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Umer Anayyat, Faiza Ahad, Tobias Achu Muluh, Syed Aqib Ali Zaidi, Faiza Usmani, Hua Yang, Mengqing Li, Hammad Ali Hassan & Xiaomei Wang. (2023) Immunotherapy: Constructive Approach for Breast Cancer Treatment. Breast Cancer: Targets and Therapy 15, pages 925-951.
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Yulei Lu, Shengming Wu, Bangde Xiang, Lequn Li & Youzhi Lin. (2020) Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway. Drug Design, Development and Therapy 14, pages 73-85.
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Le Ba Nam & Young-Sam Keum. (2020) Regulation of NRF2 by Na+/K+-ATPase: implication of tyrosine phosphorylation of Src. Free Radical Research 54:11-12, pages 883-893.
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June Lee, Jong-Su Kang, Le Ba Nam, Ok-Kyung Yoo & Young-Sam Keum. (2018) Suppression of NRF2/ARE by convallatoxin sensitises A549 cells to 5-FU-mediated apoptosis. Free Radical Research 52:11-12, pages 1416-1423.
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Sarah A. Best & Kate D. Sutherland. (2018) “Keaping” a lid on lung cancer: the Keap1-Nrf2 pathway. Cell Cycle 17:14, pages 1696-1707.
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Articles from other publishers (114)
Qun Feng, Xiaolin Xu & Shoulin Zhang. (2023) Nrf2 protein in melanoma progression, as a new means of treatment. Pigment Cell & Melanoma Research 37:2, pages 247-258.
Crossref
Crossref
Cinzia Signorini, Luciano Saso, Somayyeh Ghareghomi, Pelin Telkoparan-Akillilar, Giulia Collodel & Elena Moretti. (2024) Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility. Antioxidants 13:2, pages 193.
Crossref
Crossref
Hangping Chen, Yifan Qian, Chensheng Jiang, Leilei Tang, Jiawen Yu, Lingdi Zhang, Yiyang Dai & Guojun Jiang. (2024) Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870:2, pages 166984.
Crossref
Crossref
Lan Yao, Xiang Zhu, Yunyi Shan, Liang Zhang, Jing Yao & Hui Xiong. (2024) Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation. Small.
Crossref
Crossref
Maya M Moubarak, Antonio C Pagano Zottola, Claire M Larrieu, Sylvain Cuvellier, Thomas Daubon & Océane C B Martin. (2024) Exploring the multifaceted role of NRF2 in brain physiology and cancer: A comprehensive review. Neuro-Oncology Advances 6:1.
Crossref
Crossref
Mustafa Ileriturk, Duygu Ileriturk, Ozge Kandemir, Nurhan Akaras, Hasan Simsek, Ender Erdogan & Fatih M. Kandemir. (2023) Naringin attenuates oxaliplatin‐induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model. Journal of Biochemical and Molecular Toxicology 38:1.
Crossref
Crossref
Babatunde Fasipe & Ismail Laher. (2023) Nrf2 modulates the benefits of evening exercise in type 2 diabetes. Sports Medicine and Health Science 5:4, pages 251-258.
Crossref
Crossref
Narasimha M. Beeraka, Jin Zhang, Subhankar Mandal, Hemanth Vikram P. R.Junqi Liu, Namitha B. M.Di Zhao, Prashanth Vishwanath, Gurupadayya B. M.Ruitai Fan. (2023) Screening fructosamine-3-kinase (FN3K) inhibitors, a deglycating enzyme of oncogenic Nrf2: Human FN3K homology modelling, docking and molecular dynamics simulations. PLOS ONE 18:11, pages e0283705.
Crossref
Crossref
Jing Cui, Yao Guo, Tao Yin, Shanmiao Gou, Jiongxin Xiong, Xueyi Liang, Chong Lu & Tao Peng. (2023) USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. Biomedicine & Pharmacotherapy 166, pages 115359.
Crossref
Crossref
Steffanus Pranoto Hallis, Beam Ju Go, Jun Min Yoo, Geun Hee Cho & Mi-Kyoung Kwak. (2023) Toward a Better Understanding of NRF2/NFE2L2 and BCRP/ABCG2 in Therapy Resistance in Cancer. Drug Targets and Therapeutics 2:2, pages 111-123.
