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ORIGINAL ARTICLE

β2-Adrenoceptor Polymorphisms Predict Response to β2-Agonists in Children with Acute Asthma

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Pages 383-388 | Published online: 02 Jul 2009

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Maria Gabriella Matera, Paola Rogliani, Giuseppe Novelli & Mario Cazzola. (2023) The impact of genomic variants on patient response to inhaled bronchodilators: a comprehensive update. Expert Opinion on Drug Metabolism & Toxicology 19:5, pages 285-295.
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Xia Zhou, Ya-Jie Dang, Gui-Fang Wang & Xian-Qiao Jin. (2017) Effects of Aspergillus fumigatus on glucocorticoid receptor and β2-adrenergic receptor expression in a rat model of asthma. Experimental Lung Research 43:4-5, pages 197-207.
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Yaron Finkelstein, Facundo Garcia Bournissen, Janine R. Hutson & Michael Shannon. (2009) Polymorphism of the ADRB2 Gene and Response to Inhaled Beta- agonists in Children with Asthma: A Meta-analysis. Journal of Asthma 46:9, pages 900-905.
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Rebecca L. Watkinson, Kevin Looi, Ingrid A. Laing, Antonella Cianferoni & Anthony Kicic. (2021) Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis. Frontiers in Immunology 12.
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Leila Karimi, Susanne J. Vijverberg, Marjolein Engelkes, Natalia Hernandez‐Pacheco, Niloufar Farzan, Patricia Soares, Maria Pino‐Yanes, Andrea L. Jorgensen, Celeste Eng, Somnath Mukhopadhyay, Maximilian Schieck, Michael Kabesch, Esteban G. Burchard, Fook Tim Chew, Yang Yie Sio, Uroš Potočnik, Mario Gorenjak, Daniel B. Hawcutt, Colin N. Palmer, Steve Turner, Hettie M. Janssens, Anke H. Maitland‐van der Zee & Katia M. C. Verhamme. (2021) ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta‐analysis . Clinical & Experimental Allergy 51:9, pages 1157-1171.
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Shalini Sinha, Bimal Prasad Jit, A. Raj Kumar Patro, Aisurya Ray, Snehadhini Dehury, Sarmila Sahoo, Rajendra Kumar Behera, Pradeep Kumar Mohanty, Pinaki Panigrahi & Padmalaya Das. (2020) Influence of rs1042713 and rs1042714 polymorphisms of β2-adrenergic receptor gene with erythrocyte cAMP in sickle cell disease patients from Odisha State, India. Annals of Hematology 99:12, pages 2737-2745.
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Keiko Hikino, Shinobu Kobayashi, Erika Ota, Taisei Mushiroda & Tohru Kobayashi. (2019) The Influence of Beta-2 Adrenergic Receptor Gene Polymorphisms on Albuterol Therapy for Patients With Asthma: Protocol for a Systematic Review and Meta-Analysis. JMIR Research Protocols 8:9, pages e14759.
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N Jovicic, T Babic, S Dragicevic, B Nestorovic & A Nikolic. (2018) ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma . Balkan Journal of Medical Genetics 21:1, pages 33-38.
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Ashgan Abdallah Alghobashy, Sahar A Elsharawy, Usama M Alkholy, Nermin Abdalmonem, Mohamed Ali Abdou, Maha A A Basset & Heba Fouad Pasha. (2018) B2 adrenergic receptor gene polymorphism effect on childhood asthma severity and response to treatment. Pediatric Research 83:3, pages 597-605.
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Suzanne Schuh, Judy Sweeney, Stephen B. Freedman, Allan L. Coates, David W. Johnson, Graham Thompson, Jocelyn Gravel, Francine M. Ducharme, Roger Zemek, Amy C. Plint, Darcy Beer, Terry Klassen, Sarah Curtis, Karen Black, Darcy Nicksy & Andrew R. Willan. (2016) Magnesium nebulization utilization in management of pediatric asthma (MagNUM PA) trial: study protocol for a randomized controlled trial. Trials 17:1.
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Puneet Kaur Sahi, Shivaram Shastri, Rakesh Lodha, Neerja Gupta, R. M. Pandey, Sushil Kumar Kabra & Madhulika Kabra. (2016) ADRB2 polymorphism and salbutamol responsiveness in Northern Indian children with mild to moderate exacerbation of asthma. Indian Pediatrics 53:3, pages 211-215.
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Srinivas Bandaru, Jyothy Akka, Vijaya Kumar Marri, Mallika Alvala, Deepika Ponnala & Hema Prasad Mundluru. (2015) Analysis of ADRB2 (Arg16Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics. Inflammation 38:6, pages 2146-2155.
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Mariëlle W. Pijnenburg & Stanley Szefler. (2015) Personalized medicine in children with asthma. Paediatric Respiratory Reviews 16:2, pages 101-107.
