Advanced search
Publication Cover
Acta Oncologica Volume 56, 2017 - Issue 4
Journal homepage
15,478
Views
183
CrossRef citations to date
0
Altmetric
REVIEW

HIF-1 in cancer therapy: two decade long story of a transcription factor

Sourabh SoniPharmacology and Toxicology Lab, Food and Nutraceuticals Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India; ;Academy of Scientific and Innovative Research, New Delhi, IndiaView further author information
&
Yogendra S. PadwadPharmacology and Toxicology Lab, Food and Nutraceuticals Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India; ;Academy of Scientific and Innovative Research, New Delhi, IndiaCorrespondence[email protected]
View further author information
Pages 503-515 | Received 28 Oct 2016, Accepted 26 Feb 2017, Published online: 30 Mar 2017

Citations (183)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Samantha M. Ruff & Timothy M. Pawlik. (2024) Emerging therapies targeting growth factors in hepatocellular carcinoma. Expert Opinion on Pharmacotherapy 25:3, pages 255-262.
Read now
Fatima Khatoon, Sabeeha Ali, Vijay Kumar, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Salem Hussain Alharethi, Asimul Islam & Md. Imtaiyaz Hassan. (2023) Pharmacological features, health benefits and clinical implications of honokiol. Journal of Biomolecular Structure and Dynamics 41:15, pages 7511-7533.
Read now
Yogesh Singh, Kulkarni Swanand Sanjay, Pradeep Kumar, Satwinder Singh & Suresh Thareja. (2023) Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors. Journal of Biomolecular Structure and Dynamics 41:8, pages 3524-3541.
Read now
Erin Clapper, Giovanna Di Trapani & Kathryn F. Tonissen. (2021) The regulation of bcr-abl in hypoxia is through the mTOR pathway. Leukemia & Lymphoma 62:4, pages 967-978.
Read now
Jaclyn J Renfrow, Michael H Soike, Waldemar Debinski, Shakti H Ramkissoon, Ryan T Mott, Mark B Frenkel, Jann N Sarkaria, Glenn J Lesser & Roy E Strowd. (2018) Hypoxia-Inducible Factor 2α: A Novel Target in Gliomas. Future Medicinal Chemistry 10:18, pages 2227-2236.
Read now

Articles from other publishers (178)

Md. Kamrul Hasan Arnab, Md. Rabiul Islam & Mohammad Saydur Rahman. (2024) A comprehensive review on phytochemicals in the treatment and prevention of pancreatic cancer: Focusing on their mechanism of action. Health Science Reports 7:5.
Crossref
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber & Anupam Bishayee. (2023) Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review. Cancer and Metastasis Reviews 43:1, pages 501-574.
Crossref
Ambika Murugesan, C Bharath, Sekar Balakrishnan, Saravanan Kandasamy, Indra Priyadharshini & Saranyan Ravi. (2024) Expression of HIF-1α and Nestin in oral squamous cell carcinoma and its association with vasculogenic mimicry. Journal of Cancer Research and Therapeutics 20:1, pages 176-180.
Crossref
Yan Zhao, Cheng Xing, Yating Deng, Can Ye & Hongling Peng. (2024) HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies. Genes & Diseases 11:1, pages 234-251.
Crossref
Yashasvi Bhat, M. R. Thrishna & Satarupa Banerjee. (2023) Molecular targets and therapeutic strategies for triple-negative breast cancer. Molecular Biology Reports 50:12, pages 10535-10577.
Crossref
Yi Pan, Longcai Liu, Xiaozhou Mou & Yu Cai. (2023) Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment. ACS Nano 17:21, pages 20875-20924.
Crossref
Swanand Kulkarni, Dyuti Bhandary, Yogesh Singh, Vikramdeep Monga & Suresh Thareja. (2023) Boron in cancer therapeutics: An overview. Pharmacology & Therapeutics 251, pages 108548.
Crossref
Prabha Panneerselvan, Keerthana Vasanthakumar, Karthi Muthuswamy, Vasanth Krishnan & Selvakumar Subramaniam. (2023) Insights on the functional dualism of nitric oxide in the hallmarks of cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:6, pages 189001.
Crossref
Vahid Asghariazar, Mahtab Kadkhodayi, Mehdi Sarailoo, Amir Ghaffari Jolfayi & Behzad Baradaran. (2023) MicroRNA-143 as a potential tumor suppressor in cancer: An insight into molecular targets and signaling pathways. Pathology - Research and Practice 250, pages 154792.
Crossref
Dan Chen, Wenjing Wang, Qingxia Zhu, Qinya Wang, Daoyi Quan, Yun Zeng, Ke Li, Yun Zhou, Changhu Liu, Wenhua Zhan & Yonghua Zhan. (2023) In vivo real-time monitoring of the development of hypoxia and angiogenesis in cervical cancer. Chemical Engineering Journal 473, pages 145498.
Crossref
Roy Strowd, Benjamin Ellingson, Catalina Raymond, Jingwen Yao, Patrick Y. Wen, Manmeet Ahluwalia, Anna Piotrowski, Arati Desai, Jennifer L. Clarke, Frank S. Lieberman, Serena Desideri, L. Burt Nabors, Xiaobu Ye & Stuart Grossman. (2023) Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastoma. Journal of Neuro-Oncology 165:1, pages 101-112.
Crossref
Neha Masarkar, Suman Kumar Ray, Zirha Saleem & Sukhes Mukherjee. (2023) Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer . Journal of Complementary and Integrative Medicine 0:0.
Crossref
Vahideh Tarhriz, Leila Abkhooie & Mostafa Moradi Sarabi. (2023) Regulation of HIF-1 by MicroRNAs in Various Cardiovascular Diseases. Current Cardiology Reviews 19:5.
Crossref
Ricardo González-Ruiz, Lilia Leyva-Carrillo, Alma B. Peregrino-Uriarte & Gloria Yepiz-Plascencia. (2023) The combination of hypoxia and high temperature affects heat shock, anaerobic metabolism, and pentose phosphate pathway key components responses in the white shrimp (Litopenaeus vannamei). Cell Stress and Chaperones 28:5, pages 493-509.
Crossref
Genevieve M. Abd, Madison C. Laird, Jennifer C. Ku & Yong Li. (2023) Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise. Frontiers in Oncology 13.
