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Connective Tissue Research Volume 60, 2019 - Issue 6
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Original Articles

Resveratrol inhibits the development of obesity-related osteoarthritis via the TLR4 and PI3K/Akt signaling pathways

Xiaolei XuDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, China;Department of Nutrition and Food Hygiene, School of Public Health, Beihua University, Jilin, ChinaView further author information
,
Xudan LiuDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
,
Yingchun YangDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
,
Jianyi HeDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
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Hailun GuDepartment of Orthopedics, Shengjing Hospital, China Medical University, Shenyang, ChinaView further author information
,
Mengqi JiangDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
,
Yue HuangDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
,
Xiaotong LiuDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaView further author information
&
Li LiuDepartment of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, ChinaCorrespondence[email protected]
View further author information
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Pages 571-582 | Received 16 Oct 2018, Accepted 18 Mar 2019, Published online: 04 Apr 2019

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Mingzheng Wu, Feng Liu, Li Yan, Ruokun Huang, Rui Hu, Jin Zhu, Shanqing Li & Chao Long. (2022) MiR-145-5p restrains chondrogenic differentiation of synovium-derived mesenchymal stem cells by suppressing TLR4. Nucleosides, Nucleotides & Nucleic Acids 41:7, pages 625-642.
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Xiaolei Xu, Xudan Liu, Yingchun Yang, Jianyi He, Mengqi Jiang, Yue Huang, Xiaotong Liu, Li Liu & Hailun Gu. (2020) Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells. Drug Design, Development and Therapy 14, pages 2079-2090.
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Articles from other publishers (29)

