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Acta Oncologica Volume 48, 2009 - Issue 3
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Original Article

Midgut carcinoid patients display increased numbers of regulatory T cells in peripheral blood with infiltration into tumor tissue

Sofia Vikman Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
,
Roberta Sommaggio Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
,
Manuel De La Torre Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
,
Kjell Öberg Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden
,
Magnus Essand Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
,
Valeria Giandomenico Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; Department of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden
,
Angelica Loskog Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
&
Thomas H. Tötterman Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, SwedenCorrespondence[email protected]
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Pages 391-400 | Received 15 Apr 2008, Published online: 08 Jul 2009

Citations (29)

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Saladin Sawan, Deborah J. Burt, Peter L. Stern, Cathrine Holland & Eyad Elkord. (2011) Circulating Regulatory T Cells in Endometrial Cancer: A Role for Age and Menopausal Status. Immunological Investigations 40:1, pages 62-75.
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Articles from other publishers (28)

Shahnaz D. Vellani, Anthony Nigro, Shangari Varatharajan, Lance D. Dworkin & Justin Fortune Creeden. (2023) Emerging Immunotherapeutic and Diagnostic Modalities in Carcinoid Tumors. Molecules 28:5, pages 2047.
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F. Sesti, G. Puliani, T. Feola, F. Campolo, F. Sciarra, V. Hasenmajer, A. Lenzi, A. Faggiano, A. M. Isidori, M. A. Venneri & E. Giannetta. (2022) Characterization of circulating immune cells and correlation with Tie2/Angiopoietins level in well differentiated neuroendocrine gastroenteropancreatic tumors: a cross-sectional analysis. Endocrine 80:1, pages 221-230.
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Giulia Arrivi & Nicola Fazio. (2022) Gastroenteropancreatic Neuroendocrine Neoplasms (GEP NENs): The Role of Checkpoint Inhibitors. Current Cancer Drug Targets 22:8, pages 629-638.
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Eloisa Martins da Silva, Victor Yuji Yariwake, Renan Willian Alves, Daniele Ribeiro de Araujo & Vinicius Andrade-Oliveira. (2022) Crosstalk between incretin hormones, Th17 and Treg cells in inflammatory diseases. Peptides 155, pages 170834.
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Alejandro Garcia-Alvarez, Jorge Hernando Cubero & Jaume Capdevila. (2022) What Is the Status of Immunotherapy in Neuroendocrine Neoplasms?. Current Oncology Reports 24:4, pages 451-461.
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Lulu Tanno, Salma Naheed, Jonathan Dunbar, Jo Tod, Maria A. Lopez, Julian Taylor, Maria Machado, Bryan Green, Margaret Ashton-Key, Serena J. Chee, Oliver Wood, Neil W. Pearce, Gareth J. Thomas, Peter S. Friedmann, Judith Cave & Christian H. Ottensmeier. (2022) Analysis of Immune Landscape in Pancreatic and Ileal Neuroendocrine Tumours Demonstrates an Immune Cold Tumour Microenvironment. Neuroendocrinology 112:4, pages 370-383.
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Antonia Busse, Liliana H. Mochmann, Christiane Spenke, Ruza Arsenic, Franziska Briest, Korinna Jöhrens, Hedwig Lammert, Bence Sipos, Anja A. Kühl, Ralph Wirtz, Marianne Pavel, Michael Hummel, Daniel Kaemmerer, Richard P. Baum & Patricia Grabowski. (2020) Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment. Cancers 12:11, pages 3448.
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Claudia von Arx, Giuseppina Rea, Maria Napolitano, Alessandro Ottaiano, Fabiana Tatangelo, Francesco Izzo, Antonella Petrillo, Ottavia Clemente, Antonella Di Sarno, Gerardo Botti, Stefania Scala & Salvatore Tafuto. (2020) Effect of Octreotide Long-Acting Release on Tregs and MDSC Cells in Neuroendocrine Tumour Patients: A Pivotal Prospective Study. Cancers 12:9, pages 2422.
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Renuka V. Iyer, Bhavana Konda, Christos Fountzilas, Sarbajit Mukherjee, Dwight Owen, Kristopher Attwood, Chong Wang, Orla Maguire, Hans Minderman, Sheryl‐Ann Suffren, Karen Hicks, John Wilton, Robert Bies, Danielle Casucci, Diane Reidy‐Lagunes & Manisha Shah. (2020) Multicenter phase 2 trial of nintedanib in advanced nonpancreatic neuroendocrine tumors. Cancer 126:16, pages 3689-3697.
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Vinicius Kannen, Michael Bader, Juliana Y. Sakita, Sergio A. Uyemura & Jeremy A. Squire. (2020) The Dual Role of Serotonin in Colorectal Cancer. Trends in Endocrinology & Metabolism 31:8, pages 611-625.
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Lotte D. de Hosson, Tim J. Takkenkamp, Gursah Kats-Ugurlu, Grietje Bouma, Marian Bulthuis, Elisabeth G. E. de Vries, Martijn van Faassen, Ido P. Kema & Annemiek M. E. Walenkamp. (2020) Neuroendocrine tumours and their microenvironment. Cancer Immunology, Immunotherapy 69:8, pages 1449-1459.
