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Current Eye Research Volume 45, 2020 - Issue 3: Ocular Regeneration
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Understanding the complexity of retina and pluripotent stem cell derived retinal organoids with single cell RNA sequencing: current progress, remaining challenges and future prospective

Darin Zertia Institute of Genetic Medicine, Newcastle University, Newcastle, UKView further author information
,
Joseph Collina Institute of Genetic Medicine, Newcastle University, Newcastle, UKView further author information
,
Rachel Queenb Bioinformatics Core Facility, Newcastle University, Newcastle upon Tyne, UKView further author information
,
Simon J. Cockellb Bioinformatics Core Facility, Newcastle University, Newcastle upon Tyne, UKView further author information
&
Majlinda Lakoa Institute of Genetic Medicine, Newcastle University, Newcastle, UKCorrespondence[email protected]
View further author information
Pages 385-396 | Received 13 Sep 2019, Accepted 22 Oct 2019, Published online: 03 Feb 2020

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Elizabeth J. Rossin, Lucia Sobrin & Leo A. Kim. (2021) Single-cell RNA sequencing: An overview for the ophthalmologist. Seminars in Ophthalmology 36:4, pages 191-197.
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Articles from other publishers (19)

Hongkun Zhao & Fei Yan. (2023) Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery. Stem Cell Reviews and Reports 20:2, pages 495-508.
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Sofia Ahsanuddin & Albert Y. Wu. (2023) Single-cell transcriptomics of the ocular anterior segment: a comprehensive review. Eye 37:16, pages 3334-3350.
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Kai Chen, Yinhao Wang, Youyuan Huang, Xinxin Liu, Xiaodong Tian, Yinmo Yang & Aimei Dong. (2023) Cross-species scRNA-seq reveals the cellular landscape of retina and early alterations in type 2 diabetes mice. Genomics 115:4, pages 110644.
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Rohan Subramanian & Debashis Sahoo. (2022) Boolean implication analysis of single-cell data predicts retinal cell type markers. BMC Bioinformatics 23:1.
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Yuntian Xue, Bin Lin, Jacqueline T. Chen, William C. Tang, Andrew W. Browne & Magdalene J. Seiler. (2022) The Prospects for Retinal Organoids in Treatment of Retinal Diseases. Asia-Pacific Journal of Ophthalmology 11:4, pages 314-327.
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Fei Liu, Yayun Qin, Yuwen Huang, Pan Gao, Jingzhen Li, Shanshan Yu, Danna Jia, Xiang Chen, Yuexia Lv, Jiayi Tu, Kui Sun, Yunqiao Han, James Reilly, Xinhua Shu, Qunwei Lu, Zhaohui Tang, Chengqi Xu, Daji Luo & Mugen Liu. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLOS Genetics 18:3, pages e1009841.
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Connor Finkbeiner, Isabel Ortuño-Lizarán, Akshayalakshmi Sridhar, Marcus Hooper, Sidnee Petter & Thomas A. Reh. (2022) Single-cell ATAC-seq of fetal human retina and stem-cell-derived retinal organoids shows changing chromatin landscapes during cell fate acquisition. Cell Reports 38:4, pages 110294.
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Harini V. Gudiseva, Vrathasha Vrathasha, Jie He, Devesh Bungatavula, Joan M. O’Brien & Venkata R. M. Chavali. (2021) Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes. Genes 12:12, pages 2015.
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Valerio Caputo, Claudia Strafella, Andrea Termine, Carlo Fabrizio, Paola Ruffo, Andrea Cusumano, Emiliano Giardina, Federico Ricci & Raffaella Cascella. (2021) Epigenomic signatures in age-related macular degeneration: Focus on their role as disease modifiers and therapeutic targets. European Journal of Ophthalmology 31:6, pages 2856-2867.
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Jinyan Li, Yijia Chen, Shuai Ouyang, Jingyu Ma, Hui Sun, Lixia Luo, Shuyi Chen & Yizhi Liu. (2021) Generation and Staging of Human Retinal Organoids Based on Self-Formed Ectodermal Autonomous Multi-Zone System. Frontiers in Cell and Developmental Biology 9.
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Xiaochen Fan, Emine K. Bilir, Olivia A. Kingston, Rachel A. Oldershaw, Victoria R. Kearns, Colin E. Willoughby & Carl M. Sheridan. (2021) Replacement of the Trabecular Meshwork Cells—A Way Ahead in IOP Control?. Biomolecules 11:9, pages 1371.
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Mengling You, Rong Rong, Zhou Zeng, Haibo Li, Xiaobo Xia & Dan Ji. (2021) Single‐cell RNA sequencing: A new opportunity for retinal research . WIREs RNA 12:5.
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Peixi Ying, Chang Huang, Yan Wang, Xi Guo, Yuchen Cao, Yuxi Zhang, Sheng Fu, Lin Chen, Guoguo Yi & Min Fu. (2021) Single-Cell RNA Sequencing of Retina:New Looks for Gene Marker and Old Diseases. Frontiers in Molecular Biosciences 8.
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Jingxue Zhang, Shen Wu, Zi-Bing Jin & Ningli Wang. (2021) Stem Cell-Based Regeneration and Restoration for Retinal Ganglion Cell: Recent Advancements and Current Challenges. Biomolecules 11:7, pages 987.
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Andrew P. Voigt, Nathaniel K. Mullin, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz & Robert F. Mullins. (2021) Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. Progress in Retinal and Eye Research 83, pages 100934.
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Julia Oswald, Evgenii Kegeles, Tomas Minelli, Pavel Volchkov & Petr Baranov. (2021) Transplantation of miPSC/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas. Molecular Therapy - Methods & Clinical Development 21, pages 180-198.
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David A. Antonetti, Paolo S. Silva & Alan W. Stitt. (2021) Current understanding of the molecular and cellular pathology of diabetic retinopathy. Nature Reviews Endocrinology 17:4, pages 195-206.
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Kamil Kruczek & Anand Swaroop. (2020) Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies. Stem Cells 38:10, pages 1206-1215.
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Justin D. Silverman, Kimberly Roche, Sayan Mukherjee & Lawrence A. David. (2020) Naught all zeros in sequence count data are the same. Computational and Structural Biotechnology Journal 18, pages 2789-2798.
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