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Original Articles

Performance-Modifying Influences in Dry Powder Inhalation Systems

Pages 346-353 | Received 04 Apr 1994, Published online: 12 Jun 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Yuta Miyazaki, Hikaru Sugihara, Akio Nishiura, Kazunori Kadota, Yuichi Tozuka & Hirofumi Takeuchi. (2017) Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion. Drug Development and Industrial Pharmacy 43:1, pages 30-41.
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Eike Cordts & Hartwig Steckel. (2014) Formulation Considerations for Dry Powder Inhalers. Therapeutic Delivery 5:6, pages 675-689.
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Jeffry G Weers, Thomas E Tarara & Andrew R Clark. (2007) Design of fine particles for pulmonary drug delivery. Expert Opinion on Drug Delivery 4:3, pages 297-313.
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Dina El-Sabawi, Stephen Edge, Robert Price & Paul M. Young. (2006) Continued Investigation Into the Influence of Loaded Dose on the Performance of Dry Powder Inhalers: Surface Smoothing Effects. Drug Development and Industrial Pharmacy 32:10, pages 1135-1138.
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A. Lähde, J. Raula, E. I. Kauppinen, W. Watanabe, P. P. Ahonen & D. P. Brown. (2006) Aerosol Synthesis of Inhalation Particles via a Droplet-to-Particle Method. Particulate Science and Technology 24:1, pages 71-84.
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Matthew Bunker, Martyn Davies & Clive Roberts. (2005) Towards screening of inhalation formulations: measuring interactions with atomic force microscopy. Expert Opinion on Drug Delivery 2:4, pages 613-624.
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H W Frijlink & A H De Boer. (2004) Dry powder inhalers for pulmonary drug delivery. Expert Opinion on Drug Delivery 1:1, pages 67-86.
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C. U. YURTERI, M. K. MAZUMDER, N. GRABLE, G. AHUJA, S. TRIGWELL, A. S. BIRIS, R. SHARMA & R. A. SIMS. (2002) Electrostatic Effects on Dispersion, Transport, and Deposition of Fine Pharmaceutical Powders: Development of an Experimental Method for Quantitative Analysis. Particulate Science and Technology 20:1, pages 59-79.
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Articles from other publishers (31)

