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Research Article

The Distribution of YKL-40 in Osteoarthritic and Normal Human Articular Cartilage

Pages 171-179 | Published online: 12 Jul 2009

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Frederick D. Coffman. (2008) Chitinase 3-Like-1 (CHI3L1): A Putative Disease Marker at the Interface of Proteomics and Glycomics. Critical Reviews in Clinical Laboratory Sciences 45:6, pages 531-562.
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Leonardo Punzi, Francesca Oliviero & Mario Plebani. (2005) New Biochemical Insights into the Pathogenesis of Osteoarthritis and the Role of Laboratory Investigations in Clinical Assessment. Critical Reviews in Clinical Laboratory Sciences 42:4, pages 279-309.
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Maren Dreiner, Tobias Munk, Frank Zaucke, Anna-Maria Liphardt & Anja Niehoff. (2022) Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals. Scientific Reports 12:1.
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Guangdi Li, Mi Zhang, Yuan Huang, Jiafei Yang, Lianghong Dong, Hao Shi, Long Li, Riguang Liu & Jiangwei Li. (2021) The relationship between abnormal Core binding factor-β expression in human cartilage and osteoarthritis. BMC Musculoskeletal Disorders 22:1.
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Marzena Mazur, Anna Zielińska, Marcin M. Grzybowski, Jacek Olczak & Jakub Fichna. (2021) Chitinases and Chitinase-Like Proteins as Therapeutic Targets in Inflammatory Diseases, with a Special Focus on Inflammatory Bowel Diseases. International Journal of Molecular Sciences 22:13, pages 6966.
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Ting Zhao, Zhongping Su, Yingchang Li, Xiaoren Zhang & Qiang You. (2020) Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy 5:1.
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Adel Ebrahim, Amany Ibrahim Mustafa, Ola Samir El‐Shimi & Mai Abdallah Fathy. (2019) Serum YKL40: A novel potential link between inflammation and dyslipidemia in acne vulgaris. Journal of Cosmetic Dermatology 19:5, pages 1219-1223.
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Harpal K. Gahunia & Kenneth P. H. Pritzker. 2020. Articular Cartilage of the Knee. Articular Cartilage of the Knee 3 70 .
Ayda Pouyafar, Milad Zadi Heydarabad, Soltanali Mahboob, Ahad Mokhtarzadeh & Reza Rahbarghazi. (2018) Angiogenic potential of YKL-40 in the dynamics of tumor niche. Biomedicine & Pharmacotherapy 100, pages 478-485.
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Sefa Ciftci, Huseyin Tugrul Celik, Pinar Atukeren, Nurdan Ciftci, Mustafa Saygin Deniz, Yasemin Coskun Yavuz, Fatmanur Hacievliyagil Kazanci, Sümeyye Gök, Hilmi Demirin & Muhammet Ramazan Yigitoglu. (2016) Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever. Journal of Clinical Laboratory Analysis 30:6, pages 1158-1163.
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Marta Szychlinska, Francesca Trovato, Michelino Di Rosa, Lucia Malaguarnera, Lidia Puzzo, Rosy Leonardi, Paola Castrogiovanni & Giuseppe Musumeci. (2016) Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles. International Journal of Molecular Sciences 17:3, pages 359.
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Ümit Dündar, Gülşah Aşık, Alper Murat Ulaşlı, Şükrü Sınıcı, Fatima Yaman, Özlem Solak, Hasan Toktaş & Selma Eroğlu. (2016) Assessment of pulsed electromagnetic field therapy with Serum YKL-40 and ultrasonography in patients with knee osteoarthritis. International Journal of Rheumatic Diseases 19:3, pages 287-293.
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A. Speziali, M. Delcogliano, M. Tei, G. Placella, M. Chillemi, R. Tiribuzi & G. Cerulli. (2015) Chondropenia: current concept review. MUSCULOSKELETAL SURGERY 99:3, pages 189-200.
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Ting-Hsien Kao, Yi-Jen PengHsi-Kai Tsou, Donald M. Salter & Herng-Sheng Lee. (2014) Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation. Journal of Neurosurgery: Spine 21:4, pages 653-661.
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Yuen Yee Ho, Murray Baron, Anneliese D. Recklies, Peter J. Roughley & John S. Mort. (2014) Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1. BBA Clinical 1, pages 2-11.
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Gamze Kilic, Erkan Kilic, Ozgür Akgul & Salih Ozgocmen. (2014) Decreased Femoral Cartilage Thickness in Patients With Systemic Sclerosis. The American Journal of the Medical Sciences 347:5, pages 382-386.
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Tuija Väänänen, Anna Koskinen, Erja-Leena Paukkeri, Mari Hämäläinen, Teemu Moilanen, Eeva Moilanen & Katriina Vuolteenaho. (2014) YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints. Mediators of Inflammation 2014, pages 1-7.
