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Drug Metabolism Reviews Volume 38, 2006 - Issue 3
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Research Article

Role of Cytochrome P450 in Synaptocrinology: Endogenous Estrogen Synthesis in the Brain Hippocampus

Gen Murakami Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Nobuaki Tanabe Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Hiro-taka Ishii Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Mari Ogiue-Ikeda Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Project of Special Coordinate Funds for Promoting Science and Technology, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Tomokazu Tsurugizawa Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Hideo Mukai Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Yasushi Hojo Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Norio Takata Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Project of Special Coordinate Funds for Promoting Science and Technology, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Aizo Furukawa Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Tetsuya Kimoto Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
&
Suguru Kawato Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan; Project of Special Coordinate Funds for Promoting Science and Technology, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
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Pages 353-369 | Published online: 09 Oct 2008

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Anna Haduch & Władysława Anna Daniel. (2018) The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders. Drug Metabolism Reviews 50:4, pages 415-429.
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Eiji Munetsuna, Minoru Hattori & Takeshi Yamazaki. (2014) Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices. Endocrine Research 39:4, pages 168-172.
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Articles from other publishers (28)

Ruby Vajaria, DeAsia Davis, Kongkidakorn Thaweepanyaporn, Janine Dovey, Slawomir Nasuto, Evangelos Delivopoulos, Francesco Tamagnini, Philip Knight & Nandini Vasudevan. (2024) Estrogen and testosterone secretion from the mouse brain. Steroids 204, pages 109398.
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Javed Iqbal, Maryam Bibi, Geng-Di Huang, Yan-Xue Xue, Jabbar Zaman Khan Khatttak, Mei Yang & Xiao-Jian Jia. (2023) Differential regulation of hippocampal transcriptome by circulating estrogen. Functional & Integrative Genomics 23:4.
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María C. Burguete, Teresa Jover-Mengual, María Castelló-Ruiz, Mikahela A. López-Morales, José M. Centeno, Alicia Aliena-Valero, Enrique Alborch, Germán Torregrosa & Juan B. Salom. (2023) Cerebroprotective Effect of 17β-Estradiol Replacement Therapy in Ovariectomy-Induced Post-Menopausal Rats Subjected to Ischemic Stroke: Role of MAPK/ERK1/2 Pathway and PI3K-Independent Akt Activation. International Journal of Molecular Sciences 24:18, pages 14303.
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Íñigo Azcoitia, Alicia Hernández-Vivanco, Nuria Cano-Adamuz & Pablo Méndez. (2022) Synthesis and impact of neuroestradiol on hippocampal neuronal networks. Current Opinion in Endocrine and Metabolic Research 24, pages 100335.
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Muhammad Fahad Raza, Muhammad Anwar, Arif Husain, Muhmmad Rizwan, Zhiguo Li, Hongyi Nie, Pavol Hlaváč, M. Ajmal Ali, Ahmed Rady & Songkun Su. (2022) Differential gene expression analysis following olfactory learning in honeybee (Apis mellifera L.). PLOS ONE 17:2, pages e0262441.
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Antonietta Santoro, Elena Mele, Marianna Marino, Andrea Viggiano, Stefania Lucia Nori & Rosaria Meccariello. (2021) The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery. International Journal of Molecular Sciences 22:2, pages 972.
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Gonda Konings, Linda Brentjens, Bert Delvoux, Tero Linnanen, Karlijn Cornel, Pasi Koskimies, Marlies Bongers, Roy Kruitwagen, Sofia Xanthoulea & Andrea Romano. (2018) Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery. Frontiers in Pharmacology 9.
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Marissa Kraynak, Matthew T. Flowers, Robert A. Shapiro, Amita Kapoor, Jon E. Levine & David H. Abbott. (2017) Extraovarian gonadotropin negative feedback revealed by aromatase inhibition in female marmoset monkeys. American Journal of Physiology-Endocrinology and Metabolism 313:5, pages E507-E514.
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C. V. Rao. (2017) Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women. Reproductive Sciences 24:3, pages 355-368.
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Yangang Zhao, Yanlan Yu, Yuanyuan Zhang, Li He, Linli Qiu, Jikai Zhao, Mengying Liu & Jiqiang Zhang. (2017) Letrozole regulates actin cytoskeleton polymerization dynamics in a SRC-1 dependent manner in the hippocampus of mice. The Journal of Steroid Biochemistry and Molecular Biology 167, pages 86-97.
