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Journal of Psychoactive Drugs Volume 44, 2012 - Issue 5
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Original Articles

Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot Study

Merlene Miller M.A. AminoStream, Inc, Indianapolis, IN, USA; Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA
,
Amanda LC Chen Ph.D. Department Engineering and Management of Advanced Technology, Chang Jung Christian University, Taiwan, ROCCorrespondence[email protected]
,
Stan D. Stokes M.S. Lee Clinic, Winchester, VA, USA
,
Susan Silverman N.P.N.D. Previously with Bridging the Gaps, where the research was accomplished
,
Abdalla Bowirrat M.D.Ph.D. Clinical Neuroscience and Population Genetics, EMMS Nazareth Hospital, Israel
,
Matthew Manka Ph.D. AminoStream, Inc, Indianapolis, IN, USA
,
Debra Manka N.H.D. AminoStream, Inc, Indianapolis, IN, USA
,
David K. Miller Ph.D. AminoStream, Inc, Indianapolis, IN, USA; Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA
,
Kenneth Perrine Ph.D. Department of Neurological Surgery, Weill Cornell College of Medicine, New York, NY, USA
,
Thomas JH Chen Ph.D. Department of Occupational Safety and Health, Chang Jung Christian University, Taiwan, ROC
,
John A. Bailey M.D. Department of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL
,
William Downs B.S. Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA
,
Roger L. Waite D.C. Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA
,
Margaret A. Madigan B.S.N. Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA
,
Eric R. Braverman M.D. Department of Neurological Surgery, Weill Cornell College of Medicine, New York, NY, USA; Research Assistant (UD,MK), PATH Foundation, New York, NY, USA
,
Uma Damle B.A. Research Assistant (UD,MK), PATH Foundation, New York, NY, USA
,
Mallory Kerner Research Assistant (UD,MK), PATH Foundation, New York, NY, USA
,
John Giordano M.A.C.Ph.D. [Hon] G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA
,
Siobhan Morse M.H.A. G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA
,
Marlene Oscar-Berman Ph.D. Departments of Psychiatry and Anatomy & Neurobiology, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA
,
Debmalya Barh Ph.D. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India
&
Kenneth Blum Ph.D. Department of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL; Department of Nutrigenomic and Personalized Medicine, Reward Deficiency Solutions LLC, San Diego, CA, US; Scientific Officer and Chairman of the Board (KB), LifeGen, Inc., San Diego, CA, USA; Research Assistant (UD,MK), PATH Foundation, New York, NY, USA; Departments of Psychiatry and Anatomy & Neurobiology, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA; Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India; Dominion Diagnostics, LLC, North Kingstown, RI; Malibu Beach Recovery Center, Malibu Beach, CA, USA; Global Integrated Services Unit, University of Vermont Center for Clinical & Translational Science, College of Medicine, Burlington, VTCorrespondence[email protected]
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Pages 398-409 | Published online: 06 Dec 2012

Citations (14)

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Kenneth Blum, Bruce Steinberg, Marjorie C Gondre-Lewis, David Baron, Edward J Modestino, Rajendra D Badgaiyan, B William Downs, Debasis Bagchi, Raymond Brewer, Thomas McLaughlin, Abdalla Bowirrat & Mark Gold. (2021) A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing “Precision Behavioral Management”. Psychology Research and Behavior Management 14, pages 2115-2134.
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Kenneth Blum, Stephen J. Schoenthaler, Marlene Oscar-Berman, John Giordano, Margaret A. Madigan, Eric R. Braverman & David Han. (2014) Drug Abuse Relapse Rates Linked to Level of Education: Can We Repair Hypodopaminergic-Induced Cognitive Decline With Nutrient Therapy?. The Physician and Sportsmedicine 42:2, pages 130-145.
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Articles from other publishers (12)

