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Drug Metabolism Reviews Volume 39, 2007 - Issue 1
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Research Article

Pharmacogenetic Screening of the Gene Deletion and Duplications of CYP2D6

Irma Meijerman Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology & Experimental Therapy Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
,
Linda M. Sanderson Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology & Experimental Therapy Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
,
Paul H.M. Smits Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology & Experimental Therapy Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
,
Jos H. Beijnen Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology & Experimental Therapy Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
&
Jan H.M. Schellens Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands; Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands; Department of Medical Oncology & Experimental Therapy Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
Pages 45-60 | Published online: 09 Oct 2008

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Zhi-Xu He, Xiao-Wu Chen, Zhi-Wei Zhou & Shu-Feng Zhou. (2015) Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine. Drug Metabolism Reviews 47:4, pages 470-519.
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Taimour Langaee, Issam Hamadeh, Arlene B. Chapman, John G. Gums & Julie A. Johnson. (2015) A Novel Simple Method for Determining CYP2D6 Gene Copy Number and Identifying Allele(s) with Duplication/Multiplication. PLOS ONE 10:1, pages e0113808.
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Anuradha Ramamoorthy, David A. Flockhart, Naoya Hosono, Michiaki Kubo, Yusuke Nakamura & Todd C. Skaar. (2010) Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays. Pharmacogenetics and Genomics 20:7, pages 451-454.
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Murali Subramanian, Michael Low, Charles W. Locuson & Timothy S. Tracy. (2009) CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis. Drug Metabolism and Disposition 37:8, pages 1682-1689.
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