Crossref
Yu-De Chu, Chun-Wei Chen, Ming-Wei Lai, Siew-Na Lim & Wey-Ran Lin. (2023) Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly. World Journal of Gastroenterology 29:29, pages 4499-4527.
Crossref
Hongyuan Lu, Yan Zhu, Wenwu Liu, Yuanyuan Yan, Xiaowen Jiang, Qinbiao Wang, Yanyun Zhao, Miao He & Minjie Wei. (2023) A Comprehensive Description of Hypoxia-inducible Factor 2α Inhibitors as Anticancer Agents: A Mini-review. Current Medicinal Chemistry 30:25, pages 2835-2849.
Crossref
Sarah E. Lacher, Cara Skon-Hegg, Brian L. Ruis, Jennifer Krznarich & Matthew Slattery. (2023) An antioxidant response element regulates the HIF1α axis in breast cancer cells. Free Radical Biology and Medicine 204, pages 243-251.
Crossref
Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin & Yao-An Shen. (2023) Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance. Journal of Experimental & Clinical Cancer Research 42:1.
Crossref
Teow J. Phua. (2023) Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis. Frontiers in Aging 4.
Crossref
Elisa Pinto, Filippo Pelizzaro, Fabio Farinati & Francesco Paolo Russo. (2023) Angiogenesis and Hepatocellular Carcinoma: From Molecular Mechanisms to Systemic Therapies. Medicina 59:6, pages 1115.
Crossref
Ping Wang, Yanli Zhang, Quande Lin, Jian Zhou, Xiaodong Lv & Yongping Song. (2023) Hsa_circ_0111738 Inhibits Tumor Progression and Angiogenesis in Multiple Myeloma by Sponging miR-1233-3p to Regulate HIF-1 Signaling Pathway. Archives of Medical Research 54:4, pages 299-309.
Crossref
Jonathan Elliott. (2023) Therapeutics of managing reduced red cell mass associated with chronic kidney disease – Is there a case for earlier intervention?. Journal of Veterinary Pharmacology and Therapeutics 46:3, pages 145-157.
Crossref
Elena Puris, Sabrina Petralla, Seppo Auriola, Heidi Kidron, Gert Fricker & Mikko Gynther. (2023) Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells. Journal of Pharmaceutical Sciences.
Crossref
Leslie Chaltel-Lima, Fabiola Domínguez, Lenin Domínguez-Ramírez & Paulina Cortes-Hernandez. (2023) The Role of the Estrogen-Related Receptor Alpha (ERRa) in Hypoxia and Its Implications for Cancer Metabolism. International Journal of Molecular Sciences 24:9, pages 7983.
Crossref
Nora Astrain-Redin, Carmen Sanmartin, Arun K. Sharma & Daniel Plano. (2023) From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment. Journal of Medicinal Chemistry 66:6, pages 3703-3731.
Crossref
J.A. García-Arnés & N. García-Casares. (2023) Doping and sports endocrinology: growth hormone, IGF-1, insulin, and erythropoietin. Revista Clínica Española (English Edition) 223:3, pages 181-187.
Crossref
J.A. García-Arnés & N. García-Casares. (2023) Endocrinología del dopaje y los deportes: hormona de crecimiento, IGF-1, insulina y eritropoyetina. Revista Clínica Española 223:3, pages 181-187.
Crossref
Mohsen Karami Fath, Setareh Garousi, Mehran Mottahedi, Nasim Ghasemzadeh, Kiana Salmani, Fatemeh Olfati, Miad Beit Saeed, Sina Sotoudeh & Ghasem Barati. (2023) The role of hypoxia-inducible factors in breast cancer stem cell specification. Pathology - Research and Practice 243, pages 154349.
Crossref
Ji Yoon Kim, Hayoung Cho, Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee & So Hee Kwon. (2023) HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma. Cancers 15:4, pages 1123.
Crossref
Katja R. Worth, Ioanna Papandreou & Ester M. Hammond. (2022) How the histological structure of some lung cancers shaped almost 70 years of radiobiology. British Journal of Cancer 128:3, pages 407-412.
Crossref
Mohamed K. Abdel-Rafei, Moustafa A. Askar, Khaled S. Azab, Gharieb S. El-Sayyad, Mohamed Abd El Kodous, Neama M. El Fatih, Ghada El Tawill & Noura M. Thabet. (2023) FA-HA-Amygdalin@Fe2O3 and/or γ-Rays Affecting SIRT1 Regulation of YAP/TAZ-p53 Signaling and Modulates Tumorigenicity of MDA-MB231 or MCF-7 Cancer Cells. Current Cancer Drug Targets 23:2, pages 118-144.
Crossref
Natalie C. Sondermann, Sonja Faßbender, Frederick Hartung, Anna M. Hätälä, Katharina M. Rolfes, Christoph F.A. Vogel & Thomas Haarmann-Stemmann. (2023) Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway. Biochemical Pharmacology 208, pages 115371.
Crossref
Elena Puris, Gert Fricker & Mikko Gynther. (2023) The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy. Pharmaceutics 15:2, pages 364.
Crossref
Nikhil Ponnoor Anto & Rashmi Mittal. 2023. Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer. Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer 99 122 .
Suman Kumar Ray & Sukhes Mukherjee. (2023) Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks. Current Molecular Medicine 23:1, pages 44-53.
Crossref
Hellen Franciane Gonçalves Barbosa & Antonio Claudio Tedesco. 2023. Nanomaterials for Photodynamic Therapy. Nanomaterials for Photodynamic Therapy 227 260 .
Neha Masarkar, Suman Kumar Ray, Pragati Raghuwanshi, Ashish K. Yadav & Sukhes Mukherjee. 2023. Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Hypoxia in Cancer: Significance and Impact on Cancer Therapy 275 295 .
A. K. Kade, P. P. Polyakov, S. A. Zanin & Z. M. Dzhidzhikhiya. 2023. Double-Outlet Right Ventricle. Double-Outlet Right Ventricle 61 87 .
Bich Phuong Bui, Phuong Linh Nguyen, Kyeong Lee & Jungsook Cho. (2022) Hypoxia-Inducible Factor-1: A Novel Therapeutic Target for the Management of Cancer, Drug Resistance, and Cancer-Related Pain. Cancers 14:24, pages 6054.
Crossref
Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong & Ning Ren. (2022) Characteristics of the cancer stem cell niche and therapeutic strategies. Stem Cell Research & Therapy 13:1.
