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Aerosol Science and Technology Volume 56, 2022 - Issue 4
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Original Articles

Validating CFD predictions of nasal spray deposition: Inclusion of cloud motion effects for two spray pump designs

Arun V. Kolanjiyila Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
,
Sana Hosseinia Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
,
Ali Alfaifia Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
,
Dale Farkasa Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
,
Ross Walengab Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USAView further author information
,
Andrew Babiskinb Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USAView further author information
,
Michael Hindlec Department of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
,
Laleh Golshahia Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USAView further author information
&
P. Worth Longesta Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Virginia, USACorrespondence[email protected]
View further author information
 show all
Pages 305-322 | Received 28 Jul 2021, Accepted 22 Nov 2021, Published online: 28 Dec 2021

Citations (14)

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Read on this site (1)

Karthik Sridhar, Sriram Chari & Clement Kleinstreuer. (2023) A computational study of droplet-spray formation from pressurized metered dose inhalers with applications to drug deposition in a human lung-airway model. Aerosol Science and Technology 57:5, pages 434-449.
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Articles from other publishers (13)

Veruska Malavé, Kavita Jeerage, Edward Garboczi & Tara Lovestead. (2023) 3D computational fluid and particle dynamics simulations: metrics of aerosol capture by impaction filters * . Journal of Breath Research 18:1, pages 016002.
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J.S. Kimbell, G.J.M. Garcia, J.D. Schroeter, P. Sheth, E.L. VallorzIIIIII, B. Saluja, A.H. Babiskin, G. Tian & R.L. Walenga. (2023) Nasal steroid spray simulations using measured spray characteristics in healthy and rhinitic nasal passages. Journal of Aerosol Science 174, pages 106246.
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Zhiwei Shen, Jingliang Dong, Liam Milton-McGurk, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis & Shaokoon Cheng. (2023) Numerical analysis of airflow and particle deposition in multi-fidelity designs of nasal replicas following nasal administration. Computer Methods and Programs in Biomedicine 241, pages 107778.
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Mohammad Mehedi Hasan Akash, Yueying Lao, Pallavi A. Balivada, Phoebe Ato, Nogaye K. Ka, Austin Mituniewicz, Zachary Silfen, Julie D. Suman, Arijit Chakravarty, Diane Joseph-McCarthy & Saikat Basu. (2023) On a model-based approach to improve intranasal spray targeting for respiratory viral infections. Frontiers in Drug Delivery 3.
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Ming‐Liang Tan, Sajeev Chandran, Rebeka Jereb, Khondoker Alam, Robert Bies, Darby Kozak, Ross Walenga, Maxime Le Merdy & Andrew Babiskin. (2023) Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report. CPT: Pharmacometrics & Systems Pharmacology.
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Marit Kleven, Narinder P. Singh, John C. Messina, Per G. Djupesland & Kiao Inthavong. (2023) Development of computational fluid dynamics methodology for characterization of exhalation delivery system performance in a nasal airway with Draf-III surgery. Journal of Aerosol Science 169, pages 106121.
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M.A. Modaresi, G. Heidarinejad, R. Maddahian & B. Firoozabadi. (2023) Developing mucociliary clearance model for the numerical simulation of two-way coupling particulate flow inside the nasal cavity in the presence of deep breathing. Journal of Aerosol Science 169, pages 106120.
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Arun V. Kolanjiyil, Ross Walenga, Andrew Babiskin, Laleh Golshahi, Michael Hindle & Worth Longest. (2023) Establishing quantitative relationships between changes in nasal spray in vitro metrics and drug delivery to the posterior nasal region. International Journal of Pharmaceutics 635, pages 122718.
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Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Michael Hindle & P. Worth Longest. (2022) Development of a High-Dose Infant Air-Jet Dry Powder Inhaler (DPI) with Passive Cyclic Loading of the Formulation. Pharmaceutical Research 39:12, pages 3317-3330.
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Hadrien Calmet, David Oks, Alfonso Santiago, Guillaume Houzeaux, Antoine Le Corfec, Laura Deruyver, Clement Rigaut, Pierre Lambert, Benoit Haut & Jonathan Goole. (2022) Validation and Sensitivity analysis for a nasal spray deposition computational model. International Journal of Pharmaceutics 626, pages 122118.
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Hadrien Calmet, Alfonso Santiago, Juan Carlos Cajas, Cristobal Langdon, Beatriz Eguzkitza & Guillaume Houzeaux. (2022) Fluid–structure interaction of human nasal valves under sniff conditions and transport of inhaled aerosols: A numerical study. Journal of Aerosol Science 165, pages 106040.
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Arun V. Kolanjiyil, Ali Alfaifi, Ghali Aladwani, Laleh Golshahi & Worth Longest. (2022) Importance of Spray–Wall Interaction and Post-Deposition Liquid Motion in the Transport and Delivery of Pharmaceutical Nasal Sprays. Pharmaceutics 14:5, pages 956.
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hadrien calmet, Alfonso Santiago, Juan Carlos Cajas, Cristobal Langdon, Beatriz Eguzkitza & Guillaume Houzeaux. (2022) Fluid-Structure Interaction of Human Nasal Valves Under Sniff Conditions and Transport of Inhaled Aerosols: A Numerical Study. SSRN Electronic Journal.
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