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Research Article

Formulation and In Vivo Evaluation of Self-Nanoemulsifying Granules for Oral Delivery of a Combination of Ezetimibe and Simvastatin

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Pages 1285-1296 | Published online: 20 Oct 2008

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Meraj Alam, Shakeeb Ahmed, Nikita  , Goldie Moon, Mohd. Aqil & Yasmin Sultana. (2018) Chemical engineering of a lipid nano-scaffold for the solubility enhancement of an antihyperlipidaemic drug, simvastatin; preparation, optimization, physicochemical characterization and pharmacodynamic study. Artificial Cells, Nanomedicine, and Biotechnology 46:8, pages 1908-1919.
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Kritika Sharma, Kulyash Kumar & Neeraj Mishra. (2016) Nanoparticulate carrier system: a novel treatment approach for hyperlipidemia. Drug Delivery 23:3, pages 684-699.
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Faiyaz Shakeel, Nazrul Haq, Fars K. Alanazi & Ibrahim A. Alsarra. (2014) Thermodynamic modeling for solubility prediction of indomethacin in self-nanoemulsifying drug delivery system (SNEDDS) and its individual components. Drug Development and Industrial Pharmacy 40:9, pages 1240-1245.
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Sandip S. Chavhan, Kailash C. Petkar & Krutika K. Sawant. (2013) Simvastatin nanoemulsion for improved oral delivery: design, characterisation, in vitro and in vivo studies. Journal of Microencapsulation 30:8, pages 771-779.
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Fady Ibrahim, Pavel Gershkovich, Olena Sivak, Ellen K. Wasan & Kishor M. Wasan. (2013) Pharmacokinetics and tissue distribution of amphotericin B following oral administration of three lipid-based formulations to rats. Drug Development and Industrial Pharmacy 39:9, pages 1277-1283.
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Shan Ren, Huiling Mu, Fadi Alchaer, Azeddine Chtatou & Anette Müllertz. (2013) Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology. Drug Development and Industrial Pharmacy 39:5, pages 799-806.
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André B. da Fonseca Antunes, Bruno G. De Geest, Chris Vervaet & Jean Paul Remon. (2013) Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs. Drug Development and Industrial Pharmacy 39:5, pages 791-798.
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Amrita Bajaj, Monica R. P. Rao, Ishwar Khole & Ghansham Munjapara. (2013) Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate. Drug Development and Industrial Pharmacy 39:5, pages 635-645.
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Vikas Bali, Mushir Ali & Javed Ali. (2010) Novel nanoemulsion for minimizing variations in bioavailability of ezetimibe. Journal of Drug Targeting 18:7, pages 506-519.
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Seitaro Kamiya, Takurou Kurita, Atsuo Miyagishima & Masayuki Arakawa. (2009) Preparation of griseofulvin nanoparticle suspension by high-pressure homogenization and preservation of the suspension with saccharides and sugar alcohols. Drug Development and Industrial Pharmacy 35:8, pages 1022-1028.
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Barbara Sterle Zorec, Špela Zupančič, Zoran Lavrič & Rok Dreu. (2021) Particle properties and drug metastable solubility of simvastatin containing PVP matrix particles prepared by electrospraying technique. European Journal of Pharmaceutical Sciences 158, pages 105649.
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Mona F. Arafa, Rasha A. Alshaikh, Magdy M. Abdelquader & Gamal M. El Maghraby. (2021) Co-processing of Atorvastatin and Ezetimibe for Enhanced Dissolution Rate: In Vitro and In Vivo Correlation. AAPS PharmSciTech 22:2.
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Kruti Borderwala, Ganesh Swain, Namrata Mange, Jaimini Gandhi, Manisha Lalan, Gautam Singhvi & Pranav Shah. (2020) Optimization of Solid Lipid Nanoparticles of Ezetimibe in Combination with Simvastatin Using Quality by Design (QbD). Nanoscience & Nanotechnology-Asia 10:4, pages 404-418.
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Ganesh Shevalkar & Pradeep Vavia. (2019) Solidified nanostructured lipid carrier (S-NLC) for enhancing the oral bioavailability of ezetimibe. Journal of Drug Delivery Science and Technology 53, pages 101211.