Crossref
Jooyoung Lee, Jiye Kim, Ryunjin Lee, Eunkyeong Lee, Tae Gyu Choi, Amy Sinyoung Lee, Young-In Yoon, Gil-Chun Park, Jung-Man Namgoong, Sung-Gyu Lee & Eunyoung Tak. (2022) Therapeutic strategies for liver diseases based on redox control systems. Biomedicine & Pharmacotherapy 156, pages 113764.
Crossref
Jia-Qi Xu, Yan-Li Fu, Jing Zhang, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Zhi-Wei Zhang & Zhong-Yan Zhou. (2022) Targeting glycolysis in non-small cell lung cancer: Promises and challenges. Frontiers in Pharmacology 13.
Crossref
Francesco Locatelli & Lucia Del Vecchio. (2022) Hypoxia-Inducible Factor–Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs?. Journal of the American Society of Nephrology 33:11, pages 1966-1979.
Crossref
Francesco Locatelli, Roberto Minutolo, Luca De Nicola & Lucia Del Vecchio. (2022) Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors. Drugs 82:16, pages 1565-1589.
Crossref
Nur Selvi Gunel, Nuri Yildirim, Neslihan Pinar Ozates, Latife Merve Oktay, Bakiye Goker Bagca, Fatma Sogutlu, Aydin Ozsaran, Mehmet Korkmaz & Cigir Biray Avci. (2022) Investigation of cytotoxic and apoptotic effects of disodium pentaborate decahydrate on ovarian cancer cells and assessment of gene profiling. Medical Oncology 40:1.
Crossref
Deyamira Matuz-Mares, Héctor Vázquez-Meza & María Magdalena Vilchis-Landeros. (2022) NOX as a Therapeutic Target in Liver Disease. Antioxidants 11:10, pages 2038.
Crossref
Oluyomi Stephen Adeyemi, Lawrence Boluwatife Afolabi, Damilare Emmanuel Rotimi, Dubem Sharon Ofume, Anne Adebukola Adeyanju, Oluwakemi Josephine Awakan & Tobiloba Christiana Elebiyo. (2022) Targeting of Hypoxia for Therapeutic Strategy in the Varied Physiological States. The Open Biochemistry Journal 16:1.
Crossref
Karolina Kozal & Anna Krześlak. (2022) The Role of Hypoxia-Inducible Factor Isoforms in Breast Cancer and Perspectives on Their Inhibition in Therapy. Cancers 14:18, pages 4518.
Crossref
Edwin Cevallos Barrera, Edson Zangiacomi Martinez, Mariangela Ottoboni Brunaldi, Eduardo Antonio Donadi, Ajith Kumar Sankarankutty, Rafael Kemp & José Sebastiao dos Santos. (2022) Influence of high altitude on the expression of HIF-1 and on the prognosis of Ecuadorian patients with gastric adenocarcinoma. Oncotarget 13:1, pages 1043-1053.
Crossref
Rita Ribeiro, Maria João Carvalho, João Goncalves & João Nuno Moreira. (2022) Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities. Frontiers in Molecular Biosciences 9.
Crossref
Keqi Xin, Bo Hu, Ling Han & Qunli Yu. (2022) Study on the HIF ‐1α regulated by glycolytic pathways and mitochondrial function in yaks of different altitudes during postmortem aging . Journal of Food Biochemistry 46:8.
Crossref
Zhaoping Qiu, Weijie Guo, Bo Dong, Yu Wang, Pan Deng, Chi Wang, Jinpeng Liu, Qing Zhang, Rudolf Grosschedl, Zhiyong Yu, Jiong Deng & Yadi Wu. (2022) EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1α pathway. Proceedings of the National Academy of Sciences 119:28.
Crossref
Iljin Kim, Sanga Choi, Seongkyeong Yoo, Mingyu Lee & In-San Kim. (2022) Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment. Cancers 14:14, pages 3321.
Crossref
Fabian Fischer, Giovanna Grigolon, Christoph Benner & Michael Ristow. (2022) Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection. Physiological Reviews 102:3, pages 1449-1494.
Crossref
Hongyang Liu, Junhu Wan, Quanling Feng, Jingyu Li, Jun Liu & Shihong Cui. (2021) Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway. Journal of Cell Communication and Signaling 16:2, pages 253-270.
Crossref
Ana Belén Herrera-Campos, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Mónica Fernández-Cortés, Luis M. Montuenga, F. Javier Oliver & Angel Garcia-Diaz. (2022) Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System. Cancers 14:11, pages 2740.
Crossref
Xu Jing, Lutao Du, Shuang Shi, Aijun Niu, Jing Wu, Yunshan Wang & Chuanxin Wang. (2022) Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p. Frontiers in Pharmacology 13.
Crossref
Zhaowu Ma, Xiaoqiang Xiang, Shiya Li, Peng Xie, Quan Gong, Boon-Cher Goh & Lingzhi Wang. (2022) Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds. Seminars in Cancer Biology 80, pages 379-390.
Crossref
Karuna Mittal, Jaspreet Kaur, Shaligram Sharma, Nivya Sharma, Guanhao Wei, Ishita Choudhary, Precious Imhansi-Jacob, Nagini Maganti, Shrikant Pawar, Padmashree Rida, Michael S. Toss, Mohammed Aleskandarany, Emiel A. Janssen, Håvard Søiland, Meenakshi. V. Gupta, Michelle D. Reid, Emad A. Rakha & Ritu Aneja. (2022) Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4. Molecular Cancer Research 20:4, pages 596-606.
Crossref
Lavanya Ponnusamy, Sathan Raj Natarajan & Ravi Manoharan. (2022) MARK2 potentiate aerobic glycolysis‐mediated cell growth in breast cancer through regulating mTOR/HIF‐1α and p53 pathways. Journal of Cellular Biochemistry 123:4, pages 759-771.
Crossref
Bin Shi, Fang-Fang Xu, Cai-Ping Xiang, Chuan-Yan Li, Ping Fan & Hao Wang. (2022) HIF1α/VEGF Feedback Loop Contributes to 5-Fluorouracil Resistance. Frontiers in Pharmacology 13.
Crossref
Ildiko Szanto. (2022) NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation. International Journal of Molecular Sciences 23:5, pages 2702.
Crossref
Anna Benedetti, Chiara Turco, Giulia Fontemaggi & Francesco Fazi. (2022) Non-Coding RNAs in the Crosstalk between Breast Cancer Cells and Tumor-Associated Macrophages. Non-Coding RNA 8:1, pages 16.
