreoretinopathy: a revised concept of retinal injury and response. British Journal of Ophthalmology, pages bjo-2023-324417.
Crossref
Akinari Yamamoto, Manabu Miyata & Akitaka Tsujikawa. (2024) Ophthalmologists’ assessment of the handling characteristics of the novel Finesse Reflex Handle in comparison to those of a conventional handle. Scientific Reports 14:1.
Crossref
Dongyue Wang, Yi Chen, Jiakun Li, Erman Wu, Tong Tang, Rajeev K. Singla, Bairong Shen & Ming Zhang. (2024) Natural Products for the Treatment of Age-Related Macular Degeneration. Phytomedicine, pages 155522.
Crossref
Matthew B. Appell, Jahnavi Pejavar, Ashwin Pasupathy, Sri Vishnu Kiran Rompicharla, Saed Abbasi, Kiersten Malmberg, Patricia Kolodziejski & Laura M. Ensign. (2024) Next generation therapeutics for retinal neurodegenerative diseases. Journal of Controlled Release 367, pages 708-736.
Crossref
Yicen J. Zheng, Mikayla D. Dilbeck, John R. Economides & Jonathan C. Horton. (2024) Permanent transduction of retinal ganglion cells by rAAV2-retro. Experimental Eye Research 240, pages 109793.
Crossref
Helena Vanluchene, Oriane Gillon, Karen Peynshaert, Stefaan C. De Smedt, Niek Sanders, Koen Raemdonck & Katrien Remaut. (2024) Less is more: Self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells. European Journal of Pharmaceutics and Biopharmaceutics 196, pages 114204.
Crossref
Dean Henze, Joseph A. Majdi & Ethan D. Cohen. (2024) Effect of epiretinal electrical stimulation on the glial cells in a rabbit retinal eyecup model. Frontiers in Neuroscience 18.
Crossref
Isa van der Veen, Andrea Heredero Berzal, Céline Koster, Anneloor L. M. A. ten Asbroek, Arthur A. Bergen & Camiel J. F. Boon. (2024) The Road towards Gene Therapy for X-Linked Juvenile Retinoschisis: A Systematic Review of Preclinical Gene Therapy in Cell-Based and Rodent Models of XLRS. International Journal of Molecular Sciences 25:2, pages 1267.
Crossref
Sumel Ashique, Neeraj Mishra, Sourav Mohanto, B.H. Jaswanth Gowda, Shubneesh Kumar, Amisha S. Raikar, Priya Masand, Ashish Garg, Priyanka Goswami & Ivan Kahwa. (2024) Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks. Heliyon 10:1, pages e23810.
Crossref
Ralf Schweiggert. 2024. Handbook on Natural Pigments in Food and Beverages. Handbook on Natural Pigments in Food and Beverages 75 126 .
Xue Xia & Xinzheng Guo. (2023) Adeno-associated virus vectors for retinal gene therapy in basic research and clinical studies. Frontiers in Medicine 10.
Crossref
Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, Abdelrahman Y. Fouda, Ajay Ashok, Ala Moshiri, Alain Chedotal, Amberlynn A. Reed, Amjad Askary, An-Jey A. Su, Anna La Torre, Archana Jalligampala, Ariadna Silva-Lepe, Arupratan Das, Barbara Wirostko, Benjamin J. Frankfort, Benjamin Sivyer, Bhagwat Alapure, Brent Young, Brian Clark, Bryan William Jones, Chase Hellmer, Claire Mitchell, Claire Ufongene, Dan Goldman, David Feldheim, David H. Gutmann, David J. Calkins, David Krizaj, David M. Gamm, Diana C. Lozano, Diane E. Bovenkamp, Dong Feng Chen, Elena Vecino Cordero, Ephraim F. Trakhtenberg, Feng Tian, Fengquan Zhou, Gillian J. McLellan, Harry A. Quigley, Hashem Abu Serhan, James R. Tribble, Jason Meyer, Jeff Gross, Jeff S. Mumm, Jeremy M. Sivak, Jingliang Simon Zhang, Jiun L. Do, Jonathan Crowston, Julie Chen, Juliette McGregor, Kalyan C. Vinnakota, Kang-Chieh Huang, Karen Peynshaert, Katherine E. Uyhazi, Keith Martin, Ken Muller, Kevin K. Park, Kin-Sang Cho, Kun-Che Chang, Larry Benowitz, Leonard A. Levin, Levi Todd, Lies De Groef, Lieve Moons, Luis Alarcon-Martinez, Mandeep S. Singh, Manuel Vidal-Sanz, Mariana S. Silveira, Marina Pavlou, Matthew B. Veldman, Matthew Van Hook, Melanie Samuel, Mengming Hu, Micalla Peng, Michael Young, Michel Cayouette, Mohammad H. Geranmayeh, Mollie Woodworth, Monica Vetter, Nicholas R. Marsh-Armstrong, Pete A. Williams, Pratheepa Kumari Rasiah, Preeti Subramanian, Qi N. Cui, Rebecca M. Sappington, Reem Amine, Richard Eva, Robert J. JohnstonJrJr, Roman J. Giger, Ross Ethier, Sadaf Abed, Sehrish Nizar Ali Momin, Seth Blackshaw, Shane A. Liddelow, Stella Mary, Stephen Atolagbe, Supraja Varadarajan, Tareq I. Nabhan, Tasneem Khatib, Tasneem Putliwala Sharma, Thomas Brunner, Tom Greenwell, Tonia S. Rex, Trent Watkins, Tudor C. Badea, V. Vrathasha, Venkata Ramana Murthy Chavali, Viviane M. Oliveira-Valença, Wai Lydia Tai, Wyndham M. Batchelor, Xian-Jie Yang, Yong Park, Yuan Pan, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack & Thomas V. Johnson. (2023) Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Molecular Neurodegeneration 18:1.
