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Connective Tissue Research Volume 44, 2003 - Issue 1
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Research Article

Over- and Ectopic Expression of Wnt3 Causes Progressive Loss of Ameloblasts in Postnatal Mouse Incisor Teeth

S. E. Millar Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
E. Koyama Department of Anatomy, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
S. T. Reddy Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
T. Andl Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
T. Gaddapara Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
R. Piddington Department of Anatomy, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
&
C. W. Gibson Department of Anatomy, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
 show all
Pages 124-129 | Published online: 06 Aug 2009

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Kevin A. Tompkins. (2011) Wnt Proteins in Mineralized Tissue Development and Homeostasis. Connective Tissue Research 52:6, pages 448-458.
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Jianfei Liang, Jing Wang, Chen Ye, Yi Bai, Yibo Tong, Yashu Li, Yaoting Ji & Yufeng Zhang. (2023) Ptip is essential for tooth development via regulating Wnt pathway. Oral Diseases 30:3, pages 1451-1461.
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Thimios A. Mitsiadis, Pierfrancesco Pagella, Helder Gomes Rodrigues, Alexander Tsouknidas, Liza L. Ramenzoni, Freddy Radtke, Albert Mehl & Laurent Viriot. (2023) Notch Signaling Pathway in Tooth Shape Variations throughout Evolution. Cells 12:5, pages 761.
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Emily D. Woodruff, Bonnie K. Kircher, Brooke A. Armfield, Julie K. Levy, Jonathan I. Bloch & Martin J. Cohn. (2022) Domestic cat embryos reveal unique transcriptomes of developing incisor, canine, and premolar teeth. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 338:8, pages 516-531.
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Chatvadee Kornsuthisopon, Suphalak Photichailert, Nunthawan Nowwarote, Kevin A. Tompkins & Thanaphum Osathanon. (2022) Wnt signaling in dental pulp homeostasis and dentin regeneration. Archives of Oral Biology 134, pages 105322.
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Florian Hermans, Lara Hemeryck, Ivo Lambrichts, Annelies Bronckaers & Hugo Vankelecom. (2021) Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh. Frontiers in Cell and Developmental Biology 9.
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Tingsheng Yu & Ophir D. Klein. (2020) Molecular and cellular mechanisms of tooth development, homeostasis and repair. Development 147:2.
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Donald Singer, Kristina Thamm, Heng Zhuang, Jana Karbanová, Yan Gao, Jemma Victoria Walker, Heng Jin, Xiangnan Wu, Clarissa R Coveney, Pauline Marangoni, Dongmei Lu, Portia Rebecca Clare Grayson, Tulay Gulsen, Karen J Liu, Stefano Ardu, Angus KT Wann, Shouqing Luo, Alexander C Zambon, Anton M Jetten, Christopher Tredwin, Ophir D Klein, Massimo Attanasio, Peter Carmeliet, Wieland B Huttner, Denis Corbeil & Bing Hu. (2018) Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics. The EMBO Journal 38:2.
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Sun-Hun Kim, Yong-Ouk You, Hyun-Mi Ko & Hyun-Jin Kim. (2018) Expression and Localization of Keap1 During Amelogenesis in the Developing Molar Germ of Rats. International Journal of Oral Biology 43:4, pages 177-183.
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Mei Yang, Wushuang Huang, Fang Yang, Tingting Zhang, Changning Wang & Yaling Song. (2018) Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway. Biochemical and Biophysical Research Communications 501:1, pages 206-211.
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Bin Zhang, Bo Meng, Edward Viloria, Adrien Naveau, Bernhard Ganss & Andrew H. Jheon. (2018) The Role of Epithelial <b><i>Stat3</i></b> in Amelogenesis during Mouse Incisor Renewal. Cells Tissues Organs 205:2, pages 63-71.
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Adrien Naveau, Bin Zhang, Bo Meng, McGarrett T Sutherland, Michaela Prochazkova, Timothy Wen, Pauline Marangoni, Kyle B Jones, Timothy C Cox, Bernhard Ganss, Andrew H Jheon & Ophir D Klein. (2017) Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor . Journal of Bone and Mineral Research 32:11, pages 2219-2231.