Crossref
Jhansi Nathan & Arunkumar Ramachandran. (2021) Efficacy of marine biomolecules on angiogenesis by targeting hypoxia inducible factor/vascular endothelial growth factor signaling in zebrafish model. Journal of Biochemical and Molecular Toxicology 36:2.
Crossref
Yiwei Huang, Zhencong Chen, Tao Lu, Guoshu Bi, Ming Li, Jiaqi Liang, Zhengyang Hu, Yuansheng Zheng, Jiacheng Yin, Junjie Xi, Zongwu Lin, Cheng Zhan, Wei Jiang, Qun Wang & Lijie Tan. (2021) HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer. Journal of Experimental & Clinical Cancer Research 40:1.
Crossref
Limeng Cai, Minfeng Ying & Hao Wu. (2021) Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy. Frontiers in Oncology 11.
Crossref
Nuria Vilaplana-Lopera, Maxym Besh & Eui Jung Moon. (2021) Targeting Hypoxia: Revival of Old Remedies. Biomolecules 11:11, pages 1604.
Crossref
Zheng Li, Hao Fan, Jiacheng Cao, Guangli Sun, Sen Wang, Jialun Lv, Zhe Xuan, Yiwen Xia, Linjun Wang, Diancai Zhang, Hao Xu & Zekuan Xu. (2021) Natriuretic peptide receptor a promotes gastric malignancy through angiogenesis process. Cell Death & Disease 12:11.
Crossref
Jens Kleinehr, Janine J. Wilden, Yvonne Boergeling, Stephan Ludwig & Eike R. Hrincius. (2021) Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets. Viruses 13:10, pages 2068.
Crossref
Yu-Hsuan Kuo, Ti-Chun Chan, Hong-Yue Lai, Tzu-Ju Chen, Li-Ching Wu, Chung-Hsi Hsing & Chien-Feng Li. (2021) Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma. Frontiers in Oncology 11.
Crossref
Amaya Lopez-PascualPaul TrayhurnJ. Alfredo MartínezPedro González-Muniesa. (2021) Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance. Antioxidants & Redox Signaling 35:8, pages 642-687.
Crossref
Qi Mu & Masoud Najafi. (2021) Modulation of the tumor microenvironment (TME) by melatonin. European Journal of Pharmacology 907, pages 174365.
Crossref
Linling Zhang, Jingjing Ke, Shengping Min, Nan Wu, Fei Liu, Zhen Qu, Wei Li, Hongtao Wang, Zhongqing Qian & Xiaojing Wang. (2021) Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial–Mesenchymal Transition in Hypoxic NSCLC Cells via the HIF-1α/PFKP Axis. Frontiers in Oncology 11.
Crossref
Cong Hu, Masae Iwasaki, Zhigang Liu, Bincheng Wang, Xiaomeng Li, Han Lin, Jun Li, Jia V. Li, Qingquan Lian & Daqing Ma. (2021) Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: Implication of reducing cancer recurrence risk. Journal of Advanced Research 31, pages 1-12.
Crossref
Hannah BollandTiffany S. MaSyafiq RamleeKristijan RamadanEster M. Hammond. (2021) Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review. Biochemical Society Transactions 49:3, pages 1251-1263.
Crossref
Valeria Ramundo, Giuliana Giribaldi & Elisabetta Aldieri. (2021) Transforming Growth Factor-β and Oxidative Stress in Cancer: A Crosstalk in Driving Tumor Transformation. Cancers 13:12, pages 3093.
Crossref
Xueqi Sun, Qirui Huang, Fang Peng, Jian Wang, Weidong Zhao & Guangxiu Guo. (2021) Expression and Clinical Significance of HKII and HIF-1α in Grade Groups of Prostate Cancer. Frontiers in Genetics 12.
Crossref
Qin Liu, Zhichao Liu, Zhipeng Gao, Guanjun Chen, Changyan Liu, Zhenghuang Wan, Chanyou Chen, Chen Zeng, Yunjie Zhao & Lei Pan. (2021) Insights into Temperature and Hypoxia Tolerance in Cowpea Weevil via HIF-1. Pathogens 10:6, pages 704.
Crossref
Xueyan Ding, Yajie Chang, Siquan Wang, Dong Yan, Jiakui Yao & Guoqiang Zhu. (2021) Transcriptomic Analysis of the Effect of GAT-2 Deficiency on Differentiation of Mice Naïve T Cells Into Th1 Cells In Vitro. Frontiers in Immunology 12.
Crossref
Congwang Zhang, Lijun Li, Yipeng Zhang & Changchun Zeng. (2021) Hereditary Leiomyomatosis and Renal Cell Cancer: Recent Insights Into Mechanisms and Systemic Treatment. Frontiers in Oncology 11.
Crossref
Mónica Vara‐Pérez, Matteo Rossi, Chris Van den Haute, Hannelore Maes, Maria Livia Sassano, Vivek Venkataramani, Bernhard Michalke, Erminia Romano, Kristine Rillaerts, Abhishek D Garg, Corentin Schepkens, Francesca M Bosisio, Jasper Wouters, Ana Isabel Oliveira, Peter Vangheluwe, Wim Annaert, Johannes V Swinnen, Jean Marie Colet, Joost J van den Oord, Sarah‐Maria Fendt, Massimiliano Mazzone & Patrizia Agostinis. (2021) BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis. The EMBO Journal 40:10.
Crossref
Lara R. S. Fonseca, Gonçalo R. Silva, Ângelo Luís, Henrique J. Cardoso, Sara Correia, Cátia V. Vaz, Ana P. Duarte & Sílvia Socorro. (2021) Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function. Molecules 26:10, pages 2941.
Crossref
Daria Artemova, Polina Vishnyakova, Elena Khashchenko, Andrey Elchaninov, Gennady Sukhikh & Timur Fatkhudinov. (2021) Endometriosis and Cancer: Exploring the Role of Macrophages. International Journal of Molecular Sciences 22:10, pages 5196.
Crossref
Ivana Špaková, Miroslava Rabajdová, Helena Mičková, Wolfgang F. Graier & Mária Mareková. (2021) Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells. Scientific Reports 11:1.
Crossref
Karim Taouis, Keltouma Driouch, Rosette Lidereau & François Lallemand. (2021) Molecular Functions of WWOX Potentially Involved in Cancer Development. Cells 10:5, pages 1051.
