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Journal of Psychoactive Drugs Volume 43, 2011 - Issue 2
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Original Articles

Neurogenetics and Clinical Evidence for the Putative Activation of the Brain Reward Circuitry by a Neuroadaptagen: Proposing an Addiction Candidate Gene Panel Map

Thomas J.H. Chen Ph.D. Department of Occupational Safety and Health, Chang Jung Christian University, Taiwan, Republic of China
,
Kenneth Blum Ph.D. Department of Psychiatry, University of Florida School of Medicine and Mcknight Brain Institute, Gainesville, FL, USA; Department of Nutrigenomics and Personalized Medicine, LifeGen, Inc., San Diego, CA, USA; Department of Holistic Medicine, Holistic Addiction Treatment Center, North Miami Beach, FL, USA; Department of Research, National Institute of Holistic Studies, North Miami Beach, FL, USACorrespondence[email protected]
,
Amanda L.C. Chen Ph.D. Engineering and Management of Advanced Technology, Chang Jung Christian University, Taiwan, Republic of China
,
Abdalla Bowirrat Ph.D.M.D. Clinical Neuroscience & Population Genetics & Department of Neurology, Ziv Medical Center, Safad, Israel
,
William B. Downs B.Sc. Department of Nutrigenomics and Personalized Medicine, LifeGen, Inc., San Diego, CA, USA
,
Margret A. Madigan B.S.N. Department of Nutrigenomics, LifeGen, Inc., San Diego, CA, USA
,
Roger L. Waite D.C. Department of Nutrigenomics, LifeGen, Inc., San Diego, CA, USA
,
John A. Bailey M.D. Department of Psychiatry, University of Florida School of Medicine and Mcknight Brain Institute, Gainesville, FL, USA
,
Mallory Kerner Department of Clinical Neurology, Path Foundation NY, New York, USA
,
Swetha Yeldandi B.Sc. Department of Clinical Neurology, Path Foundation NY, New York, USA
,
Neil Majmundar Department of Clinical Neurology, Path Foundation NY, New York, USA
,
John Giordano M.A.C.Ph.D.(hon) Department of Holistic Medicine, Holistic Addiction Treatment Center, North Miami Beach, FL, USA
,
Siohban Morse M.Sc. Department of Research, National Institute of Holistic Studies, North Miami Beach, FL, USA
,
David Miller Ph.D. Lifestream Inc., Prescott, AZ, USA
,
Frank Fornari Ph.D. Dominion Diagnostics Inc., North Kingstown, RI, USA
&
Eric R. Braverman M.D. Department of Neurosurgery, Weill Cornell College of Medicine, New York, New York, USA; Department of Clinical Neurology, Path Foundation NY, New York, USA
 show all
Pages 108-127 | Published online: 25 Jul 2011

Citations (29)

