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Original Article

Cancer patients without a known primary: Incidence and survival trends in Sweden 1960–2007

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Pages 915-920 | Received 04 May 2008, Published online: 13 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Elie Rassy & Nicholas Pavlidis. (2020) The diagnostic challenges of patients with carcinoma of unknown primary. Expert Review of Anticancer Therapy 20:9, pages 775-783.
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Chong S. Kim, Malek B. Hannouf, Sisira Sarma, George B. Rodrigues, Peter K. Rogan, Salaheddin M. Mahmud, Eric Winquist, Muriel Brackstone & Gregory S. Zaric. (2015) Identification and survival outcomes of a cohort of patients with cancer of unknown primary in Ontario, Canada. Acta Oncologica 54:10, pages 1781-1787.
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Odd Terje Brustugun & Åslaug Helland. (2014) Rapid reduction in the incidence of cancer of unknown primary. A population-based study. Acta Oncologica 53:1, pages 134-137.
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Anne Kirstine Hundahl Møller, Karen Damgaard Pedersen, Anita Gothelf & Gedske Daugaard. (2010) Paclitaxel, cisplatin and gemcitabine in treatment of carcinomas of unknown primary site, a phase II study. Acta Oncologica 49:4, pages 423-430.
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Sakura Sakakibara, Laura Pazzagli & Marie Linder. (2024) Consistency between the National Patient Register and the Swedish Cancer Register. Pharmacoepidemiology and Drug Safety 33:4.
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Julie A. Bytnar, Jie Lin, Joel T. Moncur, Craig D. Shriver & Kangmin Zhu. (2023) Cancers of unknown primary: Survival by histologic type, demographic features, and treatment in the U.S. Military Health System. Cancer Epidemiology 82, pages 102316.
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Peng Qi, Yifeng Sun, Xin Liu, Sheng Wu, Yixin Wo, Qinghua Xu, Qifeng Wang, Xichun Hu & Xiaoyan Zhou. (2022) Clinicopathological, molecular and prognostic characteristics of cancer of unknown primary in China: An analysis of 1420 cases. Cancer Medicine 12:2, pages 1177-1188.
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Atsuko Sugimoto, Kanae Nakamura, Kousuke Kuwahara, Noriko Matsumoto, Kotoho Oki & Rei Ogawa. (2022) Squamous Cell Carcinoma of Unknown Primary that Metastasized to an Inguinal Lymph Node: A Case Report. Journal of Nippon Medical School 89:4, pages 454-459.
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Yoo-Kyung Boo, Dayeon Park, Jiwon Lim, Hyun-Sook Lim & Young-Joo Won. (2021) Descriptive epidemiology of cancer of unknown primary in South Korea, 1999–2017. Cancer Epidemiology 74, pages 102000.
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Christina Große-Thie, Claudia Maletzki, Christian Junghanss & Kathie Schmidt. (2021) Long-term survivor of metastatic squamous-cell head and neck carcinoma with occult primary after cetuximab-based chemotherapy: A case report. World Journal of Clinical Cases 9:24, pages 7092-7098.
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Timothée Olivier, Eugenio Fernandez, Intidhar Labidi-Galy, Pierre-Yves Dietrich, Veronica Rodriguez-Bravo, Giulia Baciarello, Karim Fizazi & Anna Patrikidou. (2021) Redefining cancer of unknown primary: Is precision medicine really shifting the paradigm?. Cancer Treatment Reviews 97, pages 102204.
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Yoshinobu Ishiwata, Tomohiro Kaneta, Shintaro Nawata, Hitoshi Iizuka & Daisuke Utsunomiya. (2020) Feasibility of prognosis assessment for cancer of unknown primary origin using texture analysis of 18F-fluorodeoxyglucose PET/computed tomography images of largest metastatic lymph node. Nuclear Medicine Communications 42:1, pages 86-92.
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Michael S Lee & Hanna K Sanoff. (2020) Cancer of unknown primary. BMJ, pages m4050.
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Elie Rassy & Nicholas Pavlidis. (2020) Progress in refining the clinical management of cancer of unknown primary in the molecular era. Nature Reviews Clinical Oncology 17:9, pages 541-554.
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G. R. Boeckel, M. Pouyiourou, L. Claßen, T. Bochtler & A. Krämer. (2020) Diagnostik und Therapie von Krebserkrankungen mit unbekanntem Primärtumor (CUP-Syndrom)Diagnostic and treatment of cancer of unknown primary site (CUP syndrome). best practice onkologie 15:3, pages 76-84.
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Elie Rassy & Nicholas Pavlidis. (2019) The currently declining incidence of cancer of unknown primary. Cancer Epidemiology 61, pages 139-141.
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C.M. Vajdic, O. Perez-Concha, J.J. Rhee, T. Dobbins, R.L. Ward, A.L. Schaffer, M.T. van Leeuwen, M.A. Laaksonen, G. Craigen & S.A. Pearson. (2019) Health-related predictors of cancer registry-notified cancer of unknown primary site (CUP). Cancer Epidemiology 61, pages 1-7.
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C.M. Vajdic, O. Perez-Concha, T. Dobbins, R.L. Ward, A.L. Schaffer, M.T. van Leeuwen, J.J. Rhee, M.A. Laaksonen, G. Craigen & S.A. Pearson. (2019) Demographic, social and lifestyle risk factors for cancer registry-notified cancer of unknown primary site (CUP). Cancer Epidemiology 60, pages 156-161.