Crossref
Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto & Daqing Ma. (2021) Inhalational Anesthetics Inhibit Neuroglioma Cell Proliferation and Migration via miR-138, -210 and -335. International Journal of Molecular Sciences 22:9, pages 4355.
Crossref
Johannes Kasper, Nicole Hilbert, Tim Wende, Michael Karl Fehrenbach, Florian Wilhelmy, Katja Jähne, Clara Frydrychowicz, Gordian Hamerla, Jürgen Meixensberger & Felix Arlt. (2021) On the Prognosis of Multifocal Glioblastoma: An Evaluation Incorporating Volumetric MRI. Current Oncology 28:2, pages 1437-1446.
Crossref
Alexander E. Kabakov & Anna O. Yakimova. (2021) Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing. Cancers 13:5, pages 1102.
Crossref
Carolina Bernauer, Y. K. Stella Man, Julia C. Chisholm, Elise Y. Lepicard, Simon P. Robinson & Janet M. Shipley. (2020) Hypoxia and its therapeutic possibilities in paediatric cancers. British Journal of Cancer 124:3, pages 539-551.
Crossref
Jieun Seo, Kyeong Seog Kim, Jong-Wan Park, Joo-Youn Cho, Hak Chang, Junji Fukuda, Ki Yong Hong & Yang-Sook Chun. (2021) Metastasis-on-a-chip reveals adipocyte-derived lipids trigger cancer cell migration via HIF-1α activation in cancer cells. Biomaterials 269, pages 120622.
Crossref
Siyao Li, Lu Wen, Xiaoru Hu, Qingqing Wei & Zheng Dong. (2021) HIF in Nephrotoxicity during Cisplatin Chemotherapy: Regulation, Function and Therapeutic Potential. Cancers 13:2, pages 180.
Crossref
Karolina Kozal, Paweł Jóźwiak & Anna Krześlak. (2021) Contemporary Perspectives on the Warburg Effect Inhibition in Cancer Therapy. Cancer Control 28, pages 107327482110412.
Crossref
Naseim Elzakra & Yong Kim. 2021. Cancer Metabolomics. Cancer Metabolomics 243 260 .
Yanping Li, Xiao-Xin Sun, David Z. Qian & Mu-Shui Dai. (2020) Molecular Crosstalk Between MYC and HIF in Cancer. Frontiers in Cell and Developmental Biology 8.
Crossref
Yuanyuan Kang, Mi Ryung Roh, Suvi Rajadurai, Anpuchchelvi Rajadurai, Raj Kumar, Ching-Ni Njauw, Zhenlong Zheng & Hensin Tsao. (2020) Hypoxia and HIF-1α Regulate Collagen Production in Keloids. Journal of Investigative Dermatology 140:11, pages 2157-2165.
Crossref
Donglu Wu, Jingji Jin, Zhidong Qiu, Da Liu & Haoming Luo. (2020) Functional Analysis of O-GlcNAcylation in Cancer Metastasis. Frontiers in Oncology 10.
Crossref
Antonio Marra, Dario Trapani, Giulia Viale, Carmen Criscitiello & Giuseppe Curigliano. (2020) Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies. npj Breast Cancer 6:1.
Crossref
Matthew J. Kling, Nagendra K. Chaturvedi, Varun Kesherwani, Don W. Coulter, Timothy R. McGuire, J. Graham Sharp & Shantaram S. Joshi. (2020) Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery. Oncotarget 11:40, pages 3633-3645.
Crossref
Christopher M. Bailey, Yan Liu, Gong Peng, Huixia Zhang, Miao He, Duxin Sun, Pan Zheng, Yang Liu & Yin Wang. (2020) Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer. Nanomedicine: Nanotechnology, Biology and Medicine 29, pages 102278.
Crossref
Jelena Korac-Prlic, Marina Degoricija, Katarina Vilović, Benedikt Haupt, Tonči Ivanišević, Lucija Franković, Sergei Grivennikov & Janoš Terzić. (2020) Targeting Stat3 signaling impairs the progression of bladder cancer in a mouse model. Cancer Letters 490, pages 89-99.
Crossref
Iljin Kim & Jong-Wan Park. (2020) Hypoxia-driven epigenetic regulation in cancer progression: A focus on histone methylation and its modifying enzymes. Cancer Letters 489, pages 41-49.
Crossref
Dorothea R. Morris, Yue Qu, Anurodh Agrawal, Roberto P. Garofalo & Antonella Casola. (2020) HIF-1α Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus. Viruses 12:10, pages 1088.
Crossref
Antônio F. da Silva Filho, Lucas B. Tavares, Maira G. R. Pitta, Eduardo I. C. Beltrão & Moacyr J. B. M. Rêgo. (2020) Galectin-3 is modulated in pancreatic cancer cells under hypoxia and nutrient deprivation. Biological Chemistry 401:10, pages 1153-1165.
Crossref
Jaclyn J. Renfrow, Michael H. Soike, James L. West, Shakti H. Ramkissoon, Linda Metheny-Barlow, Ryan T. Mott, Carol A. Kittel, Ralph B. D’AgostinoJr.Jr., Stephen B. Tatter, Adrian W. Laxton, Mark B. Frenkel, Gregory A. Hawkins, Denise Herpai, Stephanie Sanders, Jann N. Sarkaria, Glenn J. Lesser, Waldemar Debinski & Roy E. Strowd. (2020) Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor. Scientific Reports 10:1.
Crossref
Kah Ni Tan, Vicky M. Avery & Catalina Carrasco-Pozo. (2020) Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer. International Journal of Molecular Sciences 21:18, pages 6622.
Crossref
Agata Gabryelska, Filip Franciszek Karuga, Bartosz Szmyd & Piotr Białasiewicz. (2020) HIF-1α as a Mediator of Insulin Resistance, T2DM, and Its Complications: Potential Links With Obstructive Sleep Apnea. Frontiers in Physiology 11.
Crossref
Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Jianwei Li, Yang Li, Hua Qu, Ruikai Du, Ying Zhang, Feng Xu, Yuheng Li, Caizhi Liu, Guohui Zhong, Shuai Liang, Zizhong Liu, Xingcheng Gao, Xiaoyan Jin, Yingxian Li & Dazhuo Shi. (2020) Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination. Frontiers in Pharmacology 11.
Crossref
Robert Y. Hapke & Scott M. Haake. (2020) Hypoxia-induced epithelial to mesenchymal transition in cancer. Cancer Letters 487, pages 10-20.
