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Original Articles

Pharmepéna-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of 5-Methoxy-N, N-Dimethyl-Tryptamine

Pages 403-407 | Published online: 06 Sep 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Alan K. Davis, Sara So, Rafael Lancelotta, Joseph P. Barsuglia & Roland R. Griffiths. (2019) 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse 45:2, pages 161-169.
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Albert Garcia-Romeu & William A. Richards. (2018) Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions. International Review of Psychiatry 30:4, pages 291-316.
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D. Eric Brush, Steven B. Bird & Edward W. Boyer. (2004) Monoamine Oxidase Inhibitor Poisoning Resulting from Internet Misinformation on Illicit Substances. Journal of Toxicology: Clinical Toxicology 42:2, pages 191-195.
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Articles from other publishers (54)

Annie C. Souza, Bryan C. Souza, Arthur França, Marzieh Moradi, Nicholy C. Souza, Katarina E. Leão, Adriano B. L. Tort, Richardson N. Leão, Vítor Lopes-dos-Santos & Sidarta Ribeiro. (2024) 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats. Scientific Reports 14:1.
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Stephan C. Tap. (2024) The potential of 5‐methoxy‐ N,N ‐dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action . Addiction Biology 29:4.
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Gustavo Almeida e Silva, Vinícius Galvão Wakui, Lucília Kato & Cássia A. Marquezin. (2024) Spectroscopic behavior of bufotenine and bufotenine N-oxide: Solvent and pH effects and interaction with biomembrane models. Biochimica et Biophysica Acta (BBA) - Biomembranes 1866:4, pages 184304.
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Kenneth Shinozuka, Burton J. TabaacAlejandro ArenasBryce D. BeutlerKirsten CherianViviana D. EvansChelsey FasanoOwen S. Muir. (2024) Psychedelic Therapy: A Primer for Primary Care Clinicians—N,N-Dimethyltryptamine and Ayahuasca. American Journal of Therapeutics 31:2, pages e112-e120.
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Michellen Santos de Carvalho, Guilherme Vieira Botelho de Almeida, Karuppusamy Arunachalam, Edson Moleta Colodel, Camilo Eduardo Barcenas Olaya & Domingos Tabajara de Oliveira Martins. (2024) Evaluation of the toxicity of the hydroethanolic extract of the stem bark of Virola elongata (Benth.) Warb. in in vitro and in vivo models. Journal of Ethnopharmacology 319, pages 117171.
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Anya Ragnhildstveit, Ryan Khan, Paul Seli, Lisa Claire Bass, River Jude August, Miriam Kaiyo, Nathaniel Barr, Laura Kate Jackson, Michael Santo Gaffrey, Joseph Peter Barsuglia & Lynnette Astrid Averill. (2023) 5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study. Frontiers in Psychiatry 14.
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Ana María Ortiz Bernal, Charles L. Raison, Rafael L. Lancelotta & Alan K. Davis. (2022) Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence. Frontiers in Psychiatry 13.
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Claudius Lenz, Sebastian Dörner, Felix Trottmann, Christian Hertweck, Alexander Sherwood & Dirk Hoffmeister. (2022) Assessment of Bioactivity‐Modulating Pseudo‐Ring Formation in Psilocin and Related Tryptamines. ChemBioChem 23:13.
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Johannes T. Reckweg, Malin V. Uthaug, Attila Szabo, Alan K. Davis, Rafael Lancelotta, Natasha L. Mason & Johannes G. Ramaekers. (2022) The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT). Journal of Neurochemistry 162:1, pages 128-146.
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Anna O Ermakova, Fiona Dunbar, James Rucker & Matthew W Johnson. (2021) A narrative synthesis of research with 5-MeO-DMT. Journal of Psychopharmacology 36:3, pages 273-294.
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Justin C. Strickland & Matthew W. Johnson. 2022. Behavioral Pharmacology of Drug Abuse: Current Status. Behavioral Pharmacology of Drug Abuse: Current Status 105 132 .
Shaun L. Greene. 2022. Novel Psychoactive Substances. Novel Psychoactive Substances 495 532 .
Máté Kapitány-Fövény, Ornella Corazza, Shanna Marrinan & Zsolt Demetrovics. 2020. The Cambridge Handbook of Substance and Behavioral Addictions. The Cambridge Handbook of Substance and Behavioral Addictions 307 325 .
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Nathan D. Sepeda, John M. Clifton, Laura Y. Doyle, Rafael Lancelotta, Roland R. Griffiths & Alan K. Davis. (2020) Inhaled 5-methoxy-N,N-dimethyltryptamine: Supportive context associated with positive acute and enduring effects. Journal of Psychedelic Studies 4:2, pages 114-122.
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Malin V Uthaug, Rafael Lancelotta, Attila Szabo, Alan K Davis, Jordi Riba & Johannes G Ramaekers. (2019) Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment. Psychopharmacology 237:3, pages 773-785.
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Alan K. Davis, Lynnette A. Averill, Nathan D. Sepeda, Joseph P. Barsuglia & Timothy Amoroso. (2020) Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans. Chronic Stress 4, pages 247054702093956.
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Joseph J. Palamar & Patricia Acosta. (2020) A qualitative descriptive analysis of effects of psychedelic phenethylamines and tryptamines. Human Psychopharmacology: Clinical and Experimental 35:1.
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Christopher B. Germann. (2019) 5-Methoxy-N,N-dimethyltryptamine: An Ego-Dissolving Endogenous Neurochemical Catalyst of Creativity. Activitas Nervosa Superior 61:4, pages 170-216.
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Helena Horta-Tricallotis, Javier Echeverría, Verónica Lema, Alethia Quirgas & Alejandra Vidal. (2019) Enema syringes in South Andean hallucinogenic paraphernalia: evidence of their use in funerary contexts of the Atacama and neighboring zones (ca. AD 500–1500). Archaeological and Anthropological Sciences 11:11, pages 6197-6219.
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M. V. Uthaug, R. Lancelotta, K. van Oorsouw, K. P. C. Kuypers, N. Mason, J. Rak, A. Šuláková, R. Jurok, M. Maryška, M. Kuchař, T. Páleníček, J. Riba & J. G. Ramaekers. (2019) A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology 236:9, pages 2653-2666.
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M. Rosaria Varì, Simona Pichini, Raffaele Giorgetti & Francesco P. Busardò. (2018) New psychoactive substances—Synthetic stimulants. WIREs Forensic Science 1:2.
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Joseph Barsuglia, Alan K. Davis, Robert Palmer, Rafael Lancelotta, Austin-Marley Windham-Herman, Kristel Peterson, Martin Polanco, Robert Grant & Roland R. Griffiths. (2018) Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study. Frontiers in Psychology 9.
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Alan K Davis, Joseph P Barsuglia, Rafael Lancelotta, Robert M Grant & Elise Renn. (2018) The epidemiology of 5-methoxy- N, N -dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption . Journal of Psychopharmacology 32:7, pages 779-792.
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Xi-Ling Jiang, Hong-Wu Shen & Ai-Ming Yu. (2016) Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms. Pharmacological Reports 68:3, pages 608-615.
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