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Aerosol Science and Technology Volume 52, 2018 - Issue 4
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Articles

Deposition of micrometer-sized aerosol particles in neonatal nasal airway replicas

S. TaverniniDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
,
T. K. ChurchChiesi Limited, Chippenham, Wiltshire, United KingdomORCID Iconhttp://orcid.org/0000-0001-8032-1178
ORCID Icon,
D. A. LewisChiesi Limited, Chippenham, Wiltshire, United KingdomORCID Iconhttp://orcid.org/0000-0002-6045-6902
ORCID Icon,
M. NogaDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada
,
A. R. MartinDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada
&
W. H. FinlayDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, CanadaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5310-7977
ORCID Icon
Pages 407-419 | Received 02 Oct 2017, Accepted 28 Nov 2017, Published online: 29 Dec 2017

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John Chen, Warren H. Finlay, Reinhard Vehring & Andrew R. Martin. (2024) Characterizing regional drug delivery within the nasal airways. Expert Opinion on Drug Delivery 21:4, pages 537-551.
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John Valerian Corda, B Satish Shenoy, Kamarul Arifin Ahmad, Leslie Lewis, Prakashini K, Anoop Rao & Mohammad Zuber. (2023) Micro- and nanoparticle transport and deposition in a realistic neonatal and infant nasal upper airway. International Journal of Modelling and Simulation 0:0, pages 1-16.
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S. Tavernini, M. Kiaee, D. J. Farina, A. R. Martin & W. H. Finlay. (2019) Development of a filter that mimics tracheobronchial deposition of respirable aerosols in humans. Aerosol Science and Technology 53:7, pages 802-816.
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Xin Heng, Jinghai Yi & Donovan B. Yeates. (2019) Fluidic and thermal properties of heliox enable the efficient generation and delivery of high concentrations of solid-phase, fine particle aerosols from viscous liquids. Aerosol Science and Technology 53:6, pages 609-629.
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P. Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L. Thomas, Ahmad El-Achwah & Michael Hindle. (2019) Use of computational fluid dynamics deposition modeling in respiratory drug delivery. Expert Opinion on Drug Delivery 16:1, pages 7-26.
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Andrew R. Martin, Charles P. Moore & Warren H. Finlay. (2018) Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery. Expert Opinion on Drug Delivery 15:12, pages 1175-1188.
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Articles from other publishers (20)