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Iveta Putnová, Hana Dosedělová, Vitezslav Bryja, Marie Landová, Marcela Buchtová & Jan Štembírek. (2017) Angled Growth of the Dental Lamina Is Accompanied by Asymmetrical Expression of the WNT Pathway Receptor Frizzled 6. Frontiers in Physiology 8.
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Ying Jin, Chenglin Wang, Si Cheng, Zhihe Zhao & Juan Li. (2017) MicroRNA control of tooth formation and eruption. Archives of Oral Biology 73, pages 302-310.
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Masashi Shin, Maiko Suzuki, Xiaomu Guan, Charles E. Smith & John D. Bartlett. (2016) Murine matrix metalloproteinase-20 overexpression stimulates cell invasion into the enamel layer via enhanced Wnt signaling. Scientific Reports 6:1.
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Zheqiong Yang, Anamaria Balic, Frederic Michon, Emma Juuri & Irma Thesleff. (2015) Mesenchymal Wnt/β-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10. Stem Cells 33:5, pages 1670-1681.
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Tian Yu, Ana Angelova Volponi, Rebecca Babb, Zhengwen An & Paul T. Sharpe. 2015. Craniofacial Development. Craniofacial Development 187 212 .
Bingmei Wang, Hanliang Li, Ying Liu, Xin Lin, Yao Lin, Ye Wang, Xuefeng Hu & Yanding Zhang. (2014) Expression patterns of WNT/?-CATENIN signaling molecules during human tooth development. Journal of Molecular Histology 45:5, pages 487-496.
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Jimmy Kuang‐Hsien Hu, Vagan Mushegyan & Ophir D. Klein. (2013) On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. genesis 52:2, pages 79-92.
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Maria Jussila, Emma Juuri & Irma Thesleff. 2013. Stem Cells in Craniofacial Development and Regeneration. Stem Cells in Craniofacial Development and Regeneration 109 134 .
Frederic Michon, Andrew H. Jheon, Kerstin Seidel & Ophir D. Klein. 2013. Stem Cells in Craniofacial Development and Regeneration. Stem Cells in Craniofacial Development and Regeneration 315 327 .
Maitane Aurrekoetxea, Jon Lopez, Patricia García, Gaskon Ibarretxe & Fernando Unda. (2012) Enhanced Wnt/β‐catenin signalling during tooth morphogenesis impedes cell differentiation and leads to alterations in the structure and mineralisation of the adult tooth. Biology of the Cell 104:10, pages 603-617.
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Emma Juuri, Kan Saito, Laura Ahtiainen, Kerstin Seidel, Mark Tummers, Konrad Hochedlinger, Ophir D. Klein, Irma Thesleff & Frederic Michon. (2012) Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors. Developmental Cell 23:2, pages 317-328.
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Li Peng, Yong Li, Kate Shusterman, Melissa Kuehl & Carolyn W. Gibson. (2012) Wnt‐RhoA signaling is involved in dental enamel development. European Journal of Oral Sciences 119:s1, pages 41-49.
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Renato Menezes, Ariadne Letra, Ana H. Kim, Erika C. Küchler, Alicia Day, Patricia N. Tannure, Luise Gomes da Motta, Katiucia B.S. Paiva, Jose M. Granjeiro & Alexandre R. Vieira. (2010) Studies with Wnt genes and nonsyndromic cleft lip and palate . Birth Defects Research Part A: Clinical and Molecular Teratology 88:11, pages 995-1000.
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F. Liu & S.E. Millar. (2010) Wnt/β-catenin Signaling in Oral Tissue Development and Disease. Journal of Dental Research 89:4, pages 318-330.
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Frederic Michon, Mark Tummers, Marika Kyyr?nen, Mikko J. Frilander & Irma Thesleff. (2010) Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs. Developmental Biology 340:2, pages 355-368.
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Marika Suomalainen & Irma Thesleff. (2009) Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/β‐catenin signaling in the epithelial stem cells. Developmental Dynamics 239:1, pages 364-372.
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Mahtab Lohi, Abigail S. Tucker & Paul T. Sharpe. (2009) Expression of Axin2 indicates a role for canonical Wnt signaling in development of the crown and root during pre‐ and postnatal tooth development. Developmental Dynamics 239:1, pages 160-167.
