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Research Article

Development of Fast-Dissolving Tablets of Flurbiprofen-Cyclodextrin Complexes

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Pages 697-707 | Published online: 26 Sep 2008

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Nermin M. Sheta, Sylvia A. Boshra, Mohamed A. Mamdouh & Khaled M. Abdel-Haleem. (2022) Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats. Drug Delivery 29:1, pages 1299-1311.
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Han-Bing Wang, Fei-Fei Yang, Xiu-Mei Gai, Bing-Chao Cheng, Jin-Yu Li, Hao Pan, Xing-Gang Yang & Wei-San Pan. (2017) A pH-independent instantaneous release of flurbiprofen: a study of the preparation of complexes, their characterization and in vitro/in vivo evaluation. Drug Development and Industrial Pharmacy 43:9, pages 1460-1471.
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Tansel Comoglu & Burcu Unal. (2015) Preparation and evaluation of an orally fast disintegrating tablet formulation containing a hydrophobic drug. Pharmaceutical Development and Technology 20:1, pages 60-64.
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Jie Xie, Fan Yang, Xiangjun Shi, Xingyi Zhu, Weike Su & Ping Wang. (2013) Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. Drug Development and Industrial Pharmacy 39:6, pages 826-835.
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Articles from other publishers (31)

Heybet Kerem Polat, Aslıhan Arslan, Sedat Ünal, Muhammet Kerim Haydar, Eren Aytekin, Sefa Gözcü, Nasıf Fatih Karakuyu & Behzad Mokhtare. (2023) Formulation Development of Dual Drug-Loaded Thermosensitive Ocular In Situ Gel Using Factorial Design. Journal of Pharmaceutical Innovation 18:2, pages 768-788.
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Ji Yu, Jin Xie, Huijuan Xie, Qi Hu, Zhenfeng Wu, Xinfu Cai, Zhiping Guo, Junzhi Lin, Li Han & Dingkun Zhang. (2022) Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception. Molecular Pharmaceutics 19:9, pages 3007-3025.
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Sarah El Masri, Steven Ruellan, Maha Zakhour, Lizette Auezova & Sophie Fourmentin. (2022) Cyclodextrin-based low melting mixtures as a solubilizing vehicle: Application to non-steroidal anti-inflammatory drugs. Journal of Molecular Liquids 353, pages 118827.
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Jyi Jun Liw, Xin-Yi Teoh, Angela Xing Yee Teoh & Siok-Yee Chan. (2022) The Effect of Carrier-Drug Ratios on Dissolution Performances of Poorly Soluble Drug in Crystalline Solid Dispersion System. Journal of Pharmaceutical Sciences 111:1, pages 95-101.
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Aliaa Nabil ElMeshad, Khaled M. Abdel-Haleem, Nabaweya A. Abdel Gawad, Mohamed Ahmed El-Nabarawi & Nermin M. Sheta. (2020) Core in Cup Ethylmorphine Hydrochloride Tablet for Dual Fast and Sustained Pain Relief: Formulation, Characterization, and Pharmacokinetic Study. AAPS PharmSciTech 21:7.
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F.G. Senjoti, P. Timmins, B.R. Conway & A.M. Smith. (2020) Optimizing ophthalmic delivery of a poorly water soluble drug from an aqueous in situ gelling system. European Journal of Pharmaceutics and Biopharmaceutics 154, pages 1-7.
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Caroline Deckmann Nicoletti, Marcella de Sá Haddad Queiroz, Carolina Guimarães de Souza Lima, Fernando de Carvalho da Silva, Debora Omena Futuro & Vitor Francisco Ferreira. (2020) An improved method for the preparation of β-lapachone:2-hydroxypropyl-β-cyclodextrin inclusion complexes. Journal of Drug Delivery Science and Technology 58, pages 101777.
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Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed & Khalid M. El-Say. (2019) Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation. Pharmaceutics 11:1, pages 11.
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Sarah Reiser, Miaotian Sun, Monika Johannsen & Michael Türk. (2018) Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen. The Journal of Supercritical Fluids 132, pages 91-98.
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. 2016. Bio-Targets and Drug Delivery Approaches. Bio-Targets and Drug Delivery Approaches 437 457 .
Natascia Mennini, Francesca Maestrelli, Marzia Cirri & Paola Mura. (2016) Analysis of physicochemical properties of ternary systems of oxaprozin with randomly methylated-ß-cyclodextrin and l -arginine aimed to improve the drug solubility. Journal of Pharmaceutical and Biomedical Analysis 129, pages 350-358.
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Shashi Ravi Suman Rudrangi, Waseem Kaialy, Muhammad U. Ghori, Vivek Trivedi, Martin J. Snowden & Bruce David Alexander. (2016) Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process. European Journal of Pharmaceutics and Biopharmaceutics 104, pages 164-170.
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Francesca Maestrelli, Marco Bragagni & Paola Mura. (2016) Advanced formulations for improving therapies with anti-inflammatory or anaesthetic drugs: A review. Journal of Drug Delivery Science and Technology 32, pages 192-205.
