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Connective Tissue Research Volume 49, 2008 - Issue 3-4
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Original

The Activities of Heparan Sulfate and its Analogue Heparin are Dictated by Biosynthesis, Sequence, and Conformation

Mark A. Skidmore School of Biological Sciences, University of Liverpool, Liverpool, England
,
Scott E. Guimond School of Biological Sciences, University of Liverpool, Liverpool, England
,
Tim R. Rudd School of Biological Sciences, University of Liverpool, Liverpool, England
,
David G. Fernig School of Biological Sciences, University of Liverpool, Liverpool, England
,
Jeremy E. Turnbull School of Biological Sciences, University of Liverpool, Liverpool, England
&
Edwin A. Yates School of Biological Sciences, University of Liverpool, Liverpool, England
Pages 140-144 | Published online: 06 Aug 2009

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Zhihong Liu, Yutao Wang & Na Zhang. (2012) Micelle-like nanoassemblies based on polymer–drug conjugates as an emerging platform for drug delivery. Expert Opinion on Drug Delivery 9:7, pages 805-822.
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Annemarie Danielsson, Sergey A. Samsonov, Adam Liwo & Adam K. Sieradzan. (2023) Extension of the SUGRES-1P Coarse-Grained Model of Polysaccharides to Heparin. Journal of Chemical Theory and Computation 19:17, pages 6023-6036.
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Aleksandra M. Kozlowski, Edwin A. Yates, Johannes P. Roubroeks, Kristoffer Tømmeraas, Flemming H. Larsen, Alan M. Smith & Gordon A. Morris. (2023) Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer. Carbohydrate Polymers 308, pages 120649.
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Janis Kay Shute. (2023) Heparin, Low Molecular Weight Heparin, and Non-Anticoagulant Derivatives for the Treatment of Inflammatory Lung Disease. Pharmaceuticals 16:4, pages 584.
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Aleksandra Maria Kozlowski, Vlad Dinu, Thomas MacCalman, Alan Mark Smith, Johannes Peter Roubroeks, Edwin Alexander Yates, Stephen Ernest Harding & Gordon Alistair Morris. (2023) Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation. Polysaccharides 4:2, pages 88-98.
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Xiaolin Cui, Cesar R Alcala-Orozco, Kenzie Baer, Jun Li, Caroline A Murphy, Mitch Durham, Gabriella Lindberg, Gary J Hooper, Khoon S Lim & Tim B F Woodfield. (2022) 3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs. Biofabrication 14:3, pages 034101.
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Changkai Bu & Lan Jin. (2021) NMR Characterization of the Interactions Between Glycosaminoglycans and Proteins. Frontiers in Molecular Biosciences 8.
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Aleksandra M. Kozlowski, Edwin A. Yates, Johannes P. Roubroeks, Kristoffer Tømmeraas, Alan M. Smith & Gordon A. Morris. (2021) Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation. ACS Applied Materials & Interfaces 13:4, pages 5551-5563.
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Robin A. JeanneretCharlotte E. DaltonJohn M. Gardiner. (2019) Synthesis of Heparan Sulfate- and Dermatan Sulfate-Related Oligosaccharides via Iterative Chemoselective Glycosylation Exploiting Conformationally Disarmed [2.2.2] l -Iduronic Lactone Thioglycosides . The Journal of Organic Chemistry 84:23, pages 15063-15078.
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Victor Nurcombe, Ling Ling, Hubert Hondermarck, Simon M. Cool & Raymond A. A. Smith. (2019) Bringing Heparan Sulfate Glycomics Together with Proteomics for the Design of Novel Therapeutics: A Historical Perspective. PROTEOMICS 19:21-22.
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Edwin A Yates, John T Gallagher & Marco Guerrini. (2019) Introduction to the Molecules Special Edition Entitled ‘Heparan Sulfate and Heparin: Challenges and Controversies’: Some Outstanding Questions in Heparan Sulfate and Heparin Research. Molecules 24:7, pages 1399.
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N. Kareem, E. Yates, M. Skidmore & D. Hoole. (2018) In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. Fish & Shellfish Immunology 74, pages 213-222.
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Maria Mytilinaiou, Dragana Nikitovic, Aikaterini Berdiaki, Antonis Kostouras, Antonis Papoutsidakis, Aristidis M. Tsatsakis & George N. Tzanakakis. (2017) Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression. IUBMB Life 69:11, pages 824-833.
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Bethanie I. Ayerst, Catherine L.R. Merry & Anthony J. Day. (2017) The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications. Pharmaceuticals 10:4, pages 54.
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Marco Mende, Christin Bednarek, Mirella Wawryszyn, Paul Sauter, Moritz B. Biskup, Ute Schepers & Stefan Bräse. (2016) Chemical Synthesis of Glycosaminoglycans. Chemical Reviews 116:14, pages 8193-8255.
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Barbara Mulloy, John Hogwood, Elaine Gray, Rebecca Lever & Clive P. Page. (2015) Pharmacology of Heparin and Related Drugs. Pharmacological Reviews 68:1, pages 76-141.