Salma Nassor Juma, Junguang Liao, Yuping Huang, Rexhina Vlashi, Qingwan Wang, Bocong Wu, Dan Wang, Mengrui Wu & Guiqian Chen. (2024) Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies. Genes & Diseases 11:3, pages 100986.
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Ziyue Jia, Jiale Zhang, Xintong Yang, Huiyou Chen, Yuxing Wang, Opoku Bonsu Francis, Yuanchao Li, Zhanbiao Liu, Shaozhuo Zhang & Qilong Wang. (2024) Bioactive components and potential mechanisms of Biqi Capsule in the treatment of osteoarthritis: based on chondroprotective and anti-inflammatory activity. Frontiers in Pharmacology 15.
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Jianbang Su, Minghao Yu, Haochen Wang & Yingliang Wei. (2023) Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials. Phytotherapy Research 37:10, pages 4321-4352.
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Zhen-Yu Luo, Zun-Han Liu, Hao-Da Yu, An-Jing Chen, Ze Du, Yong-Rui Cai, Xiao-Xue Fu, Shu-E Jin, Jia-Li Chen, Zong-Ke Zhou & Wei-Nan Zeng. (2023) Multifunctional mesoporous polydopamine near-infrared photothermal controlled release of kartogenin for cartilage repair. Materials & Design 231, pages 112007.
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Yaguang Han, Jun Wu, Zhenyu Gong, Yiqin Zhou, Haobo Li, Yi Chen & Qirong Qian. (2022) Identification and development of the novel 7-genes diagnostic signature by integrating multi cohorts based on osteoarthritis. Hereditas 159:1.
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Tianwen Sun, Fei Wang, Gaojian Hu & Zhizhou Li. (2022) Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways. Nutrition & Metabolism 19:1.
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Cheng-Yu Shentu, Ge Yan, Dong-Chen Xu, Yong Chen & Li-Hua Peng. (2022) Emerging pharmaceutical therapeutics and delivery technologies for osteoarthritis therapy. Frontiers in Pharmacology 13.
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Karen S. Coutinho-Wolino, Patricia P. Almeida, Denise Mafra & Milena B. Stockler-Pinto. (2022) Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives. Nutrition Research 107, pages 96-116.
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Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Sadia Ghousia Baig, Mohammad Taheri & Seyed Abdulmajid Ayatollahi. (2022) Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway. Cancer Cell International 22:1.
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Shenglei Yang, Mingli Sun & Xinan Zhang. (2022) Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials. Frontiers in Pharmacology 13.
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Prabhakar Busa, Sing-Ong Lee, Niancih Huang, Yaswanth Kuthati & Chih-Shung Wong. (2022) Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study. Antioxidants 11:6, pages 1209.
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Weiwei Zheng, Xinle Li, Jie Li, Xiaoyu Wang, Daquan Liu, Lidong Zhai, Beibei Ding, Guang Li, Yuting Sun, Hiroki Yokota & Ping Zhang. (2022) Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model. Annals of the New York Academy of Sciences 1512:1, pages 141-153.
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Hong Yi, Wei Zhang, Sheng-Yu Cui, Jian-Bo Fan, Xin-Hui Zhu & Wei Liu. (2021) Identification and validation of key long non-coding RNAs in resveratrol protect against IL-1β-treated chondrocytes via integrated bioinformatic analysis. Journal of Orthopaedic Surgery and Research 16:1.
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Omnia A. Nour, Hamdy A. Ghoniem, Manar A. Nader & Ghada M. Suddek. (2021) Impact of protocatechuic acid on high fat diet-induced metabolic syndrome sequelae in rats. European Journal of Pharmacology 907, pages 174257.
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Mariyam Khalid, Juma Alkaabi, Moien A. B. Khan & Abdu Adem. (2021) Insulin Signal Transduction Perturbations in Insulin Resistance. International Journal of Molecular Sciences 22:16, pages 8590.
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Qiongxin Liang, Jing Dong, Senye Wang, Wenjing Shao, Adel F. Ahmed, Yan Zhang & Wenyi Kang. (2021) Immunomodulatory effects of Nigella sativa seed polysaccharides by gut microbial and proteomic technologies. International Journal of Biological Macromolecules 184, pages 483-496.
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Yijun Liu, Ding Zhao, Xue Wang, Ying Dong & Fupeng Ding. (2021) LncRNA KCNQ1OT1 attenuates osteoarthritic chondrocyte dysfunction via the miR-218-5p/PIK3C2A axis. Cell and Tissue Research 385:1, pages 115-126.
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Evdokia Valsamidou, Aristea Gioxari, Charalampia Amerikanou, Panagiotis Zoumpoulakis, George Skarpas & Andriana C. Kaliora. (2021) Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies. Nutrients 13:5, pages 1420.
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Antonia RuJia Sun, Anjaneyulu Udduttula, Jian Li, Yanzhi Liu, Pei-Gen Ren & Peng Zhang. (2021) Cartilage tissue engineering for obesity-induced osteoarthritis: Physiology, challenges, and future prospects. Journal of Orthopaedic Translation 26, pages 3-15.
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Arunaksharan Narayanankutty. (2020) Phytochemicals as PI3K/ Akt/ mTOR Inhibitors and Their Role in Breast Cancer Treatment. Recent Patents on Anti-Cancer Drug Discovery 15:3, pages 188-199.
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Xu-zhao Li & Shuai-nan Zhang. (2020) Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine. Chinese Medicine 15:1.
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Hong Yi, Wei Zhang, Zhi-Ming Cui, Sheng-Yu Cui, Jian-Bo Fan, Xin-Hui Zhu & Wei Liu. (2020) Resveratrol alleviates the interleukin-1β-induced chondrocytes injury through the NF-κB signaling pathway. Journal of Orthopaedic Surgery and Research 15:1.
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Milad Ashrafizadeh, Ali Zarrabi, Masoud Najafi, Saeed Samarghandian, Reza Mohammadinejad & Kwang Seok Ahn. (2020) Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review. Phytotherapy Research 34:11, pages 2867-2888.
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Hyewon Park, Jinpyo Hong, Yuhua Yin, Yongbum Joo, Youngmo Kim, Juhee Shin, Hyeok Hee Kwon, Nara Shin, Hyo Jung Shin, Jaewon Beom, Dong Woon Kim & Jinhyun Kim. (2020) TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Scientific Reports 10:1.
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DRT Sari, A Safitri, JRK Cairns & F Fatchiyah. (2020) Virtual screening of black rice anthocyanins as antiobesity through inhibiting TLR4 and JNK pathway. Journal of Physics: Conference Series 1665:1, pages 012024.
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Milad Ashrafizadeh, Masoud Najafi, Sima Orouei, Amirhossein Zabolian, Hossein Saleki, Negar Azami, Negin Sharifi, Kiavash Hushmandi, Ali Zarrabi & Kwang Seok Ahn. (2020) Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities. Biomedicines 8:8, pages 261.
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Xingfang Yu, Gang Zheng, Zhichao Hu, Shangkun Tang, Jianchen Xu, Ping Shang, Qian Tang & Haixiao Liu. (2020) Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2. Food & Function 11:6, pages 5513-5524.
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Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, Yessica Zamudio-Cuevas, Karina Martínez-Flores & Fernando Mijares-Díaz. (2020) Multifactor dimensionality reduction reveals a strong gene–gene interaction between STC1 and COL11A1 genes as a possible risk factor of knee osteoarthritis. Molecular Biology Reports 47:4, pages 2627-2634.
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Weiwei Zhang, Xinle Li, Jie Li, Xiaoyu Wang, Daquan Liu, Lidong Zhai, Beibei Ding, Guang Li, Yuting Sun, Hiroki Yokota & Ping Zhang. (2021) Mechanical Loading Mitigates Osteoarthritis Symptoms by Regulating the Inflammatory Microenvironment. SSRN Electronic Journal.
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