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Christian Lorentz. 2018. Geriatrische Onkologie. Geriatrische Onkologie 583 587 .
William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster & David S. Morrison. (2017) Cancers of unknown primary diagnosed during hospitalization: a population-based study. BMC Cancer 17:1.
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Klaus Kraywinkel & Sylke Ruth Zeissig. (2017) Epidemiologie des CUP-Syndroms in DeutschlandEpidemiology of CUP syndrome in Germany. Der Onkologe 23:12, pages 966-973.
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Christian Lorentz. 2017. Geriatrische Onkologie. Geriatrische Onkologie 1 5 .
Eiji Nakamura, Takeshi Oda, Hiroshi Yasunaga & Shigeaki Aoyagi. (2016) A Case of Femoral Arterial Bleeding by an Unknown Origin Metastatic Groin Lymph Nodes Carcinoma. Annals of Vascular Diseases 9:1, pages 62-65.
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Eri Oda, Daisuke Hashimoto, Yuko Shiomi, Koji Ohnishi, Hiromitsu Hayashi, Akira Chikamoto, Motohiro Takeya & Hideo Baba. (2015) A case of occult intrahepatic cholangiocarcinoma diagnosed by autopsy. Surgical Case Reports 1:1.
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Matias Riihimäki, Akseli Hemminki, Kristina Sundquist & Kari Hemminki. (2014) Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site. BMC Cancer 14:1.
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Rudolf Kaaks, Disorn Sookthai, Kari Hemminki, Alwin Krämer, Heiner Boeing, Elisabet Wirfält, Elisabete Weiderpass, Kim Overvad, Anne Tjønneland, Anja Olsen, Petra H. Peeters, H. B(as) Bueno‐de‐Mesquita, Salvatore Panico, Valeria Pala, Paolo Vineis, J. Ramón Quirós, Eva Ardanaz, María‐José Sánchez, Maria‐Dolores Chirlaque, Nerea Larrañaga, Paul Brennan, Dimitrios Trichopoulos, Antonia Trichopoulou, Pagona Lagiou, Göran Hallmans, Kay‐Tee Khaw, Timothy J. Key, Elio Riboli & Federico Canzian. (2014) Risk factors for cancers of unknown primary site: Results from the prospective EPIC cohort. International Journal of Cancer 135:10, pages 2475-2481.
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David H. Brewster, Jaroslaw Lang, Lesley A. Bhatti, Catherine S. Thomson & Karin A. Oien. (2014) Descriptive epidemiology of cancer of unknown primary site in Scotland, 1961–2010. Cancer Epidemiology 38:3, pages 227-234.
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Matias Riihimäki, Hauke Thomsen, Akseli Hemminki, Kristina Sundquist & Kari Hemminki. (2013) Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer. BMC Cancer 13:1.
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Margareta Randén, Maria Helde-Frankling, Sara Runesdotter & Peter Gunvén. (2013) Unfavorable cancers of unknown primaries: presentation and prognostic factors. A population-based 8-year experience. Medical Oncology 30:4.
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D Urban, A Rao, M Bressel, Y R Lawrence & L Mileshkin. (2013) Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities. British Journal of Cancer 109:5, pages 1318-1324.
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M. Riihimäki, A. Hemminki, K. Sundquist & K. Hemminki. (2013) Time trends in survival from cancer of unknown primary: Small steps forward. European Journal of Cancer 49:10, pages 2403-2410.
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Kari Hemminki, Matias Riihimäki, Kristina Sundquist & Akseli Hemminki. (2013) Site‐specific survival rates for cancer of unknown primary according to location of metastases. International Journal of Cancer 133:1, pages 182-189.
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Hao Liu, Kari Hemminki, Jan Sundquist, Bernd Holleczek, Alexander Katalinic, Katharina Emrich & Hermann Brenner. (2013) Second primary cancers after cancer of unknown primary in Sweden and Germany. European Journal of Cancer Prevention 22:3, pages 210-214.
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G. Hübner. (2012) CUP-SyndromCUP syndrome. Der Onkologe 19:1, pages 8-14.
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Eric Yaovi Amela, Géraldine Lauridant-Philippin, Sophie Cousin, Thomas Ryckewaert, Antoine Adenis & Nicolas Penel. (2012) Management of “unfavourable” carcinoma of unknown primary site: Synthesis of recent literature. Critical Reviews in Oncology/Hematology 84:2, pages 213-223.
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K. Hemminki, M. Bevier, A. Hemminki & J. Sundquist. (2012) Survival in cancer of unknown primary site: population-based analysis by site and histology. Annals of Oncology 23:7, pages 1854-1863.
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K. Hemminki, H. Liu, A. Heminki & J. Sundquist. (2012) Power and limits of modern cancer diagnostics: cancer of unknown primary. Annals of Oncology 23:3, pages 760-764.
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X. Shu, H. Liu, J. Ji, K. Sundquist, A. Försti, J. Sundquist & K. Hemminki. (2012) Subsequent cancers in patients diagnosed with cancer of unknown primary (CUP): etiological insights?. Annals of Oncology 23:1, pages 269-275.
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Kari HemminkiJianguang JiJan SundquistXiaochen Shu. (2011) Familial Risks in Cancer of Unknown Primary: Tracking the Primary Sites. Journal of Clinical Oncology 29:4, pages 435-440.
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