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Anna Koumarianou, Krystallenia I. Alexandraki, Göran Wallin, Gregory Kaltsas & Kosmas Daskalakis. (2020) Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review. Journal of Clinical Medicine 9:6, pages 1777.
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Tal Grenader, Marianne E. Pavel, Philippe B. Ruszniewski, Jarosław B. Ćwikła, Alexandria T. Phan, Markus Raderer, Eva Sedláčková, Guillaume Cadiot, Edward M. Wolin, Jaume Capdevila, Lucy Wall, Guido RindiXuan-Mai Truong Thanh & Martyn E. Caplin. (2020) Prognostic value of the neutrophil/lymphocyte ratio in enteropancreatic neuroendocrine tumors. Anti-Cancer Drugs 31:3, pages 216-222.
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Giovanni Vitale, Silvia Carra, Francesco Ferraù, Elia Guadagno, Antongiulio Faggiano & Annamaria Colao. (2020) Gastroenteropancreatic neuroendocrine neoplasms and inflammation: A complex cross-talk with relevant clinical implications. Critical Reviews in Oncology/Hematology 146, pages 102840.
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Amaral Horacio. (2020) Chilean experience using “Theranostics” for treating metastatic neuroendocrine tumors with [177Lu]Lu DOTA-TATE. Archives of Clinical Gastroenterology, pages 036-040.
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Wu-Hu Zhang, Wen-Quan Wang, He-Li Gao, Xian-Jun Yu & Liang Liu. (2019) The tumor immune microenvironment in gastroenteropancreatic neuroendocrine neoplasms. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1872:2, pages 188311.
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Florian Bösch, Katharina Brüwer, Annelore Altendorf-Hofmann, Christoph J Auernhammer, Christine Spitzweg, C Benedikt Westphalen, Stefan Boeck, Gabriele Schubert-Fritschle, Jens Werner, Volker Heinemann, Thomas Kirchner, Martin Angele & Thomas Knösel. (2019) Immune checkpoint markers in gastroenteropancreatic neuroendocrine neoplasia. Endocrine-Related Cancer 26:3, pages 293-301.
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M Cives, J Strosberg, S Al Diffalha & D Coppola. (2019) Analysis of the immune landscape of small bowel neuroendocrine tumors. Endocrine-Related Cancer 26:1, pages 119-130.
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Mauro Cives, Eleonora Pelle’, Davide Quaresmini, Francesca Maria Rizzo, Marco Tucci & Franco Silvestris. (2019) The Tumor Microenvironment in Neuroendocrine Tumors: Biology and Therapeutic Implications. Neuroendocrinology 109:2, pages 83-99.
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Thomas Cuny, Wouter de Herder, Anne Barlier & Leo J Hofland. (2018) Role of the tumor microenvironment in digestive neuroendocrine tumors. Endocrine-Related Cancer 25:11, pages R519-R544.
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Matthias M. Weber & Christian Fottner. (2018) Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia. Oncology Research and Treatment 41:5, pages 306-312.
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Mauro Cives & Jonathan Strosberg. (2017) Treatment Strategies for Metastatic Neuroendocrine Tumors of the Gastrointestinal Tract. Current Treatment Options in Oncology 18:3.
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Vito Amoroso, Giorgio Maria Agazzi, Elisa Roca, Nicola Fazio, Alessandra Mosca, Marco Ravanelli, Francesca Spada, Roberto Maroldi & Alfredo Berruti. (2017) Regression of advanced neuroendocrine tumors among patients receiving placebo. Endocrine-Related Cancer 24:2, pages L13-L16.
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Ashley K. Clift, Panagiotis Drymousis, Adil Al-Nahhas, Harpreet Wasan, John Martin, Sture Holm & Andrea Frilling. (2015) Incidence of Second Primary Malignancies in Patients with Neuroendocrine Tumours. Neuroendocrinology 102:1-2, pages 26-32.
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Chris M. van der Loos, Onno J. de Boer, Claire Mackaaij, Lisette T. Hoekstra, Thomas M. van Gulik & Joanne Verheij. (2012) Accurate Quantitation of Ki67-positive Proliferating Hepatocytes in Rabbit Liver by a Multicolor Immunohistochemical (IHC) Approach Analyzed with Automated Tissue and Cell Segmentation Software. Journal of Histochemistry & Cytochemistry 61:1, pages 11-18.
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Mark Kidd & Irvin M Modlin. (2011) Small intestinal neuroendocrine cell pathobiology: ‘carcinoid’ tumors. Current Opinion in Oncology 23:1, pages 45-52.
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Eun Sook Hwang. (2010) This month in APR. Archives of Pharmacal Research 33:11, pages 1699-1701.
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S. Müller, D. Poehnert, J. A. Müller, G. W. F. Scheumann, M. Koch & R. Lück. (2010) Regulatory T Cells in Peripheral Blood, Lymph Node, and Thyroid Tissue in Patients with Medullary Thyroid Carcinoma. World Journal of Surgery 34:7, pages 1481-1487.
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