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Shashi Ravi Suman Rudrangi, Vivek Trivedi, John C. Mitchell, Stephen Richard Wicks & Bruce David Alexander. (2015) Preparation of olanzapine and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the solubility and dissolution properties. International Journal of Pharmaceutics 494:1, pages 408-416.
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Sanjay Dey, Sankha Chattopadhyay & Bhaskar Mazumder. (2014) Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release. BioMed Research International 2014, pages 1-12.
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Fan Zeng, Ling Wang, Wenjing Zhang, Kejing Shi & Li Zong. (2013) Formulation and In Vivo Evaluation of Orally Disintegrating Tablets of Clozapine/Hydroxypropyl-β-cyclodextrin Inclusion Complexes. AAPS PharmSciTech 14:2, pages 854-860.
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P. J. Salústio, J. F. Pinto, P. C. Costa & H. M. Cabral-Marques. (2012) Release profiles of indometacin in β-cyclodextrin complexes from HPMC capsules. Journal of Inclusion Phenomena and Macrocyclic Chemistry 75:1-2, pages 101-109.
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H. O. Ammar, M. Ghorab, A. A. Mahmoud, T. S. Makram & S. H. Noshi. (2011) Topical liquid crystalline gel containing lornoxicam/cyclodextrin complex. Journal of Inclusion Phenomena and Macrocyclic Chemistry 73:1-4, pages 161-175.
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P.J. Salústio, G. Feio, J.L. Figueirinhas, H.M. Cabral-Marques, P.C. Costa & J.F. Pinto. (2012) Release profile of ibuprofen in β-cyclodextrin complexes from two different solid dosage forms. Powder Technology 221, pages 245-251.
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Hong-Liang Lin, Shan-Yang Lin, Chih-Cheng Lin, Cheng-Hung Hsu, Tieh-Kang Wu & Yu-Ting Huang. (2012) Mechanical grinding effect on thermodynamics and inclusion efficiency of loratadine–cyclodextrin inclusion complex formation. Carbohydrate Polymers 87:1, pages 512-517.
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José Lamartine Soares-Sobrinho, Monica Felts de La Roca Soares, Pedro José Rolim-Neto & Juan J. Torres-Labandeira. (2010) Physicochemical study of solid-state benznidazole–cyclodextrin complexes. Journal of Thermal Analysis and Calorimetry 106:2, pages 319-325.
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P.J. Sal?stio, H.M. Cabral-Marques, P.C. Costa & J.F. Pinto. (2011) Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: ?-Cyclodextrin complex. European Journal of Pharmaceutics and Biopharmaceutics 78:1, pages 58-66.
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Kenjirou Higashi, Saori Ideura, Haruka Waraya, Kunikazu Moribe & Keiji Yamamoto. (2011) Structural Evaluation of Crystalline Ternary γ-Cyclodextrin Complex. Journal of Pharmaceutical Sciences 100:1, pages 325-333.
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Eman Atef, Harsh Chauhan, Michelle Ceresia & Charles Pidgeon. (2010) Using Raman spectroscopy in tablet moisture surface analysis: Tablet surface markers. Journal of Pharmaceutical and Biomedical Analysis 53:4, pages 852-859.
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Yassin El-Said Hamza & Mona Hassan Aburahma. (2009) Design and In Vitro Evaluation of Novel Sustained-Release Double-Layer Tablets of Lornoxicam: Utility of Cyclodextrin and Xanthan Gum Combination. AAPS PharmSciTech 10:4.
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Yan-Mei Liu, Gang-Yi Liu, Yun Liu, Shui-Jun Li, Jing-Ying Jia, Meng-Qi Zhang, Chuan Lu, Yong-Mei Zhang, Xue-Ning Li & Chen Yu. (2009) Pharmacokinetic and bioequivalence comparison between orally disintegrating and conventional tablet formulations of flurbiprofen: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy chinese male volunteers. Clinical Therapeutics 31:8, pages 1787-1795.
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Jin-Ki Kim, Myung-Sun Kim, Jeong-Sook Park & Chong-Kook Kim. (2009) Thermo-reversible flurbiprofen liquid suppository with HP-β-CD as a solubility enhancer: improvement of rectal bioavailability. Journal of Inclusion Phenomena and Macrocyclic Chemistry 64:3-4, pages 265-272.
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Shaimaa M. Badr-Eldin, Seham A. Elkheshen & Mahmoud M. Ghorab. (2008) Inclusion complexes of tadalafil with natural and chemically modified β-cyclodextrins. I: Preparation and in-vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics 70:3, pages 819-827.
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Amber Vyas, Shailendra Saraf & Swarnlata Saraf. (2008) Cyclodextrin based novel drug delivery systems. Journal of Inclusion Phenomena and Macrocyclic Chemistry 62:1-2, pages 23-42.
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Marcílio S. S. Cunha-Filho, Bruno Dacunha-Marinho, Juan J. Torres-Labandeira, Ramón Martínez-Pacheco & Mariana Landin. (2007) Characterization of β-lapachone and methylated β-cyclodextrin solid-state systems. AAPS PharmSciTech 8:3, pages E68-E77.
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Ali Al-Marzouqi, Baboucarr Jobe, Giovanna Corti, Marzia Cirri & Paola Mura. (2007) Physicochemical characterization of drug-cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques. Journal of Inclusion Phenomena and Macrocyclic Chemistry 57:1-4, pages 223-231.
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