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Gen Murakami. (2016) Distinct Effects of Estrogen on Mouse Maternal Behavior: The Contribution of Estrogen Synthesis in the Brain. PLOS ONE 11:3, pages e0150728.
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Christopher Gabor, Jennifer Lymer, Anna Phan & Elena Choleris. (2015) Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice. Physiology & Behavior 149, pages 53-60.
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Yasushi Hojo, Arisa Munetomo, Hideo Mukai, Muneki Ikeda, Rei Sato, Yusuke Hatanaka, Gen Murakami, Yoshimasa Komatsuzaki, Tetsuya Kimoto & Suguru Kawato. (2015) Estradiol rapidly modulates spinogenesis in hippocampal dentate gyrus: Involvement of kinase networks. Hormones and Behavior 74, pages 149-156.
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L. Remage‐Healey, S. D. Jeon & N. R. Joshi. (2013) Recent Evidence for Rapid Synthesis and Action of Oestrogens During Auditory Processing in a Songbird. Journal of Neuroendocrinology 25:11, pages 1024-1031.
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M. Baudry, X. Bi & C. Aguirre. (2013) Progesterone–estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience 239, pages 280-294.
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Chen Bian, Kongjiang Zhu, Li Yang, Sen Lin, Shurong Li, Bingyin Su & Jiqiang Zhang. (2012) Gonadectomy differentially regulates steroid receptor coactivator‐1 and synaptic proteins in the hippocampus of adult female and male C57BL/6 mice. Synapse 66:10, pages 849-857.
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Yuuki Ooishi, Suguru Kawato, Yasushi Hojo, Yusuke Hatanaka, Shimpei Higo, Gen Murakami, Yoshimasa Komatsuzaki, Mari Ogiue-Ikeda, Tetsuya Kimoto & Hideo Mukai. (2012) Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen. The Journal of Steroid Biochemistry and Molecular Biology 131:1-2, pages 37-51.
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Dongmei Zhang, Qiang Guo, Chen Bian, Jiqiang Zhang, Sen Lin & Bingyin Su. (2011) Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague–Dawley rats. Brain Research 1382, pages 88-97.
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Hideo Mukai, Tetsuya Kimoto, Yasushi Hojo, Suguru Kawato, Gen Murakami, Shimpei Higo, Yusuke Hatanaka & Mari Ogiue-Ikeda. (2010) Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochimica et Biophysica Acta (BBA) - General Subjects 1800:10, pages 1030-1044.
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C. de Jaeger & P. Cherin. (2009) Place du neurostéroïde prégnénolone dans le système nerveux : rôle physiologique et implications pathogéniques. Médecine & Longévité 1:2, pages 102-111.
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Eiji Munetsuna, Yasushi Hojo, Minoru Hattori, Hirotaka Ishii, Suguru Kawato, Atsuhiko Ishida, Shiro A. J. Kominami & Takeshi Yamazaki. (2009) Retinoic Acid Stimulates 17β-Estradiol and Testosterone Synthesis in Rat Hippocampal Slice Cultures. Endocrinology 150:9, pages 4260-4269.
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Shimpei Higo, Yasushi Hojo, Hirotaka Ishii, Toshihiro Kominami, Kohei Nakajima, Donald Poirier, Tetsuya Kimoto & Suguru Kawato. (2009) Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus. Biochemical and Biophysical Research Communications 385:1, pages 62-66.
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Yusuke Hatanaka, Hideo Mukai, Kenji Mitsuhashi, Yasushi Hojo, Gen Murakami, Yoshimasa Komatsuzaki, Rei Sato & Suguru Kawato. (2009) Androgen rapidly increases dendritic thorns of CA3 neurons in male rat hippocampus. Biochemical and Biophysical Research Communications 381:4, pages 728-732.
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Yasushi Hojo, Gen Murakami, Hideo Mukai, Shimpei Higo, Yusuke Hatanaka, Mari Ogiue-Ikeda, Hirotaka Ishii, Tetsuya Kimoto & Suguru Kawato. (2008) Estrogen synthesis in the brain—Role in synaptic plasticity and memory. Molecular and Cellular Endocrinology 290:1-2, pages 31-43.
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Suguru Kawato, Yasushi Hojo, Hideo Mukai, Gen Murakami, Mari Ogiue-Ikeda, Hirotaka Ishii & Tetsuya Kimoto. 2008. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders 143 169 .
L. Kancheva, M. Hill, H. Včeláková, J. Vrbíková, T. Pelikánová & L. Stárka. (2007) The identification and simultaneous quantification of neuroactive androstane steroids and their polar conjugates in the serum of adult men, using gas chromatography–mass spectrometry. Steroids 72:11-12, pages 792-801.
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Hirotaka Ish, Tomokazu Tsurugizawa, Mari Ogiue-Ikeda, Makoto Asashima, Hideo Mukai, Gen Murakami, Yasushi Hojo, Tetsuya Kimoto & Suguru Kawato. (2016) Local Production of Sex Hormones and Their Modulation of Hippocampal Synaptic Plasticity. The Neuroscientist 13:4, pages 323-334.
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Darrell W. Brann, Krishnan Dhandapani, Chandramohan Wakade, Virendra B. Mahesh & Mohammad M. Khan. (2007) Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications. Steroids 72:5, pages 381-405.
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