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Hemoglobin
international journal for hemoglobin research
Volume 30, 2006 - Issue 2
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PROCEEDINGS 15th ICOCTaiwan, April 2005

Iron Mobilization From Transferrin And Non-Transferrin-Bound-Iron by Deferiprone. Implications in the Treatment of Thalassemia, Anemia of Chronic Disease, Cancer and Other Conditions

Pages 183-200 | Published online: 07 Jul 2009

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Read on this site (7)

Ibrahim H. Bucak, Habip Almis, Samet Benli & Mehmet Turgut. (2017) The Assessment of Skin Color and Iron Levels in Pediatric Patients with β-Thalassemia Major Using a Visual Skin Color Chart. Hemoglobin 41:2, pages 120-123.
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Christina N Kontoghiorghe, Annita Kolnagou & George J Kontoghiorghes. (2013) Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals. Expert Opinion on Investigational Drugs 22:5, pages 591-618.
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Pavla Černá, Dana Kotyzová & Vladislav Eybl. (2011) The Effect Of The Oral Iron Chelator Deferiprone On The Liver Damage Induced By Tamoxifen In Female Rats. Hemoglobin 35:3, pages 255-261.
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G J Kontoghiorghes, A Kolnagou, C-T Peng, S V Shah & A Aessopos. (2010) Safety issues of iron chelation therapy in patients with normal range iron stores including thalassaemia, neurodegenerative, renal and infectious diseases. Expert Opinion on Drug Safety 9:2, pages 201-206.
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George J. Kontoghiorghes, Aglaia Efstathiou, Stella Ioannou-Loucaides & Annita Kolnagou. (2008) Chelators Controlling Metal Metabolism and Toxicity Pathways: Applications in Cancer Prevention, Diagnosis and Treatment. Hemoglobin 32:1-2, pages 217-227.
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Articles from other publishers (32)

