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Research Article

Cytochromes P450—A Family of Proteins and Scientists–Understanding their Relationships

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Pages 209-225 | Published online: 09 Oct 2008

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Steven N Hart & Xiao-bo Zhong. (2008) P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 439-452.
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Yang Zhang, Xianrun Pan, Tianyu Shi, Zhifeng Gu, Zhaochang Yang, Minghao Liu, Yi Xu, Yu Yang, Liping Ren, Xiaoming Song, Hao Lin & Kejun Deng. (2023) P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes. Journal of Advanced Research.
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Rajalakshmi Kumar, Manikandan Jayaraman, Krishna Ramadas & Adithan Chandrasekaran. (2020) Insight into the structural and functional analysis of the impact of missense mutation on cytochrome P450 oxidoreductase. Journal of Molecular Graphics and Modelling 100, pages 107708.
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Han Zheng, Xin Li, Lin Shi, Ying Jing, Qingqing Song, Yanan Chen, Lilong He, Fengde Wang, Jianwei Gao & Yuping Bi. (2019) Genome-Wide Identification and Analysis of the Cytochrome B5 Protein Family in Chinese Cabbage ( Brassica rapa L. ssp. Pekinensis ) . International Journal of Genomics 2019, pages 1-16.
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L. Zhu, L. Lu, S. Wang, J. Wu, J. Shi, T. Yan, C. Xie, Q. Li, M. Hu & Z. Liu. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 297 329 .
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Mária Tomková, Satya Prakash Panda, Ondřej Šeda, Alice Baxová, Martina Hůlková, Bettie Sue Siler Masters & Pavel Martásek. (2015) Genetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort. Pharmacogenomics 16:3, pages 205-215.
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Manthena V. S. Varma, Renato J. Scialis, Jian Lin, Yi-An Bi, Charles J. Rotter, Theunis C. Goosen & Xin Yang. (2014) Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide. The AAPS Journal 16:4, pages 736-748.
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Richard B. Silverman & Mark W. Holladay. 2014. The Organic Chemistry of Drug Design and Drug Action. The Organic Chemistry of Drug Design and Drug Action 357 422 .
Satya P. Panda, Anyonya R. Guntur, Srikanth R. Polusani, Roberto J. Fajardo, Peter T. Gakunga, Linda J. Roman & Bettie Sue Masters. (2013) Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development. PLoS ONE 8:9, pages e75638.
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Hirokazu Yokoyama, Yukishige Okamura & Toshifumi Hibi. (2013) Method for Detecting NADPH-Cytochrome P450 Reductase in Liver Microsomal Fractions by Using Native Polyacrylamide Gel Electrophoresis and NADPH-Diaphorase Staining. American Journal of Analytical Chemistry 04:06, pages 301-305.
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Jaime A. Yáñez, Stephen W.J. Wang, Ian W. Knemeyer, Mark A. Wirth & Kevin B. Alton. (2011) Intestinal lymphatic transport for drug delivery. Advanced Drug Delivery Reviews 63:10-11, pages 923-942.
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Christopher C. Marohnic, Warren J. Huber III, J. Patrick Connick, James R. Reed, Karen McCammon, Satya P. Panda, Pavel Martásek, Wayne L. Backes & Bettie Sue S. Masters. (2011) Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization. Archives of Biochemistry and Biophysics 513:1, pages 42-50.
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Chuanwu XiaSatya P. Panda, Christopher C. Marohnic, Pavel Martásek, Bettie Sue Masters & Jung-Ja P. Kim. (2011) Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proceedings of the National Academy of Sciences 108:33, pages 13486-13491.
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Hirokazu Komatsu, Kazuhito Tanabe & Sei-ichi Nishimoto. (2011) 13C-labeled indolequinone-DTPA-Gd conjugate for NMR probing cytochrome:P450 reductase-mediated one-electron reduction. Bioorganic & Medicinal Chemistry Letters 21:2, pages 790-793.
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Xia Yang, Bin Zhang, Cliona Molony, Eugene Chudin, Ke Hao, Jun Zhu, Andrea Gaedigk, Christine Suver, Hua Zhong, J. Steven Leeder, F. Peter Guengerich, Stephen C. Strom, Erin Schuetz, Thomas H. Rushmore, Roger G. Ulrich, J. Greg Slatter, Eric E. Schadt, Andrew Kasarskis & Pek Yee Lum. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research 20:8, pages 1020-1036.
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Makiko Kusama, Kazuya Maeda, Koji Chiba, Akinori Aoyama & Yuichi Sugiyama. (2008) Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data. Pharmaceutical Research 26:4, pages 822-835.
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Zhongqiu Liu, Stephen Wang & Ming Hu. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 263 288 .
Michel Kranendonk, Christopher C. Marohnic, Satya P. Panda, Maria Paula Duarte, Jos? Santos Oliveira, Bettie Sue Siler Masters & Jos? Rueff. (2008) Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley?Bixler syndrome variants of cytochrome P450 oxidoreductase. Archives of Biochemistry and Biophysics 475:2, pages 93-99.
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Vanesa G. Martinez, Kaye J. Williams, Ian J. Stratford, Martin Clynes & Robert O’Connor. (2008) Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: Possible mechanisms involved. Toxicology in Vitro 22:3, pages 582-588.
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Hong Soon Kang, Martin Angers, Ju Youn Beak, Xiying Wu, Jeffrey M. Gimble, Taira Wada, Wen Xie, Jennifer B. Collins, Sherry F. Grissom & Anton M. Jetten. (2007) Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism. Physiological Genomics 31:2, pages 281-294.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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