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Niels-Christian Reichardt, Manuel Martín-Lomas & Soledad Penadés. (2016) Opportunities for glyconanomaterials in personalized medicine. Chemical Communications 52:92, pages 13430-13439.
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John Gallagher. (2015) Fell–Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra. International Journal of Experimental Pathology 96:4, pages 203-231.
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Krastyu G. Ugrinov, Stefan D. Freed, Clayton L. Thomas & Shaun W. Lee. (2015) A Multiparametric Computational Algorithm for Comprehensive Assessment of Genetic Mutations in Mucopolysaccharidosis Type IIIA (Sanfilippo Syndrome). PLOS ONE 10:3, pages e0121511.
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Mariana A. Soares, Felipe C. O. B. Teixeira, Miguel Fontes, Ana L?cia Ar?as, Marcelo G. Leal, Mauro S. G. Pav?o & Mariana P. Stelling. (2015) Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration. BioMed Research International 2015, pages 1-8.
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Nerea Guedes, Sebastian Kopitzki, Begoña Echeverria, Raquel Pazos, Elisabete Elosegui, Javier Calvo & Niels-Christian Reichardt. (2015) Solid-phase assembly of glycosaminoglycan oligosaccharide precursors. RSC Advances 5:13, pages 9325-9327.
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D. Nikitovic, M. Mytilinaiou, Ai. Berdiaki, N.K. Karamanos & G.N. Tzanakakis. (2014) Heparan sulfate proteoglycans and heparin regulate melanoma cell functions. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:8, pages 2471-2481.
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Leyla Gasimli, Hope E. Stansfield, Alison V. Nairn, Haiying Liu, Janet L. Paluh, Bo Yang, Jonathan S. Dordick, Kelley W. Moremen & Robert J. Linhardt. (2012) Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. Glycoconjugate Journal 30:5, pages 497-510.
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Victor Nurcombe, William Birch & Simon Cool. 2013. Handbook of Biofunctional Surfaces. Handbook of Biofunctional Surfaces 617 636 .
A. A. Mokrushin & L. I. Pavlinova. (2012) Effects of Heparin on Synaptic Activity in the Hemorrhagic Stroke Model in Vitro. Bulletin of Experimental Biology and Medicine 152:6, pages 684-687.
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Jonas Åberg, Olof Eriksson, Erika Spens, Jonathan Nordblom, Per Mattsson, Johan Sjödahl, Mikael Svensson & Håkan Engqvist. (2010) Calcium Sulfate Spinal Cord Scaffold: A Study on Degradation and Fibroblast Growth Factor 1 Loading and Release. Journal of Biomaterials Applications 26:6, pages 667-685.
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Atsuko Yoneda, Maria E. Lendorf, John R. Couchman & Hinke A. B. Multhaupt. (2011) Breast and Ovarian Cancers. Journal of Histochemistry & Cytochemistry 60:1, pages 9-21.
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Barbara Mulloy, Sanaullah Khan & Stephen J. Perkins. (2011) Molecular architecture of heparin and heparan sulfate: Recent developments in solution structural studies. Pure and Applied Chemistry 84:1, pages 65-76.
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C. Przybylski, F. Gonnet, Y. Hersant, D. Bonnaffé, H. Lortat-Jacob & R. Daniel. (2010) Desorption Electrospray Ionization Mass Spectrometry of Glycosaminoglycans and Their Protein Noncovalent Complex. Analytical Chemistry 82:22, pages 9225-9233.
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Marie-Jeanne Clément, Bérangère Tissot, Lionel Chevolot, Elisabeth Adjadj, Yuguo Du, Patrick A Curmi & Régis Daniel. (2010) NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity. Glycobiology 20:7, pages 883-894.
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Benito Casu, Annamaria Naggi & Giangiacomo Torri. (2010) Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer. Matrix Biology 29:6, pages 442-452.
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Mahroo K. Parsi, Julian R.J. Adams, John Whitelock & Mark A. Gibson. (2010) LTBP-2 has multiple heparin/heparan sulfate binding sites. Matrix Biology 29:5, pages 393-401.
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Andrew K Powell, Yassir A Ahmed, Edwin A Yates & Jeremy E Turnbull. (2010) Generating heparan sulfate saccharide libraries for glycomics applications. Nature Protocols 5:5, pages 821-833.
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Timothy R. Rudd, Rohanah Hussain, Giuliano Siligardi & Edwin A. Yates. (2010) Raman and Raman optical activity of glycosaminoglycans. Chemical Communications 46:23, pages 4124.
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Takahisa Kanekiyo & Guojun Bu. (2009) Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake. Journal of Biological Chemistry 284:48, pages 33352-33359.
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E. Okina, T. Manon‐Jensen, J. R. Whiteford & J. R. Couchman. (2009) Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scandinavian Journal of Medicine & Science in Sports 19:4, pages 479-489.
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Ulf Lindahl & Jin‐ping Li. 2009. 105 159 .

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