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Aerosol Science and Technology Volume 48, 2014 - Issue 10
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Original Articles

In Vitro Assessment of Dose Delivery Performance of Dry Powders for Inhalation

Keith T. UngNovartis Pharmaceutical Corp., San Carlos, California, USA;Faculty of Pharmacy, University of Sydney, Sydney, AustraliaCorrespondence[email protected]
,
Nagaraja RaoNovartis Pharmaceutical Corp., San Carlos, California, USA
,
Jeffry G. WeersNovartis Pharmaceutical Corp., San Carlos, California, USA
,
Andrew R. ClarkNovartis Pharmaceutical Corp., San Carlos, California, USA
&
Hak-Kim ChanFaculty of Pharmacy, University of Sydney, Sydney, Australia
Pages 1099-1110 | Received 31 Mar 2014, Accepted 09 Aug 2014, Published online: 09 Sep 2014

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Shahriar Milani, Homa Faghihi, Abdolhosein Roulholamini Najafabadi, Mohsen Amini, Hamed Montazeri & Alireza Vatanara. (2020) Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization. Drug Development and Industrial Pharmacy 46:3, pages 403-411.
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Articles from other publishers (29)

Bryan Newman, Andrew Babiskin, Elizabeth Bielski, Susan Boc, Sneha Dhapare, Lanyan Fang, Katharine Feibus, Anubhav Kaviratna, Bing V. Li, Markham C. Luke, Tian Ma, Michael Spagnola, Ross L. Walenga, Zhong Wang, Liang Zhao, Nashwa El-Gendy, Craig M. Bertha, Mohammed Abd El-Shafy & Dhaval K. Gaglani. (2022) Scientific and regulatory activities initiated by the U.S. Food and drug administration to foster approvals of generic dry powder inhalers: Bioequivalence perspective. Advanced Drug Delivery Reviews 190, pages 114526.
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Matthew J. Owen, Umit Celik, Subash K. Chaudhary, Jasper H. N. Yik, John S. Patton, Mei-chang Kuo, Dominik R. Haudenschild & Gang-yu Liu. (2022) Production of Inhalable Ultra-Small Particles for Delivery of Anti-Inflammation Medicine via a Table-Top Microdevice. Micromachines 13:9, pages 1382.
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Hui Wang, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Mani Ordoubadi, David Lechuga-Ballesteros & Reinhard Vehring. (2022) Inhalable microparticle platform based on a novel shell-forming lipid excipient and its feasibility for respirable delivery of biologics. European Journal of Pharmaceutics and Biopharmaceutics 177, pages 308-322.
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Jeffry Weers. (2022) Suboptimal Inspiratory Flow Rates With Passive Dry Powder Inhalers: Big Issue or Overstated Problem?. Frontiers in Drug Delivery 2.
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Roberto Walter Dal Negro, Paola Turco & Massimiliano Povero. (2022) Lung Function Can Predict the Expected Inspiratory Airflow Rate through Dry Powder Inhalers in Asthmatic Adolescents. Children 9:3, pages 377.
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Gajendra Singh, Patricia Tang, Shaokoon Cheng, Hak-Kim Chan & Agisilaos Kourmatzis. (2022) From laminar to turbulent flow in a dry powder inhaler: The effect of simple design modifications. International Journal of Pharmaceutics 616, pages 121556.
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Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui & Robert O. Williams III. (2022) The Development of Thin-Film Freezing and Its Application to Improve Delivery of Biologics as Dry Powder Aerosols. KONA Powder and Particle Journal 39:0, pages 176-192.
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Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Nikolaos Bouropoulos, Emmanuel Panteris, Melpomeni Akrivou, Ioannis S. Vizirianakis, Zeeshan Ahmad & Dimitrios G. Fatouros. (2021) Engineered mucoadhesive microparticles of formoterol/budesonide for pulmonary administration. European Journal of Pharmaceutical Sciences 165, pages 105955.
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Yoen-Ju Son, Danforth P. Miller & Jeffry G. Weers. (2021) Optimizing Spray-Dried Porous Particles for High Dose Delivery with a Portable Dry Powder Inhaler. Pharmaceutics 13:9, pages 1528.
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Roberto W. Dal Negro, Paola Turco & Massimiliano Povero. (2021) The contribution of patients’ lung function to the inspiratory airflow rate achievable through a DPIs’ simulator reproducing different intrinsic resistance rates. Multidisciplinary Respiratory Medicine 16.
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Hana Douafer, Véronique Andrieu, Emmanuel Wafo, Michelle Sergent & Jean Michel Brunel. (2021) Feasibility of an inhaled antibiotic/adjuvant dry powder combination using an experimental design approach. International Journal of Pharmaceutics 599, pages 120414.