Crossref
Cláudia Carvalho, Luísa Lemos, Pedro Antas & Miguel C. Seabra. (2023) Gene therapy for inherited retinal diseases: exploiting new tools in genome editing and nanotechnology. Frontiers in Ophthalmology 3.
Crossref
Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut, Félix Sauvage & Karen Peynshaert. (2023) Exploring light for advanced drug delivery & surgery in the eye. Macedonian Pharmaceutical Bulletin 69:03, pages 3-4.
Crossref
Qintuo Pan, Shengjian Lu, Mengyun Li, Huirong Pan, Lixu Wang, Yiyang Mao, Wencan Wu & Yikui Zhang. (2022) Vitrectomy and ILM peeling in rhesus macaque: pitfalls and tips for success. Eye 37:11, pages 2257-2264.
Crossref
Diana Rafael, Marcelo Guerrero, Adolfo Marican, Diego Arango, Bruno Sarmento, Roser Ferrer, Esteban F. Durán-Lara, Simon J. Clark & Simo SchwartzJr.Jr.. (2023) Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds. Pharmaceutics 15:5, pages 1484.
Crossref
Wei Li, Liang Chen, Zhongwei Gu, Zhoujiang Chen, Hong Li, Zhongxia Cheng, Hanmei Li & Liang Zou. (2023) Co-delivery of microRNA-150 and quercetin by lipid nanoparticles (LNPs) for the targeted treatment of age-related macular degeneration (AMD). Journal of Controlled Release 355, pages 358-370.
Crossref
Mehrnoosh Rafiei, Jin Teng Chung & Ying Chau. (2023) Roles of biomaterials in modulating the innate immune response in ocular therapy. Frontiers in Drug Delivery 3.
Crossref
Divyesh H. Shastri, Ana Catarina Silva & Hugo Almeida. (2023) Ocular Delivery of Therapeutic Proteins: A Review. Pharmaceutics 15:1, pages 205.
Crossref
Jiwei Tao, Jinglei Yang, Yubo Wu, Xin Ye, Yun Zhang, Jianbo Mao, Jun Wang, Yiqi Chen & Lijun Shen. (2022) INTERNAL LIMITING MEMBRANE PEELING DISTORTS THE RETINAL LAYERS AND INDUCES SCOTOMA FORMATION IN THE PERIFOVEAL TEMPORAL MACULA. Retina 42:12, pages 2276-2283.
Crossref
Daiheon Lee, Gijung Kwak, Thomas V. Johnson & Jung Soo Suk. (2022) Formulation and Evaluation of Polymer‐Based Nanoparticles for Intravitreal Gene‐Delivery Applications. Current Protocols 2:12.
Crossref
M. Ross, A. Obolensky, E. Averbukh, M. Desrosiers, R. Ezra-Elia, H. Honig, E. Yamin, A. Rosov, H. Dvir, E. Gootwine, E. Banin, D. Dalkara & R. Ofri. (2021) Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia. Gene Therapy 29:10-11, pages 624-635.
Crossref
Xurxo García-Otero, Cristina Mondelo-García, Enrique Bandín-Vilar, Noemí Gómez-Lado, Jesús Silva-Rodríguez, David Rey-Bretal, M. Victoria Otero-Espinar, Alfredo Adan, Miguel González-Barcia, Pablo Aguiar, Francisco J. Otero-Espinar & Anxo Fernández-Ferreiro. (2022) PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model. International Journal of Pharmaceutics 627, pages 122261.
