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Research Article

Continued Investigation Into the Influence of Loaded Dose on the Performance of Dry Powder Inhalers: Surface Smoothing Effects

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Pages 1135-1138 | Published online: 25 Sep 2008

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Saurabh Sarkar, Bruna Minatovicz, Kyrre Thalberg & Bodhisattwa Chaudhuri. (2017) Mechanistic investigation of mixing and segregation of ordered mixtures: experiments and numerical simulations. Drug Development and Industrial Pharmacy 43:10, pages 1677-1685.
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Eva Maria Littringer, Axel Mescher, Susanna Eckhard, Hartmuth Schröttner, Christoph Langes, Manfred Fries, Ulrich Griesser, Peter Walzel & Nora Anne Urbanetz. (2012) Spray Drying of Mannitol as a Drug Carrier—The Impact of Process Parameters on Product Properties. Drying Technology 30:1, pages 114-124.
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Susan Hoe, Paul M. Young & Daniela Traini. (2011) Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler®. Drug Development and Industrial Pharmacy 37:11, pages 1365-1375.
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Cai Y. Ma, Thai T. H. Nguyen, Parmesh Gajjar, Ioanna D. Styliari, Robert B. HammondPhilip J. WithersDarragh MurnaneKevin J. Roberts. (2023) Predicting the Strength of Cohesive and Adhesive Interparticle Interactions for Dry Powder Inhalation Blends of Terbutaline Sulfate with α-Lactose Monohydrate. Molecular Pharmaceutics.
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Jiayi Li, Sibo Ma, Xianhong He, Ying Sun, Xin Zhang, Jian Guan & Shirui Mao. (2023) Exploring the influence of magnesium stearate content and mixing modality on the rheological properties and in vitro aerosolization of dry powder inhaler. International Journal of Pharmaceutics 642, pages 123179.
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Tingting Liu, Shiqing Tong, Qianqian Liao, Li Pan, Maosheng Cheng, Jukka Rantanen, Dongmei Cun & Mingshi Yang. (2023) Role of dispersion enhancer selection in the development of novel tratinterol hydrochloride dry powder inhalation formulations. International Journal of Pharmaceutics 635, pages 122702.
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Ying Sun, Duo Yu, Jiayi Li, Jianan Zhao, Yu Feng, Xin Zhang & Shirui Mao. (2022) Elucidation of lactose fine size and drug shape on rheological properties and aerodynamic behavior of dry powders for inhalation. European Journal of Pharmaceutics and Biopharmaceutics 179, pages 47-57.
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Ying Sun, Lu Qin, Jiayi Li, Jian Su, Ruxiao Song, Xin Zhang, Jian Guan & Shirui Mao. (2021) Elucidating the Effect of Fine Lactose Ratio on the Rheological Properties and Aerodynamic Behavior of Dry Powder for Inhalation. The AAPS Journal 23:3.
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P. Gajjar, I.D. Styliari, T.T.H. Nguyen, J. Carr, X. Chen, J.A. Elliott, R.B. Hammond, T.L. Burnett, K. Roberts, P.J. Withers & D. Murnane. (2020) 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches. European Journal of Pharmaceutics and Biopharmaceutics 151, pages 32-44.
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Mohammad A. M. Momin, Bhamini Rangnekar, Shubhra Sinha, Chen-Yi Cheung, Gregory M. Cook & Shyamal C. Das. (2019) Inhalable Dry Powder of Bedaquiline for Pulmonary Tuberculosis: In Vitro Physicochemical Characterization, Antimicrobial Activity and Safety Studies. Pharmaceutics 11:10, pages 502.
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Bhamini Rangnekar, Mohammad A.M. Momin, Basanth Babu Eedara, Shubhra Sinha & Shyamal C. Das. (2019) Bedaquiline containing triple combination powder for inhalation to treat drug-resistant tuberculosis. International Journal of Pharmaceutics 570, pages 118689.
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Mohammad A.M. Momin, Ian G. Tucker & Shyamal C. Das. (2018) High dose dry powder inhalers to overcome the challenges of tuberculosis treatment. International Journal of Pharmaceutics 550:1-2, pages 398-417.
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Bernice Mei Jin Tan, Lai Wah Chan & Paul Wan Sia Heng. (2018) Characterizing the Surface Roughness Length Scales of Lactose Carrier Particles in Dry Powder Inhalers. Molecular Pharmaceutics 15:4, pages 1635-1642.
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Ahmed O. Shalash & Mustafa M. A. Elsayed. (2017) A New Role of Fine Excipient Materials in Carrier-Based Dry Powder Inhalation Mixtures: Effect on Deagglomeration of Drug Particles During Mixing Revealed. AAPS PharmSciTech 18:8, pages 2862-2870.
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Niklas Renner, Hartwig Steckel, Nora Urbanetz & Regina Scherließ. (2017) Nano- and Microstructured model carrier surfaces to alter dry powder inhaler performance. International Journal of Pharmaceutics 518:1-2, pages 20-28.
