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Original Articles

Effects of Age on Deposition of Inhaled Aerosols in the Human Lung

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Pages 349-357 | Received 10 Jul 1985, Accepted 11 Sep 1985, Published online: 06 Jun 2007

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GaryL. Ginsberg, Bahman Asgharian, JuliaS. Kimbell, JamesS. Ultman & AnnieM. Jarabek. (2007) Modeling Approaches for Estimating the Dosimetry of Inhaled Toxicants in Children. Journal of Toxicology and Environmental Health, Part A 71:3, pages 166-195.
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Harvey J. Clewell, Justin Teeguarden, Tracy McDonald, Ramesh Sarangapani, Greg Lawrence, Tammie Covington, Robinan Gentry & Annette Shipp. (2002) Review and Evaluation of the Potential Impact of Age- and Gender-Specific Pharmacokinetic Differences on Tissue Dosimetry. Critical Reviews in Toxicology 32:5, pages 329-389.
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William D. Bennett Kirby L. Zeman. (1998) DEPOSITION OF FINE PARTICLES IN CHILDREN SPONTANEOUSLY BREATHING AT REST. Inhalation Toxicology 10:9, pages 831-842.
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I. Ping Chung, RobertF. Phalen & Derek Dunn-Rankin. (1993) Predicted Aerosol Aspiration Efficiency for Infants, Children, and Adults. Applied Occupational and Environmental Hygiene 8:7, pages 639-644.
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StephenD. Arnold & RoyM. Buchan. (1991) Exposure to Ribavirin Aerosol. Applied Occupational and Environmental Hygiene 6:4, pages 271-279.
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Emily L. Kolewe, Saurav Padhye, Ian R. Woodward, Yu Feng, Jenna W. Briddell & Catherine A. Fromen. (2023) A Pediatric Upper Airway Library to Evaluate Interpatient Variability of In Silico Aerosol Deposition. AAPS PharmSciTech 24:6.
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Puchanee Larpruenrudee, Gunther Paul, Suvash C. Saha, Shahid Husain, HamidReza Mortazavy Beni, Christopher Lawrence, Xuzhen He, Yuantong Gu & Mohammad Saidul Islam. 2023. Digital Human Modeling and Medicine. Digital Human Modeling and Medicine 253 274 .
Md.M. Rahman, Ming Zhao, Mohammad S. Islam, Kejun Dong & Suvash C. Saha. (2022) Nanoparticle transport and deposition in a heterogeneous human lung airway tree: An efficient one path model for CFD simulations. European Journal of Pharmaceutical Sciences 177, pages 106279.
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Emily L. Kolewe, Saurav Padhye, Ian R. Woodward, Jinyong Wee, Tariq Rahman, Yu Feng, Jenna W. Briddell & Catherine A. Fromen. (2022) Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models. Computers in Biology and Medicine 149, pages 106058.
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Radoslav Böhm, Martin Bulko & Karol Holý. (2022) INFLUENCE OF AIRWAY GEOMETRY ON RADON RISK ASSESSMENT IN ADULTS AND CHILDREN (MICRODOSIMETRIC APPROACH). Radiation Protection Dosimetry 198:9-11, pages 802-808.
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Ziwei Wang, Muhammad Azher Hassan, Wenhong Fan, Ying Wang, Xiarui Fan & Zhaomin Dong. (2022) Estimating the deposition of polycyclic aromatic hydrocarbons in human airways: The role of particle size. Atmospheric Pollution Research 13:7, pages 101461.
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Md. M. Rahman, Ming Zhao, Mohammad S. Islam, Kejun Dong & Suvash C. Saha. (2021) Aerosol Particle Transport and Deposition in Upper and Lower Airways of Infant, Child and Adult Human Lungs. Atmosphere 12:11, pages 1402.
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Md.M. Rahman, Ming Zhao, Mohammad S. Islam, Kejun Dong & Suvash C. Saha. (2021) Aging effects on airflow distribution and micron-particle transport and deposition in a human lung using CFD-DPM approach. Advanced Powder Technology 32:10, pages 3506-3516.
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Mohammad S. Islam, Puchanee Larpruenrudee, Suvash C. Saha, Oveis Pourmehran, Akshoy Ranjan Paul, Tevfik Gemci, Richard Collins, Gunther Paul & Yuantong Gu. (2021) How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways. Physics of Fluids 33:8.
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Mohammad S. Islam, Puchanee Larpruenrudee, Sheikh I. Hossain, Mohammad Rahimi-Gorji, Yuantong Gu, Suvash C. Saha & Gunther Paul. (2021) Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung. International Journal of Environmental Research and Public Health 18:12, pages 6239.