Crossref
Crossref
Jesús Alonso Gándara-Mireles, Ismael Lares-Asseff, Elio Aarón Reyes Espinoza, Ignacio Villanueva Fierro, Verónica Loera Castañeda, Lourdes Patricia Cordova Hurtado, Carla Díaz González, Leslie Patrón Romero & Horacio Almanza Reyes. (2022) Impact of single-nucleotide variants and nutritional status on population pharmacokinetics of Doxorubicin, and its effect on cardiotoxicity in children with leukemia. Journal of Oncology Pharmacy Practice 29:6, pages 1290-1305.
Crossref
Crossref
Zhiyan Qin, Jianxun Song, Junyuan Huang, Shiqin Jiang, Gengyi Zhang, Min Huang, Zhiying Huang & Jing Jin. (2023) Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2. Phytomedicine 118, pages 154945.
Crossref
Crossref
Tamaeh Monteiro-Alfredo, Jéssica Maurino dos Santos, Kátia Ávila Antunes, Janielle Cunha, Debora da Silva Baldivia, Ana Salomé Pires, Inês Marques, Ana Margarida Abrantes, Maria Filomena Botelho, Lúcia Monteiro, Ana Cristina Gonçalves, Wellington Henrique Botelho, Ana Paula de Araújo Boleti, Célia Cabral, Paulo J. Oliveira, Edson Lucas dos Santos, Paulo Matafome & Kely de Picoli Souza. (2023) Acrocomia aculeata associated with doxorubicin: cardioprotection and anticancer activity. Frontiers in Pharmacology 14.
Crossref
Crossref
Narasimha M. Beeraka, Jin Zhang, Di Zhao, Junqi Liu, Chinnappa A U, Hemanth Vikram PR, Priyanka Shivaprakash, Namitha Bannimath, Prasath Manogaran, Mikhail Y. Sinelnikov, Gurupadayya Bannimath & Ruitai Fan. (2023) Combinatorial Implications of Nrf2 Inhibitors with FN3K Inhibitor: In vitro Breast
Cancer Study. Current Pharmaceutical Design 29:30, pages 2408-2425.
Crossref
Crossref
Darinka Gjorgieva Ackova, Viktorija Maksimova, Katarina Smilkov, Brigitta Buttari, Marzia Arese & Luciano Saso. (2023) Alkaloids as Natural NRF2 Inhibitors: Chemoprevention and Cytotoxic Action in Cancer. Pharmaceuticals 16:6, pages 850.
Crossref
Crossref
Ahmad Almatroudi, Khaled S. Allemailem, Wanian M. Alwanian, Basmah F. Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A. Almatroodi & Arshad Husain Rahmani. (2023) Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways. International Journal of Molecular Sciences 24:10, pages 8630.
Crossref
Crossref
M Poornashree, Hitesh Kumar, Ramkishan Ajmeer, Rupshee Jain & Vikas Jain. (2022) Dual role of Nrf2 in cancer: molecular mechanisms, cellular functions and therapeutic interventions. Molecular Biology Reports 50:2, pages 1871-1883.
Crossref
Crossref
Kun Zhuang, Hailing Tang, Hanqing Guo & Shanshan Yuan. (2023) Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling by enhancing peroxiredoxin-1 expression in GES-1 cells. Microbial Pathogenesis 174, pages 105937.
Crossref
Crossref
Paul C. Moore, Kurt W. Henderson & Marie Classon. 2023.
Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S. Allemailem, Amjad Ali Khan & Saleh A. Almatroodi. (2022) The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. Molecules 27:24, pages 9009.
Crossref
Crossref
Atefeh Khodakarami, Sara Adibfar, Vahid Karpisheh, Shiva Abolhasani, Pooya Jalali, Hamed Mohammadi, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat-Farsangi & Farhad Jadidi-Niaragh. (2022) The molecular biology and therapeutic potential of Nrf2 in leukemia. Cancer Cell International 22:1.
Crossref
Crossref
Heba Bassiony Ghanem, Rehab Galal El-Sharkawy & Rania Hosny Taha. (2022) Anchoring of Nanocomposites Based on Novel Metal Nanocomplexes/Nanocarbonaceous Surfaces and Assessing Their In Vivo Anticancer Effects on Ehrlich Ascites Tumor. ACS Omega 7:45, pages 41627-41640.
Crossref
Crossref
Kyung-Soo Chun & Sang Hoon Joo. (2022) Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance. Biomolecules & Therapeutics 30:6, pages 479-489.