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Iftikhar Khan, Sozan Hussein, Chahinez Houacine, Sajid Khan Sadozai, Yamir Islam, Ruba Bnyan, Abdelbary Elhissi & Sakib Yousaf. (2021) Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers. International Journal of Pharmaceutics 598, pages 120376.
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Agata Dorosz, Marta Żaczek & Arkadiusz Moskal. (2021) Dynamics of aerosol generation and release – Dry powder inhaler performance considerations. Journal of Aerosol Science 151, pages 105673.
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Stephen P. Newman & Hak-Kim Chan. (2020) In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation. Advanced Drug Delivery Reviews 167, pages 135-147.
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Sawittree Sahakijpijarn, Chaeho Moon, Xiangyu Ma, Yongchao Su, John J. Koleng, Andrei Dolocan & Robert O. WilliamsIIIIII. (2020) Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations. International Journal of Pharmaceutics 586, pages 119490.
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Andrew R. ClarkJeffry G. WeersRajiv Dhand. (2020) The Confusing World of Dry Powder Inhalers: It Is All About Inspiratory Pressures, Not Inspiratory Flow Rates. Journal of Aerosol Medicine and Pulmonary Drug Delivery 33:1, pages 1-11.
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Myrna B. Dolovich, Andreas Kuttler, Thomas J. Dimke & Omar S. Usmani. (2019) Biophysical model to predict lung delivery from a dual bronchodilator dry-powder inhaler. International Journal of Pharmaceutics: X 1, pages 100018.
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Mai Babenko, Jean-Marie R. Peron, Waseem Kaialy, Gianpiero Calabrese, Raid G. Alany & Amr ElShaer. (2019) 1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations. International Journal of Pharmaceutics 564, pages 318-328.
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Wesam G. Ammari, Mohammad Khalil Mohammad & Rabab F. Tayyem. (2019) The impact of patients' real-life environmental temperature and humidity use conditions of tiotropium dry powder inhaler on its aerosol emission characteristics. European Journal of Pharmaceutical Sciences 133, pages 137-144.
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Chaeho Moon, Hugh D. C. Smyth, Alan B. Watts & Robert O. WilliamsIIIIII. (2019) Delivery Technologies for Orally Inhaled Products: an Update. AAPS PharmSciTech 20:3.
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Jeffry G. WeersYoen-Ju SonMark GluskerAlfred HaynesDaniel HuangNani KadrichuJohn LeXue LiRichard MalcolmsonDanforth P. MillerThomas E. TararaKeith UngAndy Clark. (2019) Idealhalers Versus Realhalers: Is It Possible to Bypass Deposition in the Upper Respiratory Tract?. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:2, pages 55-69.
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Stewart Yeung, Daniela Traini, David Lewis & Paul M. Young. (2018) Dosing challenges in respiratory therapies. International Journal of Pharmaceutics 548:1, pages 659-671.
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Conor A. RuzyckiAndrew R. MartinReinhard VehringWarren H. Finlay. (2018) An In Vitro Examination of the Effects of Altitude on Dry Powder Inhaler Performance . Journal of Aerosol Medicine and Pulmonary Drug Delivery 31:4, pages 221-236.
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Anthony J. Hickey. 2018. Inhaled Pharmaceutical Product Development Perspectives. Inhaled Pharmaceutical Product Development Perspectives 85 92 .
Jeffry Weers & Andy Clark. (2016) The Impact of Inspiratory Flow Rate on Drug Delivery to the Lungs with Dry Powder Inhalers. Pharmaceutical Research 34:3, pages 507-528.
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Nazareth Eliana Ceschan, Verónica Bucalá, María Verónica Ramírez-Rigo & Hugh David Charles Smyth. (2016) Impact of feed counterion addition and cyclone type on aerodynamic behavior of alginic-atenolol microparticles produced by spray drying. European Journal of Pharmaceutics and Biopharmaceutics 109, pages 72-80.
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Keith T. Ung, Nagaraja Rao, Jeffry G. Weers, Daniel Huang & Hak-Kim Chan. (2016) Design of spray dried insulin microparticles to bypass deposition in the extrathoracic region and maximize total lung dose. International Journal of Pharmaceutics 511:2, pages 1070-1079.
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Keith T. Ung & Hak-Kim Chan. (2016) Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalers. European Journal of Pharmaceutical Sciences 84, pages 46-54.
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Sharon Shui Yee Leung, Patricia Tang, Qi Zhou, Zhenbo Tong, Cassandra Leung, Janwit Decharaksa, Runyu Yang & Hak-Kim Chan. (2015) De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal 17:6, pages 1407-1416.
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