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Sarwar Beg, O.P. Katare & Bhupinder Singh. (2017) Formulation by design approach for development of ultrafine self-nanoemulsifying systems of rosuvastatin calcium containing long-chain lipophiles for hyperlipidemia management. Colloids and Surfaces B: Biointerfaces 159, pages 869-879.
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Bhupinder Singh, Babita Garg, Ranjot Kaur, Atul Jain, Rajendra Kumar & O P Katare. 2016. Fabrication and Self-Assembly of Nanobiomaterials. Fabrication and Self-Assembly of Nanobiomaterials 91 115 .
Rehmana Rashid, Dong Wuk Kim, Fakhar ud Din, Omer Mustapha, Abid Mehmood Yousaf, Jong Hyuck Park, Jong Oh Kim, Chul Soon Yong & Han-Gon Choi. (2015) Effect of hydroxypropylcellulose and Tween 80 on physicochemical properties and bioavailability of ezetimibe-loaded solid dispersion. Carbohydrate Polymers 130, pages 26-31.
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Gamaleldin I. Harisa & Mohamed M. Badran. (2015) Simvastatin nanolipid carriers decreased hypercholesterolemia induced cholesterol inclusion and phosphatidylserine exposure on human erythrocytes. Journal of Molecular Liquids 208, pages 202-210.
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Mangal S. Nagarsenker, Ankitkumar S. Jain & Sanket M. Shah. 2015. Targeted Drug Delivery : Concepts and Design. Targeted Drug Delivery : Concepts and Design 411 431 .
Shasha Rao, Angel Tan, Nicky Thomas & Clive A. Prestidge. (2014) Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases. Journal of Controlled Release 193, pages 174-187.
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N. S. Desai & M. S. Nagarsenker. (2013) Design and Evaluation of Self-Nanoemulsifying Pellets of Repaglinide. AAPS PharmSciTech 14:3, pages 994-1003.
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Huiling Mu, René Holm & Anette Müllertz. (2013) Lipid-based formulations for oral administration of poorly water-soluble drugs. International Journal of Pharmaceutics 453:1, pages 215-224.
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Shantanu Bandyopadhyay, O.P. Katare & Bhupinder Singh. (2012) Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides. Colloids and Surfaces B: Biointerfaces 100, pages 50-61.
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Haibing He, Bo Shi, Cuifang Cai & Xing Tang. (2011) Preparation of lovastatin matrix sustained-release pellets by extrusion-spheronization combined with microcrystal dispersion technique. Archives of Pharmacal Research 34:11, pages 1931-1938.
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Jyoti Wadhwa, Anroop Nair & Rachna Kumria. (2011) Self-emulsifying therapeutic system: a potential approach for delivery of lipophilic drugs. Brazilian Journal of Pharmaceutical Sciences 47:3, pages 447-465.
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Radheshyam Tiwari & Kamla Pathak. (2011) Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: Comparative analysis of characteristics, pharmacokinetics and tissue uptake. International Journal of Pharmaceutics 415:1-2, pages 232-243.
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Radheshyam Tiwari & Kamla Pathak. (2011) Statins therapy: a review on conventional and novel formulation approaches. Journal of Pharmacy and Pharmacology 63:8, pages 983-998.
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Vikas Bali, Mushir Ali & Javed Ali. (2011) Nanocarrier for the enhanced bioavailability of a cardiovascular agent: In vitro, pharmacodynamic, pharmacokinetic and stability assessment. International Journal of Pharmaceutics 403:1-2, pages 46-56.
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Abhijit A Date, Neha Desai, Rahul Dixit & Mangal Nagarsenker. (2010) Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine 5:10, pages 1595-1616.
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Rahul P. Dixit & Mangal S. Nagarsenker. (2010) Optimized Microemulsions and Solid microemulsion Systems of Simvastatin: Characterization and In Vivo Evaluation. Journal of Pharmaceutical Sciences 99:12, pages 4892-4902.
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Vikas Bali, Mushir Ali & Javed Ali. (2010) Study of surfactant combinations and development of a novel nanoemulsion for minimising variations in bioavailability of ezetimibe. Colloids and Surfaces B: Biointerfaces 76:2, pages 410-420.
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