Crossref
Crossref
Hong-Yuan Tsai, Mary P. Bronner, Jordon K. March, John F. Valentine, Noah F. Shroyer, Lisa A. Lai, Teresa A. Brentnall, Sheng Pan & Ru Chen. (2022) Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. Cancer Letters 549, pages 215915.
Crossref
Crossref
Pooja G. Singh, T.S. Gopenath, Kanthesh M. Basalingappa, Ramesh Bharadwaj MN & R. Ilangovan. (2022) Understanding the Role of NRF2 Signalling in Cancer. Current Protein & Peptide Science 23:10, pages 672-683.
Crossref
Crossref
Saleh A. Almatroodi, Mohammed A. Alsahli & Arshad Husain Rahmani. (2022) Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways. Molecules 27:18, pages 5889.
Crossref
Crossref
Wenzhen Xu, Han Lu, Yuan Yuan, Zeyuan Deng, Liufeng Zheng & Hongyan Li. (2022) The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways. Foods 11:16, pages 2439.
Crossref
Crossref
Shunhao Zhang, Sining Duan, Zhuojun Xie, Wanlin Bao, Bo Xu, Wenbin Yang & Lingyun Zhou. (2022) Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress. Frontiers in Pharmacology 13.
Crossref
Crossref
Anna Rita Fetoni, Fabiola PacielloDiana Troiani. (2022) Cisplatin Chemotherapy and Cochlear Damage: Otoprotective and Chemosensitization Properties of Polyphenols. Antioxidants & Redox Signaling 36:16-18, pages 1229-1245.
Crossref
Crossref
Marina Ibragimova, Matvey Tsyganov & Nikolai Litviakov. (2022) Tumour Stem Cells in Breast Cancer. International Journal of Molecular Sciences 23:9, pages 5058.
Crossref
Crossref
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna & Vikas Jain. (2022) Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment. Frontiers in Pharmacology 13.
Crossref
Crossref
Peiheng Cai, Gaofan Sheng, Shiqin Jiang, Daifei Wang, Zhongxiang Zhao, Min Huang & Jing Jin. (2022) Comparative Proteomics Analysis Reveals the Reversal Effect of Cryptotanshinone on Gefitinib-Resistant Cells in Epidermal Growth Factor Receptor-Mutant Lung Cancer. Frontiers in Pharmacology 13.
Crossref
Crossref
Ildiko Szanto. (2022) NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation. International Journal of Molecular Sciences 23:5, pages 2702.
Crossref
Crossref
Radosveta GenchevaElias S.J. Arnér. (2022) Thioredoxin Reductase Inhibition for Cancer Therapy. Annual Review of Pharmacology and Toxicology 62:1, pages 177-196.
Crossref
Crossref
SITONG QIAN, YING FANG, CHENGYUN YAO, YONGSHENG WANG, ZHI ZHANG, XIAOHUA WANG, JIN GAO, YONG FENG, LEI SUN, RUNYUE ZOU, GUOREN ZHOU, JINJUN YE, RUIXUE XIA & HONGPING XIA. (2022) The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models. Oncology Research 30:2, pages 53-64.
Crossref
Crossref
Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu & Su Zeng. (2022) Feature, Function, and Information of Drug Transporter–Related Databases. Drug Metabolism and Disposition 50:1, pages 76-85.
Crossref
Crossref
Jessica A Scarborough & Jacob G Scott. (2022) Translation of Precision Medicine Research Into Biomarker-Informed Care in Radiation Oncology. Seminars in Radiation Oncology 32:1, pages 42-53.
Crossref
Crossref
Elias S.J. Arnér. 2022. Redox Chemistry and Biology of Thiols. Redox Chemistry and Biology of Thiols
197
218
.
Elena Fountzilas, Razelle Kurzrock, Henry Hiep Vo & Apostolia-Maria Tsimberidou. (2021) Wedding of Molecular Alterations and Immune Checkpoint Blockade: Genomics as a Matchmaker. JNCI: Journal of the National Cancer Institute 113:12, pages 1634-1647.
Crossref
Crossref
Xuemeng Si, Ning Liu, Hai Jia, Jiaqi Wang, Lina Pan, Ling Dong, Zhixing Rong, Ying Yang & Zhenlong Wu. (2021) Gut relief formula attenuates dextran sulfate sodium-induced colitis by regulating NF-κB signaling and the intestinal microbiota in mice. Food & Function 12:21, pages 10983-10993.
