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Journal of Asthma Volume 58, 2021 - Issue 6
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Immunopathogenesis

Elevated Th17 cell frequencies and Th17/Treg ratio are associated with airway hyperresponsiveness in asthmatic children

Rongying ZhengDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
, MD,
Fangmin WangDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
, MD,
Yue HuangDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
, MD,
Qiangwei XiangDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaView further author information
, MD,
Huan DaiDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCorrespondence[email protected]
View further author information
, MD &
Weixi ZhangDepartment of Pediatric Allergy and Immunology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaCorrespondence[email protected]
View further author information
, MD, PhD
Pages 707-716 | Received 03 Dec 2018, Accepted 31 Mar 2019, Published online: 13 Mar 2020

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Mona A Eldosoky, Reham Hammad, Areej Rushdi, Hanan F Ibrahim, Amany M Tawfeik, Ahmed Mora, Sarah F Fahmy, Hossam El-Ashmawy, Elham Ali, Dina H Hamed, Amena Rezk Mohammed, Alya Mashaal & Hanan Mohsen. (2023) MicroRNA-146a-5p and microRNA‐210‐3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population. Journal of Asthma and Allergy 16, pages 107-121.
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Ricardo Wesley Alberca. (2021) Asthma endotypes and COVID-19. Journal of Asthma 58:11, pages 1424-1425.
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Sherry Tong, Jordan C. Scott, Enwono Eyoh, Derek W. Werthmann, Addison E. Stone, Amelie E. Murrell, Gilberto Sabino-Santos, Ivy V. Trinh, Sruti Chandra, Debra H. Elliott, Ashley R. Smira, Jalene V. Velazquez, John Schieffelin, Bo Ning, Tony Hu, Jay K. Kolls, Samuel J. Landry, Kevin J. Zwezdaryk, James E. Robinson, Bronwyn M. Gunn, Felicia A. Rabito & Elizabeth B. Norton. (2024) Altered COVID-19 immunity in children with asthma by atopic status. Journal of Allergy and Clinical Immunology: Global 3:2, pages 100236.
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Hongchao Wang, Yuan He, Danting Dang, Yurong Zhao, Jianxin Zhao & Wenwei Lu. (2024) Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice. Foods 13:9, pages 1336.
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Yanhong Cen, Fangfang Li, Yikui Li, Kaimin Zhang, Farooq Riaz, Kuaile Zhao, Ping Wei & Fan Pan. (2024) Dimethyl fumarate alleviates allergic asthma by strengthening the Nrf2 signaling pathway in regulatory T cells. Frontiers in Immunology 15.
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Nannan Liu, Dan Wang, Jiayu Tian, Xin Wang, Hao Shi, Caihong Wang, Yi Jiang, Min Pang, Xiaozhou Fan, Jing Zhao, Liangpo Liu, Hongyan Wu, Linlin Guan, Huiqiu Zheng, Dongxing Shi & Zhihong Zhang. (2023) PM2.5-bound metals and blood metals are associated with pulmonary function and Th17/Treg imbalance: A panel study of asthmatic adults. Chemosphere 340, pages 139869.
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E. Allgire, R.A. Ahlbrand, N. Nawreen, A. Ajmani, C. Hoover, J.W. McAlees, I.P. Lewkowich & R. Sah. (2023) Altered Fear Behavior in Aeroallergen House Dust Mite Exposed C57Bl/6 Mice: A Model of Th2-skewed Airway Inflammation. Neuroscience 528, pages 75-88.
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Jingyan Li, Tianping Bao, Linxia Cao, Mengmeng Ma, Yuan Zhang & Zhaofang Tian. (2023) Effects of early postnatal hyperoxia exposure combined with early ovalbumin sensitization on lung inflammation and bacterial flora in a juvenile mouse model of asthma. Frontiers in Microbiology 14.
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Nardos Cheru, David A. Hafler & Tomokazu S. Sumida. (2023) Regulatory T cells in peripheral tissue tolerance and diseases. Frontiers in Immunology 14.
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Rony Thomas, Sai Qiao & Xi Yang. (2023) Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases. International Journal of Molecular Sciences 24:5, pages 4865.
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晶 张. (2023) Study on Airway Inflammation Index in Asthmatic Rats with Kidney-Qi Deficiency. Advances in Clinical Medicine 13:10, pages 15215-15220.
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Siti Farah Rahmawati, Rémon Vos, I. Sophie T. Bos, Huib A. M. Kerstjens, Loes E. M. Kistemaker & Reinoud Gosens. (2022) Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells. Scientific Reports 12:1.
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Lamis M.F. El-Baz, Samah M. Elaidy, Hani S. Hafez & Nahla M. Shoukry. (2022) Vismodegib, a sonic hedgehog signalling blockade, ameliorates ovalbumin and ovalbumin/lipopolysaccharide-induced airway inflammation and asthma phenotypical models. Life Sciences 310, pages 121119.
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Huanliang Liu, Huipeng Nie, Wenqing Lai, Yue Shi, Xuan Liu, Kang Li, Lei Tian, Zhuge Xi & Bencheng Lin. (2022) Different exposure modes of PM2.5 induces bronchial asthma and fibrosis in male rats through macrophage activation and immune imbalance induced by TIPE2 methylation. Ecotoxicology and Environmental Safety 247, pages 114200.
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Lingzi Hong, Tomasz Herjan, Katarzyna Bulek, Jianxin Xiao, Suzy A. A. Comhair, Serpil C. Erzurum, Xiaoxia Li & Caini Liu. (2022) Mechanisms of Corticosteroid Resistance in Type 17 Asthma. The Journal of Immunology 209:10, pages 1860-1869.
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Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Elena Pistocchini, Beatrice Ludovica Ritondo, Paola Rogliani & Alfredo Chetta. (2022) Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma. Biomedicines 10:9, pages 2330.
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Hongna Dong, Yuqiu Hao, Wei Li, Wei Yang & Peng Gao. (2022) IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic. Frontiers in Immunology 13.
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Felix Ritzmann, Lars Peter Lunding, Robert Bals, Michael Wegmann & Christoph Beisswenger. (2022) IL-17 Cytokines and Chronic Lung Diseases. Cells 11:14, pages 2132.
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Huan Dai, Rongying Zheng, Like Wang, Jinyi Wan, Yu Tong, Wei Zhao & Weixi Zhang. (2022) ICS/LABA Combined With Subcutaneous Immunotherapy Modulates the Th17/Treg Imbalance in Asthmatic Children. Frontiers in Immunology 13.
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Siti Farah Rahmawati, Maurice te Velde, Huib A. M. Kerstjens, Alexander S. S. Dömling, Matthew Robert Groves & Reinoud Gosens. (2021) Pharmacological Rationale for Targeting IL-17 in Asthma. Frontiers in Allergy 2.
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Gang Li, Liangtian Zhang, Nannan Han, Ke Zhang & Hengjie Li. (2020) Increased Th17 and Th22 Cell Percentages Predict Acute Lung Injury in Patients with Sepsis. Lung 198:4, pages 687-693.
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