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Marianna Bei. (2008) Molecular genetics of ameloblast cell lineage. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 312B:5, pages 437-444.
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Irma Thesleff. 2008. Embryos, Genes and Birth Defects. Embryos, Genes and Birth Defects 515 535 .
K. Takamori, R. Hosokawa, X. Xu, X. Deng, P. BringasJr.Jr. & Y. Chai. (2008) Epithelial Fibroblast Growth Factor Receptor 1 Regulates Enamel Formation. Journal of Dental Research 87:3, pages 238-243.
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Keiko Miyoshi, Hideya Nagata, Taigo Horiguchi, Kaori Abe, Ivan Arie Wahyudi, Yoshinobu Baba, Hidemitsu Harada & Takafumi Noma. (2008) BMP2-induced gene profiling in dental epithelial cell line. The Journal of Medical Investigation 55:3,4, pages 216-226.
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Joo-Cheol ParkSun-Hwa ParkHeung-Joong KimJong-Tae ParkSeong-Ho YounJi-Woong KimTae-Yeon LeeHo-Hyun Son. (2007) A study of APin-protein interactions using protein microarray. Journal of Korean Academy of Conservative Dentistry 32:5, pages 459.
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. (2007) Diagnosis | Severe prognathic malocclusion. Lab Animal 36:1, pages 22-23.
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Marina Grachtchouk, Jianhong Liu, Aiqin Wang, Lebing Wei, Christopher K. Bichakjian, Jonathan Garlick, Augusto F. Paulino, Thomas Giordano & Andrzej A. Dlugosz. (2006) Odontogenic Keratocysts Arise from Quiescent Epithelial Rests and Are Associated with Deregulated Hedgehog Signaling in Mice and Humans. The American Journal of Pathology 169:3, pages 806-814.
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Jong-Tae ParkYong-Seok ChoiHeung-Joong KimMoon-Jin JeongHyun-Ju OhIn-Cheol ShinJoo-Cheol ParkHo-Hyun Son. (2006) Expression and function of OD314, Apin protein during ameloblast differentiation and amelogenesis. Journal of Korean Academy of Conservative Dentistry 31:6, pages 437.
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J.D. BartlettS.E. DwyerE. BeniashZ. SkobeT.L. Payne-Ferreira. (2016) Fluorosis: A New Model and New Insights. Journal of Dental Research 84:9, pages 832-836.
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Yan Ding ZHANG, Zhi CHEN, Yi Qiang SONG, Chao LIU & Yi Ping CHEN. (2005) Making a tooth: growth factors, transcription factors, and stem cells. Cell Research 15:5, pages 301-316.
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Karianne Fjeld, P�ivi Kettunen, Tomasz Furmanek, Inger Hals Kvinnsland & Keijo Luukko. (2005) Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth. Developmental Dynamics 233:1, pages 161-166.
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Tomoyo Sasaki, Yoshihiro Ito, Xun Xu, Jun Han, Pablo BringasJr.Jr., Takeyasu Maeda, Harold C. Slavkin, Rudolf Grosschedl & Yang Chai. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Developmental Biology 278:1, pages 130-143.
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Joo-Cheol ParkSeong-Min AhnHeung-Joong KimMoon-Jin JeongMin-Ju ParkIn-Cheol ShinHo-Hyun Son. (2005) Expression of OD314 during ameloblast differentiation and maturation. Journal of Korean Academy of Conservative Dentistry 30:5, pages 423.
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Xiu-Ping Wang, Marika Suomalainen, Carolina J. Jorgez, Martin M. Matzuk, Sabine Werner & Irma Thesleff. (2004) Follistatin Regulates Enamel Patterning in Mouse Incisors by Asymmetrically Inhibiting BMP Signaling and Ameloblast Differentiation. Developmental Cell 7:5, pages 719-730.
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Johanna Pispa, Tuija Mustonen, Marja L. Mikkola, Aapo T. Kangas, Petra Koppinen, Pirjo‐Liisa Lukinmaa, Jukka Jernvall & Irma Thesleff. (2004) Tooth patterning and enamel formation can be manipulated by misexpression of TNF receptor Edar. Developmental Dynamics 231:2, pages 432-440.
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