Crossref
Crossref
Michelle van der Merwe, Gustav van Niekerk, Carla Fourie, Manisha du Plessis & Anna-Mart Engelbrecht. (2021) The impact of mitochondria on cancer treatment resistance. Cellular Oncology 44:5, pages 983-995.
Crossref
Crossref
Di Zhang, Zhilin Hou, Kelly E. Aldrich, Lizbeth Lockwood, Aaron L. Odom & Karen T. Liby. (2021) A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy. Molecular Cancer Therapeutics 20:9, pages 1692-1701.
Crossref
Crossref
Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E. Elboray & Takayoshi Suzuki. (2021)
Ca
2+
‐activated K
+
channel K
Ca
1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models
. Cancer Science 112:9, pages 3769-3783.
Crossref
Crossref
Mathilde Savall, Nadia Senni, Isabelle Lagoutte, Pierre Sohier, Renaud Dentin, Beatrice Romagnolo, Christine Perret & Pascale Bossard. (2021) Cooperation Between the NRF2 Pathway and Oncogenic β‐catenin During HCC Tumorigenesis. Hepatology Communications 5:9, pages 1490-1506.
Crossref
Crossref
Huiyuan Yu, Xin Jiang, Fangyuan Dong, Fan Zhang, Xueying Ji, Mengjuan Xue, Fan Yang, Jie Chen, Xiaona Hu & Zhijun Bao. (2021) Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway. Experimental Cell Research 405:2, pages 112689.
Crossref
Crossref
Xupeng Bai, Jie Ni, Julia Beretov, Valerie C. Wasinger, Shanping Wang, Ying Zhu, Peter Graham & Yong Li. (2021) Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis. Redox Biology 43, pages 101993.
Crossref
Crossref
Chunjie Meng, Jun Zhan, Delin Chen, Genze Shao, Hongquan Zhang, Wei Gu & Jianyuan Luo. (2021) The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2. Oncogene 40:9, pages 1706-1720.
Crossref
Crossref
Yifeng Zhang, Jing Sun, Yu Dong, Xiaoran Shen & Zhenyu Zhang. (2020)
Vicenin‐2 inhibits the
Helicobacterium pylori
infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES‐1 cells
. Journal of Biochemical and Molecular Toxicology 35:3.
Crossref
Crossref
Kevin DzoboChelene GanzNicholas Ekow ThomfordDimakatso Alice Senthebane. (2021) Cancer Stem Cell Markers in Relation to Patient Survival Outcomes: Lessons for Integrative Diagnostics and Next-Generation Anticancer Drug Development. OMICS: A Journal of Integrative Biology 25:2, pages 81-92.
Crossref
Crossref
Narasimha M. Beeraka, Venugopal R. Bovilla, Shalini H. Doreswamy, Sujatha Puttalingaiah, Asha Srinivasan & SubbaRao V. Madhunapantula. (2021) The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers. Cancers 13:2, pages 281.
Crossref
Crossref
Yang Liu, Fengchao Lang & Chunzhang Yang. (2021) NRF2 in human neoplasm: Cancer biology and potential therapeutic target. Pharmacology & Therapeutics 217, pages 107664.
Crossref
Crossref
Jingya Wang, Jin Yang, Mingnan Cao, Zhigang Zhao, Baoshan Cao & Siwang Yu. (2021) The potential roles of Nrf2/Keap1 signaling in anticancer drug interactions. Current Research in Pharmacology and Drug Discovery 2, pages 100028.
Crossref
Crossref
Laurie Freire Boullosa, Jinthe Van Loenhout & Christophe Deben. 2021. Cancer. Cancer
39
48
.
Azhwar Raghunath, Raju Nagarajan & Kiruthika Sundarraj. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases
661
682
.
Junmin Zhang, Dongzhu Duan, Zi‐Long Song, Tianyu Liu, Yanan Hou & Jianguo Fang. (2020) Small molecules regulating reactive oxygen species homeostasis for cancer therapy. Medicinal Research Reviews 41:1, pages 342-394.
Crossref
Crossref
V. S. Bityutsky, S. I. Tsekhmistrenko, О. S. Tsekhmistrenko, N. O. Tymoshok & M. Y. Spivak. (2020) Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators. Regulatory Mechanisms in Biosystems 11:4, pages 483-493.
Crossref
Crossref
Katarína SmolkováEdit MikóTünde KovácsAlberto Leguina-RuzziAdrienn SiposPéter Bai. (2020) Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism. Antioxidants & Redox Signaling 33:13, pages 966-997.
