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Acta Oncologica Volume 57, 2018 - Issue 7
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Original Articles: Supportive Care

(ICORG 05-03): prospective randomized non-inferiority phase III trial comparing two radiation schedules in malignant spinal cord compression (not proceeding with surgical decompression); the quality of life analysis

K. A. LeeRadiation Oncology Department, St Luke’s Radiation Oncology Network, Dublin, Ireland; Correspondence[email protected]
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M. DunneClinical Trials Unit, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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C. SmallRadiation Oncology Department, Galway University Hospital, Galway, Ireland; View further author information
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P. J. KellyRadiation Oncology Department, Cork University Hospital, Cork, Ireland; View further author information
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O. McArdleRadiation Oncology Department, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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J. O’SullivanRadiation Oncology Department, Belfast City Hospital, Belfast, UK; View further author information
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D. HackingRadiation Oncology Department, Whitfield Clinic, Waterford, Ireland; View further author information
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M. PomeroyRadiation Oncology Department, Galway University Hospital, Galway, Ireland; View further author information
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J. ArmstrongRadiation Oncology Department, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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M. MoriartyRadiation Oncology Department, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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A. Clayton-LeaOperational Services, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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I. ParkerRadiation Oncology Department, All Ireland Cooperative Oncology Research Group, Dublin, Ireland; View further author information
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C. D. CollinsRadiology Department, St Luke’s Radiation Oncology Network, Dublin, IrelandView further author information
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P. ThirionRadiation Oncology Department, St Luke’s Radiation Oncology Network, Dublin, Ireland; View further author information
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Pages 965-972 | Received 16 Oct 2017, Accepted 22 Jan 2018, Published online: 08 Feb 2018

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Anna Mann Nielsen, Katrine Smedegaard Storm, Michael R. T. Laursen, Vanja Remberg Gram, Laura Ann Rechner, Wiviann Ottosson, Morten Hiul Suppli, Patrik Sibolt, Claus F. Behrens, Ivan R. Vogelius & Gitte F. Persson. (2023) Interim analysis of patient-reported outcome compliance and dosimetry in a phase 3 randomized clinical trial of oesophagus-sparing spinal radiotherapy. Acta Oncologica 62:11, pages 1496-1501.
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Alexander J. Grosinger & Sara R. Alcorn. (2024) An Update on the Management of Bone Metastases. Current Oncology Reports 26:4, pages 400-408.
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Julio C Furlan, Jefferson R Wilson, Eric M Massicotte, Arjun Sahgal & Michael G Fehlings. (2022) Recent advances and new discoveries in the pipeline of the treatment of primary spinal tumors and spinal metastases: a scoping review of registered clinical studies from 2000 to 2020. Neuro-Oncology 24:1, pages 1-13.
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Erkan Topkan, Ugur Selek, Berrin Pehlivan, Ahmet Kucuk & Yasemin Bolukbasi. 2023. Advances in Radiation Oncology in Lung Cancer. Advances in Radiation Oncology in Lung Cancer 691 715 .
Francesco Cellini, Rossella Di Franco, Stefania Manfrida, Valentina Borzillo, Ernesto Maranzano, Stefano Pergolizzi, Alessio Giuseppe Morganti, Vincenzo Fusco, Francesco Deodato, Mario Santarelli, Fabio Arcidiacono, Romina Rossi, Sara Reina, Anna Merlotti, Barbara Alicja Jereczek-Fossa, Angelo Tozzi, Giambattista Siepe, Alberto Cacciola, Elvio Russi, Maria Antonietta Gambacorta, Marta Scorsetti, Umberto Ricardi, Renzo Corvò, Vittorio Donato, Paolo Muto & Vincenzo Valentini. (2021) Palliative radiotherapy indications during the COVID-19 pandemic and in future complex logistic settings: the NORMALITY model. La radiologia medica 126:12, pages 1619-1656.
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Anil Tibdewal, Alisha Sharma, Lavanya Gurram, Naveen Mummudi & Jaiprakash Agarwal. (2021) Outcomes of Palliative Radiotherapy in Metastatic Epidural Spinal Cord Compression in Lung Cancer—A Prospective Observational Study from Tata Memorial Hospital. South Asian Journal of Cancer 10:02, pages 120-126.
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A. Loblaw, K.J. George & V. Misra. (2020) Surgical and Radiotherapeutic Management of Malignant Extradural Spinal Cord Compression. Clinical Oncology 32:11, pages 745-752.
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Pierre G. Thirion, Mary T. Dunne, Paul J. Kelly, Aileen Flavin, Joe M. O’Sullivan, Dayle Hacking, Wojciech Sasiadek, Cormac Small, Maeve M. Pomeroy, Joseph Martin, Orla McArdle, Imelda Parker, Lydia S. O’Sullivan, Aoife M. Shannon, Angela Clayton-Lea, Conor D. Collins, Michael R. Stevenson, Alberto Alvarez-Iglesias, John G. Armstrong & Michael Moriarty. (2020) Non-inferiority randomised phase 3 trial comparing two radiation schedules (single vs. five fractions) in malignant spinal cord compression. British Journal of Cancer 122:9, pages 1315-1323.
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Mannat Narang, Pranshu Mohindra, Mark Mishra, William Regine & Young Kwok. (2020) Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America 34:1, pages 279-292.
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Peter J. Hoskin, Kirsten Hopkins, Vivek Misra, Tanya Holt, Rhona McMenemin, Danny Dubois, Fiona McKinna, Bernadette Foran, Krishnaswamy Madhavan, Carol MacGregor, Andrew Bates, Noelle O’Rourke, Jason F. Lester, Tim Sevitt, Daniel Roos, Sanjay Dixit, Gillian Brown, Seonaid Arnott, Sharon Shibu Thomas, Sharon Forsyth, Sandy Beare, Krystyna Reczko, Allan Hackshaw & Andre Lopes. (2019) Effect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer. JAMA 322:21, pages 2084.
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Dirk Rades, Barbara Šegedin, Antonio J. Conde-Moreno, Carlos Ferrer-Albiach, Michaela Metz, Bülent Polat, Harun Badakhshi, Andreas Schreiber, Mirko Nitsche, Jon Cacicedo & Steven E. Schild. (2019) Patient-Reported Outcomes–Secondary Analysis of the SCORE-2 Trial Comparing 4 Gy × 5 to 3 Gy × 10 for Metastatic Epidural Spinal Cord Compression. International Journal of Radiation Oncology*Biology*Physics 105:4, pages 760-764.
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Elysia K Donovan, Julianna Sienna, Gunita Mitera, Nidhi Kumar-Tyagi, Sameer Parpia & Anand Swaminath. (2019) Single versus multifraction radiotherapy for spinal cord compression: A systematic review and meta-analysis. Radiotherapy and Oncology 134, pages 55-66.
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Carsten Nieder. (2019) Patienten mit metastatischer Rückenmarkskompression profitieren von rascher multidisziplinärer Diagnostik und BehandlungPatients with metastatic spinal cord compression profit from rapid multidisciplinary diagnostics and treatment. Strahlentherapie und Onkologie 195:4, pages 367-368.
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