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Review Article

Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation

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Pages 139-158 | Received 27 Feb 2016, Accepted 06 May 2016, Published online: 09 Jun 2016

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Jingguo Li, Zhengyi Yang & Biguang Tuo. (2019) Role of OCT1 in hepatocellular carcinoma. OncoTargets and Therapy 12, pages 6013-6022.
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Nicolas Brosseau & Dindial Ramotar. (2019) The human organic cation transporter OCT1 and its role as a target for drug responses. Drug Metabolism Reviews 51:4, pages 389-407.
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Min-Chang Kim & Young-Joo Lee. (2022) Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling. Pharmaceutics 14:12, pages 2562.
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Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu & Ruizhi Zhao. (2022) Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. Journal of Pharmacy and Pharmacology 74:11, pages 1588-1597.
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Anne T. Nies, Elke Schaeffeler & Matthias Schwab. (2022) Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. Pharmacology & Therapeutics 238, pages 108268.
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James Lorenzen Boyer & Carol Jean Soroka. (2021) Bile formation and secretion: An update. Journal of Hepatology 75:1, pages 190-201.
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Giuliano Ciarimboli. (2021) Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1. Frontiers in Pharmacology 11.
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Adriano Cleis Arruda, Mauro Sérgio Perilhão, Warley Almeida Santos, Marcos Fernandes Gregnani, Alexandre Budu, José Cesar Rosa Neto, Gabriel Rufino Estrela & Ronaldo Carvalho Araujo. (2020) PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice. Molecules 25:2, pages 392.
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Charlotte J. Green, Thomas Marjot, Jeremy W. Tomlinson & Leanne Hodson. (2018) Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?. Diabetes, Obesity and Metabolism 21:4, pages 749-760.
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Ruba Al‐Abdulla, Elisa Lozano, Rocio I R Macias, Maria J Monte, Oscar Briz, Colm J O'Rourke, Maria A Serrano, Jesus M Banales, Matias A Avila, Maria L Martinez‐Chantar, Andreas Geier, Jesper B Andersen & Jose J G Marin. (2019) Epigenetic events involved in organic cation transporter 1‐dependent impaired response of hepatocellular carcinoma to sorafenib. British Journal of Pharmacology 176:6, pages 787-800.
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Anabela C. Ferretti, Florencia Hidalgo, Facundo M. Tonucci, Evangelina Almada, Alejandro Pariani, María C. Larocca & Cristián Favre. (2019) Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration. Scientific Reports 9:1.
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Kristin Bokelmann, Jürgen Brockmöller & Mladen Tzvetkov. (2018) Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1). Journal of Personalized Medicine 8:4, pages 42.
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Johanna Vollmar, Anja Lautem, Ellen Closs, Detlef Schuppan, Yong Ook Kim, Daniel Grimm, Jens U. Marquardt, Peter Fuchs, Beate K. Straub, Arno Schad, Dirk Gründemann, Jörn M. Schattenberg, Nadine Gehrke, Marcus A. Wörns, Jan Baumgart, Peter R. Galle & Tim Zimmermann. (2017) Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis. Oncotarget 8:70, pages 115667-115680.
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Ji Eun Park, Gongmi Ryoo & Wooin Lee. (2017) Alternative Splicing: Expanding Diversity in Major ABC and SLC Drug Transporters. The AAPS Journal 19:6, pages 1643-1655.
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