Crossref
Crossref
Ramin Pourakbari, Sanaz Mansouri Taher, Bashir Mosayyebi, Mohammad Hosein Ayoubi-Joshaghani, Hamid Ahmadi & Leili Aghebati-Maleki. (2020) Implications for glycosylated compounds and their anti-cancer effects. International Journal of Biological Macromolecules 163, pages 1323-1332.
Crossref
Crossref
Danfeng Xue, Xiongming Zhou & Jiaxuan Qiu. (2020) Emerging role of NRF2 in ROS-mediated tumor chemoresistance. Biomedicine & Pharmacotherapy 131, pages 110676.
Crossref
Crossref
Claudia Orrù, Silvia Giordano & Amedeo Columbano. (2020) Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases. Cancers 12:10, pages 2932.
Crossref
Crossref
Stefana Cvetković, Branislav Nastasijević, Dragana Mitić-Ćulafić, Stefana Đukanović, Dina Tenji, Jelena Knežević-Vukčević & Biljana Nikolić. (2020) New insight into the antigenotoxic activity of Gentiana lutea extracts – Protective effect against food borne mutagens. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 858-860, pages 503251.
Crossref
Crossref
Mostafa Vaghari-Tabari, Maryam Majidinia, Soheila Moein, Durdi Qujeq, Zatollah Asemi, Forough Alemi, Ramin Mohamadzadeh, Nilofar Targhazeh, Amin Safa & Bahman Yousefi. (2020) MicroRNAs and colorectal cancer chemoresistance: New solution for old problem. Life Sciences 259, pages 118255.
Crossref
Crossref
Ferbian Milas Siswanto, Ami Oguro, Saki Arase & Susumu Imaoka. (2020) WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes. Drug Metabolism and Pharmacokinetics 35:5, pages 441-455.
Crossref
Crossref
Xiaoyang Liu, Qifu Yang & Yoshimasa Nakamura. (2020) Inhibition of Drug Resistance Mechanisms Improves the Benzyl Isothiocyanate–Induced Anti-Proliferation in Human Colorectal Cancer Cells. Current Pharmacology Reports 6:5, pages 306-314.
Crossref
Crossref
Man Wang, Fei Yu, Xinzhe Chen, Peifeng Li & Kun Wang. (2020) The Underlying Mechanisms of Noncoding RNAs in the Chemoresistance of Hepatocellular Carcinoma. Molecular Therapy - Nucleic Acids 21, pages 13-27.
Crossref
Crossref
Chen Zhang, Pierre‐Yves Fortin, Guillaume Barnoin, Xue Qin, Xing Wang, Alvaro Fernandez Alvarez, Christian Bijani, Marie‐Lise Maddelein, Catherine Hemmert, Olivier Cuvillier & Heinz Gornitzka. (2020) An Artemisinin‐Derivative–(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity. Angewandte Chemie International Edition 59:29, pages 12062-12068.
Crossref
Crossref
Chen Zhang, Pierre‐Yves Fortin, Guillaume Barnoin, Xue Qin, Xing Wang, Alvaro Fernandez Alvarez, Christian Bijani, Marie‐Lise Maddelein, Catherine Hemmert, Olivier Cuvillier & Heinz Gornitzka. (2020) An Artemisinin‐Derivative–(NHC)Gold(I) Hybrid with Enhanced Cytotoxicity through Inhibition of NRF2 Transcriptional Activity. Angewandte Chemie 132:29, pages 12160-12166.
Crossref
Crossref
Xian Xu, Yang Yang, Xiaoyan Liu, Na Cao, Peng Zhang, Songhui Zhao, Donglin Chen, Li Li, Yong He, Xiaowei Dong, Kai Wang, Hanqing Lin, Naiquan Mao & Lingxiang Liu. (2020)
NFE2L2/KEAP1
Mutations Correlate with Higher Tumor Mutational Burden Value/PD-L1 Expression and Potentiate Improved Clinical Outcome with Immunotherapy
. The Oncologist 25:6, pages e955-e963.
Crossref
Crossref
Kevin DzoboCollet Dandara. (2020) Broadening Drug Design and Targets to Tumor Microenvironment? Cancer-Associated Fibroblast Marker Expression in Cancers and Relevance for Survival Outcomes. OMICS: A Journal of Integrative Biology 24:6, pages 340-351.