Crossref
Karen Peynshaert, Helena Vanluchene, Kaat De Clerck, An-Katrien Minnaert, Morgane Verhoeven, Noémie Gouspillou, Nezahat Bostan, Toshio Hisatomi, Geraldine Accou, Félix Sauvage, Kevin Braeckmans, Stefaan De Smedt & Katrien Remaut. (2022) ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery. Journal of Controlled Release 349, pages 315-326.
Crossref
Marilena Bohley, Andrea E. Dillinger, Ernst R. Tamm & Achim Goepferich. (2022) Targeted drug delivery to the retinal pigment epithelium: Untapped therapeutic potential for retinal diseases. Drug Discovery Today 27:9, pages 2497-2509.
Crossref
Kaat De Clerck, Geraldine Accou, Félix Sauvage, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut & Karen Peynshaert. (2022) Photodisruption of the Inner Limiting Membrane: Exploring ICG Loaded Nanoparticles as Photosensitizers. Pharmaceutics 14:8, pages 1716.
Crossref
Rasha A. Alshaikh, Christian Waeber & Katie B. Ryan. (2022) Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies. Advanced Drug Delivery Reviews 187, pages 114342.
Crossref
Lidawani Lambuk, Nurfatihah Azlyna Ahmad Suhaimi, Muhammad Zulfiqah Sadikan, Azliana Jusnida Ahmad Jafri, Suhana Ahmad, Nurul Alimah Abdul Nasir, Vuk Uskoković, Ramlah Kadir & Rohimah Mohamud. (2022) Nanoparticles for the treatment of glaucoma-associated neuroinflammation. Eye and Vision 9:1.
Crossref
Angela Boyce & Gary Walsh. (2022) Production, characteristics and applications of microbial heparinases. Biochimie 198, pages 109-140.
Crossref
Rakesh Nanjappa, Mikayla D. Dilbeck, John R. Economides & Jonathan C. Horton. (2022) Fundus imaging of retinal ganglion cells transduced by retrograde transport of rAAV2-retro. Experimental Eye Research 219, pages 109084.
Crossref
Diogo B. Bitoque, Cláudia F. Fernandes, Alexandra M. L. Oliveira & Gabriela A. Silva. (2022) Strategies to Improve the Targeting of Retinal Cells by Non-Viral Gene Therapy Vectors. Frontiers in Drug Delivery 2.
Crossref
Heng Jiang, Bin Yan, Zhishang Meng, Lusi Zhang, Hetian Lei & Jing Luo. (2022) The MDM2 Single-Nucleotide Polymorphism T309G Is Associated With the Development of Epimacular Membranes. Frontiers in Cell and Developmental Biology 10.
Crossref
Robert Strutt, Felix Sheffield, Nathan E. Barlow, Anthony J. Flemming, John D. Harling, Robert V. Law, Nicholas J. Brooks, Laura M. C. Barter & Oscar Ces. (2022) UV-DIB: label-free permeability determination using droplet interface bilayers. Lab on a Chip 22:5, pages 972-985.
Crossref
Helen S. Booler, Typhaine Lejeune, Steven Sorden, Margarita M. Gruebbel, Kenneth A. Schafer, Brian Short, Cindy Farman, Meg Ferrell Ramos, Bindu Bennet, Krishna Yekkala, Elke-Astrid Atzpodien, Oliver C. Turner, Jaqueline Brassard & George Foley. (2021) Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies. Toxicologic Pathology 50:2, pages 235-251.
Crossref
Luisa Frizziero, Raffaele Parrozzani, Davide Londei, Elisabetta Pilotto & Edoardo Midena. (2021) Quantification of vascular and neuronal changes in the peripapillary retinal area secondary to diabetic retinopathy. British Journal of Ophthalmology 105:11, pages 1577-1583.
Crossref
MARY ANN Stepp & A. SUE Menko. (2021) Immune responses to injury and their links to eye disease. Translational Research 236, pages 52-71.
Crossref
Aiden Eblimit, Mustafa S. Makia, Daniel Strayve, Ryan Crane, Shannon M. Conley, Tirthankar Sinha, Ghanashyam Acharya, Muayyad R. Al-Ubaidi & Muna I. Naash. (2021) Co-Injection of Sulfotyrosine Facilitates Retinal Uptake of Hyaluronic Acid Nanospheres Following Intravitreal Injection. Pharmaceutics 13:9, pages 1510.
