647
Views
31
CrossRef citations to date
0
Altmetric
Reviews

The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders

&
Pages 415-429 | Received 28 Sep 2018, Accepted 27 Nov 2018, Published online: 07 Jan 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Guiqin Liu, Xue Bai, Jianxin Yang, Yabin Duan, Junbo Zhu & Li Xiangyang. (2023) Relationship between blood–brain barrier changes and drug metabolism under high-altitude hypoxia: obstacle or opportunity for drug transport?. Drug Metabolism Reviews 55:1-2, pages 107-125.
Read now

Articles from other publishers (30)

Robert S. Foti. (2023) Cytochrome P450 and Other Drug-Metabolizing Enzymes As Therapeutic Targets. Drug Metabolism and Disposition 51:8, pages 936-949.
Crossref
Sachin Nashik Sanap, Amol Chhatrapati Bisen, Ashwini Kedar, Sristi Agrawal & Rabi Sankar Bhatta. (2023) Recent Update on Pharmacokinetics and Drug Metabolism in CNS-based Drug Discovery. Current Pharmaceutical Design 29:20, pages 1602-1616.
Crossref
Anna Haduch, Ewa Bromek, Wojciech Kuban & Władysława Anna Daniel. (2023) The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism. Metabolites 13:5, pages 629.
Crossref
William Mangione, Zackary Falls & Ram Samudrala. (2023) Effective holistic characterization of small molecule effects using heterogeneous biological networks. Frontiers in Pharmacology 14.
Crossref
Nouf Alshammari, Devaraj Venkatapura Chandrashekar, Mamunur Rashid & Reza Mehvar. (2022) Differential expression and activities of cytochrome P450 3A in the rat brain microsomes and mitochondria. Fundamental & Clinical Pharmacology 37:2, pages 359-368.
Crossref
Joanna Jastrzębska & Władysława Anna Daniel. (2023) Cocaine-Induced Time-Dependent Alterations in Cytochrome P450 and Liver Function. International Journal of Molecular Sciences 24:2, pages 1632.
Crossref
Murat Dzhaubermezov, Natalya Ekomasova, Rustam Mustafin, Lilia Gabidullina, Yuliya Galimova, Alfiya Nurgalieva, Yana Valova, Darya Prokofyeva & Elza Khusnutdinova. (2022) Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia. Genes 13:12, pages 2353.
Crossref
Anna Haduch, Ewa Bromek, Renata Pukło, Joanna Jastrzębska, Przemysław Jan Danek & Władysława Anna Daniel. (2022) The Effect of the Selective N-methyl-D-aspartate (NMDA) Receptor GluN2B Subunit Antagonist CP-101,606 on Cytochrome P450 2D (CYP2D) Expression and Activity in the Rat Liver and Brain. International Journal of Molecular Sciences 23:22, pages 13746.
Crossref
Przemysław J. Danek & Władysława A. Daniel. (2022) The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia. Cells 11:21, pages 3513.
Crossref
Aminah Alchakee, Munazza Ahmed, Leen Eldohaji, Hamid Alhaj & Maha Saber-Ayad. (2022) Pharmacogenomics in Psychiatry Practice: The Value and the Challenges. International Journal of Molecular Sciences 23:21, pages 13485.
Crossref
Władysława A. Daniel, Ewa Bromek, Przemysław J. Danek & Anna Haduch. (2022) The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions. Biochemical Pharmacology 199, pages 115006.
Crossref
Santiago G. Lago & Sabine Bahn. (2022) The druggable schizophrenia genome: from repurposing opportunities to unexplored drug targets. npj Genomic Medicine 7:1.
Crossref
Muhammad Fahad Raza, Muhammad Anwar, Arif Husain, Muhmmad Rizwan, Zhiguo Li, Hongyi Nie, Pavol Hlaváč, M. Ajmal Ali, Ahmed Rady & Songkun Su. (2022) Differential gene expression analysis following olfactory learning in honeybee (Apis mellifera L.). PLOS ONE 17:2, pages e0262441.
Crossref
Anna Haduch, Przemysław J. Danek, Wojciech Kuban, Renata Pukło, Natalia Alenina, Joanna Gołębiowska, Piotr Popik, Michael Bader & Władysława A. Daniel. (2022) Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats. Neurochemistry International 152, pages 105223.