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Abdalla Bowirrat, Igor Elman, Catherine A Dennen, Marjorie C Gondré-Lewis, Jean Lud Cadet, Jag Khalsa, David Baron, Diwanshu Soni, Mark S Gold, Thomas J McLaughlin, Debasis Bagchi, Eric R Braverman, Mauro Ceccanti, Panayotis K Thanos, Edward Justin Modestino, Keerthy Sunder, Nicole Jafari, Foojan Zeine, Rajendra D Badgaiyan, Debmalya Barh, Milan Makale, Kevin T Murphy & Kenneth Blum. (2023) Neurogenetics and Epigenetics of Loneliness. Psychology Research and Behavior Management 16, pages 4839-4857.
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Kenneth Blum, Yijun Liu, Wei Wang, Yarong Wang, Yi Zhang, Marlene Oscar-Berman, Andrew Smolen, Marcelo Febo, David Han, Thomas Simpatico, Frans J. Cronjé, Zsolt Demetrovics & Mark S Gold. (2015) rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts. Postgraduate Medicine 127:2, pages 232-241.
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Kenneth Blum, Stephen J. Schoenthaler, Marlene Oscar-Berman, John Giordano, Margaret A. Madigan, Eric R. Braverman & David Han. (2014) Drug Abuse Relapse Rates Linked to Level of Education: Can We Repair Hypodopaminergic-Induced Cognitive Decline With Nutrient Therapy?. The Physician and Sportsmedicine 42:2, pages 130-145.
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Rachel Harrison, Julia J. Rucklidge & Neville Blampied. (2013) Use of Micronutrients Attenuates Cannabis and Nicotine Abuse as Evidenced From a Reversal Design: A Case Study. Journal of Psychoactive Drugs 45:2, pages 168-178.
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Julia J Rucklidge & Bonnie J Kaplan. (2013) Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: a systematic review. Expert Review of Neurotherapeutics 13:1, pages 49-73.
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Merlene Miller, Amanda LC Chen, Stan D. Stokes, Susan Silverman, Abdalla Bowirrat, Matthew Manka, Debra Manka, David K. Miller, Kenneth Perrine, Thomas JH Chen, John A. Bailey, William Downs, Roger L. Waite, Margaret A. Madigan, Eric R. Braverman, Uma Damle, Mallory Kerner, John Giordano, Siobhan Morse, Marlene Oscar-Berman, Debmalya Barh & Kenneth Blum. (2012) Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot Study. Journal of Psychoactive Drugs 44:5, pages 398-409.
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Kenneth Blum, Amanda LC Chen, John Giordano, Joan Borsten, Thomas JH Chen, Mary Hauser, Thomas Simpatico, John Femino, Eric R. Braverman & Debmalya Barh. (2012) The Addictive Brain: All Roads Lead to Dopamine. Journal of Psychoactive Drugs 44:2, pages 134-143.
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Kenneth Blum, Tonia Werner, Stefanie Carnes, Patrick Carnes, Abdalla Bowirrat, John Giordano, Marlene-Oscar-Berman & Mark Gold. (2012) Sex, Drugs, and Rock ‘N’ Roll: Hypothesizing Common Mesolimbic Activation as a Function of Reward Gene Polymorphisms. Journal of Psychoactive Drugs 44:1, pages 38-55.
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Articles from other publishers (21)