Crossref
Crossref
Heba K. Nabih. (2020) Crosstalk between NRF2 and Dicer through metastasis regulating MicroRNAs; mir-34a, mir-200 family and mir-103/107 family. Archives of Biochemistry and Biophysics 686, pages 108326.
Crossref
Crossref
Nancy Vargas-Mendoza, Ángel Morales-González, Mauricio Morales-Martínez, Marvin A. Soriano-Ursúa, Luis Delgado-Olivares, Eli Mireya Sandoval-Gallegos, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Madrigal-Santillán & José A. Morales-Gonzalez. (2020) Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications. Biomedicines 8:5, pages 122.
Crossref
Crossref
Cinzia Calcabrini, Francesca Maffei, Eleonora Turrini & Carmela Fimognari. (2020) Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects. Frontiers in Pharmacology 11.
Crossref
Crossref
Pallab Shaw & Ansuman Chattopadhyay. (2019) Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms. Journal of Cellular Physiology 235:4, pages 3119-3130.
Crossref
Crossref
Longfa Kou, Xinyu Jiang, Huirong Huang, Xinlu Lin, Youting Zhang, Qing Yao & Ruijie Chen. (2020) The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines. Asian Journal of Pharmaceutical Sciences 15:2, pages 145-157.
Crossref
Crossref
Yi Zhao, Mu-Zi Li, Yue Shen, Jia Lin, Hao-Ran Wang, Milton Talukder & Jin-Long Li. (2019) Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice. Journal of Agricultural and Food Chemistry 68:7, pages 2031-2040.
Crossref
Crossref
Yan Chen, Tianyang Huang, Wei Shi, Jiansong Fang, Hongkuan Deng & Guozhen Cui. (2020) Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature. Journal of Molecular and Cellular Cardiology 138, pages 88-98.
Crossref
Crossref
Su Ji Kim, Hyun Soo Kim & Young Rok Seo. (2019) Understanding of ROS-Inducing Strategy in Anticancer Therapy. Oxidative Medicine and Cellular Longevity 2019, pages 1-12.
Crossref
Crossref
Hyttinen, Kannan, Felszeghy, Niittykoski, Salminen & Kaarniranta. (2019) The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology. International Journal of Molecular Sciences 20:22, pages 5800.
Crossref
Crossref
Lianrong Xu, Yan Zhao, Fei Pan, Mengxia Zhu, Liqin Yao, Yan Liu, Jiangfang Feng, Jie Xiong, Xiuhua Chen, Fanggang Ren, Yanhong Tan & Hongwei Wang. (2019) Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments. BioMed Research International 2019, pages 1-12.
Crossref
Crossref
Alina-Andreea Zimta, Diana Cenariu, Alexandru Irimie, Lorand Magdo, Seyed Mohammad Nabavi, Atanas G. Atanasov & Ioana Berindan-Neagoe. (2019) The Role of Nrf2 Activity in Cancer Development and Progression. Cancers 11:11, pages 1755.
Crossref
Crossref
Frauke Goeman, Francesca De Nicola, Stefano Scalera, Francesca Sperati, Enzo Gallo, Ludovica Ciuffreda, Matteo Pallocca, Laura Pizzuti, Eriseld Krasniqi, Giacomo Barchiesi, Patrizia Vici, Maddalena Barba, Simonetta Buglioni, Beatrice Casini, Paolo Visca, Edoardo Pescarmona, Marco Mazzotta, Ruggero De Maria, Maurizio Fanciulli, Gennaro Ciliberto & Marcello Maugeri-Saccà. (2019) Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma. Journal of Thoracic Oncology 14:11, pages 1924-1934.
Crossref
Crossref
Christine A. Houghton. (2019) Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease. Oxidative Medicine and Cellular Longevity 2019, pages 1-27.
Crossref
Crossref
Eun-Kyung Kim, MinGyeong Jang, Min-Jeong Song, Dongwoo Kim, Yosup Kim & Ho Hee Jang. (2019) Redox-Mediated Mechanism of Chemoresistance in Cancer Cells. Antioxidants 8:10, pages 471.
Crossref
Crossref
Christine C. Gana, Kimberley M. Hanssen, Denise M.T. Yu, Claudia L. Flemming, Madeleine S. Wheatley, Gwenaëlle Conseil, Susan P.C. Cole, Murray D. Norris, Michelle Haber & Jamie I. Fletcher. (2019) MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells. Biochemical Pharmacology 168, pages 237-248.
