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Research Article

Clinical Pharmacogenetics of Irinotecan (CPT-11)

, Ph.D. , M.D. &
Pages 565-574 | Published online: 09 Oct 2008

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Yasumasa Mitani, Alexander Lezhava, Aki Sakurai, Akina Horikawa, Makoto Nagakura, Yoshihide Hayashizaki & Toshihisa Ishikawa. (2009) Rapid and Cost-Effective SNP Detection Method: Application of SmartAmp2 to Pharmacogenomics Research. Pharmacogenomics 10:7, pages 1187-1197.
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Yoshinori Hasegawa, Yuichi Ando & Kaoru Shimokata. (2006) Screening for adverse reactions to irinotecan treatment using the Invader®UGT1A1 Molecular Assay. Expert Review of Molecular Diagnostics 6:4, pages 527-533.
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Congjian Shi, Zhenghong Zhang, Renfeng Xu, Yan Zhang & Zhengchao Wang. (2023) Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury. Scientific Reports 13:1.
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Ruiming Zhang, Yi Luo, Chenghao Du, Ling Wu, Yankang Wang, Yuanduan Chen, Shouqian Li, Xin Jiang & Yongmei Xie. (2023) Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment. Bioorganic & Medicinal Chemistry Letters 81, pages 129128.
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Yifan Tu, Lu Wang, Yi Rong, Vincent Tam, Taijun Yin, Song Gao, Rashim Singh & Ming Hu. (2021) Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats. eLife 10.
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Chalirmporn Atasilp, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch & Chonlaphat Sukasem. (2020) Effect of drug metabolizing enzymes and transporters in Thai colorectal cancer patients treated with irinotecan-based chemotherapy. Scientific Reports 10:1.
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Andrés López-Cortés, César Paz-y-Miño, Santiago Guerrero, Gabriela Jaramillo-Koupermann, Ángela León Cáceres, Dámaris P. Intriago-Baldeón, Jennyfer M. García-Cárdenas, Patricia Guevara-Ramírez, Isaac Armendáriz-Castillo, Paola E. Leone, Luis Abel Quiñones, Juan Pablo Cayún & Néstor W. Soria. (2019) Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. The Pharmacogenomics Journal 20:1, pages 136-158.
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Sotaro Sadahiro, Toshiyuki Suzuki, Kazutake Okada, Gota Saito, Hiroshi Miyakita, Takashi Ogimi, Lin Fung Chan & Yutaro Kamei. (2020) Oral S-1 with 24-h Infusion of Irinotecan plus Bevacizumab versus FOLFIRI plus Bevacizumab as First-Line Chemotherapy for Metastatic Colorectal Cancer: An Open-Label Randomized Phase II Trial. Oncology 98:9, pages 637-642.
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Chunlei Xu, Xushan Tang, Yanli Qu, Saifuding Keyoumu, Ning Zhou & Yong Tang. (2016) UGT1A1 gene polymorphism is associated with toxicity and clinical efficacy of irinotecan-based chemotherapy in patients with advanced colorectal cancer. Cancer Chemotherapy and Pharmacology 78:1, pages 119-130.
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Kristina K. Wolf, Brandon T. Gufford, Scott J. Brantley, Paul B. Watkins & Mary F. Paine. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 626 638 .
Sotaro Sadahiro, Toshiyuki Suzuki, Akira Tanaka, Kazutake Okada, Gota Saito & Akemi Kamijo. (2015) A Phase II Trial of Combined Chemotherapy with Oral S-1 and 24-Hour Infusions of Irinotecan plus Bevacizumab in Patients with Metastatic Colorectal Cancer. Oncology 88:6, pages 353-359.
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May Garrett, Bill Poland, Meghan Brennan, Brian Hee, Yazdi K. Pithavala & Michael A. Amantea. (2014) Population pharmacokinetic analysis of axitinib in healthy volunteers. British Journal of Clinical Pharmacology 77:3, pages 480-492.
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Mariusz Panczyk. (2014) Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years. World Journal of Gastroenterology 20:29, pages 9775.
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Jun-ichi Yamakawa, Yoshiharu Motoo, Junji Moriya, Masao Ogawa, Hiroaki Uenishi, Sumiyo Akazawa, Toshiyuki Sasagawa, Matomo Nishio & Junji Kobayashi. (2013) Role of Kampo Medicine in Integrative Cancer Therapy. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-6.
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Toshihisa Ishikawa & Yoshihide Hayashizaki. 2013. Pharmacogenomics. Pharmacogenomics 55 69 .