Feilun Yang, Yusheng Wang, Ruiping Ma, Zhenzhen Hu, Jian Zhao, Siping Sun, Hongxian Ren, Xiaole Chen, Jingguo Chen, Guoxi Zheng, Xiaoyong Ren, Zhenbo Tong, Jingliang Dong & Ya Zhang. (2024) Numerical investigation of corticosteroid aerosol transport characteristics for pediatric acute epiglottitis at different severity levels. Powder Technology 433, pages 119175.
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Emily L. Kolewe, Saurav Padhye, Ian R. Woodward, Yu Feng, Jenna W. Briddell & Catherine A. Fromen. (2023) A Pediatric Upper Airway Library to Evaluate Interpatient Variability of In Silico Aerosol Deposition. AAPS PharmSciTech 24:6.
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John Valerian Corda, Mohammad Zuber, Kamarul Arifin Ahmad, Leslie Lewis & Prakashini Koteshwar. A computational fluid dynamics study on the airflow patterns in infant and adult. A computational fluid dynamics study on the airflow patterns in infant and adult.
Mozhgan Sabz, Scott Tavernini, Kineshta Pillay, Cole Christianson, Michelle Noga, Warren H. Finlay, Hossein Rouhani & Andrew R. Martin. (2022) Variability in low-flow oxygen delivery by nasal cannula evaluated in neonatal and infant airway replicas. Respiratory Research 23:1.
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Brynn M. Murphy, John Z. Chen, Michael Rolo, Mohamed Eldam, Lynn Jordan, Sandra J. Sivananthan, Robert Kinsey, Jeffrey A. Guderian, Karl Pedersen, Mayuresh Abhyankar, William A. Petri, Christopher B. Fox, Warren H. Finlay, Reinhard Vehring & Andrew R. Martin. (2022) Intranasal delivery of a synthetic Entamoeba histolytica vaccine containing adjuvant (LecA + GLA-3 M−052 liposomes): In vitro characterization. International Journal of Pharmaceutics 626, pages 122141.
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Karl Bass, Mohammad A. M. Momin, Connor Howe, Ghali Aladwani, Sarah Strickler, Arun V. Kolanjiyil, Michael Hindle, Robert M. DiBlasi & Worth Longest. (2022) Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal Model. AAPS PharmSciTech 23:5.
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Solbee Seo, Conor A. RuzyckiBailey JohnsonHui WangReinhard VehringDan RomanykWarren H. FinlayAndrew R. Martin. (2022) Size-Specific Filtration Performance of N95 Respirators After Decontamination by Moist Heat Incubation. Journal of Aerosol Medicine and Pulmonary Drug Delivery 35:1, pages 41-49.
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John Valerian Corda, B Satish Shenoy, Kamarul Arifin Ahmad, Leslie Lewis, Prakashini K, S. M. Abdul Khader & Mohammad Zuber. (2022) Nasal airflow comparison in neonates, infant and adult nasal cavities using computational fluid dynamics. Computer Methods and Programs in Biomedicine 214, pages 106538.
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Danforth P. Miller, Thomas E. Tarara & Jeffry G. Weers. (2021) Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations. Pharmaceutics 13:11, pages 1855.
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Connor Howe, Mohammad A.M. Momin, Dale R. Farkas, Serena Bonasera, Michael Hindle & P. Worth Longest. (2021) Advancement of the Infant Air-Jet Dry Powder Inhaler (DPI): Evaluation of Different Positive-Pressure Air Sources and Flow Rates. Pharmaceutical Research 38:9, pages 1615-1632.
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Sana HosseiniTheodore A. SchumanLaleh Golshahi. (2021) Correlations to Estimate the Key Anatomical Dimensions of Pediatric Nasal Airways using Minimally Invasive Measurements of Intranasal Pressure Gradient. Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:3, pages 171-180.
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Connor HoweMichael HindleSerena BonaseraVijaya RaniP. Worth Longest. (2021) Initial Development of an Air-Jet Dry Powder Inhaler for Rapid Delivery of Pharmaceutical Aerosols to Infants. Journal of Aerosol Medicine and Pulmonary Drug Delivery 34:1, pages 57-70.
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Jingliang Dong, Jiawei Ma, Lin Tian, Kiao Inthavong, Kazuhide Ito & Jiyuan Tu. (2021) Numerical analysis of nanoparticle transport and deposition in a cynomolgus monkey nasal passage. International Journal for Numerical Methods in Biomedical Engineering 37:2.
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John V. WilkinsJrJr, Laleh Golshahi, Nausheen Rahman & Lillian Li. (2021) Evaluation of Intranasal Vaccine Delivery Using Anatomical Replicas of Infant Nasal Airways. Pharmaceutical Research 38:1, pages 141-153.
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Karl Bass & Worth Longest. (2020) Development of Dry Powder Inhaler Patient Interfaces for Improved Aerosol Delivery to Children. AAPS PharmSciTech 21:5.
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Ira Katz, John Chen, Kelvin Duong, Kaixian Zhu, Marine Pichelin, Georges Caillibotte & Andrew R. Martin. (2019) Dose variability of supplemental oxygen therapy with open patient interfaces based on in vitro measurements using a physiologically realistic upper airway model. Respiratory Research 20:1.
Crossref
Karl Bass, Dale Farkas & Worth Longest. (2019) Optimizing Aerosolization Using Computational Fluid Dynamics in a Pediatric Air-Jet Dry Powder Inhaler. AAPS PharmSciTech 20:8.
Crossref
Karl BassSusan BocMichael HindleKelley DodsonWorth Longest. (2019) High-Efficiency Nose-to-Lung Aerosol Delivery in an Infant: Development of a Validated Computational Fluid Dynamics Method. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:3, pages 132-148.
Crossref
Laleh GolshahiSana Hosseini. (2019) Intranasal Filtration of Inhaled Aerosol in Human Subjects as a Function of Nasal Pressure Drop. Journal of Aerosol Medicine and Pulmonary Drug Delivery 32:1, pages 13-23.
Crossref
Warren H. Finlay. 2019. The Mechanics of Inhaled Pharmaceutical Aerosols. The Mechanics of Inhaled Pharmaceutical Aerosols 103 116 .

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