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Drug Metabolism Reviews Volume 48, 2016 - Issue 3: Cytochrome P450: New Horizons
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Review Article

The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes

James R. ReedDepartment of Pharmacology and Experimental Therapeutics, and The Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA
&
Wayne L. BackesDepartment of Pharmacology and Experimental Therapeutics, and The Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USACorrespondence[email protected]
Pages 453-469 | Received 04 Aug 2016, Accepted 04 Aug 2016, Published online: 31 Aug 2016

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Bikash Dangi, Nadezhda Y. Davydova, Nikita E. Vavilov, Victor G. Zgoda & Dmitri R. Davydov. (2020) Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate. Xenobiotica 50:12, pages 1393-1405.
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Articles from other publishers (23)

Xiaoqing Jia, Xiaoting Zhang, Tao Zhou, Dalong Sun, Rong Li, Na Yang & Zheng Luo. (2023) Cyp3A4 *1G polymorphism is associated with alcohol drinking: A 5-year retrospective single centered population-based study in China. PLOS ONE 18:12, pages e0295184.
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Zahra Aghaali & Mohammad Reza Naghavi. (2023) Engineering of CYP82Y1, a cytochrome P450 monooxygenase: a key enzyme in noscapine biosynthesis in opium poppy. Biochemical Journal 480:23, pages 2009-2022.
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Ting Xu, Yangjun Lv, Yuhan Cui, Dongchen Liu, Tao Xu, Baiyi Lu & Xuan Yang. (2023) Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7). Nutrients 15:23, pages 4941.
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Mohammad Sahil, Tejender Singh, Soumya Ghosh & Jagannath Mondal. (2023) 3site Multisubstrate-Bound State of Cytochrome P450cam. Journal of the American Chemical Society 145:43, pages 23488-23502.
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James R. Reed, Jessie J. Guidry & Wayne L. Backes. (2022) Proteomic and Bioinformatics Analysis of Membrane Lipid Domains after Brij 98 Solubilization of Uninduced and Phenobarbital-Induced Rat Liver Microsomes: Defining the Membrane Localization of the P450 Enzyme System. Drug Metabolism and Disposition 50:4, pages 374-385.
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Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak S. Ahire, Bhagwat Prasad & Victor G. Zgoda. (2022) Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry. Biomolecules 12:2, pages 185.
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Dmitri R. Davydov & Bhagwat Prasad. (2021) Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism. Trends in Pharmacological Sciences 42:12, pages 988-997.
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Sheri Smith, Michael Lyman, Bennett Ma, Donald Tweedie & Karsten Menzel. (2021) Reaction Phenotyping of Low-Turnover Compounds in Long-Term Hepatocyte Cultures Through Persistent Selective Inhibition of Cytochromes P450. Drug Metabolism and Disposition 49:11, pages 995-1002.
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Bikash Dangi, Nadezhda Y. Davydova, Marc A. Maldonado, Deepak Ahire, Bhagwat Prasad & Dmitri R. Davydov. (2021) Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics. Archives of Biochemistry and Biophysics 708, pages 108937.
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Aratrika Saha, J. Patrick Connick, James R. Reed, Charles S. Lott & Wayne L. Backes. (2021) Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex. Biochemical Journal 478:11, pages 2163-2178.
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Bikash Dangi, Nadezhda Y. Davydova, Marc A. Maldonado, Armina Abbasi, Nikita E. Vavilov, Victor G. Zgoda & Dmitri R. Davydov. (2021) Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4. Archives of Biochemistry and Biophysics 698, pages 108677.
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J. Patrick ConnickJames R. ReedGeorge F. CawleyWayne L. Backes. (2021) Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1. Biochemical Journal 478:2, pages 377-388.
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J. Patrick Connick, James R. Reed, George F. Cawley & Wayne L. Backes. (2020) Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1. Journal of Biological Chemistry, pages jbc.RA120.015911.
Crossref
Francisco Esteves, Philippe Urban, José Rueff, Gilles Truan & Michel Kranendonk. (2020) Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding. International Journal of Molecular Sciences 21:18, pages 6669.
Crossref
Emmanuel Stephen Odinga, Michael Gatheru Waigi, Fredrick Owino Gudda, Jian Wang, Bing Yang, Xiaojie Hu, Shunyao Li & Yanzheng Gao. (2020) Occurrence, formation, environmental fate and risks of environmentally persistent free radicals in biochars. Environment International 134, pages 105172.
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Nadezhda Y. DavydovaBikash DangiMarc A. MaldonadoNikita E. Vavilov, Victor G. Zgoda & Dmitri R. Davydov. (2019) Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2. Biochemical Journal 476:23, pages 3661-3685.
Crossref
Carlo Barnaba & Ayyalusamy Ramamoorthy. (2018) Picturing the Membrane‐assisted Choreography of Cytochrome P450 with Lipid Nanodiscs. ChemPhysChem 19:20, pages 2603-2613.
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Charleen G. Don & Martin Smieško. (2018) Out‐compute drug side effects: Focus on cytochrome P450 2D6 modeling. WIREs Computational Molecular Science 8:5.
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Ilia G. Denisov, Javier L. Baylon, Yelena V. Grinkova, Emad Tajkhorshid & Stephen G. Sligar. (2017) Drug–Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4. Biochemistry 57:5, pages 805-816.
Crossref
Dmitri R. DavydovNadezhda Y. DavydovaJohn T. RodgersThomas H. RushmoreJeffrey P. Jones. (2017) Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochemical Journal 474:20, pages 3523-3542.
Crossref
Jed N. LampePhDPhD. (2017) Advances in the Understanding of Protein-Protein Interactions in Drug Metabolizing Enzymes through the Use of Biophysical Techniques. Frontiers in Pharmacology 8.
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Jean-Etienne Bassard, Birger Lindberg Møller & Tomas Laursen. (2017) Assembly of Dynamic P450-Mediated Metabolons—Order Versus Chaos. Current Molecular Biology Reports 3:1, pages 37-51.
Crossref
James R. Reed & Wayne L. Backes. (2017) Physical Studies of P450–P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Frontiers in Pharmacology 8.
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