Gerald A. Hebbink, Maarten Jaspers, Harry J.W. Peters & Bastiaan H.J. Dickhoff. (2022) Recent developments in lactose blend formulations for carrier-based dry powder inhalation. Advanced Drug Delivery Reviews 189, pages 114527.
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Jamie E. Spahn, Feng Zhang & Hugh D.C. Smyth. (2022) Mixing of dry powders for inhalation: A review. International Journal of Pharmaceutics 619, pages 121736.
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Shuji Ohsaki, Ryosuke Mitani, Saki Fujiwara, Hideya Nakamura & Satoru Watano. (2019) Effect of Particle–Wall Interaction and Particle Shape on Particle Deposition Behavior in Human Respiratory System. Chemical and Pharmaceutical Bulletin 67:12, pages 1328-1336.
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Carlos Molina, Waseem Kaialy & Ali Nokhodchi. (2019) The crucial role of leucine concentration on spray dried mannitol-leucine as a single carrier to enhance the aerosolization performance of Albuterol sulfate. Journal of Drug Delivery Science and Technology 49, pages 97-106.
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Niklas Renner, Hartwig Steckel, Nora Urbanetz & Regina Scherließ. (2017) Nano- and Microstructured model carrier surfaces to alter dry powder inhaler performance. International Journal of Pharmaceutics 518:1-2, pages 20-28.
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Waseem Kaialy. (2016) On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review. Advances in Colloid and Interface Science 235, pages 70-89.
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Waseem Kaialy. (2016) A review of factors affecting electrostatic charging of pharmaceuticals and adhesive mixtures for inhalation. International Journal of Pharmaceutics 503:1-2, pages 262-276.
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I. Pasquali, C. Merusi, G. Brambilla, E.J. Long, G.K. Hargrave & H.K. Versteeg. (2015) Optical diagnostics study of air flow and powder fluidisation in Nexthaler ® —Part I: Studies with lactose placebo formulation. International Journal of Pharmaceutics 496:2, pages 780-791.
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Irene Parisini, James L. Collett & Darragh Murnane. (2015) Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier. Asian Journal of Pharmaceutical Sciences 10:6, pages 501-512.
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Yohei Sakamoto, Hideya Nakamura & Satoru Watano. (2015) Development of Advanced Freeze Granulation by Supercritical Fluid and its Application to Dry Powder Inhalation. Journal of the Society of Powder Technology, Japan 52:6, pages 330-336.
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Waseem Kaialy, Tariq Hussain, Amjad Alhalaweh & Ali Nokhodchi. (2013) Towards a More Desirable Dry Powder Inhaler Formulation: Large Spray-Dried Mannitol Microspheres Outperform Small Microspheres. Pharmaceutical Research 31:1, pages 60-76.
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Tariq Hussain, Waseem Kaialy, Tong Deng, Mike S.A. Bradley, Ali Nokhodchi & David Armour-Chélu. (2013) A novel sensing technique for measurement of magnitude and polarity of electrostatic charge distribution across individual particles. International Journal of Pharmaceutics 441:1-2, pages 781-789.
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Rinku A. Tuli, Graeme A. George, Tim R. Dargaville & Nazrul Islam. (2012) Studies on the Effect of the Size of Polycaprolactone Microspheres for the Dispersion of Salbutamol Sulfate from Dry Powder Inhaler Formulations. Pharmaceutical Research 29:9, pages 2445-2455.
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V. N. P. Le, T. H. Hoang Thi, E. Robins & M. P. Flament. (2012) Dry Powder Inhalers: Study of the Parameters Influencing Adhesion and Dispersion of Fluticasone Propionate. AAPS PharmSciTech 13:2, pages 477-484.
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Rinku A. Tuli, Tim R. Dargaville, Graeme A. George & Nazrul Islam. (2012) Polycaprolactone Microspheres as Carriers for Dry Powder Inhalers: Effect of Surface Coating on Aerosolization of Salbutamol Sulfate. Journal of Pharmaceutical Sciences 101:2, pages 733-745.
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Timothy M. Crowder & Martin J. Donovan. 2011. Controlled Pulmonary Drug Delivery. Controlled Pulmonary Drug Delivery 203 222 .
F Vanderbist, B Wery, I Moyano-Pavon & A J Moës. (1999) Optimization of a Dry Powder Inhaler Formulation of Nacystelyn, a New Mucoactive Agent. Journal of Pharmacy and Pharmacology 51:11, pages 1229-1234.
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Satoru Watano. (2009) Design of nano drug for dry powder inhalation via supercritical carbon dioxide. Drug Delivery System 24:5, pages 492-498.
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Paul M. Young, Daniela Traini, Matthew Coates & Hak-Kim Chan. (2007) Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter 394:2, pages 315-319.
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H. Steckel, P. Markefka, H. teWierik & R. Kammelar. (2006) Effect of milling and sieving on functionality of dry powder inhalation products. International Journal of Pharmaceutics 309:1-2, pages 51-59.
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Jennifer M. Lobo, Helena Schiavone, Srinivas Palakodaty, Peter York, Andy Clark & Stelios T. Tzannis. (2005) SCF-Engineered Powders for Delivery of Budesonide from Passive DPI Devices. Journal of Pharmaceutical Sciences 94:10, pages 2276-2288.
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Henderik W. Frijlink & Anne H. de Boer. (2005) Trends in the technology-driven development of new inhalation devices. Drug Discovery Today: Technologies 2:1, pages 47-57.
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Mike Tobyn, John N Staniforth, David Morton, Quentin Harmer & Mike E Newton. (2004) Active and intelligent inhaler device development. International Journal of Pharmaceutics 277:1-2, pages 31-37.
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H Steckel, P Markefka, H teWierik & R Kammelar. (2004) Functionality testing of inhalation grade lactose. European Journal of Pharmaceutics and Biopharmaceutics 57:3, pages 495-505.
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Paul M. Young, Robert Price, Michael J. Tobyn, Mark Buttrum & Fiona Dey. (2004) The Influence of Relative Humidity on the Cohesion Properties of Micronized Drugs Used in Inhalation Therapy. Journal of Pharmaceutical Sciences 93:3, pages 753-761.
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Paul M. Young, Robert Price, Michael J. Tobyn, Mark Buttrum & Fiona Dey. (2003) Investigation into the Effect of Humidity on Drug–Drug Interactions Using the Atomic Force Microscope. Journal of Pharmaceutical Sciences 92:4, pages 815-822.
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Kimberly S Hayden, Kinam Park & Jennifer S Curtis. (2003) Effect of particle characteristics on particle pickup velocity. Powder Technology 131:1, pages 7-14.
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R Price, P.M Young, S Edge & J.N Staniforth. (2002) The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. International Journal of Pharmaceutics 246:1-2, pages 47-59.
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J.K. Eve, N. Patel, S.Y. Luk, S.J. Ebbens & C.J. Roberts. (2002) A study of single drug particle adhesion interactions using atomic force microscopy. International Journal of Pharmaceutics 238:1-2, pages 17-27.
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Xian Ming Zeng, Gary Peter Martin, Christopher Marriott & John Pritchard. (2001) The use of lactose recrystallised from carbopol gels as a carrier for aerosolised salbutamol sulphate. European Journal of Pharmaceutics and Biopharmaceutics 51:1, pages 55-62.
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S.K Tee, C Marriott, X.M Zeng & G.P Martin. (2000) The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate. International Journal of Pharmaceutics 208:1-2, pages 111-123.
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