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Kaveh Ahookhosh, Maysam Saidi, Habib Aminfar, Mousa Mohammadpourfard, Hamed Hamishehkar & Shadi Yaqoubi. (2020) Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data. International Journal of Pharmaceutics 587, pages 119599.
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Lingli Guo, Graham R. Johnson, Werner Hofmann, Hao Wang & Lidia Morawska. (2020) Deposition of ambient ultrafine particles in the respiratory tract of children: A novel experimental method and its application. Journal of Aerosol Science 139, pages 105465.
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Farzana Kastury, Euan Smith, Enzo Lombi, Martin W. Donnelley, Patricia L. Cmielewski, David W. Parsons, Matt Noerpel, Kirk G. Scheckel, Andrew M. Kingston, Glenn R. Myers, David Paterson, Martin D. de Jonge & Albert L. Juhasz. (2019) Dynamics of Lead Bioavailability and Speciation in Indoor Dust and X-ray Spectroscopic Investigation of the Link between Ingestion and Inhalation Pathways. Environmental Science & Technology 53:19, pages 11486-11495.
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Jyoti Kori & Pratibha. (2019) Effect of Periodic Permeability of Lung Tissue on Fluid Velocity and Nonspherical Nanoparticle Filtration. International Journal of Applied and Computational Mathematics 5:3.
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Prashant Das, Eliram Nof, Israel Amirav, Stavros C. Kassinos & Josué Sznitman. (2018) Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD). PLOS ONE 13:11, pages e0207711.
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Carmela Protano, Maurizio Manigrasso, Pasquale Avino & Matteo Vitali. (2017) Second-hand smoke generated by combustion and electronic smoking devices used in real scenarios: Ultrafine particle pollution and age-related dose assessment. Environment International 107, pages 190-195.
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James S. Brown. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 513 536 .
Azadeh A.T. Borojeni, Michelle L. Noga, Reinhard Vehring & Warren H. Finlay. (2014) Measurements of total aerosol deposition in intrathoracic conducting airway replicas of children. Journal of Aerosol Science 73, pages 39-47.
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Nicholas B. CarrigyConor A. RuzyckiLaleh GolshahiWarren H. Finlay. (2014) Pediatric In Vitro and In Silico Models of Deposition via Oral and Nasal Inhalation . Journal of Aerosol Medicine and Pulmonary Drug Delivery 27:3, pages 149-169.
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Philip Chi Lip Kwok & Hak-Kim Chan. (2014) Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews 73, pages 83-88.
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L. Golshahi, R. Vehring, M.L. Noga & W.H. Finlay. (2013) In vitro deposition of micrometer-sized particles in the extrathoracic airways of children during tidal oral breathing. Journal of Aerosol Science 57, pages 14-21.
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Lin Tian & Goodarz Ahmadi. (2012) Transport and Deposition of Micro-and Nano-Particles in Human Tracheobronchial Tree by an Asymmetric Multi-Level Bifurcation Model. The Journal of Computational Multiphase Flows 4:2, pages 159-182.
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Guilherme J.M. GarciaEarl W. TewksburyBrian A. WongJulia S. Kimbell. (2009) Interindividual Variability in Nasal Filtration as a Function of Nasal Cavity Geometry. Journal of Aerosol Medicine and Pulmonary Drug Delivery 22:2, pages 139-156.
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Anne Fairbrother, Randall Wenstel, Keith Sappington & William Wood. (2007) Framework for Metals Risk Assessment. Ecotoxicology and Environmental Safety 68:2, pages 145-227.
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Risa J. RobinsonRichard L. DoolittleJohn N. DiFlorio. (2007) Use of Asthmatic Pulmonary Function Test Data to Predict Lung Deposition. Journal of Aerosol Medicine 20:2, pages 141-162.
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C.T. Derosa, H. Choudhury & W.B. Peirano. (2016) An Integrated Exposure/ Pharmacokinetic Based Approach to the Assessment of Complex Exposures. Toxicology and Industrial Health 7:4, pages 231-248.
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