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Roberta Ramonda, Paola Frallonardo, Estella Musacchio, Stefania Vio & Leonardo Punzi. (2013) Joint and bone assessment in hand osteoarthritis. Clinical Rheumatology 33:1, pages 11-19.
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Jon M. Einarsson, Sven Bahrke, Bjarni Thor Sigurdsson, Chuen-How Ng, Petur Henry Petersen, Olafur E. Sigurjonsson, Halldor JonssonJr.Jr., Johannes Gislason, Finnbogi R. Thormodsson & Martin G. Peter. (2013) Partially acetylated chitooligosaccharides bind to YKL-40 and stimulate growth of human osteoarthritic chondrocytes. Biochemical and Biophysical Research Communications 434:2, pages 298-304.
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N. D. Mygind, K. Iversen, L. Køber, J. P. Goetze, H. Nielsen, S. Boesgaard, M. Bay, J. S. Johansen, O. W. Nielsen, V. Kirk & J. Kastrup. (2012) The inflammatory biomarker YKL ‐40 at admission is a strong predictor of overall mortality . Journal of Internal Medicine 273:2, pages 205-216.
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Yves Henrotin & Ali Mobasheri. 2013. Studies on Arthritis and Joint Disorders. Studies on Arthritis and Joint Disorders 3 31 .
Gonca Güngen, Fusun Ardic, Gülin Fιndıkoğlu & Simin Rota. (2011) The effect of mud pack therapy on serum YKL-40 and hsCRP levels in patients with knee osteoarthritis. Rheumatology International 32:5, pages 1235-1244.
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Susanne Mayer-Wagner, Judith Ernst, Markus Maier, Matthias Chiquet, Helga Joos, Peter E. Müller, Volkmar Jansson, Birte Sievers & Jörg Hausdorf. (2010) The effect of high-energy extracorporeal shock waves on hyaline cartilage of adult rats in vivo. Journal of Orthopaedic Research 28:8, pages 1050-1056.
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Beibei He, Li Wang, Jinhong Wang, Gang Li & Shuyi Zhang. (2009) Positive selection of three chitinase genes of the family 18 of glycoside hydrolases in mammals. Biologia 64:4, pages 819-825.
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K Huang & LD Wu. (2009) YKL-40: A Potential Biomarker for Osteoarthritis. Journal of International Medical Research 37:1, pages 18-24.
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Katrin Eurich, Mayuko Segawa, Satoko Toei-Shimizu & Emiko Mizoguchi. (2009) Potential role of chitinase 3-like-1 in inflammationassociated carcinogenic changes of epithelial cells. World Journal of Gastroenterology 15:42, pages 5249.
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Sandra Zivanovic, Ljiljana Petrovic-Rackov & Aleksandar Zivanovic. (2009) Arthrosonography and biomarkers in the evaluation of destructive knee cartilage osteoarthrosis. Srpski arhiv za celokupno lekarstvo 137:11-12, pages 653-658.
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Yusuf Erzin, Hafize Uzun, Adem Karatas & Aykut Ferhat Celik. (2008) Serum YKL-40 as a marker of disease activity and stricture formation in patients with Crohn's disease. Journal of Gastroenterology and Hepatology 23:8pt2, pages e357-e362.
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Gary J. Litherland, Craig Dixon, Rachel L. Lakey, Timothy Robson, Debra Jones, David A. Young, Tim E. Cawston & Andrew D. Rowan. (2008) Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent. Journal of Biological Chemistry 283:21, pages 14221-14229.
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Julia S. Johansen, Poul E. Høyer, Lars A. Larsen, Paul A. Price & Kjeld Møllgård. (2007) YKL-40 Protein Expression in the Early Developing Human Musculoskeletal System. Journal of Histochemistry & Cytochemistry 55:12, pages 1213-1228.
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Shirin Hooshmand, Do Y. Soung, Edralin A. Lucas, Sundar V. Madihally, Cathy W. Levenson & Bahram H. Arjmandi. (2007) Genistein reduces the production of proinflammatory molecules in human chondrocytes. The Journal of Nutritional Biochemistry 18:9, pages 609-614.
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Merete Ringsholt, Estrid V. S. Høgdall, Julia S. Johansen, Paul A. Price & Lise H. Christensen. (2007) YKL-40 protein expression in normal adult human tissues – an immunohistochemical study. Journal of Molecular Histology 38:1, pages 33-43.
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G Trudel, A Recklies & O Laneuville. (2007) Increased Expression of Chitinase 3-like Protein 1 Secondary to Joint Immobility. Clinical Orthopaedics & Related Research 456, pages 92-97.
