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Hemoglobin
international journal for hemoglobin research
Volume 31, 2007 - Issue 1
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Original

Rapid Detection of β-Thalassemia Alleles in Egypt Using Naturally or Amplified Created Restriction Sites and Direct Sequencing: A Step in Disease Control

Gehan Hussein Laboratory of Hematology, Saint Eloi Hospital, CHU of Montpellier, Montpellier, France; Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Manal Fawzy Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Taher El Serafi Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Emad F. Ismail Department of Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Dina El Metwally Department of Pediatrics, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
,
Mohamed A. Saber Department of Biochemistry, Tudor Belhars Research Institute, Cairo, Egypt
,
Muriel Giansily Laboratory of Hematology, Saint Eloi Hospital, CHU of Montpellier, Montpellier, France
,
Jean-François Schved Laboratory of Hematology, Saint Eloi Hospital, CHU of Montpellier, Montpellier, France
,
Serge Pissard INSERM U654, Laboratory of Biochemistry and Molecular Genetics, Henri Mondor Hospital, Créteil, France
&
Patricia Aguilar Martinez Laboratory of Hematology, Saint Eloi Hospital, CHU of Montpellier, Montpellier, FranceCorrespondence[email protected]
 show all
Pages 49-62 | Received 27 Mar 2006, Accepted 30 May 2006, Published online: 07 Jul 2009

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Biyan Chen, Peng Huang, Shang Yi, Qiuli Chen, Yanqing Tang, Qiang Zhang & Sheng He. (2015) First Detection of a Splice Site β-Thalassemia Mutation, IVS-I-6 (T > C) (HBB: c.92 + 6T > C) in a Chinese Family. Hemoglobin 39:3, pages 207-208.
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Othman E. Soliman, Sohier Yahia, Amany Shouma, Hala K. Shafiek, Ashraf E. Fouda, Hanan Azzam, Nashwa K. Abousamra, Rabab Mahfouz, Enas F. Goda & Solafa A. El-Sharawy. (2010) Reverse hybridization StripAssay detection of β-thalassemia mutations in northeast Egypt. Hematology 15:3, pages 182-186.
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Roshan Colah, Ajit Gorakshakar & Anita Nadkarni. (2010) Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders. Expert Review of Hematology 3:1, pages 103-117.
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Hosam Salah, Maha Atfy, Ayman Fathy, Mervat Atfy, Hosam Mansor & Jehan Saeed. (2010) The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients. Immunological Investigations 39:8, pages 820-832.
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Azza A.G. Tantawy, Amira A.M. Adly, Mohamed G.A. El Maaty & Shatha A.G. Amin. (2009) Subclinical Atherosclerosis In Young β-thalassemia Major Patients. Hemoglobin 33:6, pages 463-474.
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Azza A.G. Tantawy, Amira A.M. Adly, Sameh A.R. Mahdy & Ghada Z. Kamel. (2009) Spinal Cord Compression And Extramedullary Hematopoiesis in Young Egyptian β-thalassemia Patients. Hemoglobin 33:6, pages 448-462.
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Articles from other publishers (21)