Crossref
Marlaina R. Stocco & Rachel F. Tyndale. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 73 106 .
Muhammad Imran Khan, Inzemam Khan, Saeed Ahmad Khan & Waqas Nawaz. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 259 280 .
Przemysław J. Danek & Władysława A. Daniel. (2021) Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms. Cells 10:12, pages 3472.
Crossref
Przemysław J. Danek, Ewa Bromek, Anna Haduch & Władysława A. Daniel. (2021) Chronic treatment with asenapine affects cytochrome P450 2D (CYP2D) in rat brain and liver. Pharmacological aspects. Neurochemistry International 151, pages 105209.
Crossref
A. Haduch, P. Danek, W. Kuban, J. Gołebiowska, N. Alenina, P. Popik, M. Bader & W.A. Daniel. (2021) P.0906 The effects of aging and cerebral serotonin deficiency on brain and liver cytochrome P450 2D in female rats – sex differences. European Neuropsychopharmacology 53, pages S665-S666.
Crossref
W. Daniel, A. Haduch, E. Bromek, J. Jastrzębska & R. Pukło. (2021) P.0865 The effect of the NMDA receptor GluN2B subunit antagonist CP-101,606 on brain and liver cytochrome P450 2D (CYP2D). European Neuropsychopharmacology 53, pages S632-S633.
Crossref
P.J. Danek & W.A. Daniel. (2021) P.0561 Chronic treatment with iloperidone affects the cytochrome P450 2D (CYP2D) protein and activity in the brain and liver. European Neuropsychopharmacology 53, pages S412-S413.
Crossref
K. Darney, L.S. Lautz, C. Béchaux, W. Wiecek, E. Testai, B. Amzal & J.L.C.M. Dorne. (2021) Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs. Environment International 156, pages 106760.
Crossref
Katja S. Just, Harald Dormann, Mathias Freitag, Marlen Schurig, Miriam Böhme, Michael Steffens, Catharina Scholl, Thomas Seufferlein, Ingo Graeff, Matthias Schwab & Julia C. Stingl. (2021) CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System—Results From the ADRED Study. Frontiers in Pharmacology 12.
Crossref
T Sayamsmruti Panda, H. Lalremmawia & Basant K. Tiwary. (2021) Blood genomic biomarkers for early diagnosis of schizophrenia. Asian Journal of Psychiatry 59, pages 102638.
Crossref
Yun Sheng, Hanyu Yang, Tong Wu, Liang Zhu, Li Liu & Xiaodong Liu. (2021) Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances. Frontiers in Pharmacology 12.
Crossref
Emanuela Testai, Camille Bechaux, Franca M. Buratti, Keyvin Darney, Emma Di Consiglio, Emma E.J. Kasteel, Nynke I. Kramer, Leonie S. Lautz, Nicoletta Santori, Zoi‐Vasiliki Skaperda, Dimitrios Kouretas, Laura Turco & Susanna Vichi. (2021) Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems. EFSA Supporting Publications 18:4.
Crossref
Kishore K Joshi, Tarmie L Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel & Christopher Rongo. (2021) Biogenic amine neurotransmitters promote eicosanoid production and protein homeostasis. EMBO reports 22:3.
Crossref
Przemysław J. Danek, Jacek Wójcikowski & Władysława A. Daniel. (2020) The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions. Pharmacological Reports 72:6, pages 1685-1694.
Crossref
Jacek Wójcikowski, Przemysław J. Danek, Agnieszka Basińska-Ziobroń, Renata Pukło & Władysława A. Daniel. (2020) In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug–drug interactions. Pharmacological Reports 72:3, pages 612-621.
Crossref
P. Danek & W.A. Daniel. (2020) P.103 The effect of chronic treatment with the asenapine on the cytochrome P450 2D (CYP2D) activity in different brain areas. European Neuropsychopharmacology 31, pages S2-S3.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.