Crossref
Savannah E. Est-Witte, Ashley L. Farris, Stephany Y. Tzeng, Daphne L. Hutton, Dennis H. Gong, Kaitlyn G. Calabresi, Warren L. Grayson & Jordan J. Green. (2020) Non-viral gene delivery of HIF-1α promotes angiogenesis in human adipose-derived stem cells. Acta Biomaterialia 113, pages 279-288.
Crossref
Simone Negrini, Raffaele De Palma & Gilberto Filaci. (2020) Anti-Cancer Immunotherapies Targeting Telomerase. Cancers 12:8, pages 2260.
Crossref
Sumit Sahni, Josef Gillson, Kyung Chan Park, Shannon Chiang, Lionel Yi Wen Leck, Patric J. Jansson & Des R. Richardson. (2020) NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization. Biochimica et Biophysica Acta (BBA) - General Subjects 1864:8, pages 129625.
Crossref
Xing Liu, Zongpeng Zhou, Zikun Wang, Xiangming Li, Guangyu Lu & Jian Tong. (2020) SDHA‐mediated Warburg effect in malignantly transformed human bronchial epithelial cells following long‐term exposure to radon. Environmental Toxicology 35:8, pages 861-866.
Crossref
Na Shen, Yaming Wang, Xuefei Sun, Xueyan Bai, Jinglan He, Qu Cui, Jun Qian, Hong Zhu, Yuedan Chen, Ruixian Xing, Qing Liu, Yuchen Wu, Junhong Li, Wenyuan Lai, Shengjun Sun, Nan Ji & Yuanbo Liu. (2020) Expression of hypoxia‐inducible factor 1α, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors. Brain and Behavior 10:8.
Crossref
Mayra Xóchitl Durán-Maldonado, Laura Hernández-Padilla, Juan Carlos Gallardo-Pérez, Alma Laura Díaz-Pérez, Lorena Martínez-Alcantar, Homero Reyes De la Cruz, José Salud Rodríguez-Zavala, Gustavo Pacheco-Rodríguez, Joel Moss & Jesús Campos-García. (2020) Bacterial Cyclodipeptides Target Signal Pathways Involved in Malignant Melanoma. Frontiers in Oncology 10.
Crossref
Min-Seok Lee, Min-Jeong Kim & Chul-Won Lee. (2020) An Analysis of the relationship between leisure attitude and quality of life of active seniors participating in tennis: focusing on the mediating effect of stress-related growth. Korean Journal of Lesure, Recreation & Park 44:2, pages 17-29.
Crossref
Biao Yang, Han Tian & Chunling Xiao. (2020) lncRNA NONHSAT021963, which upregulates VEGF in A549 cells, mediates PM2.5 exposure-induced angiogenesis in Shenyang, China. Molecular & Cellular Toxicology.
Crossref
Francesco Locatelli & Lucia Del Vecchio. (2020) Are prolyl-hydroxylase inhibitors potential alternative treatments for anaemia in patients with chronic kidney disease?. Nephrology Dialysis Transplantation 35:6, pages 926-932.
Crossref
Chenxi Zhao, Chenming Zeng, Song Ye, Xiaoyang Dai, Qiaojun He, Bo Yang & Hong Zhu. (2020) Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding motif (TAZ): a nexus between hypoxia and cancer. Acta Pharmaceutica Sinica B 10:6, pages 947-960.
Crossref
Cristina Panuzzo, Aleksandar Jovanovski, Barbara Pergolizzi, Lucrezia Pironi, Serena Stanga, Carmen Fava & Daniela Cilloni. (2020) Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe. International Journal of Molecular Sciences 21:11, pages 3928.
Crossref
Zihuan Zhao, Dan Zhao, Ji Xia, Yi Wang & Buhai Wang. (2020) Immunoscore Predicts Survival in Early-Stage Lung Adenocarcinoma Patients. Frontiers in Oncology 10.
Crossref
Kota Koike, Masanobu Nagano, Masahiro Ebihara, Tasuku Hirayama, Mieko Tsuji, Hiroaki Suga & Hideko Nagasawa. (2020) Design, Synthesis, and Conformation–Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents. Journal of Medicinal Chemistry 63:8, pages 4022-4046.
Crossref
Kishor Pant, Seth Richard, Estanislao Peixoto & Sergio A Gradilone. (2020) Role of Glucose Metabolism Reprogramming in the Pathogenesis of Cholangiocarcinoma. Frontiers in Medicine 7.
Crossref
Jiabei Zhou, Yu Kang, Lu Chen, Hua Wang, Junqing Liu, Su Zeng & Lushan Yu. (2020) The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents. Frontiers in Pharmacology 11.
Crossref
Erin Clapper, Sicong Wang, Prahlad V. Raninga, Giovanna Di Trapani & Kathryn F. Tonissen. (2020) Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment. Antioxidants 9:3, pages 207.
Crossref
Pingfu Hou, Peicong Shi, Tao Jiang, Hang Yin, Sufang Chu, Meilin Shi, Jin Bai & Jun Song. (2019) DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer. British Journal of Cancer 122:5, pages 668-679.
Crossref
Changda Qu, Chang Yan, Weifan Cao, Fangqin Li, Yewei Qu, Ke Guan, Chengqing Si, Ze Yu & Zhangyi Qu. (2019) miR‐128‐3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1. IUBMB Life 72:3, pages 465-475.
Crossref
He-Wen Tang, Hai-Liang FengMing Wang, Qing-Li Zhu, Yu-Qin LiuYu-Xin Jiang. (2020) In vivo longitudinal and multimodal imaging of hypoxia-inducible factor 1α and angiogenesis in breast cancer. Chinese Medical Journal 133:2, pages 205-211.
Crossref
Na Shao, Yue Han, Liang Song & Wei Song. (2020) Clinical significance of hypoxia-inducible factor 1α, and its correlation with p53 and vascular endothelial growth factor expression in resectable esophageal squamous cell carcinoma. Journal of Cancer Research and Therapeutics 16:2, pages 269-275.
Crossref
Takashi Miyaji, Taro Takami, Koichi Fujisawa, Toshihiko Matsumoto, Naoki Yamamoto & Isao Sakaida. (2020) Bone marrow-derived humoral factors suppress oxidative phosphorylation, upregulate TSG-6, and improve therapeutic effects on liver injury of mesenchymal stem cells. Journal of Clinical Biochemistry and Nutrition 66:3, pages 213-223.