Richard Quansah Amissah & Igor Timofeev. 2023. Eating Disorders. Eating Disorders 981 1002 .
Anish Bajaj, Kenneth Blum, Abdalla Bowirrat, Ashim Gupta, David Baron, David Fugel, Ayo Nicholson, Taylor Fitch, B. William Downs, Debasis Bagchi, Catherine A. Dennen & Rajendra D. Badgaiyan. (2022) DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave® and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of “Dopamine Homeostasis” in the Face of the Opioid Crisis. Journal of Personalized Medicine 12:9, pages 1416.
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Margaret Madigan, Ashim Gupta, Abdalla Bowirrat, David Baron, Rajendra Badgaiyan, Igor Elman, Catherine Dennen, Eric Braverman, Mark Gold & Kenneth Blum. (2022) Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?. International Journal of Environmental Research and Public Health 19:11, pages 6395.
Crossref
Eszter Kótyuk, Marc N. Potenza, Kenneth Blum & Zsolt Demetrovics. 2022. Handbook of Substance Misuse and Addictions. Handbook of Substance Misuse and Addictions 59 74 .
Richard Quansah Amissah & Igor Timofeev. 2021. Eating Disorders. Eating Disorders 1 22 .
Eszter Kótyuk, Marc N. Potenza, Kenneth Blum & Zsolt Demetrovics. 2021. Handbook of Substance Misuse and Addictions. Handbook of Substance Misuse and Addictions 1 16 .
Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi & Mark S. Gold. (2021) Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in Psychiatry 12.
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Gilles N. Stormezand, Ronald J. H. Borra, Hans C. Klein, Peter Jan Van Laar, Ronald Boellaard & Rudi A. J. O. Dierckx. 2016. PET-CT and PET-MRI in Neurology. PET-CT and PET-MRI in Neurology 127 138 .
Marlene Oscar-Berman & Kenneth Blum. 2016. Neurophenotypes. Neurophenotypes 193 211 .
Kenneth Blum, Marcelo Febo, Panayotis K. Thanos, David Baron, James Fratantonio & Mark Gold. (2015) Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?. Molecular Neurobiology 52:3, pages 1862-1869.
Crossref
Bonnie J. Kaplan, Julia J. Rucklidge, Amy Romijn & Kevin McLeod. (2015) The Emerging Field of Nutritional Mental Health. Clinical Psychological Science 3:6, pages 964-980.
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Mark S. Gold, Rajendra D. Badgaiyan & Kenneth Blum. (2015) A Shared Molecular and Genetic Basis for Food and Drug Addiction. Psychiatric Clinics of North America 38:3, pages 419-462.
Crossref
Kenneth Blum, Panayotis K. Thanos & Mark S. Gold. (2014) Dopamine and glucose, obesity, and reward deficiency syndrome. Frontiers in Psychology 5.
Crossref
Kenneth BlumPhDPhD, Marcelo Febo, Thomas McLaughlin, Frans J. Cronjé, David Han & Mark S. Gold. (2014) Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric. Journal of Behavioral Addictions 3:3, pages 149-156.
Crossref
Thomas Mclaughlin, Marlene Oscar-Berman, Thomas Simpatico, John Giordano, Scot Jones, Debmayla Barh, William B. Downs, Roger L. Waite, Margaret Madigan, Kristina Dushaj, Raquel Lohmann, Eric R. Braverman, David Han & Kenneth Blum. (2013) Hypothesizing repetitive paraphilia behavior of a medication refractive Tourette's syndrome patient having rapid clinical attenuation with KB220Z-nutrigenomic amino-acid therapy (NAAT). Journal of Behavioral Addictions 2:2, pages 117-124.
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Kenneth Blum, David Han, John Giordano, Raquel Lohmann, Eric R. Braverman, Margaret A. Madigan, Debmalya Barh, John Femino, Mary Hauser, B. W. Downs & Thomas Simpatico. 2013. Omics for Personalized Medicine. Omics for Personalized Medicine 365 398 .
Kenneth Blum, John Femino, Scott Teitelbaum, John Giordano, Marlene Oscar-Berman & Mark GoldKenneth Blum, John Femino, Scott Teitelbaum, John Giordano, Marlene Oscar-Berman & Mark Gold. 2013. Molecular Neurobiology of Addiction Recovery. Molecular Neurobiology of Addiction Recovery 11 82 .
Megan Rodway, Annette Vance, Amany Watters, Helen Lee, Elske Bos & Bonnie J Kaplan. (2012) Efficacy and cost of micronutrient treatment of childhood psychosis. BMJ Case Reports, pages bcr2012007213.
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Abdalla Bowirrat, Thomas J. H. Chen, Marlene Oscar-Berman, Margaret Madigan, Amanda LH Chen, John A. Bailey, Eric R. Braverman, Mallory Kerner, John Giordano, Siobhan Morse, B. William Downs, Roger L. Waite, Frank Fornari, Zaher Armaly & Kenneth Blum. (2012) Neuropsychopharmacology and Neurogenetic Aspects of Executive Functioning: Should Reward Gene Polymorphisms Constitute a Diagnostic Tool to Identify Individuals at Risk for Impaired Judgment?. Molecular Neurobiology 45:2, pages 298-313.
Crossref
Kenneth Blum, Thomas J. H. Chen, John Bailey, Abdalla Bowirrat, John Femino, Amanda L. C. Chen, Thomas Simpatico, Siobhan Morse, John Giordano, Uma Damle, Mallory Kerner, Eric R. Braverman, Frank Fornari, B. William Downs, Cynthia Rector, Debmayla Barh & Marlene Oscar-Berman. (2011) Can the Chronic Administration of the Combination of Buprenorphine and Naloxone Block Dopaminergic Activity Causing Anti-reward and Relapse Potential?. Molecular Neurobiology 44:3, pages 250-268.
Crossref
Margaret Barh, Debmalya Blum & Kenneth MadiganDebmalya Barh, Margaret Madigan & Kenneth Blum. 2011. OMICS. OMICS 567 576 .

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