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Drug Development and Industrial Pharmacy Volume 35, 2009 - Issue 9
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Original Article

Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats

Alexei Merzlikine Department of Pharmaceutical Sciences, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
Charles Rotter Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
Brian Rago Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
Julie Poe Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
Curt Christoffersen Department of CNS Biology, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
V. Hayden Thomas Department of Pharmaceutical Sciences, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
,
Matthew Troutman Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USA
&
Ayman El-Kattan Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, CT, USACorrespondence[email protected]
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Pages 1082-1091 | Received 11 Nov 2008, Accepted 24 Jan 2009, Published online: 05 Oct 2009

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Fan Yu, Chenghua He, Ayman Y. Waddad, Were L. L. Munyendo, Huixia Lv, Jianping Zhou & Qiang Zhang. (2014) N-octyl-N-arginine-chitosan (OACS) micelles for gambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion. Drug Development and Industrial Pharmacy 40:6, pages 774-782.
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Xin Jin, Zhen-Hai Zhang, E. Sun, Xiao-Bin Tan, Fen-Xia Zhu & Xiao-Bin Jia. (2013) A novel drug–phospholipid complex loaded micelle for baohuoside I enhanced oral absorption: in vivo and in vivo evaluations. Drug Development and Industrial Pharmacy 39:9, pages 1421-1430.
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Qinghua Yu, Zhisheng Wang, Pengcheng Li & Qian Yang. (2013) The effect of various absorption enhancers on tight junction in the human intestinal Caco-2 cell line. Drug Development and Industrial Pharmacy 39:4, pages 587-592.
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Articles from other publishers (17)

Mauricio A. García, Gönül Hensler, Jozef Al-Gousous, Jonas Pielenhofer, Manfred Wagner, Hans Lennernäs & Peter Langguth. (2023) Novel food drug interaction mechanism involving acyclovir, chitosan and endogenous mucus. Drug Metabolism and Pharmacokinetics 49, pages 100491.
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Guihua Fang & Bo Tang. (2020) Advanced delivery strategies facilitating oral absorption of heparins. Asian Journal of Pharmaceutical Sciences 15:4, pages 449-460.
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Marlies Kubbinga, Patrick Augustijns, Mauricio A. García, Christian Heinen, Heleen M. Wortelboer, Miriam Verwei & Peter Langguth. (2019) The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir. European Journal of Pharmaceutics and Biopharmaceutics 136, pages 147-155.
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André Dagenais, Julie Desjardins, Waheed Shabbir, Antoine Roy, Dominic Filion, Rémy Sauvé & Yves Berthiaume. (2018) Loss of barrier integrity in alveolar epithelial cells downregulates ENaC expression and activity via Ca2+ and TRPV4 activation. Pflügers Archiv - European Journal of Physiology 470:11, pages 1615-1631.
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Ayman F. El-Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 331 346 .
Ayman F. El-Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 139 171 .
Ayman F. El-Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 357 376 .
Rebecca L. DiMarco, Daniel R. Hunt, Ruby E. Dewi & Sarah C. Heilshorn. (2017) Improvement of paracellular transport in the Caco-2 drug screening model using protein-engineered substrates. Biomaterials 129, pages 152-162.
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Ying LI, Yun ZHANG & Chun-Yan ZHU. (2017) Pharmacokinetics and correlation between in vitro release and in vivo absorption of bio-adhesive pellets of panax notoginseng saponins. Chinese Journal of Natural Medicines 15:2, pages 142-151.
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Muge Ates, Mustafa Sinan Kaynak & Selma Sahin. (2016) Effect of permeability enhancers on paracellular permeability of acyclovir. Journal of Pharmacy and Pharmacology 68:6, pages 781-790.
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Nuggehally R. Srinivas. (2015) The Interesting Case of Acyclovir Delivered Using Chitosan in Humans: Is it a Drug Issue or Formulation Issue?. Pharmaceutical Research 33:3, pages 543-547.
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Viviane Nart, Maria Terezinha França, Daiane Anzilaggo, Manoela Klüppel Riekes, Jadel Müller Kratz, Carlos Eduardo Maduro de Campos, Cláudia Maria Oliveira Simões & Hellen Karine Stulzer. (2015) Ball-milled solid dispersions of BCS Class IV drugs: Impact on the dissolution rate and intestinal permeability of acyclovir. Materials Science and Engineering: C 53, pages 229-238.
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Marlies Kubbinga, Mai Anh Nguyen, Petra Staubach, Steven Teerenstra & Peter Langguth. (2015) The Influence of Chitosan on the Oral Bioavailability of Acyclovir—a Comparative Bioavailability Study in Humans. Pharmaceutical Research 32:7, pages 2241-2249.
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Yuko Goto, Ayumi Masuda & Tetsuya Aiba. (2015) In vivo application of chitosan to improve bioavailability of cyanocobalamin, a form of vitamin B12, following intraintestinal administration in rats. International Journal of Pharmaceutics 483:1-2, pages 250-255.
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Elenaz Naderkhani, Astrid Erber, Nataša Škalko-Basnet & Gøril Eide Flaten. (2014) Improved Permeability of Acyclovir: Optimization of Mucoadhesive Liposomes Using the Phospholipid Vesicle-Based Permeation Assay. Journal of Pharmaceutical Sciences 103:2, pages 661-668.
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Yusuke Takizawa, Hisanao Kishimoto, Minami Nakagawa, Nasa Sakamoto, Yoshifusa Tobe, Takahito Furuya, Mikio Tomita & Masahiro Hayashi. (2013) Effects of pharmaceutical excipients on membrane permeability in rat small intestine. International Journal of Pharmaceutics 453:2, pages 363-370.
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Ayumi Masuda, Yuko Goto, Yuji Kurosaki & Tetsuya Aiba. (2012) In vivo Application of Chitosan to Facilitate Intestinal Acyclovir Absorption in Rats. Journal of Pharmaceutical Sciences 101:7, pages 2449-2456.
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