Crossref
Deyan Yordanov Yosifov, Irina Idler, Nupur Bhattacharya, Michaela Reichenzeller, Viola Close, Daria Ezerina, Annika Scheffold, Billy Michael Chelliah Jebaraj, Sabrina Kugler, Johannes Bloehdorn, Jasmin Bahlo, Sandra Robrecht, Barbara Eichhorst, Kirsten Fischer, Anja Weigel, Hauke Busch, Peter Lichter, Hartmut Döhner, Tobias P. Dick, Stephan Stilgenbauer & Daniel Mertens. (2019) Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL. Leukemia 34:1, pages 115-127.
Crossref
Thomas S. Atkinson & Marc J. Kahn. (2020) Blood doping: Then and now. A narrative review of the history, science and efficacy of blood doping in elite sport. Blood Reviews 39, pages 100632.
Crossref
Livio Racané, Lucija Ptiček, Glorija Fajdetić, Vesna Tralić-Kulenović, Marko Klobučar, Sandra Kraljević Pavelić, Mihaela Perić, Hana Čipčić Paljetak, Donatella Verbanac & Kristina Starčević. (2020) Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl)benzothiazole derivatives as potential antioxidant, antibacterial and antitumor agents. Bioorganic Chemistry 95, pages 103537.
Crossref
Dae-Gun Park, So Ra Kim, Bok Hee Woo, Ji Hye Lee & Hae Ryoun Park. (2019) Epithelial-Mesenchymal Transition-Related Gene-Expression Profile in Hypoxic Oral Cancer Cells. The Korean Journal of Oral and Maxillofacial Pathology 43:6, pages 237-243.
Crossref
Chon Phin Ong, Wai Leong Lee, Yin Quan Tang & Wei Hsum Yap. (2019) Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers 12:1, pages 48.
Crossref
Aldo Pezzuto, Giuseppe Perrone, Nicoletta Orlando, Fabrizio Citarella, Massimo Ciccozzi, Simone Scarlata & Giuseppe Tonini. (2019) A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis. Oncotarget 10:66, pages 7071-7079.
Crossref
Xing-Liang Yang, Meng-Liu Zeng, Lin Shao, Guang-Tong Jiang, Jing-Jing Cheng, Tao-Xiang Chen, Song Han, Jun Yin, Wan-Hong Liu, Xiao-Hua He & Bi-Wen Peng. (2019) NFAT5 and HIF-1α Coordinate to Regulate NKCC1 Expression in Hippocampal Neurons After Hypoxia-Ischemia. Frontiers in Cell and Developmental Biology 7.
Crossref
Qi Su, Mengying Fan, Jingjing Wang, Asmat Ullah, Mohsin Ahmad Ghauri, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang & Yanmin Zhang. (2019) Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma. Cell Death & Disease 10:12.
Crossref
Santosh Kumar Singh, Manoj Kumar Mishra & Rajesh Singh. (2019) Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells. Journal of Ovarian Research 12:1.
Crossref
Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni & Gabriella D’Orazi. (2019) Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang & Wei-Xian Chen. (2019) The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis. BMC Cancer 19:1.
Crossref
Alessia Garufi, Gianandrea Traversi, Mara Cirone & Gabriella D'Orazi. (2019) HIPK2 role in the tumor–host interaction: Impact on fibroblasts transdifferentiation CAF‐like. IUBMB Life 71:12, pages 2055-2061.
Crossref
Xiaofeng Xu, Tao Liu, Jun Wu, Yijin Wang, Ying Hong & Huaijun Zhou. (2019) Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer. Cancer Gene Therapy 26:11-12, pages 356-365.
Crossref
Sara Rodríguez-Enríquez, Álvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Silvia Cecilia Pacheco-Velázquez, Javier Alejandro Belmont-Díaz, Diana Xochiquetzal Robledo-Cadena, Jorge Luis Vargas-Navarro, Norma Angélica Corona de la Peña, Emma Saavedra & Rafael Moreno-Sánchez. (2019) Transcriptional Regulation of Energy Metabolism in Cancer Cells. Cells 8:10, pages 1225.
Crossref
Virgínia Campos Silvestrini, Guilherme Pauperio Lanfredi, Ana Paula Masson, Aline Poersch, Germano Aguiar Ferreira, Carolina Hassibe Thomé & Vítor Marcel Faça. (2019) A proteomics outlook towards the elucidation of epithelial–mesenchymal transition molecular events. Molecular Omics 15:5, pages 316-330.
Crossref
Wei‐Jian Chen, Hua Zhang, Xue‐Yi Zeng, Long Chen, Gui‐Ting Fang, Huai‐Hong Cai & Xing Zhong. (2019) Phase‐shifted pentafluorobutane nanoparticles for ultrasound imaging and ultrasound‐mediated hypoxia modulation. Journal of Cellular Biochemistry 120:10, pages 16543-16552.
Crossref
Hai‐wei Liang, Bin Luo, Li‐hua Du, Rong‐quan He, Gang Chen, Zhi‐gang Peng & Jie Ma. (2019) Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes. Cancer Medicine 8:13, pages 6021-6035.
Crossref
Milica Nedeljković & Ana Damjanović. (2019) Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge. Cells 8:9, pages 957.
Crossref
Maurizio Cammalleri, Massimo Dal Monte, Vincenzo Pavone, Mario De Rosa, Dario Rusciano & Paola Bagnoli. (2019) The uPAR System as a Potential Therapeutic Target in the Diseased Eye. Cells 8:8, pages 925.
Crossref
Musbau Adewumi Akanji, Damilare Rotimi & Oluyomi Stephen Adeyemi. (2019) Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer. Oxidative Medicine and Cellular Longevity 2019, pages 1-10.
Crossref
Bruno Luís de Castro Araujo, Jadivan Leite de Oliveira, Flavia de Miranda Corrêa, Luis Eduardo Santos Fontes, Andreia Cristina de Melo & Luiz Claudio Santos Thuler. (2019) Impact of general anaesthesia in overall and disease-free survival compared to other types of anaesthesia in patients undergoing surgery for cutaneous melanoma: a systematic review and meta-analysis protocol. BMJ Open 9:7, pages e027993.
Crossref
Marjorie Reyes-Farias & Catalina Carrasco-Pozo. (2019) The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. International Journal of Molecular Sciences 20:13, pages 3177.