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C. Jacques, A.D. Recklies, A. Levy & F. Berenbaum. (2007) HC-gp39 contributes to chondrocyte differentiation by inducing SOX9 and type II collagen expressions. Osteoarthritis and Cartilage 15:2, pages 138-146.
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Julia KzhyshkowskaAlexei GratchevSergij Goerdt. (2017) Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer. Biomarker Insights 2, pages 117727190700200.
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Heather F. Bigg, Robin Wait, Andrew D. Rowan & Tim E. Cawston. (2006) The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation. Journal of Biological Chemistry 281:30, pages 21082-21095.
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M. Petersson, E. Bucht, B. Granberg & A. Stark. (2006) Effects of arginine-vasopressin and parathyroid hormone-related protein (1–34) on cell proliferation and production of YKL-40 in cultured chondrocytes from patients with rheumatoid arthritis and osteoarthritis. Osteoarthritis and Cartilage 14:7, pages 652-659.
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DICK HEINEGÅRD, PILAR LORENZO & TORE SAXNE. 2006. Dynamics of Bone and Cartilage Metabolism. Dynamics of Bone and Cartilage Metabolism 71 84 .
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Maurizio BEVILACQUA, Jean-Pierre DEVOGELAER, Velella RIG MINI, Jean-Pierre FAMAEY & Daniel-Henri MANCOURT. (2005) Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study. International Journal of Clinical Practice 58, pages 13-19.
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Leonardo Punzi, Francesca Oliviero, Roberta Ramonda, Chiara Valvason, Paolo Sfriso & Silvano Todesco. (2013) Laboratory investigations in osteoarthritis. Aging Clinical and Experimental Research 15:5, pages 373-379.
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Douglas R. Houston, Anneliese D. Recklies, Joanne C. Krupa & Daan M.F. van Aalten. (2003) Structure and Ligand-induced Conformational Change of the 39-kDa Glycoprotein from Human Articular Chondrocytes. Journal of Biological Chemistry 278:32, pages 30206-30212.
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Frances C. Hall, Kevin C. Visconti, Regina-Celeste Ahmad, Sarah L. Parry, André M. M. Miltenburg, Harden M. McConnell, Elizabeth D. Mellins & Grete Sønderstrup. (2003) Cytokines elicited by T cell epitopes from a synovial autoantigen: Altered peptide ligands can reduce interferon-γ and interleukin-10 production. Arthritis & Rheumatism 48:8, pages 2375-2385.
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Hannah Dehn, Estrid V. S. HØgdall, Julia S. Johansen, Morten JØrgensen, Paul A. Price, Svend A. A. Engelholm & Claus K. HØgdall. (2003) Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer. Acta Obstetricia et Gynecologica Scandinavica 82:3, pages 287-293.
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K Veje, Jacob L Hyllested-Winge & Keld Ostergaard. (2003) Topographic and zonal distribution of tenascin in human articular cartilage from femoral heads: normal versus mild and severe osteoarthritis. Osteoarthritis and Cartilage 11:3, pages 217-227.
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Eric Steck, Stephen Breit, Steffen J Breusch, Matthias Axt & Wiltrud Richter. (2002) Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Biochemical and Biophysical Research Communications 299:1, pages 109-115.
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Christian Østergaard, Julia S. Johansen, Thomas Benfield, Paul A. Price & Jens D. Lundgren. (2002) YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Purulent Meningitis. Clinical and Vaccine Immunology 9:3, pages 598-604.
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Érick Vignon. (2001) Is glycoprotein YKL40 a new marker for joint disorders?. Joint Bone Spine 68:6, pages 454-456.
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Frédéric De Ceuninck, Sophie Gaufillier, Anne Bonnaud, Massimo Sabatini, Christophe Lesur & Philippe Pastoureau. (2001) YKL-40 (Cartilage gp-39) Induces Proliferative Events in Cultured Chondrocytes and Synoviocytes and Increases Glycosaminoglycan Synthesis in Chondrocytes. Biochemical and Biophysical Research Communications 285:4, pages 926-931.
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B. Volck, J.S. Johansen, M. Stoltenberg, C. Garbarsch§P.A. Price, M. Østergaard, K. Ostergaard, P. Løvgreen-Nielsen, S. Sonne-Holm & I. Lorenzen. (2001) Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis and Cartilage 9:3, pages 203-214.
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Julia S. Johansen, Tsaiwei Olee, Paul A. Price, Sanshiro Hashimoto, Robert L. Ochs & Martin Lotz. (2001) Regulation of YKL-40 production by human articular chondrocytes. Arthritis & Rheumatism 44:4, pages 826-837.
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J.R. Connor, R.A. Dodds, J.G. Emery, R.B. Kirkpatrick, M. Rosenberg & M. Gowen. (2000) Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. Osteoarthritis and Cartilage 8:2, pages 87-95.
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