Crossref
Crossref
D Ruan, Y W Zhu, A M Fouad, S J Yan, W Chen, Y N Zhang, W G Xia, S Wang, S Q Jiang, L Yang & C T Zheng. (2019) Dietary curcumin enhances intestinal antioxidant capacity in ducklings via altering gene expression of antioxidant and key detoxification enzymes. Poultry Science 98:9, pages 3705-3714.
Crossref
Crossref
Xupeng Bai, Xiaoli Gou, Peiheng Cai, Chuncao Xu, Lin Cao, Zhongxiang Zhao, Min Huang & Jing Jin. (2019) Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation. Oxidative Medicine and Cellular Longevity 2019, pages 1-20.
Crossref
Crossref
Viraj R. Sanghvi, Josef Leibold, Marco Mina, Prathibha Mohan, Marjan Berishaj, Zhuoning Li, Matthew M. Miele, Nathalie Lailler, Chunying Zhao, Elisa de Stanchina, Agnes Viale, Leila Akkari, Scott W. Lowe, Giovanni Ciriello, Ronald C. Hendrickson & Hans-Guido Wendel. (2019) The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell 178:4, pages 807-819.e21.
Crossref
Crossref
Farzane Sivandzade, Aditya Bhalerao & Luca Cucullo. (2019) Cerebrovascular and Neurological Disorders: Protective Role of NRF2. International Journal of Molecular Sciences 20:14, pages 3433.
Crossref
Crossref
Kai-Chun Cheng, Ruey-Jen Lin, Jing-Yan Cheng, Sheng-Hung Wang, Jyh-Cherng Yu, Jen-Chine Wu, Yuh-Jin Liang, Huan-Ming Hsu, John Yu & Alice L. Yu. (2019) FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. EBioMedicine 45, pages 25-38.
Crossref
Crossref
Omeed Moaven & Thomas N. Wang. (2019) Combined Modality Therapy for Management of Esophageal Cancer. Surgical Clinics of North America 99:3, pages 479-499.
Crossref
Crossref
María Paula Ceballos, Juan Pablo Rigalli, Lucila Inés Ceré, Mariana Semeniuk, Viviana Alicia Catania & María Laura Ruiz. (2019) ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma. Current Medicinal Chemistry 26:7, pages 1224-1250.
Crossref
Crossref
Weijian Sun, Yongdong Yi, Guojun Xia, Yaxin Zhao, Yaojun Yu, Liyi Li, Chunya Hua, Bin He, Beng Yang, Chengyang Yu, Chenmin Ye, Fuyang Tu, Canjin Chen, Xiaoying Xu, Zhiqiang Zheng, Wenqian Wang & Xian Shen. (2019) Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy. Molecular Therapy 27:5, pages 1039-1050.
Crossref
Crossref
Hui Cheng, Chongmei Huang, Gusheng Tang, Huiying Qiu, Lei Gao, Weiping Zhang, Jianmin Wang, Jianmin Yang & Li Chen. (2019) Emerging role of EPHX1 in chemoresistance of acute myeloid leukemia by regurlating drug‐metabolizing enzymes and apoptotic signaling. Molecular Carcinogenesis 58:5, pages 808-819.
Crossref
Crossref
Xiaojie Feng, Lei Li, Li Wang, Suxia Luo & Xupeng Bai. (2019) Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer. Bioscience Reports 39:4.
Crossref
Crossref
Emiliano Panieri & Luciano Saso. (2019) Potential Applications of NRF2 Inhibitors in Cancer Therapy. Oxidative Medicine and Cellular Longevity 2019, pages 1-34.
Crossref
Crossref
Farzane Sivandzade, Shikha Prasad, Aditya Bhalerao & Luca Cucullo. (2019) NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biology 21, pages 101059.
Crossref
Crossref
Bu Choi. (2019) Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone. Molecules 24:2, pages 278.
Crossref
Crossref
Wenjun Tu, Hong Wang, Song Li, Qiang Liu & Hong Sha. (2019) The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. Aging and disease 10:3, pages 637.
Crossref
Crossref
Chander K. Negi & Gopabandhu Jena. (2019) Nrf2, a novel molecular target to reduce type 1 diabetes associated secondary complications: The basic considerations. European Journal of Pharmacology 843, pages 12-26.
Crossref
Crossref
Manuel Matzinger, Katrin Fischhuber & Elke H. Heiss. (2018) Activation of Nrf2 signaling by natural products-can it alleviate diabetes?. Biotechnology Advances 36:6, pages 1738-1767.