Crossref
Kevin J. Cao, Elijah F. Lyons, Benjamin E. Smith, Bristol L. Denlinger, Hong Ma, Jonathan D. Shirian & Richard H. Kramer. (2021) Cyclodextrin‐Assisted Delivery of Azobenzene Photoswitches for Uniform and Long‐Term Restoration of Light Responses in Degenerated Retinas of Blind Mice. Advanced Therapeutics 4:9.
Crossref
Darya V. Telegina, Oyuna S. Kozhevnikova, Anna K. Antonenko & Nataliya G. Kolosova. (2021) Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?. International Journal of Molecular Sciences 22:14, pages 7373.
Crossref
Kevin Y. Zhang & Thomas V. Johnson. (2021) The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies. Experimental Eye Research 206, pages 108545.
Crossref
András M. Komáromy, Kristin L. Koehl & Shin Ae Park. (2021) Looking into the future: Gene and cell therapies for glaucoma. Veterinary Ophthalmology 24:S1, pages 16-33.
Crossref
Sven Schnichels, François Paquet-Durand, Marina Löscher, Teresa Tsai, José Hurst, Stephanie C. Joachim & Alexa Klettner. (2021) Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina. Progress in Retinal and Eye Research 81, pages 100880.
Crossref
Dylan E. Parsons, Soo Hyeon Lee, Young Joo Sun, Gabriel Velez, Alexander G. Bassuk, Mark Smith & Vinit B. Mahajan. (2021) Peptidomimetics Therapeutics for Retinal Disease. Biomolecules 11:3, pages 339.
Crossref
Jinjin Jiang, Xinru Zhang, Yue Tang, Shuhan Li & Jing Chen. (2020) Progress on ocular siRNA gene‐silencing therapy and drug delivery systems. Fundamental & Clinical Pharmacology 35:1, pages 4-24.
Crossref
Kevin Y. Zhang, Caitlyn Tuffy, Joseph L. Mertz, Sarah Quillen, Laurence Wechsler, Harry A. Quigley, Donald J. Zack & Thomas V. Johnson. (2021) Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells. Stem Cell Reports 16:1, pages 149-167.
Crossref
Shirin Tavakoli, Karen Peynshaert, Tatu Lajunen, Joke Devoldere, Eva M. del Amo, Marika Ruponen, Stefaan C. De Smedt, Katrien Remaut & Arto Urtti. (2020) Ocular barriers to retinal delivery of intravitreal liposomes: Impact of vitreoretinal interface. Journal of Controlled Release 328, pages 952-961.
Crossref
Suyeon You, Hyoungtai Kim, Hye-youn Jung, Boram Kim, Eun Jung Lee, Jin Woo Kim & Yoonkyung Kim. (2020) Tuning surface functionalities of sub-10 nm-sized nanocarriers to target outer retina in designing drug delivery agents for intravitreal administration. Biomaterials 255, pages 120188.
Crossref
Andrea Luaces-Rodríguez, Eva M del Amo, Cristina Mondelo-García, Noemí Gómez-Lado, Francisco Gonzalez, Álvaro Ruibal, Miguel González-Barcia, Irene Zarra-Ferro, Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro & Pablo Aguiar. (2020) PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats. European Journal of Pharmaceutics and Biopharmaceutics 154, pages 330-337.
Crossref
Sahar Awwad, Christin Henein, Nkiruka Ibeanu, Peng T. Khaw & Steve Brocchini. (2020) Preclinical challenges for developing long acting intravitreal medicines. European Journal of Pharmaceutics and Biopharmaceutics 153, pages 130-149.
Crossref
Jaakko Itkonen, Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn & Arto Urtti. (2020) Characterization, Stability, and In Vivo Efficacy Studies of Recombinant Human CNTF and Its Permeation into the Neural Retina in Ex Vivo Organotypic Retinal Explant Culture Models. Pharmaceutics 12:7, pages 611.
Crossref
Angelo Spadaro, Marco Rao, Miriam Lorenti, Mario Rosario Romano, Antonio Augello, Chiara Maria Eandi, Chiara Bianca Maria Platania, Filippo Drago & Claudio Bucolo. (2020) New Brilliant Blue G Derivative as Pharmacological Tool in Retinal Surgery. Frontiers in Pharmacology 11.
Crossref
Karen Peynshaert, Joke Devoldere, Frederik Philips, Fauve Vergauwe, Stefaan De Smedt & Katrien Remaut. (2020) Influence of pathogenic stimuli on Müller cell transfection by lipoplexes. European Journal of Pharmaceutics and Biopharmaceutics 150, pages 87-95.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.