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Connective Tissue Research Volume 44, 2003 - Issue 1
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Research Article

Activating (P253R, C278F) and Dominant Negative Mutations of FGFR2: Differential Effects on Calvarial Bone Cell Proliferation, Differentiation, and Mineralization

Chootima Ratisoontorn Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Departments of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Gao-Feng Fan Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
,
Kerry McEntee Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
&
Hyun-Duck Nah Departments of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pages 292-297 | Published online: 06 Aug 2009

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Karo Parsegian. (2023) The BMP and FGF pathways reciprocally regulate odontoblast differentiation. Connective Tissue Research 64:1, pages 53-63.
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Xiaona Lu, Antonio Jorge Forte, Kitae Eric Park, Omar Allam, Mohammad Ali Mozaffari, Michael Alperovich, Derek M. Steinbacher, Nivaldo AlonsoJohn A. Persing. (2021) Sphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis. Journal of Craniofacial Surgery 32:1, pages 67-72.
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Erica M. Siismets & Nan E. Hatch. (2020) Cranial Neural Crest Cells and Their Role in the Pathogenesis of Craniofacial Anomalies and Coronal Craniosynostosis. Journal of Developmental Biology 8:3, pages 18.
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Linnea Schmidt, Aftab Taiyab, Vida Senkus Melvin, Kenneth L. Jones & Trevor Williams. (2018) Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull. Disease Models & Mechanisms.
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Jan B. EganDavid L. MarksTara L. HogensonAnne M. VrabelAshley N. SigafoosEzequiel J. TolosaRyan M. CarrStephanie L. SafgrenElisa Enriquez HeslesLuciana L. AlmadaPaola A. Romecin-DuranEriko IguchiAryan Ala’AldeenJean-Pierre A. KocherGavin R. OliverNaresh ProdduturiDavid W. MeadAsif HossainNorine E. HunekeColleen M. TagtowSikander AilawadhiStephen M. AnsellMichaela S. BanckAlan H. BryceEstrella M. CarballidoAsher A. Chanan-KhanKelly K. CurtisErnesto ResnikChelsea D. GawryletzRonald S. GoThorvardur R. HalfdanarsonThai H. HoRichard W. JosephPrashant KapoorAaron S. MansfieldNathalie MeuriceAmulya A. Nageswara RaoGrzegorz S. NowakowskiAnimesh PardananiSameer A. ParikhJohn C. ChevilleAndrew L. FeldmanRamesh K. RamanathanSteven I. RobinsonRaoul TibesHeidi D. FinnesJennifer B. McCormickRobert R. McWilliamsAminah JatoiMrinal M. PatnaikAlvin C. SilvaEric D. WiebenTammy M. McAllister, Kandelaria M. Rumilla, Sarah E. Kerr, Konstantinos N. Lazaridis, Gianrico FarrugiaA. Keith StewartKarl J. ClarkEileen J. KennedyEric W. KleeMitesh J. BoradMartin E. Fernandez-Zapico. (2017) Molecular Modeling and Functional Analysis of Exome Sequencing–Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma. JCO Precision Oncology:1, pages 1-13.
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Ying Lin, Hongbin Gao, Siming Ai, Jacob V.P. Eswarakumar, Chuan Chen, Yi Zhu, Tao Li, Bingqian Liu, Xialin Liu, Lixia Luo, Hongye Jiang, Yonghao Li, Xiaoling Liang, Chenjin Jin, Xinhua Huang & Lin Lu. (2017) C278F mutation in FGFR2 gene causes two different types of syndromic craniosynostosis in two Chinese patients. Molecular Medicine Reports 16:4, pages 5333-5337.
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Steven Sperber & Elaine Spector. 2016. Molecular Pathology in Clinical Practice. Molecular Pathology in Clinical Practice 177 187 .
Shan-Shan Dong, Tie-Lin Yang, Han Yan, Zheng-Qin Rong, Jia-Bin Chen, Ruo-Han Hao, Xiao-Feng Chen & Yan Guo. (2014) Association analyses of FGFR2 gene polymorphisms with femoral neck bone mineral density in Chinese Han population. Molecular Genetics and Genomics 290:2, pages 485-491.
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Ronghu Ke, Jiaqi Lei, Min Ge, Tianyi Cai, Junyi Yang, Yingzhi Wu & Xiongzheng Mu. (2015) Severe Meningeal Calcification in a Crouzon Patient Carrying a Mutant C342W FGFR2. Journal of Craniofacial Surgery 26:2, pages 557-559.
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Brian U. Ang, Ryan M. Spivak, Hyun-Duck Nah & Richard E. Kirschner. (2010) Dura in the Pathogenesis of Syndromic Craniosynostosis. Journal of Craniofacial Surgery 21:2, pages 462-467.
Crossref
Pierre J. Marie. 2010. Bone and Development. Bone and Development 93 105 .
Laura M Yerges, Lambertus Klei, Jane A Cauley, Kathryn Roeder, Candace M Kammerer, Susan P Moffett, Kristine E Ensrud, Cara S Nestlerode, Lynn M Marshall, Andrew R Hoffman, Cora Lewis, Thomas F Lang, Elizabeth Barrett-Connor, Robert E Ferrell, Eric S Orwoll & Joseph M Zmuda. (2009) High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men. Journal of Bone and Mineral Research 24:12, pages 2039-2049.
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Bruce A. Havens, Dimitris Velonis, Mark S. Kronenberg, Alex C. Lichtler, Bonnie Oliver & Mina Mina. (2008) Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones. Developmental Biology 316:2, pages 336-349.
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Marja M. Hurley, Michael Naski & Pierre J. Marie. 2008. Principles of Bone Biology. Principles of Bone Biology 1103 1132 .
Cinzia Lilli, Catia Bellucci, Tiziano Baroni, Cristina Aisa, Paolo Carinci, Luca Scapoli, Francesco Carinci, Furio Pezzetti, Eleonora Lumare, Giordano Stabellini & Maria Bodo. (2007) FGF2 effects in periosteal fibroblasts bearing the FGFR2 receptor Pro253 Arg mutation. Cytokine 38:1, pages 22-31.
Crossref
Veraragavan P. Eswarakumar, Mark C. Horowitz, Rachel Locklin, Gillian M. Morriss-Kay & Peter Lonai. (2004) A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis . Proceedings of the National Academy of Sciences 101:34, pages 12555-12560.
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