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Q L Duan, J Lasky-Su, B E Himes, W Qiu, A A Litonjua, A Damask, R Lazarus, B Klanderman, C G Irvin, S P Peters, J P Hanrahan, J J Lima, F D Martinez, D Mauger, V M Chinchilli, M Soto-Quiros, L Avila, J C Celedón, C Lange, S T Weiss & K G Tantisira. (2013) A genome-wide association study of bronchodilator response in asthmatics. The Pharmacogenomics Journal 14:1, pages 41-47.
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Nancy Larocca, Dolores Moreno, Jenny Valentina Garmendia, Olga Velasquez, Joana Martin-Rojo, Carlos Talamo, Alexis Garcia & Juan Bautista De Sanctis. (2013) Beta 2 adrenergic receptor polymorphisms, at codons 16 and 27, and bronchodilator responses in adult Venezuelan asthmatic patients. Biomedical Papers 157:4, pages 374-378.
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Desmond W. Cox, Joelene Bizzintino, Giovanni Ferrari, Siew Kim Khoo, Guicheng Zhang, Siobhan Whelan, Wai Ming Lee, Yury A. Bochkov, Gary C. Geelhoed, Jack Goldblatt, James E. Gern, Ingrid A. Laing & Peter N. Le Souëf. (2013) Human Rhinovirus Species C Infection in Young Children with Acute Wheeze Is Associated with Increased Acute Respiratory Hospital Admissions. American Journal of Respiratory and Critical Care Medicine 188:11, pages 1358-1364.
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Tale M Torjussen, Monica C Munthe‐Kaas, Petter Mowinckel, Kai‐Håkon Carlsen, Dag E Undlien & Karin C Lødrup Carlsen. (2013) Childhood lung function and the association with β2‐adrenergic receptor haplotypes. Acta Paediatrica 102:7, pages 727-731.
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Bethan L. BarkerChristopher E. Brightling. (2012) Phenotyping the heterogeneity of chronic obstructive pulmonary disease. Clinical Science 124:6, pages 371-387.
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Carlos Isaza, Juan C. Sepúlveda-Arias, Bertha Inés Agudelo, William Arciniegas, Julieta Henao, Gloria L. Porras & Leonardo Beltrán. (2012) β2-adrenoreceptor polymorphisms in asthmatic and non-asthmatic schoolchildren from colombia and their relationship to treatment response. Pediatric Pulmonology 47:9, pages 848-855.
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Mario Cazzola, Clive P. Page, Luigino Calzetta & M. Gabriella Matera. (2012) Pharmacology and Therapeutics of Bronchodilators. Pharmacological Reviews 64:3, pages 450-504.
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Christopher L. Carroll, Kathleen A. Sala, Aaron R. Zucker & Craig M. Schramm. (2012) Beta-adrenergic receptor polymorphisms associated with length of ICU stay in pediatric status asthmaticus. Pediatric Pulmonology 47:3, pages 233-239.
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Peter von Homeyer & Debra A. Schwinn. (2011) Pharmacogenomics of β-Adrenergic Receptor Physiology and Response to β-Blockade. Anesthesia & Analgesia 113:6, pages 1305-1318.
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L. P. Chung, G. Waterer & P. J. Thompson. (2011) Pharmacogenetics of β2 adrenergic receptor gene polymorphisms, long-acting β-agonists and asthma. Clinical & Experimental Allergy 41:3, pages 312-326.
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I. Poziomkowska-Gesicka, E. Dzieciolowska-Baran, A. Gawlikowska-Sroka, D. Slowik-Zylka & T. Sroczynski. (2010) Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism. European Journal of Medical Research 15:S2.
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Hajer Elkout, James S McLay, Colin R Simpson & Peter J Helms. (2010) Use and safety of long-acting β 2 -agonists for pediatric asthma . Pediatric Health 4:3, pages 295-310.
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Shamsah Kazani, Michael E. Wechsler & Elliot Israel. (2010) The role of pharmacogenomics in improving the management of asthma. Journal of Allergy and Clinical Immunology 125:2, pages 295-302.
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Augusto A. Litonjua, Li Gong, Qing Ling Duan, Jaekyu Shin, Mariellen J. Moore, Scott T. Weiss, Julie A. Johnson, Teri E. Klein & Russ B. Altman. (2010) Very important pharmacogene summary ADRB2. Pharmacogenetics and Genomics 20:1, pages 64-69.
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Christopher L. Carroll, Petronella Stoltz, Craig M. Schramm & Aaron R. Zucker. (2009) ? 2 -Adrenergic Receptor Polymorphisms Affect Response to Treatment in Children With Severe Asthma Exacerbations. Chest 135:5, pages 1186-1192.
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John J Lima, Kathryn V Blake, Kelan G Tantisira & Scott T Weiss. (2009) Pharmacogenetics of asthma. Current Opinion in Pulmonary Medicine 15:1, pages 57-62.
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