Crossref
Crossref
Gan-Jian Zhao, Ning Hou, Shao-Ai Cai, Xia-Wen Liu, Ai-Qun Li, Chuan-Fang Cheng, Yin Huang, Li-Rong Li, Yun-Pei Mai, Shi-Ming Liu, Cai-Wen Ou, Zhen-Yu Xiong, Xiao-Hui Chen, Min-Sheng Chen & Cheng-Feng Luo. (2018) Contributions of Nrf2 to Puerarin Prevention of Cardiac Hypertrophy and its Metabolic Enzymes Expression in Rats. Journal of Pharmacology and Experimental Therapeutics 366:3, pages 458-469.
Crossref
Crossref
Xupeng Bai, Jie Ni, Julia Beretov, Peter Graham & Yong Li. (2018) Cancer stem cell in breast cancer therapeutic resistance. Cancer Treatment Reviews 69, pages 152-163.
Crossref
Crossref
Leyla Norouzi‐Barough, Mohammad Reza Sarookhani, Mohammadreza Sharifi, Sahar Moghbelinejad, Saranaz Jangjoo & Rasoul Salehi. (2018) Molecular mechanisms of drug resistance in ovarian cancer. Journal of Cellular Physiology 233:6, pages 4546-4562.
Crossref
Crossref
Ilaria Bellezza, Ileana Giambanco, Alba Minelli & Rosario Donato. (2018) Nrf2-Keap1 signaling in oxidative and reductive stress. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:5, pages 721-733.
Crossref
Crossref
Sarah A. Best, David P. De Souza, Ariena Kersbergen, Antonia N. Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H. Gray, Matthew E. Ritchie, Malcolm J. McConville & Kate D. Sutherland. (2018) Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment. Cell Metabolism 27:4, pages 935-943.e4.
Crossref
Crossref
Eric Ciamporcero, Martina Daga, Stefania Pizzimenti, Antonella Roetto, Chiara Dianzani, Alessandra Compagnone, Antonietta Palmieri, Chiara Ullio, Luigi Cangemi, Roberto Pili & Giuseppina Barrera. (2018) Crosstalk between Nrf2 and YAP contributes to maintaining the antioxidant potential and chemoresistance in bladder cancer. Free Radical Biology and Medicine 115, pages 447-457.
Crossref
Crossref
Weipeng Hong, Peiheng Cai, Chuncao Xu, Di Cao, Weibang Yu, Zhongxiang Zhao, Min Huang & Jing Jin. (2018) Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System. Frontiers in Pharmacology 9.
Crossref
Crossref
Akinori Yanaka. (2018) Role of NRF2 in protection of the gastrointestinal tract against oxidative stress. Journal of Clinical Biochemistry and Nutrition 63:1, pages 18-25.
Crossref
Crossref
Jianfa Wu, Lingjie Bao, Zhenbo Zhang & Xiaofang Yi. (2017) Nrf2 induces cisplatin resistance via suppressing the iron export related gene SLC40A1 in ovarian cancer cells. Oncotarget 8:55, pages 93502-93515.
Crossref
Crossref
Q Wang, J Ma, Y Lu, S Zhang, J Huang, J Chen, J-X Bei, K Yang, G Wu, K Huang, J Chen & S Xu. (2017) CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene 36:37, pages 5321-5330.
Crossref
Crossref
Hong-Quan Duong, Kyu You, Seunghoon Oh, Sahng-June Kwak & Yeon-Sun Seong. (2017) Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells. Antioxidants 6:3, pages 52.
Crossref
Crossref
Cara Chang, Yichun Hu, Susan Hogan, Nickie Mercke, Madeleine Gomez, Cindy O’Bryant, Daniel Bowles, Blessy George, Xia Wen, Lauren Aleksunes & Melanie Joy. (2017) Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin. International Journal of Molecular Sciences 18:7, pages 1333.
Crossref
Crossref
Farhad Jeddi, Narges Soozangar, Mohammad Reza Sadeghi, Mohammad Hossein Somi & Nasser Samadi. (2017) Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance. DNA Repair 54, pages 13-21.
Crossref
Crossref
Kyoung Ah Kang & Jin Won Hyun. (2017) Oxidative Stress, Nrf2, and Epigenetic Modification Contribute to Anticancer Drug Resistance. Toxicological Research 33:1, pages 1-5.
Crossref
Crossref