Advanced search
Publication Cover
Drug Metabolism Reviews Volume 51, 2019 - Issue 4
Submit an article Journal homepage
518
Views
10
CrossRef citations to date
0
Altmetric
Review Articles

Aldehyde oxidase at the crossroad of metabolism and preclinical screening

Narges CheshmazarBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; ORCID Iconhttp://orcid.org/0000-0002-9998-8121
ORCID Icon,
Siavoush DastmalchiBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; ORCID Iconhttp://orcid.org/0000-0001-9427-0770
ORCID Icon,
Mineko TeraoLaboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, ItalyORCID Iconhttp://orcid.org/0000-0002-9976-9869
ORCID Icon,
Enrico GarattiniLaboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, ItalyCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-8983-886X
ORCID Icon &
Maryam Hamzeh-MivehroudBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; ;Department of Medicinal Chemistry, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-1257-0102
ORCID Icon
Pages 428-452 | Received 02 Dec 2018, Accepted 07 Sep 2019, Published online: 24 Sep 2019

Citations (10)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Siva Nageswara Rao Gajula, Tanaaz Navin Nathani, Rashmi Madhukar Patil, Sasikala Talari & Rajesh Sonti. (2022) Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development. Drug Metabolism Reviews 54:4, pages 427-448.
Read now
Nikhilesh V. Dhuria, Bianka Haro, Amit Kapadia, Khadjia A. Lobo, Bernice Matusow, Mary A. Schleiff, Christina Tantoy & Jasleen K. Sodhi. (2021) Recent developments in predicting CYP-independent metabolism. Drug Metabolism Reviews 53:2, pages 188-206.
Read now

Articles from other publishers (8)

Zhengsheng Mao, Youjia Yu, Gen Ba, Hongmei Zhao, Qifang Shi, Yue Cao, Weiran Xie, Jinsong Zhang, Hao Sun & Feng Chen. (2024) Non-cytochrome P450 enzyme aldehyde oxidase is involved in the oxidative metabolic pathway of diquat and its detoxification effect. Pesticide Biochemistry and Physiology 199, pages 105805.
Crossref
Anam Hammid, John K. Fallon, Kati-Sisko Vellonen, Toni Lassila, Mika Reinisalo, Arto Urtti, Francisco Gonzalez, Ari Tolonen, Philip C. Smith & Paavo Honkakoski. (2023) Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues. European Journal of Pharmaceutical Sciences 191, pages 106603.
Crossref
Cyrus Khojasteh, Jasleen K. Sodhi, Jason Halladay & Donglu Zhang. (2023) The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism. Medicinal Chemistry Research 32:9, pages 2016-2033.
Crossref
Gianluca Catucci, Gianfranco Gilardi & Sheila J. Sadeghi. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 509 562 .
Mei-Mei Wang, Ming He, Hong Wang, Yun-Feng Ma, Youssef Dewer, Fan Zhang & Peng He. (2021) A candidate aldehyde oxidase in the antennae of the diamondback moth, Plutella xylostella (L.), is potentially involved in the degradation of pheromones, plant-derived volatiles and the detoxification of xenobiotics. Pesticide Biochemistry and Physiology 171, pages 104726.
Crossref
Ciarán N. Cronin, JianHua Liu, Nicole Grable, Timothy J. Strelevitz, R. Scott Obach & Anthony Carlo. (2021) Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay. Protein Expression and Purification 177, pages 105749.
Crossref
Armina Abbasi, Carolyn A. Joswig-Jones & Jeffrey P. Jones. (2020) Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey. Drug Metabolism and Disposition 48:12, pages 1364-1371.
Crossref
Julia Shanu-Wilson, Liam EvansStephen WrigleyJonathan SteeleJames Atherton & Jason Boer. (2020) Biotransformation: Impact and Application of Metabolism in Drug Discovery. ACS Medicinal Chemistry Letters 11:11, pages 2087-2107.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.