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Connective Tissue Research Volume 63, 2022 - Issue 1: Musculoskeletal Mechanotransduction
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Research Article

Inhibition of RhoA/MRTF-A signaling alleviates nucleus pulposus fibrosis induced by mechanical stress overload

Mengxiong Songa Department of Orthopaedic Surgery, Minhang Hospital, Fudan University, Shanghai, ChinaView further author information
,
Yiran Zhangb Shandong Institute of Orthopaedics and Traumatology, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Yi Sunc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Meng Kongc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Shuo Hanc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Chao Wangc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Yan Wangc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Derong Xuc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Qihao Tuc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Kai Zhuc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Chong Sunc Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Guanghui Lic Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Han Zhaod Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
&
Xuexiao Mac Department of Orthopaedics, Affiliated Hospital of Qingdao University, Qingdao, ChinaCorrespondence[email protected]
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Pages 53-68 | Received 12 Jan 2021, Accepted 01 Jul 2021, Published online: 21 Aug 2021

Citations (5)

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Karl J. Lewis. (2022) Musculoskeletal mechanobiology. Connective Tissue Research 63:1, pages 1-2.
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Articles from other publishers (4)

Zhijun Cai, Qibiao Luo, Xi Yang, Luqiao Pu, Haiyang Zong, Rongmao Shi, Pengju He, Yongqing Xu, Yang Li & Jianping Zhang. (2023) Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration. Molecular Biology Reports.
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Alberto Ruffilli, Giovanni Viroli, Simona Neri, Matteo Traversari, Francesca Barile, Marco Manzetti, Elisa Assirelli, Marco Ialuna, Fabio Vita & Cesare Faldini. (2023) Mechanobiology of the Human Intervertebral Disc: Systematic Review of the Literature and Future Perspectives. International Journal of Molecular Sciences 24:3, pages 2728.
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Kameron L. Inguito, Mandy M. Schofield, Arya D. Faghri, Ellen T. Bloom, Marissa Heino, Valerie C. West, Karl Matthew M. Ebron, Dawn M. Elliott & Justin Parreno. (2022) Stress deprivation of tendon explants or Tpm3.1 inhibition in tendon cells reduces F-actin to promote a tendinosis-like phenotype. Molecular Biology of the Cell 33:14.
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Yi Sun, Minmin Lyu, Qiuji Lu, Kenneth Cheung & Victor Leung. (2022) Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair. International Journal of Molecular Sciences 23:12, pages 6612.
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