Crossref
Ming Hong, Honglian Shi, Ning Wang, Hor-Yue Tan, Qi Wang & Yibin Feng. (2019) Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network. Frontiers in Pharmacology 10.
Crossref
Kateryna Kubaichuk & Thomas Kietzmann. (2019) Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance. Cells 8:6, pages 598.
Crossref
Gabriella D’Orazi & Mara Cirone. (2019) Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression. Cancers 11:5, pages 614.
Crossref
Ling Ma, Tianyang Qi, Shensen Wang, Miao Hao, Ali Sakhawat, Tianya Liang, Lin Zhang, Xianling Cong & Yinghui Huang. (2018) Tet methylcytosine dioxygenase 1 promotes hypoxic gene induction and cell migration in colon cancer. Journal of Cellular Physiology 234:5, pages 6286-6297.
Crossref
Kartick Patra, Samarjit Jana, Arnab Sarkar, Deba P. Mandal & Shamee Bhattacharjee. (2019) The inhibition of hypoxia-induced angiogenesis and metastasis by cinnamaldehyde is mediated by decreasing HIF-1α protein synthesis via PI3K/Akt pathway. BioFactors 45:3, pages 401-415.
Crossref
Teresa Alonso-Gordoa, María Laura García-Bermejo, Enrique Grande, Pilar Garrido, Alfredo Carrato & Javier Molina-Cerrillo. (2019) Targeting Tyrosine kinases in Renal Cell Carcinoma: “New Bullets against Old Guys”. International Journal of Molecular Sciences 20:8, pages 1901.
Crossref
Jing-Zhang Wang, Yu-Hua Zhang, Wen-Tao Du, Guang Liu, Xiang-Yang Zhang, Shu-Zhen Cheng & Xin-Hua Guo. (2019) A post-surgical adjunctive hypoxic therapy for myocardial infarction: Initiate endogenous cardiomyocyte proliferation in adults. Medical Hypotheses 125, pages 16-20.
Crossref
Takuma Hotani, Hiroyuki Mizuguchi & Fuminori Sakurai. (2019) Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors. Molecular Therapy - Oncolytics 12, pages 162-172.
Crossref
Young Wha Koh, Su Jin Lee, Jae-Ho Han, Seokjin Haam, Joonho Jung & Hyun Woo Lee. (2019) PD-L1 protein expression in non-small-cell lung cancer and its relationship with the hypoxia-related signaling pathways: A study based on immunohistochemistry and RNA sequencing data. Lung Cancer 129, pages 41-47.
Crossref
Changwei Dou, Zhenyu Zhou, Qiuran Xu, Zhikui Liu, Yuqun Zeng, Yufeng Wang, Qing Li, Liang Wang, Wei Yang, Qingguang Liu & Kangsheng Tu. (2018) Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway. Oncogene 38:8, pages 1239-1255.
Crossref
Qian Jin, Jianying Zhou, Xianrong Xu, Feihua Huang & Weihua Xu. (2019) Hypoxia‑inducible factor-1 signaling pathway influences the sensitivity of HCC827 cells to gefitinib. Oncology Letters.
Crossref
Pavithra Viswanath, Marina Radoul, Jose Luis Izquierdo-Garcia, Hema Artee Luchman, J. Gregory Cairncross, Russell O. Pieper, Joanna J. Phillips & Sabrina M. Ronen. (2018) Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner. Cancer & Metabolism 6:1.
Crossref
Silke Cameron. (2018) Gastrointestinale StromatumorenGastrointestinal stromal tumors. Wiener klinisches Magazin 21:6, pages 260-269.
Crossref
Joaquín Araos, Jonathan P. Sleeman & Boyan K. Garvalov. (2018) The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies. Clinical & Experimental Metastasis 35:7, pages 563-599.
Crossref
Ioanna Daskalaki, Ilias Gkikas & Nektarios Tavernarakis. (2018) Hypoxia and Selective Autophagy in Cancer Development and Therapy. Frontiers in Cell and Developmental Biology 6.
Crossref
Priyanshu Bhargava, Anjani Kumari, Jayarani F. Putri, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul, Durai Sundar & Renu Wadhwa. (2018) Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences. Cell Stress and Chaperones 23:5, pages 1055-1068.
Crossref
Mabel Yau, Lu Xu, Chien-Ling Huang & Chi-Ming Wong. (2018) Long Non-Coding RNAs in Obesity-Induced Cancer. Non-Coding RNA 4:3, pages 19.
Crossref
Radka Cerychova & Gabriela Pavlinkova. (2018) HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart. Frontiers in Endocrinology 9.
Crossref
S. Cameron. (2018) Gastrointestinale StromatumorenGastrointestinal stromal tumors. Der Gastroenterologe 13:5, pages 336-348.
Crossref
Thanabal Murugesan, Gurukumari Rajajeyabalachandran, Swetha Kumar, Shruthi Nagaraju & Sooriya Kumar Jegatheesan. (2018) Targeting HIF-2α as therapy for advanced cancers. Drug Discovery Today 23:7, pages 1444-1451.
Crossref
Shaoxin Cai, Xuefei Cheng, Yi Liu, Zhizun Lin, Wei Zeng, Changshun Yang, Lihang Liu, Ozor Anthony Chukwuebuka & Weihua Li. (2018) EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer. Experimental Cell Research 367:1, pages 37-46.
Crossref
Wei-Wei Tong, Guang-Hui Tong & Yong Liu. (2018) Cancer stem cells and hypoxia-inducible factors (Review). International Journal of Oncology.
Crossref
Naveen Gupta & Victor Nizet. (2018) Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Frontiers in Medicine 5.
Crossref
Jinfeng Xiang, Qiangsheng Hu, Yi Qin, Shunrong Ji, Wenyan Xu, Wensheng Liu, Si Shi, Chen Liang, Jiang Liu, Qingcai Meng, Dingkong Liang, Quanxing Ni, Jin Xu, Bo Zhang & Xianjun Yu. (2018) TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer. Cell Death & Disease 9:3.
Crossref
Alice Huertas, Ly Tu & Christophe Guignabert. (2017) New targets for pulmonary arterial hypertension. Current Opinion in Pulmonary Medicine 23:5, pages 377-385.
Crossref
Julie Fucini & Tafani Jean-Pierre. (2020) A-7 nAchR Macrophages and Nicotine Approach in Neuroprotection to COVID-19 4 Variables Equation?. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.