Antonis Kattamis, Gian Luca Forni, Yesim Aydinok & Vip Viprakasit. (2020) Changing patterns in the epidemiology of β‐thalassemia. European Journal of Haematology 105:6, pages 692-703.
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Mohsen S. Elalfy, Fatma S.E. Ebeid, Yasmin G. El Gendy, Mona M. Zaki & Amna S.A. Kalifa. (2020) Body Composition in Egyptian Children With Transfusion-dependent Thalassemia: The Impact of Nutrition and Metabolic Profile. Journal of Pediatric Hematology/Oncology 42:5, pages e334-e339.
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Tamer H. Hassan, Mohamed M. Abdel Salam, Marwa Zakaria, Mohamed Shehab, Dina T. Sarhan, El Sayed H. Zidan & Khaled M. El Gerby. (2018) Impact of Genotype of Beta Globin Gene on Hepatic and Myocardial Iron Content in Egyptian Patients with Beta Thalassemia. Indian Journal of Hematology and Blood Transfusion 35:2, pages 284-291.
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Tamer Hassan, Marwa Zakaria, Manar Fathy, Mohamed Arafa, Sherif El Gebaly, Ahmed Emam, Attia Abdel Wahab, Mohamed Shehab, Hosam Salah, Mai Malek & Khaled El Gerby. (2018) Association between genotype and disease complications in Egyptian patients with beta thalassemia: A Cross-sectional study. Scientific Reports 8:1.
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G.M. Mokhtar, M.S. El Alfy, F.S.E. Ebeid, M.A. El Sawi, M.H. Fayek, A.A.M. Adly & Asama Zaki. (2018) Hemochromatosis C282Y gene mutation as a potential susceptibility factor for iron-overload in Egyptian beta-thalassemia patients. Egyptian Journal of Medical Human Genetics 19:2, pages 103-106.
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Laila M. Sherief, Osama Dawood, Adel Ali, Hanan S. Sherbiny, Naglaa M. Kamal, Mohamed Elshanshory, Osama Abd Alazez, Mohamed Abd Alhady, Mohamed Nour & Wesam A. Mokhtar. (2017) Premature atherosclerosis in children with beta-thalassemia major: New diagnostic marker. BMC Pediatrics 17:1.
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MostafaA.S Salama, MahaY Kamal, DorenN.A Younan & GehadA.A Henish. (2017) Hypochromic microcytic anemia: a clincopathological cross-sectional study. Alexandria Journal of Pediatrics 30:1, pages 37.
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AHMED AL-AKHRAS, MOHAMED BADR, USAMA EL-SAFY, ELISABETH KOHNE, TAMER HASSAN, HADEEL ABDELRAHMAN, MOHAMED MOURAD, JOAQUIN BRINTRUP & MARWA ZAKARIA. (2016) Impact of genotype on endocrinal complications in β-thalassemia patients. Biomedical Reports 4:6, pages 728-736.
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N. EL-Fadaly, A. Abd-Elhameed, E. Abd-Elbar & M. El-Shanshory. (2015) Accuracy of Reverse Dot-Blot PCR in Detection of Different β-Globin Gene Mutations. Indian Journal of Hematology and Blood Transfusion 32:2, pages 239-243.
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Mohamed Abo El-Asrar, Nancy Samir Elbarbary, Eman Abdel Rahman Ismail & Ahmed Mohamed Elshenity. (2016) Serum YKL-40 in young patients with β-thalassemia major: Relation to hepatitis C virus infection, liver stiffness by transient elastography and cardiovascular complications. Blood Cells, Molecules, and Diseases 56:1, pages 1-8.
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Manal Michel Wilson, Hanan Al-Wakeel, Fadwa Said, Mona El-Ghamrawy, Mary Assaad & Amal El-Beshlawy. (2015) Study of the effect of HFE gene mutations on iron overload in Egyptian thalassemia patients. Egyptian Journal of Medical Human Genetics 16:2, pages 129-133.
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Ammar D. Elmezayen, Samia M. Kotb, Nadia A. Sadek & Ebtesam M. Abdalla. (2015) β-Globin Mutations in Egyptian Patients With β-Thalassemia. Laboratory Medicine 46:1, pages 8-13.
Crossref
Sherry Sze Yee Ho, Pei Tee Huan, Gek Har Leow, Leng Kee Ching, Lily Chiu, Hai Yang Law & Evelyn S. C. Koay. (2013) Rapid prenatal diagnosis of common beta‐thalassemia mutations in Southeast Asia using pyrosequencing. Prenatal Diagnosis 33:11, pages 1017-1022.
Crossref
Hanan A. Hamamy & Nasir A. S. Al-Allawi. (2012) Epidemiological profile of common haemoglobinopathies in Arab countries. Journal of Community Genetics 4:2, pages 147-167.
Crossref
G. Christopoulos, G.M. Ezzat & M. Kleanthous. (2012) Use of denaturing gradient gel electrophoresis in screening unknown β-thalassemia mutations in Egyptian patients. Egyptian Journal of Medical Human Genetics 13:3, pages 343-349.
Crossref
Rabah M. Shawky & Tarek M. Kamal. (2012) Thalassemia intermedia: An overview. Egyptian Journal of Medical Human Genetics 13:3, pages 245-255.
Crossref
A. El‐Beshlawy, A. El‐Shekha, M. Momtaz, F. Said, M. Hamdy, O. Osman, S. Meshaal, T. Gafaar & M. Petrou. (2012) Prenatal diagnosis for thalassaemia in Egypt: what changed parents' attitude?. Prenatal Diagnosis 32:8, pages 777-782.
Crossref
Rabah M. Shawky, Nermine S. Elsayed, Doaa S. Ibrahim & Neveen S. Seifeldin. (2012) Profile of genetic disorders prevalent in northeast region of Cairo, Egypt. Egyptian Journal of Medical Human Genetics 13:1, pages 45-62.
Crossref
Samia Temtamy & Mona Aglan. (2012) Consanguinity and genetic disorders in Egypt. Middle East Journal of Medical Genetics 1:1, pages 12-17.
Crossref
Johnson Kian-Kok Ng, Wen Wang, Wen-Tso Liu & Samuel S. Chong. (2010) Spatially addressable bead-based biosensor for rapid detection of beta-thalassemia mutations. Analytica Chimica Acta 658:2, pages 193-196.
Crossref
Samia A. Temtamy, Mona S. Aglan & Nagwa A. Meguid. 2010. Genetic Disorders Among Arab Populations. Genetic Disorders Among Arab Populations 219 272 .

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