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Waseem Kaialy. (2016) On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review. Advances in Colloid and Interface Science 235, pages 70-89.
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Alice Simon, Maria Inês Amaro, Lucio Mendes Cabral, Anne Marie Healy & Valeria Pereira de Sousa. (2016) Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate. International Journal of Pharmaceutics 501:1-2, pages 124-138.
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Bernice Mei Jin Tan, Celine Valeria Liew, Lai Wah Chan & Paul Wan Sia Heng. 2015. Pulmonary Drug Delivery. Pulmonary Drug Delivery 199 222 .
Eva Faulhammer, Verena Wahl, Sarah Zellnitz, Johannes G. Khinast & Amrit Paudel. (2015) Carrier-based dry powder inhalation: Impact of carrier modification on capsule filling processability and in vitro aerodynamic performance. International Journal of Pharmaceutics 491:1-2, pages 231-242.
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Hanne Kinnunen, Gerald Hebbink, Harry Peters, Deborah Huck, Lisa Makein & Robert Price. (2015) Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition. International Journal of Pharmaceutics 478:1, pages 53-59.
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Sarah Zellnitz, Hartmuth Schroettner & Nora Anne Urbanetz. (2014) Surface modified glass beads as model carriers in dry powder inhalers—Influence of drug load on the fine particle fraction. Powder Technology 268, pages 377-386.
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M. Hoppentocht, P. Hagedoorn, H.W. Frijlink & A.H. de Boer. (2014) Technological and practical challenges of dry powder inhalers and formulations. Advanced Drug Delivery Reviews 75, pages 18-31.
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Eva M. Littringer, Michael F. Noisternig, Axel Mescher, Hartmuth Schroettner, Peter Walzel, Ulrich J. Griesser & Nora A. Urbanetz. (2013) The morphology and various densities of spray dried mannitol. Powder Technology 246, pages 193-200.
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E.M. Littringer, R. Paus, A. Mescher, H. Schroettner, P. Walzel & N.A. Urbanetz. (2013) The morphology of spray dried mannitol particles — The vital importance of droplet size. Powder Technology 239, pages 162-174.
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Daniela Traini & Paul M. Young. 2013. Inhalation Drug Delivery. Inhalation Drug Delivery 31 45 .
E.M. Littringer, A. Mescher, H. Schroettner, L. Achelis, P. Walzel & N.A. Urbanetz. (2012) Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape. European Journal of Pharmaceutics and Biopharmaceutics 82:1, pages 194-204.
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Gabrielle Pilcer, Nathalie Wauthoz & Karim Amighi. (2012) Lactose characteristics and the generation of the aerosol. Advanced Drug Delivery Reviews 64:3, pages 233-256.
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Stephan G. Maas, Gerhard Schaldach, Eva M. Littringer, Axel Mescher, Ulrich J. Griesser, Doris E. Braun, Peter E. Walzel & Nora A. Urbanetz. (2011) The impact of spray drying outlet temperature on the particle morphology of mannitol. Powder Technology 213:1-3, pages 27-35.
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Paul M. Young, Owen Wood, Jesslynn Ooi & Daniela Traini. (2011) The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers. International Journal of Pharmaceutics 416:1, pages 129-135.
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Paul M. Young, Philip Kwok, Handoko Adi, Hak-Kim Chan & Daniela Traini. (2008) Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research 26:4, pages 802-810.
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Natalja Genina, Heikki Räikkönen, Jyrki Heinämäki, Osmo Antikainen, Simo Siiriä, Peep Veski & Jouko Yliruusi. (2009) Effective Modification of Particle Surface Properties Using Ultrasonic Water Mist. AAPS PharmSciTech 10:1, pages 282-288.
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Handoko Adi, Ian Larson, Herbert Chiou, Paul Young, Daniela Traini & Peter Stewart. (2008) Role of Agglomeration in the Dispersion of Salmeterol Xinafoate from Mixtures for Inhalation with Differing Drug to Fine Lactose Ratios. Journal of Pharmaceutical Sciences 97:8, pages 3140-3152.
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Paul M. Young, Doreen Roberts, Herbert Chiou, William Rae, Hak-Kim Chan & Daniela Traini. (2008) Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science 39:1, pages 82-93.
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Tingting Liu, Shiqing Tong, Qianqian Liao, Li Pan, Maosheng Cheng, Jukka Rantanen, Dongmei Cun & Mingshi Yang. (2022) Role of Dispersion Enhancer Selection in the Development of Novel Tratinterol Hydrochloride Dry Powder Inhalation Formulations. SSRN Electronic Journal.
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