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Acta Oncologica Volume 39, 2000 - Issue 6
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Research Article

The Curative and Palliative Potential of the Monoclonal Antibody MOv18 Labelled with 211At in Nude Mice with Intraperitoneally growing Ovarian Cancer Xenografts - A Long-Term Study

Håkan Andersson, Sture Lindegren, Tom Bäck, Lars Jacobsson, Gunilla Leser, György Horvath Department of Gynecological Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden
Pages 741-745 | Published online: 08 Jul 2009

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Yana Dekempeneer, Marleen Keyaerts, Ahmet Krasniqi, Janik Puttemans, Serge Muyldermans, Tony Lahoutte, Matthias D’huyvetter & Nick Devoogdt. (2016) Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle. Expert Opinion on Biological Therapy 16:8, pages 1035-1047.
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Haralabos P. Kalofonos, Michalis V. Karamouzis, Agamemnon A. Epenetos. (2001) Radioimmunoscintigraphy in Patients with Ovarian Cancer. Acta Oncologica 40:5, pages 549-557.
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Articles from other publishers (22)

Matthijs Bart C. Sevenois, Brian WM. Miller, Holger Jan Jensen, Matthias D'Huyvetter & Peter Covens. (2023) Optimized cyclotron production of 211At: The challenge of 210Po-characterization. Radiation Physics and Chemistry 212, pages 111155.
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Feize Li, Yuanyou Yang, Jiali Liao & Ning Liu. (2022) Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals. Chinese Chemical Letters 33:7, pages 3325-3338.
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Martina Sollini, Katia Marzo, Arturo Chiti & Margarita Kirienko. (2020) The five “W”s and “How” of Targeted Alpha Therapy: Why? Who? What? Where? When? and How?. Rendiconti Lincei. Scienze Fisiche e Naturali 31:2, pages 231-247.
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Narges K. Tafreshi, Michael L. Doligalski, Christopher J. Tichacek, Darpan N. Pandya, Mikalai M. Budzevich, Ghassan El-Haddad, Nikhil I. Khushalani, Eduardo G. Moros, Mark L. McLaughlin, Thaddeus J. Wadas & David L. Morse. (2019) Development of Targeted Alpha Particle Therapy for Solid Tumors. Molecules 24:23, pages 4314.
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Britta Langen, Nils Rudqvist, Khalil Helou & Eva Forssell-Aronsson. (2017) Microarray Studies on 211 At Administration in BALB/c Nude Mice Indicate Systemic Effects on Transcriptional Regulation in Nonthyroid Tissues . Journal of Nuclear Medicine 58:2, pages 346-353.
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Sadaf Aghevlian, Amanda J. Boyle & Raymond M. Reilly. (2017) Radioimmunotherapy of cancer with high linear energy transfer (LET) radiation delivered by radionuclides emitting α-particles or Auger electrons. Advanced Drug Delivery Reviews 109, pages 102-118.
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Priyanka Bhatt, Imran Vhora, Sushilkumar Patil, Jitendra Amrutiya, Chandrali Bhattacharya, Ambikanandan Misra & Rajashree Mashru. (2016) Role of antibodies in diagnosis and treatment of ovarian cancer: Basic approach and clinical status. Journal of Controlled Release 226, pages 148-167.
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Britta Langen, Nils Rudqvist, Toshima Z Parris, Emil Schüler, Johan Spetz, Khalil Helou & Eva Forssell-Aronsson. (2015) Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and time. EJNMMI Research 5:1.
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Sture Lindegren, Luciana N. S. Andrade, Tom Bäck, Camila Maria L. Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B. Tuma, Roger Chammas, Ragnar Hultborn & Per Albertsson. (2015) Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200. PLOS ONE 10:5, pages e0126298.
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Britta Langen, Nils Rudqvist, Toshima Z. Parris, Emil Schüler, Khalil Helou & Eva Forssell-Aronsson. (2013) Comparative Analysis of Transcriptional Gene Regulation Indicates Similar Physiologic Response in Mouse Tissues at Low Absorbed Doses from Intravenously Administered 211 At . Journal of Nuclear Medicine 54:6, pages 990-998.
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Sofia H.L. FrostTom BäckNicolas ChouinRagnar HultbornLars JacobssonJörgen ElgqvistHolger JensenPer AlbertssonSture Lindegren. (2013) Comparison of 211 At-PRIT and 211 At-RIT of Ovarian Microtumors in a Nude Mouse Model . Cancer Biotherapy and Radiopharmaceuticals 28:2, pages 108-114.
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Nils Rudqvist, Toshima Z Parris, Emil Schüler, Khalil Helou & Eva Forssell-Aronsson. (2012) Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles. EJNMMI Research 2:1, pages 32.
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Silvana Canevari & Mariangela Figini. 2011. Targeted Drug Strategies for Cancer and Inflammation. Targeted Drug Strategies for Cancer and Inflammation 151 179 .
Jörgen Elgqvist, Håkan Andersson, Holger Jensen, Helena Kahu, Sture Lindegren, Elisabet Warnhammar & Ragnar Hultborn. (2010) Repeated Intraperitoneal -Radioimmunotherapy of Ovarian Cancer in Mice. Journal of Oncology 2010, pages 1-5.
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Jörgen ElgqvistHåkan AnderssonElin HaglundHolger JensenHelena KahuSture LindegrenElisabet WarnhammarRagnar Hultborn. (2009) Intraperitoneal Alpha-Radioimmunotherapy in Mice Using Different Specific Activities. Cancer Biotherapy and Radiopharmaceuticals 24:4, pages 509-513.
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Håkan Andersson, Elin Cederkrantz, Tom Bäck, Chaitanya Divgi, Jörgen Elgqvist, Jakob Himmelman, György Horvath, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm & Ragnar Hultborn. (2009) Intraperitoneal α-Particle Radioimmunotherapy of Ovarian Cancer Patients: Pharmacokinetics and Dosimetry of 211 At-MX35 F(ab′) 2 —A Phase I Study . Journal of Nuclear Medicine 50:7, pages 1153-1160.
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Sture Lindegren, Sofia Frost, Tom Bäck, Elin Haglund, Jörgen Elgqvist & Holger Jensen. (2008) Direct Procedure for the Production of 211 At-Labeled Antibodies with an ε-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugate . Journal of Nuclear Medicine 49:9, pages 1537-1545.
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Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar & Lars Jacobsson. (2006) Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab′)2: therapeutic efficacy and myelotoxicity. Nuclear Medicine and Biology 33:8, pages 1065-1072.
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Jörgen Elgqvist, Håkan Andersson, Peter Bernhardt, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Bengt R. Johansson, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar & Lars Jacobsson. (2006) Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab′)2. International Journal of Radiation Oncology*Biology*Physics 66:4, pages 1228-1237.
Crossref
F. Giammarile & T. Mognetti. 2006. Les cancers ovariens. Les cancers ovariens 389 396 .
Tanya J. Shaw, Mary K. Senterman, Kerri Dawson, Colleen A. Crane & Barbara C. Vanderhyden. (2004) Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer. Molecular Therapy 10:6, pages 1032-1042.
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Manuel J. Koppe, Annemieke C. Soede, Wikke Pels, Wim J.G. Oyen, David M. Goldenberg, Robert P. Bleichrodt & Otto C. Boerman. (2003) Experimental radioimmunotherapy of small peritoneal metastases of colorectal origin. International Journal of Cancer 106:6, pages 965-972.
Crossref

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