Mohammad Hassan Hodroj & Ali Taher. (2023) Thalassemia and malignancies: Updates from the literature. Annals of the New York Academy of Sciences 1529:1, pages 14-20.
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Shumin Sun, Jie Shen, Jianwei Jiang, Fudi Wang & Junxia Min. (2023) Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduction and Targeted Therapy 8:1.
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George J. Kontoghiorghes. (2023) Iron Load Toxicity in Medicine: From Molecular and Cellular Aspects to Clinical Implications. International Journal of Molecular Sciences 24:16, pages 12928.
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George J. Kontoghiorghes. (2023) The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases. Pharmaceuticals 16:7, pages 1016.
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George J. Kontoghiorghes. (2023) Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 24:5, pages 4970.
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George J. Kontoghiorghes. (2022) New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer. International Journal of Molecular Sciences 23:22, pages 13990.
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George J. Kontoghiorghes. (2022) Questioning Established Theories and Treatment Methods Related to Iron and Other Metal Metabolic Changes, Affecting All Major Diseases and Billions of Patients. International Journal of Molecular Sciences 23:3, pages 1364.
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Yasumasa Ikeda, Masafumi Funamoto & Koichiro Tsuchiya. (2022) The role of iron in obesity and diabetes. The Journal of Medical Investigation 69:1.2, pages 1-7.
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George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous & Christina Kontoghiorghe. (2021) New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 22:11, pages 5546.
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Víctor Vinuesa & Michael J. McConnell. (2021) Recent Advances in Iron Chelation and Gallium-Based Therapies for Antibiotic Resistant Bacterial Infections. International Journal of Molecular Sciences 22:6, pages 2876.
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George J. Kontoghiorghes, Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov & Nikolay E. Polyakov. (2020) Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications. Medicines 7:8, pages 45.
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George Kontoghiorghes & Christina Kontoghiorghe. (2020) Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases. Cells 9:6, pages 1456.
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A. Valizadeh & R. Ghiasi. (2017) Theoretical approach to the molecular structure, chemical reactivity, molecular orbital analysis, spectroscopic properties (IR, UV, NMR), and NBO analysis of deferiprone. Journal of Structural Chemistry 58:7, pages 1307-1317.
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Arijit Basu, Yang-Sung Sohn, Mohamed Alyan, Rachel Nechushtai, Abraham J. Domb & Amiram Goldblum. (2016) Discovering Novel and Diverse Iron-Chelators in Silico. Journal of Chemical Information and Modeling 56:12, pages 2476-2485.
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Christina N Kontoghiorghe & George J Kontoghiorghes. (2016) New developments and controversies in iron metabolism and iron chelation therapy. World Journal of Methodology 6:1, pages 1.
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Christina Kontoghiorghe, Annita Kolnagou & George Kontoghiorghes. (2015) Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology. Molecules 20:11, pages 20841-20872.
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Ulrike Löbel, Ferdinand Schweser, Miriam Nickel, Andreas Deistung, Regine Grosse, Christian Hagel, Jens Fiehler, Angela Schulz, Monika Hartig, Jürgen R. Reichenbach, Alfried Kohlschütter & Jan Sedlacik. (2014) Brain iron quantification by MRI in mitochondrial membrane protein-associated neurodegeneration under iron-chelating therapy. Annals of Clinical and Translational Neurology 1:12, pages 1041-1046.
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Mei-pian Chen, Z. Ioav Cabantchik, Shing Chan, Godfrey Chi-fung Chan & Yiu-fai Cheung. (2014) Iron Overload and Apoptosis of HL-1 Cardiomyocytes: Effects of Calcium Channel Blockade. PLoS ONE 9:11, pages e112915.
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Annita Kolnagou. (2014) Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases. World Journal of Methodology 4:4, pages 197.
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Annalisa Dean, Maria Grazia Ferlin, Mirjana Cvijovic, Predrag Djurdjevic, Francesco Dotto, Denis Badocco, Paolo Pastore, Alfonso Venzo & Valerio B. Di Marco. (2014) Evaluation of 1,2-dimethyl-3-hydroxy-4-pyridinecarboxylic acid and of other 3-hydroxy-4-pyridinecarboxylic acid derivatives for possible application in iron and aluminium chelation therapy. Polyhedron 67, pages 520-528.
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Ibrahim A. Shaaban, Tarek A. Mohamed, Wajdi M. Zoghaib, Lee D. Wilson, Rabie S. Farag, Mahmoud S. Afifi & Yehia A. Badr. (2013) Tautomerism, Raman, infrared and ultraviolet–visible spectra, vibrational assignments, MP2 and B3LYP calculations of dienol 3,4-dihydroxypyridine, keto-enol 3-hydroxypyridin-4-one and keto-enol dimer. Journal of Molecular Structure 1043, pages 52-67.
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Louis de Léséleuc, Greg Harris, Rhonda KuoLee & Wangxue Chen. (2012) In Vitro and In Vivo Biological Activities of Iron Chelators and Gallium Nitrate against Acinetobacter baumannii . Antimicrobial Agents and Chemotherapy 56:10, pages 5397-5400.
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Robert W. Evans, Xiaole Kong & Robert C. Hider. (2012) Iron mobilization from transferrin by therapeutic iron chelating agents. Biochimica et Biophysica Acta (BBA) - General Subjects 1820:3, pages 282-290.
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Klaudia Jomova, Stanislav Baros & Marian Valko. (2012) Redox active metal-induced oxidative stress in biological systems. Transition Metal Chemistry 37:2, pages 127-134.
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Lie Michael George Limenta, Totsapol Jirasomprasert, Piyada Jittangprasert, Prapin Wilairat, Praveena Yamanont, Udom Chantharaksri, Suthat Fucharoen & Noppawan Phumala Morales. (2011) Pharmacokinetics of Deferiprone in Patients with β-Thalassaemia. Clinical Pharmacokinetics 50:1, pages 41-50.
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Annita Kolnagou, Marios Kleanthous & George J. Kontoghiorghes. (2010) Reduction of body iron stores to normal range levels in thalassaemia by using a deferiprone/deferoxamine combination and their maintenance thereafter by deferiprone monotherapy. European Journal of Haematology 85:5, pages 430-438.
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Douglas B Kell. (2009) Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Medical Genomics 2:1.
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Choon-Mee KimSung-Heui Shin. (2009) Effect of Iron-Chelator Deferiprone on the In Vitro Growth of Staphylococci. Journal of Korean Medical Science 24:2, pages 289.
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Yunpeng Ye, Sharon Bloch, Baogang Xu & Samuel Achilefu. (2007) Novel Near-Infrared Fluorescent Integrin-Targeted DFO Analogue. Bioconjugate Chemistry 19:1, pages 225-234.
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John Burgess & Maria Rangel. 2008. 167 243 .
M. Amélia Santos, Sofia Gama, João Costa Pessoa, M. Conceição Oliveira, Imre Tóth & Etelka Farkas. (2007) Complexation of Molybdenum(VI) with Bis(3‐hydroxy‐4‐pyridinone)amino Acid Derivatives. European Journal of Inorganic Chemistry 2007:12, pages 1728-1737.
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Paul V. Bernhardt. (2007) Coordination chemistry and biology of chelators for the treatment of iron overload disorders. Dalton Transactions:30, pages 3214.
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