Elizabeth D. Gilley, Abdalla Bowirrat, Ashim Gupta, John Giordano, Catherine A. Dennen, Eric Braverman, Rajendra D. Badgaiyan, Thomas McLaughlin, David Baron & Kenneth Blum. (2024) The Future is Now for Precision Genomic Addiction Medicine as a Frontline Modality for Inducing “Dopamine Homeostasis” in Reward Deficiency Syndrome (RDS). Current Pharmaceutical Biotechnology 25:1, pages 42-57.
Crossref
Mauro Ceccanti, Kenneth Blum, Abdalla Bowirrat, Catherine A. Dennen, Eric R. Braverman, David Baron, Thomas Mclaughlin, John Giordano, Ashim Gupta, Bernard W. Downs, Debasis Bagchi, Debmalya Barh, Igor Elman, Panayotis K. Thanos, Rajendra D. Badgaiyan, Drew Edwards & Mark S. Gold. (2022) Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. Journal of Personalized Medicine 12:12, pages 2015.
Crossref
Kenneth Blum, Abdalla Bowirrat, Luis Llanos Gomez, B. William Downs, Debasis Bagchi, Debmalya Barh, Edward J. Modestino, David Baron, Thomas McLaughlin, Panayotis Thanos, Mauro Ceccanti, Igor Elman, Rajendra D. Badgaiyan, Catherine Dennen, Ashim Gupta, Eric R. Braverman & Mark S. Gold. (2022) Why haven't we solved the addiction crisis?. Journal of the Neurological Sciences 442, pages 120404.
Crossref
Kenneth Blum, Catherine A. Dennen, Igor Elman, Abdalla Bowirrat, Panayotis K. Thanos, Rajendra D. Badgaiyan, B. William Downs, Debasis Bagchi, David Baron, Eric R. Braverman, Ashim Gupta, Richard Green, Thomas McLaughlin, Debmalya Barh & Mark S. Gold. (2022) Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?. Journal of Personalized Medicine 12:10, pages 1719.
Crossref
Kenneth Blum, David Han, David Baron, Shan Kazmi, Igor Elman, Luis Llanos Gomez, Marjorie C. Gondre -Lewis, Panyotis K Thanos, Eric R Braverman & Rajendra D Badgaiyan. (2022) Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases. Current Psychiatry Research and Reviews 18:2, pages 125-143.
Crossref
Margaret A. Madigan, Ashim Gupta, Abdalla Bowirrat, David Baron, Rajendra D. Badgaiyan, Igor Elman, Catherine A. Dennen, Eric R. Braverman, Mark S. Gold & Kenneth Blum. (2022) Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?. International Journal of Environmental Research and Public Health 19:11, pages 6395.
Crossref
Marjorie C. Gondré-Lewis, Igor Elman, Tanya Alim, Edwin Chapman, Beverlyn Settles-Reaves, Carine Galvao, Mark S. Gold, David Baron, Shan Kazmi, Eliot Gardner, Ashim Gupta, Catherine Dennen & Kenneth Blum. (2022) Frequency of the Dopamine Receptor D3 (rs6280) vs. Opioid Receptor µ1 (rs1799971) Polymorphic Risk Alleles in Patients with Opioid Use Disorder: A Preponderance of Dopaminergic Mechanisms?. Biomedicines 10:4, pages 870.
Crossref
Bernard W. Downs, Steve Kushner, Manashi Bagchi, Kenneth Blum, Rajendra D. Badgaiyan, Sanjoy Chakraborty & Debasis Bagchi. (2021) Etiology of Neuroinflammatory Pathologies in Neurodegenerative Diseases: A Treatise. Current Psychopharmacology 10:2, pages 123-137.
Crossref
Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi & Mark S. Gold. (2021) Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in Psychiatry 12.
Crossref
Matthew T. Rich & Mary M. Torregrossa. 2019. Neural Mechanisms of Addiction. Neural Mechanisms of Addiction 103 122 .
Mark S. Gold, Rajendra D. Badgaiyan & Kenneth Blum. (2015) A Shared Molecular and Genetic Basis for Food and Drug Addiction. Psychiatric Clinics of North America 38:3, pages 419-462.
Crossref
Kenneth Blum, David Han, John Giordano, Raquel Lohmann, Eric R. Braverman, Margaret A. Madigan, Debmalya Barh, John Femino, Mary Hauser, B. W. Downs & Thomas Simpatico. 2013. Omics for Personalized Medicine. Omics for Personalized Medicine 365 398 .

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