Mixed-beam approach in locally advanced nasopharyngeal carcinoma: IMRT followed by proton therapy boost versus IMRT-only. Evaluation of toxicity and efficacy

Daniela AlterioDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy;

Emma D’IppolitoRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy; Correspondence[email protected]

Barbara VischioniRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Piero FossatiDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy; ;Radiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Sara GandiniDepartment of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy;

http://orcid.org/0000-0002-1348-4548

Maria BonoraRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Sara RonchiRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Viviana VitoloRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Edoardo MastellaRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Giuseppe MagroRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Pierfrancesco FrancoDepartment of Oncology, Radiation Oncology, University of Torino, Turin, Italy;

http://orcid.org/0000-0003-2276-0687

Umberto RicardiDepartment of Oncology, Radiation Oncology, University of Torino, Turin, Italy;

Marco KrengliDepartment of Translational Medicine, Novara, University of Piemonte Orientale, Vercelli, Italy;

Giovanni IvaldiUnit of Radiation Oncology, ICS Maugeri, IRCSS, Pavia, Italy;

Annamaria FerrariDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy;

Giuseppi FanettiDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy; ;Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy;

Stefania ComiUnit of Medical Physics, European Institute of Oncology, Milan, Italy;

Marta TagliabueDepartment of Head and Neck Surgery and Otorhinolaryngology, IEO, European Institute of Oncology IRCCS, Milan, Italy;

Elena VerriDepartment of Medical Oncology, European Institute of Oncology, Milan, Italy;

Rosalinda RicottiRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Delia CiardoDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy;

Barbara Alicja Jereczek-FossaDivision of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy; ;Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy;

Francesca ValvoRadiation Oncology Clinical Department, National Center of Oncological Hadrontherapy, Pavia, Italy;

Roberto OrecchiaScientific Direction, European Institute of Oncology IRCCS, Milan, Italy; ;Scientific Direction, National Center of Oncological Hadrontherapy, Pavia, Italy

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Mixed-beam approach in locally advanced nasopharyngeal carcinoma: IMRT followed by proton therapy boost versus IMRT-only. Evaluation of toxicity and efficacy

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Mixed-beam approach in locally advanced nasopharyngeal carcinoma: IMRT followed by proton therapy boost versus IMRT-only. Evaluation of toxicity and efficacy

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