Kouichi Kurose, Emiko Sugiyama & Yoshiro Saito. (2012) Population Differences in Major Functional Polymorphisms of Pharmacokinetics/pharmacodynamics-related Genes in Eastern Asians and Europeans: Implications in the Clinical Trials for Novel Drug Development. Drug Metabolism and Pharmacokinetics 27:1, pages 9-54.
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Nobumitsu Hanioka, Natsuko Tanabe, Hideto Jinno, Toshiko Tanaka-Kagawa, Kenjiro Nagaoka, Shinsaku Naito, Akiko Koeda & Shizuo Narimatsu. (2010) Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sciences 87:7-8, pages 261-268.
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Qiong Zhou, Zhijie Zheng, Bijun Xia, Lan Tang, Chang Lv, Wei Liu, Zhongqiu Liu & Ming Hu. (2010) Use of Isoform-Specific UGT Metabolism to Determine and Describe Rates and Profiles of Glucuronidation of Wogonin and Oroxylin A by Human Liver and Intestinal Microsomes. Pharmaceutical Research 27:8, pages 1568-1583.
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Stephen W. J. Wang, Kaustubh H. Kulkarni, Lan Tang, Jing Rong Wang, Taijun Yin, Tomo Daidoji, Hiroshi Yokota & Ming Hu. (2009) Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities. Journal of Pharmacology and Experimental Therapeutics 329:3, pages 1023-1031.
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Patrick A. Thompson, Manish Gupta, Gary L. Rosner, Alexander Yu, Jeffrey Barrett, Lisa Bomgaars, Mark L. Bernstein, Susan M. Blaney & John Mondick. (2008) Pharmacokinetics of irinotecan and its metabolites in pediatric cancer patients: a report from the children’s oncology group. Cancer Chemotherapy and Pharmacology 62:6, pages 1027-1037.
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John F. Deeken, Rebecca Slack & John L. Marshall. (2008) Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics. Cancer 113:7, pages 1502-1510.
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Joanna Maudlin Pangilinan, Gazala N. Khan & Mark M. Zalupski. (2008) Irinotecan pharmacogenetics: an overview for the community oncologist. Community Oncology 5:2, pages 99-114.
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Tiby B. Joseph, Stephen W. J. Wang, Xing Liu, Kaustubh H. Kulkarni, Jingrong Wang, Haiyan Xu & Ming Hu. (2007) Disposition of Flavonoids via Enteric Recycling: Enzyme Stability Affects Characterization of Prunetin Glucuronidation across Species, Organs, and UGT Isoforms. Molecular Pharmaceutics 4:6, pages 883-894.
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F. Ceppa, E. Fontan, S. Cremades, R. Bihannic, A. Bousquet, L. Beauvillain & P. Burnat. (2007) Implication de?la?pharmacog?n?tique dans?les?traitements des?cancers colorectaux. La Revue de M?decine Interne 28:9, pages 594-602.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
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Andrea L. Yoder Graber, Jacqueline Ramírez, Federico Innocenti & Mark J. Ratain. (2007) UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers. Pharmacogenetics and Genomics 17:8, pages 619-627.
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Miki Nakajima, Sayaka Komagata, Yuto Fujiki, Yoshihiro Kanada, Hiromichi Ebi, Kuniaki Itoh, Hirofumi Mukai, Tsuyoshi Yokoi & Hironobu Minami. (2007) Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients. Pharmacogenetics and Genomics 17:6, pages 431-445.
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Chih-Kang Huang, Alina Dulau, Chiao-Ju Su-Rick & Qiulu Pan. (2007) Validation of Rapid Polymerase Chain Reaction-based Detection of All Length Polymorphisms in the UGT 1A1 Gene Promoter. Diagnostic Molecular Pathology 16:1, pages 50-53.
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Joanne M. Bowen, Rachel J. Gibson, Andrea M. Stringer, Thong W. Chan, Avanita S. Prabowo, Adrian G. Cummins & Dorothy M.K. Keefe. (2007) Role of p53 in irinotecan-induced intestinal cell death and mucosal damage. Anti-Cancer Drugs 18:2, pages 197-210.
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Joanne M. Bowen, Rachel J. Gibson, Adrian G. Cummins, Anna Tyskin & Dorothy M. K. Keefe. (2006) Irinotecan changes gene expression in the small intestine of the rat with breast cancer. Cancer Chemotherapy and Pharmacology 59:3, pages 337-348.
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Kazuhiro Araki, Ken‐ichi Fujita, Yuichi Ando, Fumio Nagashima, Wataru Yamamoto, Hisashi Endo, Toshimichi Miya, Keiji Kodama, Masaru Narabayashi & Yasutsuna Sasaki. (2006) Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN‐38 glucuronidation in Japanese patients with cancer . Cancer Science 97:11, pages 1255-1259.
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